LOCUS       NM_009755               3769 bp    mRNA    linear   ROD 17-APR-2022
DEFINITION  Mus musculus bone morphogenetic protein 1 (Bmp1), transcript
            variant 1, mRNA.
ACCESSION   NM_009755
VERSION     NM_009755.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3769)
  AUTHORS   Ma HY, N'Diaye EN, Caplazi P, Huang Z, Arlantico A, Jeet S, Wong A,
            Brightbill HD, Li Q, Wong WR, Sandoval W, Tam L, Newman R,
            Roose-Girma M and Ding N.
  TITLE     BMP1 is not required for lung fibrosis in mice
  JOURNAL   Sci Rep 12 (1), 5466 (2022)
   PUBMED   35361882
  REMARK    GeneRIF: BMP1 is not required for lung fibrosis in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3769)
  AUTHORS   Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y and Wang
            W.
  TITLE     FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme
            proliferation and differentiation via Lhx8/Suv39h1 complex
  JOURNAL   J Cell Mol Med 25 (6), 3051-3062 (2021)
   PUBMED   33580754
REFERENCE   3  (bases 1 to 3769)
  AUTHORS   N'Diaye EN, Cook R, Wang H, Wu P, LaCanna R, Wu C, Ye Z, Seshasayee
            D, Hazen M, Lin W, Tyagi T, Hotzel I, Tam L, Newman R, Roose-Girma
            M, Wolters PJ and Ding N.
  TITLE     Extracellular BMP1 is the major proteinase for COOH-terminal
            proteolysis of type I procollagen in lung fibroblasts
  JOURNAL   Am J Physiol Cell Physiol 320 (2), C162-C174 (2021)
   PUBMED   33206546
  REMARK    GeneRIF: Extracellular BMP1 is the major proteinase for
            COOH-terminal proteolysis of type I procollagen in lung
            fibroblasts.
REFERENCE   4  (bases 1 to 3769)
  AUTHORS   Lin JI, Feinstein TN, Jha A, McCleary JT, Xu J, Arrigo AB, Rong G,
            Maclay LM, Ridge T, Xu X and Lo CW.
  TITLE     Mutation of LRP1 in cardiac neural crest cells causes congenital
            heart defects by perturbing outflow lengthening
  JOURNAL   Commun Biol 3 (1), 312 (2020)
   PUBMED   32546759
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3769)
  AUTHORS   Eshed-Eisenbach Y, Devaux J, Vainshtein A, Golani O, Lee SJ,
            Feinberg K, Sukhanov N, Greenspan DS, Susuki K, Rasband MN and
            Peles E.
  TITLE     Precise Spatiotemporal Control of Nodal Na(+) Channel Clustering by
            Bone Morphogenetic Protein-1/Tolloid-like Proteinases
  JOURNAL   Neuron 106 (5), 806-815 (2020)
   PUBMED   32209430
  REMARK    GeneRIF: Precise Spatiotemporal Control of Nodal Na(+) Channel
            Clustering by Bone Morphogenetic Protein-1/Tolloid-like
            Proteinases.
REFERENCE   6  (bases 1 to 3769)
  AUTHORS   Takahara K, Lyons GE and Greenspan DS.
  TITLE     Bone morphogenetic protein-1 and a mammalian tolloid homologue
            (mTld) are encoded by alternatively spliced transcripts which are
            differentially expressed in some tissues
  JOURNAL   J Biol Chem 269 (51), 32572-32578 (1994)
   PUBMED   7798260
REFERENCE   7  (bases 1 to 3769)
  AUTHORS   Fukagawa M, Suzuki N, Hogan BL and Jones CM.
  TITLE     Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1),
            which is related to the Drosophila dorsoventral gene tolloid and
            encodes a putative astacin metalloendopeptidase
  JOURNAL   Dev Biol 163 (1), 175-183 (1994)
   PUBMED   8174772
REFERENCE   8  (bases 1 to 3769)
  AUTHORS   Sasaki H and Hogan BL.
  TITLE     HNF-3 beta as a regulator of floor plate development
  JOURNAL   Cell 76 (1), 103-115 (1994)
   PUBMED   8287471
REFERENCE   9  (bases 1 to 3769)
  AUTHORS   Ceci JD, Kingsley DM, Silan CM, Copeland NG and Jenkins NA.
  TITLE     An interspecific backcross linkage map of the proximal half of
            mouse chromosome 14
  JOURNAL   Genomics 6 (4), 673-678 (1990)
   PUBMED   1971251
REFERENCE   10 (bases 1 to 3769)
  AUTHORS   Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW,
            Hewick RM and Wang EA.
  TITLE     Novel regulators of bone formation: molecular clones and activities
  JOURNAL   Science 242 (4885), 1528-1534 (1988)
   PUBMED   3201241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122268.5, AK158218.1,
            BC066062.1 and CX216218.1.
            
            [WARNING] On Jun 1, 2023 this sequence was replaced by NM_009755.4.
            
            On Jan 15, 2010 this sequence version replaced NM_009755.2.
            
            Summary: This gene encodes a metalloproteinase that plays an
            essential role in the formation of the extracellular matrix and is
            also able to induce ectopic bone formation. Unlike other bone
            morphogenetic proteins, the protein encoded by this gene is not
            closely related to transforming growth factor-beta. This protein
            plays in role several developmental processes. In humans, mutations
            in this gene are associated with osteogenesis imperfecta and with
            increased bone mineral density and multiple recurrent fractures.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066062.1, AK004995.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC122268.5         144576-144583       c
            9-72                AK158218.1         2-65
            73-3756             BC066062.1         1-3684
            3757-3757           AC122268.5         98880-98880         c
            3758-3769           CX216218.1         289-300
FEATURES             Location/Qualifiers
     source          1..3769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..3769
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /note="bone morphogenetic protein 1"
                     /db_xref="GeneID:12153"
                     /db_xref="MGI:MGI:88176"
     exon            1..392
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..3199
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /EC_number="3.4.24.19"
                     /note="mammalian tolloid protein; procollagen
                     C-proteinase"
                     /codon_start=1
                     /product="bone morphogenetic protein 1 precursor"
                     /protein_id="NP_033885.2"
                     /db_xref="CCDS:CCDS36972.1"
                     /db_xref="GeneID:12153"
                     /db_xref="MGI:MGI:88176"
                     /translation="MPGVARPPLPLLSLPLLLLLLLLPRAGRPLDLADYTYDLGEEDA
                     PELLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAAVLRQQTARRPSIKAAGNSSALGG
                     QGTSGQPQRESRGRWRGRPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAM
                     RHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVH
                     ELGHVIGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMH
                     YARNTFSRGIFLDTIVPKYEVNGVKPSIGQRTRLSKGDIAQARKLYKCPACGETLQDS
                     TGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSMDLYRSRLCWYDYVEVRDGFW
                     RKAPLRGRFCGGKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDNGH
                     IQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS
                     NLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ
                     RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIW
                     QLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQ
                     YNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVL
                     HDNKHDCKEAGCEHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFVEMD
                     IESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGNRMFLRFYSDNSVQRKG
                     FQASHSTECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTF
                     EVEEETDCGYDYIELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTISKK
                     GFHLRYTSTKFQDTLHSRK"
     exon            393..506
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            507..671
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            672..789
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            790..968
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1074
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1199
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1315
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1418
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1535
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1681
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1877
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2003
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2164
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2345
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2471
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2599
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2813
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..3064
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3759
                     /gene="Bmp1"
                     /gene_synonym="Pcp; Tld"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcggcga gaaaagaaag ggagcgaccg agaggagggc gaggggacgc cggagcccag
       61 ggccggagag agccgggccg agcggggggc gggagacagg aaacgggacg ggaagaggtg
      121 gcctcggggg gagagcgcct ccccttcgcc ttcagcgctc ccttccccgt cgccccgctc
      181 ccgcgtccgg gcgcgaccgc caccgccacc gccgcccgcc agcatgcccg gcgtggcccg
      241 cccgccgctg ccgctgctgt cgctgccgct gctactgctg ctgctgctgc tcccgcgcgc
      301 cggccggccg ctggacttgg ccgactacac ctacgacctg ggcgaggagg acgccccgga
      361 gctcctcaac tacaaagacc cttgcaaggc ggctgccttc cttggggaca ttgccctgga
      421 tgaggaggac ttgagggcct tccaggtgca gcaggctgca gttctcagac agcaaacagc
      481 ccgaaggcca tccatcaaag ctgcaggaaa ctcttctgcc ctgggtggtc agggcactag
      541 tggacagccg cagagggaaa gcaggggcag atggagaggc aggcctcgga gcaggcgggc
      601 agcgacgtcc agaccggagc gggtgtggcc cgatggggtc atcccgtttg tgattggagg
      661 gaatttcacc ggcagccaga gggcagtctt ccggcaggcc atgagacact gggagaagca
      721 tacctgtgtc accttcttgg agcgcacaga tgaggacagc tatattgtat tcacctaccg
      781 accctgcggg tgctgctcct acgtgggtcg ccgaggtggg ggcccccagg ccatctccat
      841 cggcaagaac tgtgacaagt ttggcatcgt ggtccatgag ctgggccatg tcattggctt
      901 ctggcacgag cacacgcggc ccgaccggga ccgccatgtc tctattgtac gcgagaacat
      961 acagccaggg caggagtata acttcttgaa gatggaggtt caagaagtgg agtccttggg
     1021 agagacctat gactttgaca gtatcatgca ctatgcccgg aacacattct ccaggggcat
     1081 cttcttggac accattgttc ccaagtatga ggtgaatggg gtgaagcctt ccattggcca
     1141 aaggacccga ctcagcaagg gggacatcgc tcaggcccgg aagctctaca aatgcccagc
     1201 ctgtggcgag accctccaag acagcactgg caacttctcc tcccctgagt atcccaatgg
     1261 ctactctgcc cacatgcact gtgtatggcg catctctgtc acacctgggg agaagattat
     1321 tctaaacttc acatccatgg acctgtaccg tagccgcctg tgctggtatg actatgtgga
     1381 ggtgcgggat ggcttctgga gaaaggcgcc cctccgaggc cggttctgtg ggggcaaact
     1441 ccccgagccc atcgtctcca ccgacagccg cctctgggtg gaattccgaa gcagcagcaa
     1501 ctgggttgga aagggcttct ttgctgtcta tgaagccatt tgcggtggcg atgtgaaaaa
     1561 ggataatggc catatccagt ctcccaatta cccagacgat tatcggccca gcaaagtctg
     1621 catctggcgg atccaggtgt ctgagggttt ccacgtgggc ctcacgttcc agtcctttga
     1681 gattgagcgt cacgacagtt gtgcctacga ctacctggaa gtccgtgatg ggcacagcga
     1741 gagcagcaac ctcattgggc gctactgtgg ctatgagaag cctgatgaca tcaaaagcac
     1801 atccagtcgg ctctggctca agttcgtctc tgacgggtcc attaacaaag ctggcttcgc
     1861 agtcaacttt ttcaaagagg tggatgagtg ttcaaggccc aaccgcgggg gctgtgagca
     1921 gcggtgcctg aacaccctgg gcagctacaa gtgcagctgt gaccctggct atgagctggc
     1981 cccagacaag cgtcggtgtg aggctgcctg tggtggattc ctcaccaagc tcaatggctc
     2041 catcaccagc cccggttggc ccaaagagta ccctcccaac aaaaactgca tctggcagtt
     2101 ggtggccccc acccagtacc gtatctccct gcaatttgac ttcttcgaga ctgagggcaa
     2161 tgatgtgtgc aagtacgact ttgtggaggt gcgcagcgga ctcacggcgg actctaagct
     2221 gcatggcaag ttctgcggct ccgagaagcc agaggtcatc acttcccagt acaacaatat
     2281 gcgtgtggag ttcaagtctg acaatactgt gtccaaaaag ggcttcaagg cccacttctt
     2341 ctcagataag gatgaatgtt ccaaggacaa tggtggatgc cagcaagact gtgtgaacac
     2401 gttcggcagc tacgagtgtc agtgccgcag tggcttcgtc cttcacgaca acaaacatga
     2461 ctgtaaagaa gctggctgtg aacacaaggt gacatccacc agtggcacca tcaccagccc
     2521 caactggcct gacaagtacc ccagcaagaa ggagtgtacg tgggctatct ccagcacccc
     2581 tgggcaccgg gtaaagctga ctttcgtgga gatggatatt gagtctcagc ccgagtgtgc
     2641 ttatgaccac ctggaggtgt tcgatggacg tgatgccaag gcaccagtcc ttggacgatt
     2701 ctgtggcagt aagaagcctg agccagtcct ggctacaggc aaccgcatgt tcttgcgctt
     2761 ctactcagac aactcggtac agaggaaagg tttccaggca tcccactcca cagagtgtgg
     2821 gggccaagtg cgggcagatg tgaagaccaa agacctttat tcccatgccc agttcggcga
     2881 taacaactac cctggagggg tggactgcga gtgggtcatc gtggccgagg aaggctatgg
     2941 cgtggagctg gtgttccaga ccttcgaggt ggaggaggag actgactgtg gctatgacta
     3001 catagagctc tttgatggct acgacagcac agctcccaga ctggggcgct actgtggttc
     3061 tgggcctccc gaggaagtgt actcggctgg agattctgtc ctggtgaagt tccactctga
     3121 cgacaccatc tccaagaaag gcttccacct gcggtacaca agcaccaagt tccaggacac
     3181 actccacagc aggaagtgac ctctgcccct gcttggtagc gggaactgga gtcctgcttc
     3241 cctcaatcac ccagactgga cagcaggggt gacaggcaga tggtgacaca ttgtccctca
     3301 cccccaggca ccagggccag tgggccaggt gtcaacagga ggcaagggac ttggactccc
     3361 tgtaagccag ttccccatgc cctcctgtca gtggggccgg ggaaccggag ctttcactga
     3421 gacacttgaa gtgaccattc ctccttgggg ccctgcctgg ggtaagacag tctctgtgca
     3481 ggaccctgcg ggcttctctg ccgtctttac acactgtatt gtgtatagcc ggtgtcccta
     3541 atctttattg taacgtacat ttcctgcccc ttctccagcc ttgatttggt tttatattga
     3601 cccaccactt ctatgcttcc tgggtatccc ctgggagccg tgacggggag ctagagaaga
     3661 gagagtggat gaataagaca gggcttctct taggcccact ggctcatcag ccacaccagg
     3721 gcaccccagc caataaacag aaagtgttac agccaatata aaaaaaaaa
//
