LOCUS       NM_007552               3470 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Bmi1 polycomb ring finger oncogene (Bmi1), transcript
            variant 1, mRNA.
ACCESSION   NM_007552 XM_911114 XM_921906 XM_921909
VERSION     NM_007552.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3470)
  AUTHORS   Hoffmann,J., Schutze,T.M., Kolodziejczyk,A., Kuster,K., Krankel,A.,
            Reinhardt,S., Derihaci,R.P., Birdir,C., Wimberger,P., Koseki,H. and
            Albert,M.
  TITLE     Canonical and non-canonical PRC1 differentially contribute to
            regulation of neural stem cell fate
  JOURNAL   Life Sci Alliance 8 (4), e202403006 (2025)
   PUBMED   39933923
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3470)
  AUTHORS   Tam,H., Xu,Y., An,J., Schoneberg,T., Schulz,A., Muppidi,J.R. and
            Cyster,J.G.
  TITLE     Phosphatidylserine phospholipase A1 enables GPR34-dependent immune
            cell accumulation in the peritoneal cavity
  JOURNAL   J Exp Med 221 (11) (2024)
   PUBMED   39412501
REFERENCE   3  (bases 1 to 3470)
  AUTHORS   Hsu,Y.C., Luo,C.W., Chang,S.J., Lai,C.Y., Yang,Y.T., Chen,Y.Z.,
            Liu,W.T., Wu,C.C., Sun,C.K., Hou,M.F. and Pan,M.R.
  TITLE     Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting
            Metastasis in Colorectal Cancer
  JOURNAL   Cancer Genomics Proteomics 21 (5), 523-532 (2024)
   PUBMED   39191496
  REMARK    GeneRIF: Targeting Bmi1 for Enhancing Anoikis Sensitivity and
            Inhibiting Metastasis in Colorectal Cancer.
REFERENCE   4  (bases 1 to 3470)
  AUTHORS   Dou,Z., Lu,F., Hu,J., Li,B. and Li,X.
  TITLE     CBX7 silencing promoted liver regeneration by interacting with BMI1
            and activating the Nrf2/ARE signaling pathway
  JOURNAL   Sci Rep 14 (1), 11008 (2024)
   PUBMED   38744845
  REMARK    GeneRIF: CBX7 silencing promoted liver regeneration by interacting
            with BMI1 and activating the Nrf2/ARE signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3470)
  AUTHORS   Lu,J., Sun,W., Liu,B., Zhang,J., Wang,R., Goltzman,D. and Miao,D.
  TITLE     Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via
            Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced
            Epithelial-Mesenchymal Transition
  JOURNAL   Int J Biol Sci 20 (6), 2008-2026 (2024)
   PUBMED   38617548
  REMARK    GeneRIF: Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and
            Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced
            Epithelial-Mesenchymal Transition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3470)
  AUTHORS   Alkema,M.J., Bronk,M., Verhoeven,E., Otte,A., van 't Veer,L.J.,
            Berns,A. and van Lohuizen,M.
  TITLE     Identification of Bmi1-interacting proteins as constituents of a
            multimeric mammalian polycomb complex
  JOURNAL   Genes Dev 11 (2), 226-240 (1997)
   PUBMED   9009205
REFERENCE   7  (bases 1 to 3470)
  AUTHORS   Haupt,Y., Barri,G. and Adams,J.M.
  TITLE     Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral
            insertion locus
  JOURNAL   Mol Biol Rep 17 (1), 17-20 (1992)
   PUBMED   1287475
REFERENCE   8  (bases 1 to 3470)
  AUTHORS   Reddy,B.A., Etkin,L.D. and Freemont,P.S.
  TITLE     A novel zinc finger coiled-coil domain in a family of nuclear
            proteins
  JOURNAL   Trends Biochem Sci 17 (9), 344-345 (1992)
   PUBMED   1412709
  REMARK    Review article
REFERENCE   9  (bases 1 to 3470)
  AUTHORS   Haupt,Y., Alexander,W.S., Barri,G., Klinken,S.P. and Adams,J.M.
  TITLE     Novel zinc finger gene implicated as myc collaborator by
            retrovirally accelerated lymphomagenesis in E mu-myc transgenic
            mice
  JOURNAL   Cell 65 (5), 753-763 (1991)
   PUBMED   1904009
REFERENCE   10 (bases 1 to 3470)
  AUTHORS   van Lohuizen,M., Verbeek,S., Scheijen,B., Wientjens,E., van der
            Gulden,H. and Berns,A.
  TITLE     Identification of cooperating oncogenes in E mu-myc transgenic mice
            by provirus tagging
  JOURNAL   Cell 65 (5), 737-752 (1991)
   PUBMED   1904008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928680.5.
            
            On Feb 22, 2023 this sequence version replaced NM_007552.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M64279.1, BC053708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AL928680.5         24264-24591
            329-459             AL928680.5         28915-29045
            460-556             AL928680.5         29345-29441
            557-612             AL928680.5         29961-30016
            613-663             AL928680.5         30103-30153
            664-772             AL928680.5         30297-30405
            773-812             AL928680.5         30491-30530
            813-911             AL928680.5         30787-30885
            912-992             AL928680.5         31108-31188
            993-3470            AL928680.5         31274-33751
FEATURES             Location/Qualifiers
     source          1..3470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 12.9 cM"
     gene            1..3470
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="Bmi1 polycomb ring finger oncogene"
                     /db_xref="GeneID:12151"
                     /db_xref="MGI:MGI:88174"
     exon            1..328
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..459
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1322
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="polycomb group RING finger protein 4; B lymphoma
                     Mo-MLV insertion region 1; polycomb group ring finger 4"
                     /codon_start=1
                     /product="polycomb complex protein BMI-1"
                     /protein_id="NP_031578.2"
                     /db_xref="CCDS:CCDS15711.1"
                     /db_xref="GeneID:12151"
                     /db_xref="MGI:MGI:88174"
                     /translation="MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIV
                     RYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHP
                     SADAANGSNEDRGEVADEEKRIITDDEIISLSIEFFDQSRLDRKVNKEKPKEEVNDKR
                     YLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGP
                     LPLKYRVRPTCKRMKMSHQRDGLTNAGELESDSGSDKANSPAGGVPSTSSCLPSPSTP
                     VQSPHPQFPHISSTMNGTSNSPSANHQSSFASRPRKSSLNGSSATSSG"
     exon            460..556
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            557..612
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            613..663
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            664..772
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            773..812
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            813..911
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..992
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            993..3470
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2765..2770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="hexamer: ATTAAA"
     polyA_site      2786
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="major polyA site"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="hexamer: AATAAA"
     polyA_site      2977
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="major polyA site"
     regulatory      3451..3456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="hexamer: AATAAA"
     polyA_site      3470
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /note="major polyA site"
ORIGIN      
        1 ctcccccgag cgcggccggg aggcggcggc tgcgccgagg aggaggagag gccccgagga
       61 ggcggcggcg gaggccgcgc ggaggcggag gaggccgcgc gggaggagga ggccgcagcg
      121 cgcgagcagg aggccggcgg gggagcggca tgagcggagc gcggcggccg tggctgctct
      181 cggccgcgct cggtgcccat tgacagcggc ggcggcggct cgctccaaga tggccgcttg
      241 gctcgcattc attttatgct gaacgacttt taactttcat tgtcttttcc gcccgctcag
      301 atcgcctcgc gccggccgct ctttccggga tcttttatca agcagaaatg catcgaacaa
      361 ccagaatcaa gatcactgag ctaaatcccc acttaatgtg tgtcctgtgt ggagggtact
      421 tcattgatgc cactaccata atagaatgtc tacattcctt ctgtaaaaca tgtattgtac
      481 gttacttgga gaccagcaag tattgtccta tttgtgatgt ccaggttcac aaaaccagac
      541 cactcctgaa cataaggtca gataaaactc ttcaagatat tgtatacaaa ttagtcccag
      601 ggcttttcaa aaatgagatg aagagaagaa gagattttta tgcagctcac ccgtcagctg
      661 atgctgccaa tggctccaat gaagaccgag gagaagttgc agatgaggag aagaggatta
      721 taactgatga tgagataata agcttgtcta ttgagttctt tgatcagagc agattggatc
      781 ggaaagtaaa taaagagaag cctaaggaag aggtgaatga taaaaggtac ttacgatgcc
      841 cagcagcaat gactgtgatg cacttgagaa agtttctcag gagtaaaatg gacataccca
      901 atactttcca gattgacgtc atgtatgaag aggaaccttt aaaggattac tacacgctaa
      961 tggacattgc ctacatttat acctggagaa gaaatggccc actacctttg aaatacagag
     1021 ttcggccaac ttgcaaaaga atgaagatga gtcaccagag ggatggactg acgaatgctg
     1081 gagagctgga aagtgactct gggagtgaca aggccaacag cccagccgga ggtgttccct
     1141 ccacctcttc ctgtttgccc agtcccagca ctccagtgca gtctcctcac ccacagttcc
     1201 ctcacatttc cagtaccatg aatggaacca gcaacagccc cagtgctaac caccaatctt
     1261 cctttgccag tagacctcga aaatcatcac taaatgggtc atcagcaact tcatctggtt
     1321 aggactgtta aggaaaagat ttttcaaccc cctgatttag ttaccttcat tcattacagc
     1381 tttatagatg cttaatacat gtgactgtcg tccagtttgc ttccttttgt agtgacttta
     1441 aatttggcca taaatgatgg actagatgtg atacttcata tggatgttaa gtggaaagat
     1501 tgattctttc tctaaagaat tggattctga gaaggattct gtgttaggaa agatgtgaaa
     1561 tgatttctgt gaccactgtt tggatctgga aatgttctac agtgggtaga cattgggcca
     1621 tagtttgtta atctcaatta atgcctacat tacattctct ttgattgttc ttgttattat
     1681 gctgttctgt gaacctgtag aaaacaagtg ctttttatct tgaaattcag caaatggaaa
     1741 gaataagcat agaatactgc attctgtgca gccacgtcac tgtgaataac aatttcttgc
     1801 atatttagcc attttaattc ctgtttgatt tttacttctc tgttgctaca caaaatgatc
     1861 aaaggaaact tgttttacaa tctgtatgcc taaaaagcgg gtactaccgt ttattttact
     1921 gacttgttga aatgattcac ttttgtaaga atcagatggc attatgcttg ttgtacaatg
     1981 ccatattggt atatgacata acaggaaaca gtattgtatg atatatttat aaatactatg
     2041 aaaatattgt gtttcatgca ttcaaaaaca gttgtaaact tctccaaatg ggttcgacct
     2101 ttgcggatat cacagtgcac ccaatgctga ggcttaccac cagcacagaa tttgttttaa
     2161 tgttgataac cagtttcaaa ttcttttcca cttagaagca aatggcagat cttcatagtt
     2221 ctggcttttc tccaataaga ctttcaaaat taatattgca gtaaagaaaa attttaacca
     2281 aggcaaatat agtgtttaat tttccattgg ttaaaataga attaatgttt ttaaattctg
     2341 tttatcagtg gaattctaaa atagatttta aagtcaacca gctaattgct gaagtaaagc
     2401 attttatcta caattttatt ttagtgtatg tggcacaagt gtaatttcaa atttaagagt
     2461 tgttttcata gttaaaggaa tctgccttca ctgtaacgtc tggaaacaga aacaatttgt
     2521 tatgatttct acagggattt ttaatagagc aaacatgttg aatttaaaat atgaatgacc
     2581 cctccaagtc tcagttttgc tttggtcgaa cttagcgtgt gtttatcagc catcagttat
     2641 ttgtgaggat gttaattccg tatgaatatt gtttcatgtt tgtatgggaa actgtagcta
     2701 agcatttcat tgtctgcagt ctgcagaaga agcacaattg tattgctttg tcttgcttgt
     2761 agccattaaa tcattacttt tacacacatt gctgttaact tctgctttct ttaaagattt
     2821 agtaaatgat gttttatgaa gccacaagat acatatattt ttattttgac ctaaatttgt
     2881 acagtcccat tgtgtgtgtg tcatttctaa ttatagatgt aaaattaaat ttcattttta
     2941 attggaaaat tcaataaaaa gatattcatt tagaaaatac tatgctcttt aattaaaatt
     3001 ttgctatgaa aagcacagtg tgcagaagtt ttgggaaccc tgtagtggat tgtaagagct
     3061 aaaacctaag gaaaatactt tgttgtcttc aaatgatgtt gttagtaaat gctttgttgt
     3121 atattgctcg aaagcccaat gaaagaagta tctgcttatt tacaatcttt gaagcaaaag
     3181 ttaccaatgt ttgccaattt tggtgaattt aactcatttt tctagacttt tctcgaggtt
     3241 ttcatggtgt tacctaagac aaaagacatc tcaccctcta tgatggactt acttctgaga
     3301 gtgcgtttga ggcacttatg gcttactaag cagtgtgtca ccatacttga aaacacttcc
     3361 atttattgta tctgggatga ggctttttac ccttactcaa tttgaaaatt gcttaagctt
     3421 aaatgatatt tcagtcaaaa tttgtctttt aataaaacaa cagaaagatg
//
