LOCUS       NM_138313               4641 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus BCL2 modifying factor (Bmf), transcript variant 1,
            mRNA.
ACCESSION   NM_138313
VERSION     NM_138313.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4641)
  AUTHORS   El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh
            S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T and
            Voss AK.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   2  (bases 1 to 4641)
  AUTHORS   Zhi Z, Ouyang Z, Ren Y, Cheng Y, Liu P, Wen Y and Shao Y.
  TITLE     Non-canonical phosphorylation of Bmf by p38 MAPK promotes its
            apoptotic activity in anoikis
  JOURNAL   Cell Death Differ 29 (2), 323-336 (2022)
   PUBMED   34462553
  REMARK    GeneRIF: Non-canonical phosphorylation of Bmf by p38 MAPK promotes
            its apoptotic activity in anoikis.
REFERENCE   3  (bases 1 to 4641)
  AUTHORS   Singh PK, Roukounakis A, Weber A, Das KK, Sohm B, Villunger A,
            Garcia-Saez AJ and Hacker G.
  TITLE     Dynein light chain binding determines complex formation and
            posttranslational stability of the Bcl-2 family members Bmf and Bim
  JOURNAL   Cell Death Differ 27 (2), 434-450 (2020)
   PUBMED   31189926
  REMARK    GeneRIF: Dynein light chain binding determines complex formation
            and posttranslational stability of the Bcl-2 family members Bmf and
            Bim.
REFERENCE   4  (bases 1 to 4641)
  AUTHORS   Sul OJ, Rajasekaran M, Park HJ, Suh JH and Choi HS.
  TITLE     MicroRNA-29b Enhances Osteoclast Survival by Targeting
            BCL-2-Modifying Factor after Lipopolysaccharide Stimulation
  JOURNAL   Oxid Med Cell Longev 2019, 6018180 (2019)
   PUBMED   31093317
  REMARK    GeneRIF: miR-29b binds to the 3'-UTR of Bmf.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4641)
  AUTHORS   Delbridge ARD, Kueh AJ, Ke F, Zamudio NM, El-Saafin F, Jansz N,
            Wang GY, Iminitoff M, Beck T, Haupt S, Hu Y, May RE, Whitehead L,
            Tai L, Chiang W, Herold MJ, Haupt Y, Smyth GK, Thomas T, Blewitt
            ME, Strasser A and Voss AK.
  TITLE     Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation
            and Female-Specific Neural Tube Defects
  JOURNAL   Cell Rep 27 (2), 442-454 (2019)
   PUBMED   30970248
REFERENCE   6  (bases 1 to 4641)
  AUTHORS   Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman
            PM, Day CL, Adams JM and Huang DC.
  TITLE     Differential targeting of prosurvival Bcl-2 proteins by their
            BH3-only ligands allows complementary apoptotic function
  JOURNAL   Mol Cell 17 (3), 393-403 (2005)
   PUBMED   15694340
REFERENCE   7  (bases 1 to 4641)
  AUTHORS   Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY,
            Huang DC and Hinds MG.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   8  (bases 1 to 4641)
  AUTHORS   Morales AA, Olsson A, Celsing F, Osterborg A, Jondal M and Osorio
            LM.
  TITLE     Expression and transcriptional regulation of functionally distinct
            Bmf isoforms in B-chronic lymphocytic leukemia cells
  JOURNAL   Leukemia 18 (1), 41-47 (2004)
   PUBMED   14574334
REFERENCE   9  (bases 1 to 4641)
  AUTHORS   Cory S, Huang DC and Adams JM.
  TITLE     The Bcl-2 family: roles in cell survival and oncogenesis
  JOURNAL   Oncogene 22 (53), 8590-8607 (2003)
   PUBMED   14634621
  REMARK    Review article
REFERENCE   10 (bases 1 to 4641)
  AUTHORS   Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L,
            Cheney RE, Huang DC and Strasser A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084658.1, AK040622.1 and AL929381.9.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_138313.5.
            
            On Sep 13, 2016 this sequence version replaced NM_138313.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084658.1, AK040622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AK084658.1         3-54
            53-1799             AK040622.1         2-1748
            1800-4641           AL929381.9         22998-25839         c
FEATURES             Location/Qualifiers
     source          1..4641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.4 cM"
     gene            1..4641
                     /gene="Bmf"
                     /note="BCL2 modifying factor"
                     /db_xref="GeneID:171543"
                     /db_xref="MGI:MGI:2176433"
     exon            1..147
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..840
                     /gene="Bmf"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bcl-2-modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform 1"
                     /protein_id="NP_612186.2"
                     /db_xref="CCDS:CCDS16578.1"
                     /db_xref="GeneID:171543"
                     /db_xref="MGI:MGI:2176433"
                     /translation="MPGAGVFWKQYRAVCRGLLPRQLAPAAVAAAARATASHRSPLEF
                     APFFPIECGHQAPRVFFTLDPGAEPWHHNSEAETLSWSHPGEMEPPQCVEELEDDVFQ
                     SEDGEPGTQPGGLLSADLFAQSQLDCPLSRLQLFPLTHCCGPGLRPISQEDKATQTLS
                     PASPSQGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAGSPLGEQPPEGQFLQHRAEV
                     QIARKLQCIADQFHRLHTQQHQQNRDRAWWQVFLFLQNLALNRQENREGVGPW"
     exon            148..277
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            278..574
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            575..738
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            739..4641
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcctcat cagctgtttg cgggatgccc ggagcgggcg tattttggaa acaataccgc
       61 gcggtgtgcc gtggcctcct cccgcgccag ctcgcgcctg cagcagtcgc tgccgcagcc
      121 cgcgccaccg cctcccaccg cagcccgctg gagtttgccc ccttcttccc aatcgagtgt
      181 gggcaccaag ccccccgagt gttcttcacc ctggaccctg gcgcagagcc ctggcatcac
      241 aactcggagg ctgagacgct gtcctggagt cacccaggag agatggagcc acctcagtgt
      301 gtggaggagc tagaagatga tgtgttccag tcagaggatg gggagccagg gacacagcct
      361 gggggcttgc tctctgctga cctgtttgcc cagagccagc tggactgtcc cctcagtcga
      421 ctccagctct tccctctcac ccattgctgt ggtcccggac tccggcccat aagccaggaa
      481 gacaaggcca ctcagaccct cagtccagct tccccaagcc agggtgtcat gctgccttgt
      541 ggggtgacag aggaacccca gagactcttt tacggcaacg ctggctacag gcttcctctc
      601 cctgccagtt tccctgcagg ctcacccctt ggggagcagc cccctgaagg acagttcctt
      661 cagcaccgag cagaggtgca gatcgccaga aagcttcagt gtattgcaga ccagttccat
      721 cggcttcata cgcaacaaca ccagcagaac cgagaccgtg cgtggtggca ggtcttcctt
      781 ttccttcaaa acctcgccct gaacagacaa gaaaacaggg aaggggtggg gccctggtga
      841 ggctggaccg ccctggccgg atggatcacc aggaatgcag tctgggagga cagatactgt
      901 cttgttaagt tttgttatcc gtaactttct atccatgtgt acatattaca tgccccagtg
      961 ggatcttctt tccccgttca gaacctccac tgaggatggg ggcctttgtc aaacactgtt
     1021 gaaggagagg cagctgtgtc tgctggtaga gttcctaagg ctctgaagat gaccagttgg
     1081 tgatgttctc caggaagtgg actgagactt gctaccggag ctggttaagt caggttaggc
     1141 tcccagtacc atcaaacatg tcagccttcc ttcgtgcctg atggatcatg gctttaaccc
     1201 accaggaccc tgtctgggag cctcctggct aagatcaact gtgccttggc tagcccgatt
     1261 cacgtctggg ttcccacttg gcacagccag cgcccaccgc atgggctcag ggattcttac
     1321 tcagacgctg tcaacttccg gaagacctca gggagggtcg gacttctcca agaacccctc
     1381 aaaggtgcca caaaatgaat caaacttgag aggcttcaag tctgactcgg tcctacatgg
     1441 aagccccttg attggtcccc aagggtgcaa actactgcca cctttgctgg agccaagtag
     1501 ccagtcacca tgccgttgta cccagcggcc tgtgcctttg tcagctctgt tttcagaaga
     1561 ccctgccaat gactggactg gatctgtctg catccatctc agcagaagca cttggagatg
     1621 gggtgggctt gctgggggcg tgggaaccca gcagccatcc cactgataag ttggtcccgg
     1681 gggaatccta gacctcttgg tttccttgga aacgtgtacc tcctccccct tacccccatt
     1741 ccttttctgt acctagcggg atacaggaag aagctaggac tgaggctttg tcagctgaaa
     1801 agtgactttg gaagtaacag acaatgttta gaccatggaa actgcagagc tgacacatct
     1861 tgaatctccc tttagctttc agctaggcca gaaaggagag ttctagaacc cagcaggacc
     1921 ttagctgcct gggagctcct tccttctctc cccgctgcag tgctcaggga gggaacgaaa
     1981 agcagctgat cttagaaatt aagtcctaag tgttatgtat gtaaggaaag acattggtgc
     2041 tataatgaag atgagccaag gctcaaagaa agatggcttc cctagacaaa gaagaacaca
     2101 ggattattca aggactttgg aggagaaact cagagtagac tcaaattgaa caagcccagt
     2161 gactccccat tctgcagaag tggggggggg gggcggattt cagtaccata aaagggcacc
     2221 ggatctcctg ggtgtccagt tgggcaggtt tctccctgcc aaggctaccg acagaggggg
     2281 ctcatagagg ctgaggtcca gcctgtgccc tgctctctag gctgcacatc ctgatgtggg
     2341 cagggtctgc ccagagtaag gaatgtcttt cctaatttgc acaaaggtac tgtgtgcact
     2401 ctcagtggtc ctgaggagga ccttaaggca tgtgtataag cctttgtgtt tttctgctca
     2461 gatgacctgg agatattacc tcttcttggc cacaatcatt tttctcaggg tctataccat
     2521 agttcgtctg ctaagaaagt gggtttctgt ttgcaaggag aggggaccca agtaatgaat
     2581 atgaagactg gttctgaggg tgggcttgat tatttgtgaa gcccagcctt cctacatccc
     2641 accctccctg cagtttagat gtgtgtggga catatgtggt cttccccttt cctggatcaa
     2701 ggctatgaca ggcaggcttc tggtatgtgc ttggtacatg tgctgcaata catgtgcttg
     2761 atggtacatg cgtgcccctc cccatacaga accttgtact tcagttatct ttaacataac
     2821 ttagtagact ttccatctgt cctaaggcat gactgtcagc ttcagcaacc ttgctaggtg
     2881 caggctgggt accctgtggc ctgagaactg agcccagagt ttgacctgaa cattgagcct
     2941 ggaccaggca gaagctggtc agaatgtact gtctccattt tgggccaagc cgggaccaaa
     3001 cttactaact caggcaagcc agggtgaaac ttaaaccctc ttttatcttt aacctgaatc
     3061 caggctggag ttgaagctca atgataaagg gcttgcctgt cggtcaagag accctcggat
     3121 ggatcccagg actgtaaaat ataaataaat aaaaatatgc cccctctctc caacctcttg
     3181 gaggcagctg gcagcccagc tcaaggaggc aagaggttcc ccctggctgc ttgctttaat
     3241 tggccggtga tctctgcctg gtgaattggt tttatagtct ctgagtccag cccctggaca
     3301 acccctcccc tttgcctctc cagaactcca ggagcttggc tgtctctagt gaagagtgga
     3361 gattcagatt ctgagggagg gagggagggt ctgacctgtg tggtgacctg taaccagctg
     3421 aaggcaacag gcttttgtgg tgtgctgagg atggggggtg ggagaagagc tggaaaactc
     3481 tgtagaaatg ccctagagga acagaagccc tgtattcagg ggccaaactg ctctactaat
     3541 tcacaatccc caggaggcat ttctaaaagc cagtgaacag atctggagag gaacatcccc
     3601 cagtcccgtc actgactccc ccagggagac tggggtggta cgcaggagag tggggggagg
     3661 gtgggcactt tgcctggccc tgtctctctg tttcaaagtt tggctgtgct gttcagttgt
     3721 ccccagtggc cttgtcttgc tcaatcagag gtggaaaaag atcacctccc ggtgacctcc
     3781 ttcaggcccc aggggatggg ctgtgtccag agctatgtgg cagagcttgt ttccagagcc
     3841 cagagaggcc ccgctggcct gccttgctgc cccagtggcg aaacgcaagc ccaacactga
     3901 gcatggcagg gagtgggtgt tggggacagt ctagccaagg cccctgtctg tcccaagctt
     3961 tccaggaact aagcagtgag gtcactgtga cagtcctgcc tggtcagcga ggagaatatt
     4021 ctgagctttc ccgctctggg acttactggg gagggggcgg gtaccagtgt atggagtaac
     4081 aagacatcag ccttcgtggc tctgcaggat ttgggggaat cagtacagtg gccactgtgg
     4141 ctgctatgaa gataaggcct tttggagaca ggctatcctg gcctgatacc ctggttggac
     4201 ctagagggat acagggtgga gccacagtca tttcaagttc cctggggttc ctgtgggctg
     4261 cagacctagg ggacagagcc tcaaggaaga cagcagaaca aagctgagct cttccatata
     4321 tgccagcttt ggccaaggtg ctatgaggtc tgtgacccca ggcttgcact gcccctttct
     4381 ctacagttgt ctgatgtcca ccccatctct gggttcacag aaactgacac ggggagaccc
     4441 agcgagatgt agcatttcct tcatccccag tctggttggc ccggggtctg ggcatcctgc
     4501 cttaaggaaa ggaatgggga ccattatttt ttaacctgta tataatattt gacctttttt
     4561 tggttcttta tatgtataca tgtgtaaata tcctctcatc catcaagtgg tacagttttt
     4621 aataaaacca tttaaagcag a
//
