LOCUS       NM_009756               1325 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus bone morphogenetic protein 10 (Bmp10), mRNA.
ACCESSION   NM_009756
VERSION     NM_009756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1325)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 1325)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   3  (bases 1 to 1325)
  AUTHORS   Li,H., Tang,Q., Yang,T., Wang,Z., Li,D., Wang,L., Li,L., Chen,Y.,
            Huang,H., Zhang,Y. and Chen,Y.
  TITLE     Segregation of morphogenetic regulatory function of Shox2 from its
            cell fate guardian role in sinoatrial node development
  JOURNAL   Commun Biol 7 (1), 385 (2024)
   PUBMED   38553636
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1325)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1325)
  AUTHORS   Fiore,R., Rahim,B., Christoffels,V.M., Moorman,A.F. and
            Puschel,A.W.
  TITLE     Inactivation of the Sema5a gene results in embryonic lethality and
            defective remodeling of the cranial vascular system
  JOURNAL   Mol Cell Biol 25 (6), 2310-2319 (2005)
   PUBMED   15743826
  REMARK    Erratum:[Mol Cell Biol. 2020 Sep 28;40(20):e00409-20. doi:
            10.1128/MCB.00409-20.. PMID: 32989048]
REFERENCE   6  (bases 1 to 1325)
  AUTHORS   Kang,J.O. and Sucov,H.M.
  TITLE     Convergent proliferative response and divergent morphogenic
            pathways induced by epicardial and endocardial signaling in fetal
            heart development
  JOURNAL   Mech Dev 122 (1), 57-65 (2005)
   PUBMED   15582777
REFERENCE   7  (bases 1 to 1325)
  AUTHORS   Lickert,H., Takeuchi,J.K., Von Both,I., Walls,J.R., McAuliffe,F.,
            Adamson,S.L., Henkelman,R.M., Wrana,J.L., Rossant,J. and
            Bruneau,B.G.
  TITLE     Baf60c is essential for function of BAF chromatin remodelling
            complexes in heart development
  JOURNAL   Nature 432 (7013), 107-112 (2004)
   PUBMED   15525990
REFERENCE   8  (bases 1 to 1325)
  AUTHORS   Chen,H., Shi,S., Acosta,L., Li,W., Lu,J., Bao,S., Chen,Z., Yang,Z.,
            Schneider,M.D., Chien,K.R., Conway,S.J., Yoder,M.C., Haneline,L.S.,
            Franco,D. and Shou,W.
  TITLE     BMP10 is essential for maintaining cardiac growth during murine
            cardiogenesis
  JOURNAL   Development 131 (9), 2219-2231 (2004)
   PUBMED   15073151
  REMARK    GeneRIF: Results describe an essential role of bone morphogenetic
            protein 10 in regulating cardiac growth and chamber maturation.
REFERENCE   9  (bases 1 to 1325)
  AUTHORS   Gaussin,V., Van de Putte,T., Mishina,Y., Hanks,M.C., Zwijsen,A.,
            Huylebroeck,D., Behringer,R.R. and Schneider,M.D.
  TITLE     Endocardial cushion and myocardial defects after cardiac
            myocyte-specific conditional deletion of the bone morphogenetic
            protein receptor ALK3
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2878-2883 (2002)
   PUBMED   11854453
REFERENCE   10 (bases 1 to 1325)
  AUTHORS   Neuhaus,H., Rosen,V. and Thies,R.S.
  TITLE     Heart specific expression of mouse BMP-10 a novel member of the
            TGF-beta superfamily
  JOURNAL   Mech Dev 80 (2), 181-184 (1999)
   PUBMED   10072785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155726.4 and BC145983.1.
            
            On Aug 7, 2015 this sequence version replaced NM_009756.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate the mature protein, which
            binds to the activin receptor-like kinase 1 (ALK1) and plays
            important roles in cardiovascular development including
            cardiomyocyte proliferation and regulation of heart size, closure
            of the ductus arteriosus, angiogenesis and ventricular
            trabeculation. Homozygous knockout mice for this gene exhibit
            impaired heart development and embryonic lethality. [provided by
            RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145983.1, BY000749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC155726.4         62567-62574
            9-1325              BC145983.1         1-1317
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.96 cM"
     gene            1..1325
                     /gene="Bmp10"
                     /gene_synonym="b2b2711Clo"
                     /note="bone morphogenetic protein 10"
                     /db_xref="GeneID:12154"
                     /db_xref="MGI:MGI:1338820"
     exon            1..373
                     /gene="Bmp10"
                     /gene_synonym="b2b2711Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1305
                     /gene="Bmp10"
                     /gene_synonym="b2b2711Clo"
                     /note="BMP-10"
                     /codon_start=1
                     /product="bone morphogenetic protein 10 preproprotein"
                     /protein_id="NP_033886.2"
                     /db_xref="CCDS:CCDS51838.1"
                     /db_xref="GeneID:12154"
                     /db_xref="MGI:MGI:1338820"
                     /translation="MGSLVLPLSAVFCLVAHSASGSPIMGLEQSPLEEDMPFFDDIFT
                     EQDGIDFNTLLQSMKNEFLKTLNLSDIPVQDTGRVDPPEYMLELYNKFATDRTSMPSA
                     NIIRSFKNEDLFSQPVTFNGLRKYPLLFNVSIPHHEEVVMAELRLYTLVQRDRMMYDG
                     VDRKITIFEVLESADGSEEERSMLVLVSTEIYGTNSEWETFDVTDATRRWQKSGPSTH
                     QLEIHIESRQNQAEDTGRGQLEIDMSAQNKHDPLLVVFSDDQSNDKEQKEELNELITH
                     EQDLDLDSDAFFSGPDEEALLQMRSNMIDDSSARIRRNAKGNYCKKTPLYIDFKEIGW
                     DSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLD
                     PISILYLDKGVVTYKFKYEGMAVSECGCR"
     exon            374..1325
                     /gene="Bmp10"
                     /gene_synonym="b2b2711Clo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccttcct aggttggcct gggagctgag cagagagtca tggggtctct ggttctgccg
       61 ctgagcgccg tcttctgcct ggtggctcac tcggcttctg gcagccccat tatgggcctt
      121 gagcagtcgc ccctggaaga agacatgccc ttctttgatg atatcttcac ggagcaagat
      181 ggtattgact tcaacacact gctgcagagc atgaagaacg agtttctcaa gacgctgaac
      241 ttgtcggaca ttcctgtgca ggacacgggc agagtggatc caccagagta catgctggag
      301 ctctacaaca aattcgccac agaccggacc tccatgccgt ctgctaacat catccggagc
      361 ttcaagaacg aagatctgtt ttctcaacca gtcactttta atgggctccg gaaatatcct
      421 ctcctcttca atgtgtctat ccctcaccat gaagaggtcg tcatggctga actgcggttg
      481 tacacgctgg tgcagagaga tcgcatgatg tatgatggcg tggaccgtaa aattaccatt
      541 tttgaggtac tagagagtgc agacggtagc gaggaggaga ggagcatgct ggtcttagta
      601 tcaacagaga tctacggaac caacagtgag tgggagacat ttgacgtcac agatgccacc
      661 agacgttggc aaaagtcagg cccatcaacc catcagctgg agatccacat agaaagcaga
      721 caaaaccaag ctgaggacac cggaagggga caactggaaa tagatatgag tgcccaaaat
      781 aagcatgacc ctttgctggt tgtgttttct gatgaccaaa gcaatgacaa ggagcagaaa
      841 gaagaactga acgaattgat cacccatgag caggatctgg acctggactc agatgctttc
      901 ttcagtgggc ccgatgaaga ggctctgctg cagatgaggt cgaacatgat tgatgattcg
      961 tccgctcgga tcaggaggaa cgccaagggg aactactgta agaagacccc actatacatc
     1021 gacttcaagg agattgggtg ggactcctgg atcatcgctc ctcctgggta tgaagcctat
     1081 gagtgccggg gtgtgtgtaa ctaccctctg gcggagcacc tcacacctac aaaacacgca
     1141 attattcagg ccttggtcca cctcaagaat tcccagaaag cttccaaagc ctgctgtgtg
     1201 cccacgaagc tggatcccat ctccatcctc tatttagata aaggtgtcgt cacctacaag
     1261 tttaaatatg aagggatggc tgtgtctgag tgtggctgta gataggagag gagaggcgtc
     1321 ccatg
//
