LOCUS       NM_172309               2623 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus basic helix-loop-helix ARNT like 2 (Bmal2), transcript
            variant 1, mRNA.
ACCESSION   NM_172309
VERSION     NM_172309.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Zhou,M., Aziz,M., Li,J., Jha,A., Ma,G., Murao,A. and Wang,P.
  TITLE     BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance
  JOURNAL   Front Immunol 15, 1426682 (2024)
   PUBMED   38938563
  REMARK    GeneRIF: BMAL2 promotes eCIRP-induced macrophage endotoxin
            tolerance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Dantas-Ferreira,R., Ciocca,D., Vuillez,P., Dumont,S., Boitard,C.,
            Rogner,U.C. and Challet,E.
  TITLE     Deletion of the Clock Gene Bmal2 Leads to Alterations in
            Hypothalamic Clocks, Circadian Regulation of Feeding, and Energy
            Balance
  JOURNAL   J Neurosci 44 (19), e1886232024 (2024)
   PUBMED   38531632
  REMARK    GeneRIF: Deletion of the Clock Gene Bmal2 Leads to Alterations in
            Hypothalamic Clocks, Circadian Regulation of Feeding, and Energy
            Balance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Lebailly,B., Langa,F., Boitard,C., Avner,P. and Rogner,U.C.
  TITLE     The circadian gene Arntl2 on distal mouse chromosome 6 controls
            thymocyte apoptosis
  JOURNAL   Mamm Genome 28 (1-2), 1-12 (2017)
   PUBMED   27671790
  REMARK    GeneRIF: Our results identify Arntl2 as a gene controlling
            thymocyte apoptosis and proliferation along with Th17 development
            through the IL-21 pathway.
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Ha,N.H., Long,J., Cai,Q., Shu,X.O. and Hunter,K.W.
  TITLE     The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility
            Gene for Estrogen Receptor-Negative Breast Cancer
  JOURNAL   PLoS Genet 12 (9), e1006267 (2016)
   PUBMED   27656887
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Brady,J.J., Chuang,C.H., Greenside,P.G., Rogers,Z.N., Murray,C.W.,
            Caswell,D.R., Hartmann,U., Connolly,A.J., Sweet-Cordero,E.A.,
            Kundaje,A. and Winslow,M.M.
  TITLE     An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic
            Self-Sufficiency
  JOURNAL   Cancer Cell 29 (5), 697-710 (2016)
   PUBMED   27150038
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Dardente,H., Fortier,E.E., Martineau,V. and Cermakian,N.
  TITLE     Cryptochromes impair phosphorylation of transcriptional activators
            in the clock: a general mechanism for circadian repression
  JOURNAL   Biochem J 402 (3), 525-536 (2007)
   PUBMED   17115977
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Hung,M.S., Avner,P. and Rogner,U.C.
  TITLE     Identification of the transcription factor ARNTL2 as a candidate
            gene for the type 1 diabetes locus Idd6
  JOURNAL   Hum Mol Genet 15 (18), 2732-2742 (2006)
   PUBMED   16893914
  REMARK    GeneRIF: Arntl2 exhibited a six-fold upregulation in spleens of the
            NOD.C3H 6.VIII congenic strain compared with the NOD control
            strain, strain-specific splice variants and a large number of
            polymorphisms in both coding and non-coding regions.
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Kondo,J., Sato,F., Fujimoto,K., Kusumi,T., Imanaka,T., Kawamoto,T.,
            Uk,B., Noshiro,M., Kato,Y., Sato,T. and Kijima,H.
  TITLE     57Arg in the bHLH transcription factor DEC2 is essential for the
            suppression of CLOCK/BMAL2-mediated transactivation
  JOURNAL   Int J Mol Med 17 (6), 1053-1056 (2006)
   PUBMED   16685415
  REMARK    GeneRIF: These findings demonstrate that (57)Arg in the basic
            region of DEC2 is essential for its activity in suppressing
            CLOCK/BMAL2-mediated transactivation.
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Marion,J.F., Yang,C., Caqueret,A., Boucher,F. and Michaud,J.L.
  TITLE     Sim1 and Sim2 are required for the correct targeting of mammillary
            body axons
  JOURNAL   Development 132 (24), 5527-5537 (2005)
   PUBMED   16291793
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Okano,T., Sasaki,M. and Fukada,Y.
  TITLE     Cloning of mouse BMAL2 and its daily expression profile in the
            suprachiasmatic nucleus: a remarkable acceleration of Bmal2
            sequence divergence after Bmal gene duplication
  JOURNAL   Neurosci Lett 300 (2), 111-114 (2001)
   PUBMED   11207387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY005163.1, AK019506.1 and BY604501.1.
            
            On Jan 25, 2014 this sequence version replaced NM_172309.1.
            
            Summary: This gene encodes a basic helix-loop-helix transcription
            factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS
            proteins play important roles in adaptation to low atmospheric and
            cellular oxygen levels, exposure to certain environmental
            pollutants, and diurnal oscillations in light and temperature. This
            protein forms a transcriptionally active heterodimer with the
            circadian Clock protein, the structurally related Mop4, and
            hypoxia-inducible factors, such as Hif1alpha. Consistent with its
            role as a biologically relevant partner of circadian and hypoxia
            factors, this protein is coexpressed in regions of the brain such
            as the thalamus, hypothalamus, and amygdala. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108965.2, AY005163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1740              AY005163.1         1-1740
            1741-2616           AK019506.1         2124-2999
            2617-2623           BY604501.1         400-406
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..2623
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /note="basic helix-loop-helix ARNT like 2"
                     /db_xref="GeneID:272322"
                     /db_xref="MGI:MGI:2684845"
     CDS             1..1740
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /note="isoform 1 is encoded by transcript variant 1; aryl
                     hydrocarbon receptor nuclear translocator-like protein 2;
                     brain-muscle-ARNT-like protein 2; brain and muscle
                     ARNT-like 2; basic helix-loop-helix ARNT-like protein 2;
                     aryl hydrocarbon receptor nuclear translocator-like 2"
                     /codon_start=1
                     /product="basic helix-loop-helix ARNT-like protein 2
                     isoform 1"
                     /protein_id="NP_758513.1"
                     /db_xref="CCDS:CCDS20702.1"
                     /db_xref="GeneID:272322"
                     /db_xref="MGI:MGI:2684845"
                     /translation="MEFPRKRRGRDSQPLQSEFMTDTTVESLPQNPFASLLSTRTGVS
                     APSGIREAHSQMEKRRRDKMNHLIQKLSSMIPPHIPTAHKLDKLSVLRRAVQYLRSLR
                     GMTELYLGENSKPSFIQDKELSHLILKAAEGFLFVVGCERGRIFYVSKSVSKTLRYDQ
                     ASLIGQNLFDFLHPKDVAKVKEQLSCDGSPREKPIDTKTSQVYSHPYTGRPRMHSGSR
                     RSFFFRMKSCTVPVKEEQPCSSCSKKKDHRKFHTVHCTGYLRSWPLNVVGMEKESGGG
                     KDSGPLTCLVAMGRLHPYIVPQKSGKINVRPAEFITRFAMNGKFVYVDQRATAILGYL
                     PQELLGTSCYEYFHQDDHSSLTDKHKAVLQSKEKILTDSYKFRVKDGAFVTLKSEWFS
                     FTNPWTKELEYIVSVNTLVLGRSETRLSLLHCGGSSQSSEDSFRQSCINVPGVSTGTV
                     LGAGSIGTDIANEVLSLQRLHSSSPEDASPSEEVRDDCSVNGGNAYGPASTREPFAVS
                     PSETEVLEAARQHQSTEPAHPHGPLPGDSAQLGFDVLCDSDSIDMAAFMNYLEAEGGL
                     GDPGDFSDIQWAL"
     exon            1..47
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            48..149
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            150..307
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            308..387
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            388..480
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            481..595
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            596..736
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            737..977
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1084
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1235
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1297
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1406
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1494
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1603
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..2623
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2591
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /note="major polyA site"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="Bmal2"
                     /gene_synonym="4632430A05Rik; Arntl2; bHLHe6; CLIF; MOP9"
                     /note="major polyA site"
ORIGIN      
        1 atggagtttc caaggaaacg cagaggcaga gattcccagc cactccagtc agaattcatg
       61 acagacacaa cagtggaaag tcttccccag aatccctttg cctctcttct ttcaacaaga
      121 acaggagtat cagcgcccag tggcatcagg gaagctcaca gccagatgga aaagcgtcgg
      181 agagacaaga tgaaccatct gattcagaaa ctgtcatcta tgatccctcc acacatcccc
      241 acggcccaca aactggacaa gctcagcgtc ttgaggaggg cggtgcagta cttgaggtct
      301 ctgagaggca tgacagagct ttacttagga gaaaactcta aaccttcatt tattcaggat
      361 aaggaactca gtcacttaat cctcaaggca gcagaaggct tcctgtttgt ggttggatgc
      421 gaaagaggga gaatttttta cgtttctaag tctgtctcca aaacactgcg ttatgatcag
      481 gctagcttga taggacagaa tttgtttgac ttcttacacc caaaagacgt cgccaaagta
      541 aaggaacaac tttcttgtga tggttcacca agagagaaac ctatagacac caaaacctct
      601 caggtttaca gtcaccccta cactgggcga ccacgcatgc attctggctc cagacgatct
      661 ttcttcttta gaatgaagag ctgtaccgtc cctgtcaaag aagagcagcc atgctcgtcc
      721 tgctcaaaga agaaagacca tagaaaattc cacaccgtcc attgcactgg atacttgaga
      781 agctggcctc tgaatgttgt tggcatggag aaagagtcgg gtggtgggaa ggacagcggt
      841 cctcttacct gccttgtggc tatgggacgg ttgcatccat acattgtccc tcaaaagagt
      901 ggcaagatca acgtgagacc ggctgagttc ataactcgct tcgcaatgaa cgggaaattc
      961 gtctatgttg accaaagggc aacggcaatt ttaggatacc tgcctcagga acttttggga
     1021 acttcatgtt atgaatattt tcatcaggat gaccacagta gtttgactga caagcacaaa
     1081 gcagttctgc agagtaagga gaaaatactt acagactcat acaaattcag agtgaaggat
     1141 ggtgccttcg tgactctgaa gagtgagtgg ttcagcttca caaacccttg gaccaaagag
     1201 ctggagtaca ttgtgtctgt caacacattg gttttggggc gcagtgagac caggctgtct
     1261 ttgcttcatt gcggcggcag cagccagtcc tccgaagact catttagaca atcctgcatc
     1321 aatgtgcccg gtgtatccac ggggaccgtc cttggtgctg ggagtattgg aacagatatt
     1381 gcaaatgagg ttctgagttt acagagatta cactcttcat ccccagaaga tgcaagccct
     1441 tcagaagaag tgagagatga ctgcagtgta aatggtggga atgcctatgg gcctgcatcc
     1501 actagggagc cttttgcagt gagcccttct gaaacagagg tcctggaggc tgccaggcaa
     1561 caccagagca ctgaacccgc ccaccctcac ggaccacttc ccggtgacag tgcccagctg
     1621 ggttttgatg tcctgtgtga cagtgacagc atagacatgg ctgcattcat gaattacctc
     1681 gaagcagagg ggggcctggg tgaccctggg gacttcagtg acatccagtg ggcactctag
     1741 cattttggct ttgtacttta acatgagaat catttcagag tgtttcattg acaaaacact
     1801 gtactcttga gcactgtatt ggtacatttt ttatctctta ttactagtct actgactttt
     1861 atatatctgc cctttattct cactgggatg tgcggagtca cacatgctcc tccaaagaga
     1921 aacagccaag tttatcaatc cctctttaca cagtgagaag gcagcttggg ggtcaggctg
     1981 ccatattttt gctaaaatat tctgaccaaa aactgctacc aaccatattg ttagggcttt
     2041 ttttaaatat atatatactt ttgtttttga gtttgggatt tttgttttgt tctgtctgtt
     2101 ttctgttttt gtcttcaaga cagggtttct ctgtgtagcc ctggctgtct tgtaactcac
     2161 tctgtagacc aggctggcct tgaactcaaa gatccgcctg cctcttcctc ccaagtgttg
     2221 agattaaagc catatatcac aattcccagc ttaaatacag tccctaaaat catgaggcaa
     2281 tgagaaatca cttagaagcc aactttcttc taataatttg gaatttagaa ggcattttta
     2341 aaaagtaact aacccagagg tagctcaaat ggagtgtaag aattaggatg atttaaaatt
     2401 ctggcccagg aatgcagctc aggtgacaga gtccttgcct agcaccaagt cttgggttca
     2461 gttcctagca ctgtaaacca atttgggtgc acactttgta atcctggcac tcaggaggat
     2521 cataaattca aagccagcct tggcacaaag cagattgaag gtcagcctgg gattcacgaa
     2581 accctgtctt ttaaaataaa taaaaaaaga ttatttaaat ttc
//
