LOCUS       NM_001311140            4593 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus BCL2 modifying factor (Bmf), transcript variant 2,
            mRNA.
ACCESSION   NM_001311140 XM_006498853
VERSION     NM_001311140.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4593)
  AUTHORS   El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh
            S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T and
            Voss AK.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   2  (bases 1 to 4593)
  AUTHORS   Zhi Z, Ouyang Z, Ren Y, Cheng Y, Liu P, Wen Y and Shao Y.
  TITLE     Non-canonical phosphorylation of Bmf by p38 MAPK promotes its
            apoptotic activity in anoikis
  JOURNAL   Cell Death Differ 29 (2), 323-336 (2022)
   PUBMED   34462553
  REMARK    GeneRIF: Non-canonical phosphorylation of Bmf by p38 MAPK promotes
            its apoptotic activity in anoikis.
REFERENCE   3  (bases 1 to 4593)
  AUTHORS   Singh PK, Roukounakis A, Weber A, Das KK, Sohm B, Villunger A,
            Garcia-Saez AJ and Hacker G.
  TITLE     Dynein light chain binding determines complex formation and
            posttranslational stability of the Bcl-2 family members Bmf and Bim
  JOURNAL   Cell Death Differ 27 (2), 434-450 (2020)
   PUBMED   31189926
  REMARK    GeneRIF: Dynein light chain binding determines complex formation
            and posttranslational stability of the Bcl-2 family members Bmf and
            Bim.
REFERENCE   4  (bases 1 to 4593)
  AUTHORS   Sul OJ, Rajasekaran M, Park HJ, Suh JH and Choi HS.
  TITLE     MicroRNA-29b Enhances Osteoclast Survival by Targeting
            BCL-2-Modifying Factor after Lipopolysaccharide Stimulation
  JOURNAL   Oxid Med Cell Longev 2019, 6018180 (2019)
   PUBMED   31093317
  REMARK    GeneRIF: miR-29b binds to the 3'-UTR of Bmf.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4593)
  AUTHORS   Delbridge ARD, Kueh AJ, Ke F, Zamudio NM, El-Saafin F, Jansz N,
            Wang GY, Iminitoff M, Beck T, Haupt S, Hu Y, May RE, Whitehead L,
            Tai L, Chiang W, Herold MJ, Haupt Y, Smyth GK, Thomas T, Blewitt
            ME, Strasser A and Voss AK.
  TITLE     Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation
            and Female-Specific Neural Tube Defects
  JOURNAL   Cell Rep 27 (2), 442-454 (2019)
   PUBMED   30970248
REFERENCE   6  (bases 1 to 4593)
  AUTHORS   Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman
            PM, Day CL, Adams JM and Huang DC.
  TITLE     Differential targeting of prosurvival Bcl-2 proteins by their
            BH3-only ligands allows complementary apoptotic function
  JOURNAL   Mol Cell 17 (3), 393-403 (2005)
   PUBMED   15694340
REFERENCE   7  (bases 1 to 4593)
  AUTHORS   Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY,
            Huang DC and Hinds MG.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   8  (bases 1 to 4593)
  AUTHORS   Morales AA, Olsson A, Celsing F, Osterborg A, Jondal M and Osorio
            LM.
  TITLE     Expression and transcriptional regulation of functionally distinct
            Bmf isoforms in B-chronic lymphocytic leukemia cells
  JOURNAL   Leukemia 18 (1), 41-47 (2004)
   PUBMED   14574334
REFERENCE   9  (bases 1 to 4593)
  AUTHORS   Cory S, Huang DC and Adams JM.
  TITLE     The Bcl-2 family: roles in cell survival and oncogenesis
  JOURNAL   Oncogene 22 (53), 8590-8607 (2003)
   PUBMED   14634621
  REMARK    Review article
REFERENCE   10 (bases 1 to 4593)
  AUTHORS   Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L,
            Cheney RE, Huang DC and Strasser A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929381.9.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by
            NM_001311140.3.
            
            On Sep 13, 2016 this sequence version replaced NM_001311140.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region compard to variant 1. The encoded isoform (2) is
            shorter and has a distinct N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089218.1, SRR17253012.5627298.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AL929381.9         41612-41840         c
            230-526             AL929381.9         40957-41253         c
            527-690             AL929381.9         39323-39486         c
            691-4593            AL929381.9         22998-26900         c
FEATURES             Location/Qualifiers
     source          1..4593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.4 cM"
     gene            1..4593
                     /gene="Bmf"
                     /note="BCL2 modifying factor"
                     /db_xref="GeneID:171543"
                     /db_xref="MGI:MGI:2176433"
     exon            1..229
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..792
                     /gene="Bmf"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bcl-2-modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform 2"
                     /protein_id="NP_001298069.1"
                     /db_xref="CCDS:CCDS79835.1"
                     /db_xref="GeneID:171543"
                     /db_xref="MGI:MGI:2176433"
                     /translation="MSPGEMEPPQCVEELEDDVFQSEDGEPGTQPGGLLSADLFAQSQ
                     LDCPLSRLQLFPLTHCCGPGLRPISQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFY
                     GNAGYRLPLPASFPAGSPLGEQPPEGQFLQHRAEVQIARKLQCIADQFHRLHTQQHQQ
                     NRDRAWWQVFLFLQNLALNRQENREGVGPW"
     exon            230..526
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            527..690
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            691..4593
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgttaggag ggaacctggc tgctctacaa ttcctggctc ttgtttttgc tgcttagcct
       61 ggagttcaga cttcgccgag agcctggagg ttcctgctta ggaagtgtgt gtgtgtgtgt
      121 gtgtgtgtgt gcacataagt atgttgtgca cttttgtata gtcagtaagt gtccccttct
      181 gagcctccac agccacttac agaggctagt cttgcttcta tgtccccagg agagatggag
      241 ccacctcagt gtgtggagga gctagaagat gatgtgttcc agtcagagga tggggagcca
      301 gggacacagc ctgggggctt gctctctgct gacctgtttg cccagagcca gctggactgt
      361 cccctcagtc gactccagct cttccctctc acccattgct gtggtcccgg actccggccc
      421 ataagccagg aagacaaggc cactcagacc ctcagtccag cttccccaag ccagggtgtc
      481 atgctgcctt gtggggtgac agaggaaccc cagagactct tttacggcaa cgctggctac
      541 aggcttcctc tccctgccag tttccctgca ggctcacccc ttggggagca gccccctgaa
      601 ggacagttcc ttcagcaccg agcagaggtg cagatcgcca gaaagcttca gtgtattgca
      661 gaccagttcc atcggcttca tacgcaacaa caccagcaga accgagaccg tgcgtggtgg
      721 caggtcttcc ttttccttca aaacctcgcc ctgaacagac aagaaaacag ggaaggggtg
      781 gggccctggt gaggctggac cgccctggcc ggatggatca ccaggaatgc agtctgggag
      841 gacagatact gtcttgttaa gttttgttat ccgtaacttt ctatccatgt gtacatatta
      901 catgccccag tgggatcttc tttccccgtt cagaacctcc actgaggatg ggggcctttg
      961 tcaaacactg ttgaaggaga ggcagctgtg tctgctggta gagttcctaa ggctctgaag
     1021 atgaccagtt ggtgatgttc tccaggaagt ggactgagac ttgctaccgg agctggttaa
     1081 gtcaggttag gctcccagta ccatcaaaca tgtcagcctt ccttcgtgcc tgatggatca
     1141 tggctttaac ccaccaggac cctgtctggg agcctcctgg ctaagatcaa ctgtgccttg
     1201 gctagcccga ttcacgtctg ggttcccact tggcacagcc agcgcccacc gcatgggctc
     1261 agggattctt actcagacgc tgtcaacttc cggaagacct cagggagggt cggacttctc
     1321 caagaacccc tcaaaggtgc cacaaaatga atcaaacttg agaggcttca agtctgactc
     1381 ggtcctacat ggaagcccct tgattggtcc ccaagggtgc aaactactgc cacctttgct
     1441 ggagccaagt agccagtcac catgccgttg tacccagcgg cctgtgcctt tgtcagctct
     1501 gttttcagaa gaccctgcca atgactggac tggatctgtc tgcatccatc tcagcagaag
     1561 cacttggaga tggggtgggc ttgctggggg cgtgggaacc cagcagccat cccactgata
     1621 agttggtccc gggggaatcc tagacctctt ggtttccttg gaaacgtgta cctcctcccc
     1681 cttaccccca ttccttttct gtacctagcg ggatacagga agaagctagg actgaggctt
     1741 tgtcagctga aaagtgactt tggaagtaac agacaatgtt tagaccatgg aaactgcaga
     1801 gctgacacat cttgaatctc cctttagctt tcagctaggc cagaaaggag agttctagaa
     1861 cccagcagga ccttagctgc ctgggagctc cttccttctc tccccgctgc agtgctcagg
     1921 gagggaacga aaagcagctg atcttagaaa ttaagtccta agtgttatgt atgtaaggaa
     1981 agacattggt gctataatga agatgagcca aggctcaaag aaagatggct tccctagaca
     2041 aagaagaaca caggattatt caaggacttt ggaggagaaa ctcagagtag actcaaattg
     2101 aacaagccca gtgactcccc attctgcaga agtggggggg gggggcggat ttcagtacca
     2161 taaaagggca ccggatctcc tgggtgtcca gttgggcagg tttctccctg ccaaggctac
     2221 cgacagaggg ggctcataga ggctgaggtc cagcctgtgc cctgctctct aggctgcaca
     2281 tcctgatgtg ggcagggtct gcccagagta aggaatgtct ttcctaattt gcacaaaggt
     2341 actgtgtgca ctctcagtgg tcctgaggag gaccttaagg catgtgtata agcctttgtg
     2401 tttttctgct cagatgacct ggagatatta cctcttcttg gccacaatca tttttctcag
     2461 ggtctatacc atagttcgtc tgctaagaaa gtgggtttct gtttgcaagg agaggggacc
     2521 caagtaatga atatgaagac tggttctgag ggtgggcttg attatttgtg aagcccagcc
     2581 ttcctacatc ccaccctccc tgcagtttag atgtgtgtgg gacatatgtg gtcttcccct
     2641 ttcctggatc aaggctatga caggcaggct tctggtatgt gcttggtaca tgtgctgcaa
     2701 tacatgtgct tgatggtaca tgcgtgcccc tccccataca gaaccttgta cttcagttat
     2761 ctttaacata acttagtaga ctttccatct gtcctaaggc atgactgtca gcttcagcaa
     2821 ccttgctagg tgcaggctgg gtaccctgtg gcctgagaac tgagcccaga gtttgacctg
     2881 aacattgagc ctggaccagg cagaagctgg tcagaatgta ctgtctccat tttgggccaa
     2941 gccgggacca aacttactaa ctcaggcaag ccagggtgaa acttaaaccc tcttttatct
     3001 ttaacctgaa tccaggctgg agttgaagct caatgataaa gggcttgcct gtcggtcaag
     3061 agaccctcgg atggatccca ggactgtaaa atataaataa ataaaaatat gccccctctc
     3121 tccaacctct tggaggcagc tggcagccca gctcaaggag gcaagaggtt ccccctggct
     3181 gcttgcttta attggccggt gatctctgcc tggtgaattg gttttatagt ctctgagtcc
     3241 agcccctgga caacccctcc cctttgcctc tccagaactc caggagcttg gctgtctcta
     3301 gtgaagagtg gagattcaga ttctgaggga gggagggagg gtctgacctg tgtggtgacc
     3361 tgtaaccagc tgaaggcaac aggcttttgt ggtgtgctga ggatgggggg tgggagaaga
     3421 gctggaaaac tctgtagaaa tgccctagag gaacagaagc cctgtattca ggggccaaac
     3481 tgctctacta attcacaatc cccaggaggc atttctaaaa gccagtgaac agatctggag
     3541 aggaacatcc cccagtcccg tcactgactc ccccagggag actggggtgg tacgcaggag
     3601 agtgggggga gggtgggcac tttgcctggc cctgtctctc tgtttcaaag tttggctgtg
     3661 ctgttcagtt gtccccagtg gccttgtctt gctcaatcag aggtggaaaa agatcacctc
     3721 ccggtgacct ccttcaggcc ccaggggatg ggctgtgtcc agagctatgt ggcagagctt
     3781 gtttccagag cccagagagg ccccgctggc ctgccttgct gccccagtgg cgaaacgcaa
     3841 gcccaacact gagcatggca gggagtgggt gttggggaca gtctagccaa ggcccctgtc
     3901 tgtcccaagc tttccaggaa ctaagcagtg aggtcactgt gacagtcctg cctggtcagc
     3961 gaggagaata ttctgagctt tcccgctctg ggacttactg gggagggggc gggtaccagt
     4021 gtatggagta acaagacatc agccttcgtg gctctgcagg atttggggga atcagtacag
     4081 tggccactgt ggctgctatg aagataaggc cttttggaga caggctatcc tggcctgata
     4141 ccctggttgg acctagaggg atacagggtg gagccacagt catttcaagt tccctggggt
     4201 tcctgtgggc tgcagaccta ggggacagag cctcaaggaa gacagcagaa caaagctgag
     4261 ctcttccata tatgccagct ttggccaagg tgctatgagg tctgtgaccc caggcttgca
     4321 ctgccccttt ctctacagtt gtctgatgtc caccccatct ctgggttcac agaaactgac
     4381 acggggagac ccagcgagat gtagcatttc cttcatcccc agtctggttg gcccggggtc
     4441 tgggcatcct gccttaagga aaggaatggg gaccattatt ttttaacctg tatataatat
     4501 ttgacctttt tttggttctt tatatgtata catgtgtaaa tatcctctca tccatcaagt
     4561 ggtacagttt ttaataaaac catttaaagc aga
//
