LOCUS       NP_031578                324 aa            linear   ROD 11-MAR-2025
DEFINITION  polycomb complex protein BMI-1 [Mus musculus].
ACCESSION   NP_031578 XP_916207 XP_926999 XP_927002
VERSION     NP_031578.2
DBSOURCE    REFSEQ: accession NM_007552.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 324)
  AUTHORS   Hoffmann,J., Schutze,T.M., Kolodziejczyk,A., Kuster,K., Krankel,A.,
            Reinhardt,S., Derihaci,R.P., Birdir,C., Wimberger,P., Koseki,H. and
            Albert,M.
  TITLE     Canonical and non-canonical PRC1 differentially contribute to
            regulation of neural stem cell fate
  JOURNAL   Life Sci Alliance 8 (4), e202403006 (2025)
   PUBMED   39933923
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 324)
  AUTHORS   Tam,H., Xu,Y., An,J., Schoneberg,T., Schulz,A., Muppidi,J.R. and
            Cyster,J.G.
  TITLE     Phosphatidylserine phospholipase A1 enables GPR34-dependent immune
            cell accumulation in the peritoneal cavity
  JOURNAL   J Exp Med 221 (11) (2024)
   PUBMED   39412501
REFERENCE   3  (residues 1 to 324)
  AUTHORS   Hsu,Y.C., Luo,C.W., Chang,S.J., Lai,C.Y., Yang,Y.T., Chen,Y.Z.,
            Liu,W.T., Wu,C.C., Sun,C.K., Hou,M.F. and Pan,M.R.
  TITLE     Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting
            Metastasis in Colorectal Cancer
  JOURNAL   Cancer Genomics Proteomics 21 (5), 523-532 (2024)
   PUBMED   39191496
  REMARK    GeneRIF: Targeting Bmi1 for Enhancing Anoikis Sensitivity and
            Inhibiting Metastasis in Colorectal Cancer.
REFERENCE   4  (residues 1 to 324)
  AUTHORS   Dou,Z., Lu,F., Hu,J., Li,B. and Li,X.
  TITLE     CBX7 silencing promoted liver regeneration by interacting with BMI1
            and activating the Nrf2/ARE signaling pathway
  JOURNAL   Sci Rep 14 (1), 11008 (2024)
   PUBMED   38744845
  REMARK    GeneRIF: CBX7 silencing promoted liver regeneration by interacting
            with BMI1 and activating the Nrf2/ARE signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 324)
  AUTHORS   Lu,J., Sun,W., Liu,B., Zhang,J., Wang,R., Goltzman,D. and Miao,D.
  TITLE     Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via
            Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced
            Epithelial-Mesenchymal Transition
  JOURNAL   Int J Biol Sci 20 (6), 2008-2026 (2024)
   PUBMED   38617548
  REMARK    GeneRIF: Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and
            Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced
            Epithelial-Mesenchymal Transition.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 324)
  AUTHORS   Alkema,M.J., Bronk,M., Verhoeven,E., Otte,A., van 't Veer,L.J.,
            Berns,A. and van Lohuizen,M.
  TITLE     Identification of Bmi1-interacting proteins as constituents of a
            multimeric mammalian polycomb complex
  JOURNAL   Genes Dev 11 (2), 226-240 (1997)
   PUBMED   9009205
REFERENCE   7  (residues 1 to 324)
  AUTHORS   Haupt,Y., Barri,G. and Adams,J.M.
  TITLE     Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral
            insertion locus
  JOURNAL   Mol Biol Rep 17 (1), 17-20 (1992)
   PUBMED   1287475
REFERENCE   8  (residues 1 to 324)
  AUTHORS   Reddy,B.A., Etkin,L.D. and Freemont,P.S.
  TITLE     A novel zinc finger coiled-coil domain in a family of nuclear
            proteins
  JOURNAL   Trends Biochem Sci 17 (9), 344-345 (1992)
   PUBMED   1412709
  REMARK    Review article
REFERENCE   9  (residues 1 to 324)
  AUTHORS   Haupt,Y., Alexander,W.S., Barri,G., Klinken,S.P. and Adams,J.M.
  TITLE     Novel zinc finger gene implicated as myc collaborator by
            retrovirally accelerated lymphomagenesis in E mu-myc transgenic
            mice
  JOURNAL   Cell 65 (5), 753-763 (1991)
   PUBMED   1904009
REFERENCE   10 (residues 1 to 324)
  AUTHORS   van Lohuizen,M., Verbeek,S., Scheijen,B., Wientjens,E., van der
            Gulden,H. and Berns,A.
  TITLE     Identification of cooperating oncogenes in E mu-myc transgenic mice
            by provirus tagging
  JOURNAL   Cell 65 (5), 737-752 (1991)
   PUBMED   1904008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928680.5.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_916207.1, XP_926999.1, XP_927002.1, NP_031578.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M64279.1, BC053708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 12.9 cM"
     Protein         1..324
                     /product="polycomb complex protein BMI-1"
                     /note="polycomb group RING finger protein 4; B lymphoma
                     Mo-MLV insertion region 1; polycomb group ring finger 4"
                     /calculated_mol_wt=36577
     Region          5..101
                     /region_name="RING-HC_PCGF4"
                     /note="RING finger found in polycomb group RING finger
                     protein 4 (PCGF4) and similar proteins; cd16736"
                     /db_xref="CDD:438394"
     Site            order(5..13,15,17,21,23..24,26..27,29..30,32..36,39..42,
                     44..45,66,69..72,74,78,81..82,84,86,89..90,93..94,97)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:438394"
     Region          81..95
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P25916.1)"
     Region          130..224
                     /region_name="RAWUL_PCGF4"
                     /note="RING finger- and WD40-associated ubiquitin-like
                     (RAWUL) domain found in polycomb group RING finger protein
                     4 (PCGF4); cd17165"
                     /db_xref="CDD:340685"
     Region          160..180
                     /region_name="Interaction with PHC2.
                     /evidence=ECO:0000250|UniProtKB:P35226"
                     /note="propagated from UniProtKB/Swiss-Prot (P25916.1)"
     Region          162..226
                     /region_name="Interaction with E4F1.
                     /evidence=ECO:0000250|UniProtKB:P35226"
                     /note="propagated from UniProtKB/Swiss-Prot (P25916.1)"
     Region          232..324
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25916.1)"
     CDS             1..324
                     /gene="Bmi1"
                     /gene_synonym="Bmi-1; Pcgf4"
                     /coded_by="NM_007552.5:348..1322"
                     /db_xref="CCDS:CCDS15711.1"
                     /db_xref="GeneID:12151"
                     /db_xref="MGI:MGI:88174"
ORIGIN      
        1 mhrttrikit elnphlmcvl cggyfidatt iieclhsfck tcivrylets kycpicdvqv
       61 hktrpllnir sdktlqdivy klvpglfkne mkrrrdfyaa hpsadaangs nedrgevade
      121 ekriitddei islsieffdq srldrkvnke kpkeevndkr ylrcpaamtv mhlrkflrsk
      181 mdipntfqid vmyeeeplkd yytlmdiayi ytwrrngplp lkyrvrptck rmkmshqrdg
      241 ltnagelesd sgsdkanspa ggvpstsscl pspstpvqsp hpqfphisst mngtsnspsa
      301 nhqssfasrp rksslngssa tssg
//
