LOCUS       NM_001411976            2644 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus basic helix-loop-helix ARNT like 1 (Bmal1), transcript
            variant 6, mRNA.
ACCESSION   NM_001411976 XM_006507248
VERSION     NM_001411976.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Yao,N., Kinouchi,K., Katoh,M., Ashtiani,K.C., Abdelkarim,S.,
            Morimoto,H., Torimitsu,T., Kozuma,T., Iwahara,A., Kosugi,S.,
            Komuro,J., Kato,K., Tonomura,S., Nakamura,T., Itoh,A.,
            Yamaguchi,S., Yoshino,J., Irie,J., Hashimoto,H., Yuasa,S.,
            Satoh,A., Mikami,Y., Uchida,S., Ueki,T., Nomura,S., Baldi,P.,
            Hayashi,K. and Itoh,H.
  TITLE     Maternal circadian rhythms during pregnancy dictate metabolic
            plasticity in offspring
  JOURNAL   Cell Metab 37 (2), 395-412 (2025)
   PUBMED   39814018
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   O'Siorain,J.R., Cox,S.L., Payet,C., Nally,F.K., He,Y.,
            Drewinksi,T.T., Kennedy,O.D., Dowling,J.K., Mellett,M., Early,J.O.
            and Curtis,A.M.
  TITLE     Time-of-day control of mitochondria regulates NLRP3 inflammasome
            activation in macrophages
  JOURNAL   FASEB J 38 (24), e70235 (2024)
   PUBMED   39686706
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Yoshida,Y., Nishikawa,N., Fukuoka,K., Tsuruta,A., Otsuki,K.,
            Fukuda,T., Terada,Y., Tanihara,T., Kumamoto,T., Tsukamoto,R.,
            Nishi,T., Oyama,K., Hamamura,K., Mayanagi,K., Koyanagi,S., Ohdo,S.
            and Matsunaga,N.
  TITLE     Monocyte/Macrophage-Specific Loss of ARNTL Suppresses Chronic
            Kidney Disease-Associated Cardiac Impairment
  JOURNAL   Int J Mol Sci 25 (23), 13009 (2024)
   PUBMED   39684718
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Nakabo,S., Sandoval-Heglund,D., Hanata,N., Brooks,S., Hoffmann,V.,
            Zhang,M., Ambler,W., Manna,Z., Poncio,E., Hasni,S., Islam,S.,
            Dell'Orso,S. and Kaplan,M.J.
  TITLE     The circadian clock gene BMAL1 modulates autoimmunity features in
            lupus
  JOURNAL   Front Immunol 15, 1465185 (2024)
   PUBMED   39664388
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Rakshit,K., Brown,M.R., Javeed,N., Lee,J.H., Ordog,T. and
            Matveyenko,A.V.
  TITLE     Core circadian transcription factor Bmal1 mediates beta cell
            response and recovery from pro-inflammatory injury
  JOURNAL   iScience 27 (11), 111179 (2024)
   PUBMED   39524327
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Dunlap,J.C.
  TITLE     Molecular bases for circadian clocks
  JOURNAL   Cell 96 (2), 271-290 (1999)
   PUBMED   9988221
  REMARK    Review article
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Takahata,S., Sogawa,K., Kobayashi,A., Ema,M., Mimura,J., Ozaki,N.
            and Fujii-Kuriyama,Y.
  TITLE     Transcriptionally active heterodimer formation of an Arnt-like PAS
            protein, Arnt3, with HIF-1a, HLF, and clock
  JOURNAL   Biochem Biophys Res Commun 248 (3), 789-794 (1998)
   PUBMED   9704006
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Gekakis,N., Staknis,D., Nguyen,H.B., Davis,F.C., Wilsbacher,L.D.,
            King,D.P., Takahashi,J.S. and Weitz,C.J.
  TITLE     Role of the CLOCK protein in the mammalian circadian mechanism
  JOURNAL   Science 280 (5369), 1564-1569 (1998)
   PUBMED   9616112
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Wolting,C.D. and McGlade,C.J.
  TITLE     Cloning and chromosomal localization of a new member of the
            bHLH/PAS transcription factor family
  JOURNAL   Mamm Genome 9 (6), 463-468 (1998)
   PUBMED   9585435
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156605.13.
            
            On Sep 13, 2022 this sequence version replaced XM_006507248.4.
            
            Summary: The protein encoded by this gene is a basic
            helix-loop-helix protein that forms a heterodimer with Clock. This
            heterodimer binds E-box enhancer elements upstream of Period (Per1,
            Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates
            transcription of these genes. Per and Cry proteins heterodimerize
            and repress their own transcription by interacting in a feedback
            loop with Clock/Arntl complexes. Defects in this gene have been
            linked to infertility, problems with gluconeogenesis and
            lipogenesis, and altered sleep patterns. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (6).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.814319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC156605.13        86797-86930
            135-207             AC156605.13        113910-113982
            208-360             AC156605.13        159936-160088
            361-381             AC156605.13        160688-160708
            382-420             AC156605.13        162543-162581
            421-462             AC156605.13        162807-162848
            463-620             AC156605.13        164285-164442
            621-700             AC156605.13        166403-166482
            701-793             AC156605.13        170747-170839
            794-911             AC156605.13        172464-172581
            912-1061            AC156605.13        174730-174879
            1062-1308           AC156605.13        178473-178719
            1309-1415           AC156605.13        180837-180943
            1416-1566           AC156605.13        182627-182777
            1567-1655           AC156605.13        183610-183698
            1656-1779           AC156605.13        185289-185412
            1780-1873           AC156605.13        187902-187995
            1874-1976           AC156605.13        192080-192182
            1977-2644           AC156605.13        192745-193412
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.17 cM"
     gene            1..2644
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /note="basic helix-loop-helix ARNT like 1"
                     /db_xref="GeneID:11865"
                     /db_xref="MGI:MGI:1096381"
     exon            1..134
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            135..207
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            208..360
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2137
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /note="isoform 6 is encoded by transcript variant 6; aryl
                     hydrocarbon receptor nuclear translocator-like protein 1;
                     brain and muscle ARNT-like 1; basic helix-loop-helix
                     ARNT-like protein 1"
                     /codon_start=1
                     /product="basic helix-loop-helix ARNT-like protein 1
                     isoform 6"
                     /protein_id="NP_001398905.1"
                     /db_xref="GeneID:11865"
                     /db_xref="MGI:MGI:1096381"
                     /translation="MADQRMDISSTISDFMSPGPTDLLSGSLGTSGVDCNRKRKGSAT
                     DYQLDDFAFEESMDTDKDDPHGRLEYAEHQGRIKNAREAHSQIEKRRRDKMNSFIDEL
                     ASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILR
                     AADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS
                     DTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFASTC
                     SKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHMVPQ
                     PANGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHL
                     AECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLA
                     NVLEGGDPTFPQLTAPPHSMDSMLPSGEDSFVVGGPKRTHPTVPGIPGGTRAGAGKIG
                     RMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSTGLL
                     PGQAQETPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAG
                     LGGPVDFSDLPWPL"
     exon            361..381
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            382..420
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..462
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..620
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            621..700
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            701..793
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..911
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1061
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1308
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1415
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1566
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1655
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1779
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1873
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1976
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2644
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="Bmal1"
                     /gene_synonym="Arnt3; Arntl; bHLHe5; BMAL1b; bmal1b';
                     MOP3"
                     /note="major polyA site"
ORIGIN      
        1 agtggtgcga catttaggga aggcagaaag taggtcaggg acggaggtgc ctgtttaccc
       61 gcgccggact tgccgccgcc gccgccgcgg gatccgagtg cgggtgcggg cgcgggcgct
      121 cgcagcgagc cacggtgttg ttggctgcag tgaatgcttt tggaaccaaa cttaaggctt
      181 caaatgtgga accctaggcc ttcattgcac cttccttcca atggcggacc agagaatgga
      241 catttcctca accatcagcg acttcatgtc tccgggcccc accgacctac tctccggttc
      301 cctgggcacc agtggtgtgg actgcaatcg caagaggaaa ggcagtgcca ctgactacca
      361 acttgatgac tttgcttttg aagaaagtat ggacacagac aaagatgacc ctcatggaag
      421 gttagaatat gcagaacacc aaggaaggat caagaatgca agggaggccc acagtcagat
      481 tgaaaagagg cgtcgggaca aaatgaacag tttcattgat gaattggctt ctttggtacc
      541 aacatgcaat gcaatgtcca ggaagttaga taaactcacc gtgctaagga tggctgttca
      601 gcacatgaaa actttgagag gtgccaccaa cccatacaca gaagcaaact acaagccaac
      661 atttctatca gatgacgaac tgaaacacct aattctcagg gcagcagatg gatttttgtt
      721 tgtcgtagga tgtgaccgag ggaagatcct ctttgtctcc gagtctgtct tcaagatcct
      781 caattatagc cagaatgacc ttattggcca gagcttgttt gactacctgc atccaaaaga
      841 tattgccaaa gttaaggaac agctatcttc ctcggacact gcgccccggg agcgactcat
      901 tgatgccaag actggacttc cggttaaaac ggatataacc cctgggccct cccggctatg
      961 ctctggagcc cgccgctctt tcttctgtag aatgaagtgc aacaggcctt cagtaaaggt
     1021 ggaagataag gacttcgcct ctacctgttc aaagaaaaaa gcagatcgaa aaagcttctg
     1081 cacaatccac agcacaggct atttgaaaag ctggccaccc acgaagatgg ggctggacga
     1141 agacaatgag ccagacaacg agggctgcaa cctcagctgc ctcgttgcaa tcgggcgcct
     1201 gcactcgcac atggttccac aaccagcgaa cggggaaata cgggtgaaat ctatggagta
     1261 cgtttctcga cacgcaatag atgggaaatt tgtttttgta gatcagaggg cgacagctat
     1321 tttggcgtat ctaccacagg aacttctagg tacatcatgt tatgagtatt ttcatcaaga
     1381 cgacatagga cacctcgcag aatgtcacag gcaagtttta cagacaagag aaaagatcac
     1441 aactaattgc tataagttta agatcaaaga tggttctttt atcacgctac gaagtcgatg
     1501 gttcagtttc atgaacccgt ggaccaagga agttgaatac attgtctcaa ccaacactgt
     1561 tgttttagcc aatgtcctgg aaggcgggga cccaaccttc ccgcagctaa cagcaccccc
     1621 ccacagcatg gacagcatgc tgccctctgg agaagattcc tttgttgtag gtggcccaaa
     1681 gaggactcat cccactgtcc caggcattcc agggggaacc agagccggag caggaaaaat
     1741 aggtcgaatg atcgcggagg aaatcatgga aatccacagg ataagagggt catcgccttc
     1801 cagctgtggc tccagcccgc tgaacatcac aagtacgcct ccccctgatg cctcttctcc
     1861 aggaggcaag aagattctaa atggagggac tccagacatt ccttccactg gactattacc
     1921 agggcaggct caggagaccc cagggtatcc ctattctgat agttcttcta ttcttggtga
     1981 gaacccccac ataggcatcg atatgataga taacgaccaa ggatcaagta gtcccagtaa
     2041 cgatgaggca gcaatggctg tcatcatgag cctcttggaa gcagatgcgg ggctgggtgg
     2101 ccccgttgac tttagtgact tgccatggcc gctgtagaca ctacatttgc tttggcaaca
     2161 gctgcagtat caaagtgcat taatggtgaa gttttacagt ctgtgaagct tactggatag
     2221 agagagaaca gcttttatgt actgactcca taaaagccac ctcagagcca ttgatacaag
     2281 tcaatctacc atgtgtaact tcagacaaag tggaactaaa cctgctccag tgtttcctca
     2341 tcattgagtt tgggctagct gtggatagct tgcattaatt gtatattttg gattttgttt
     2401 gtgttgaatt ttttaatcat tgtgcacaga agcatcattg gtagctttta tatgcaaaat
     2461 ggtcatttca gatgtatggt gtttttacac tacaaagaag tcccccatgt ggatatttct
     2521 tatactaatt gtatcataaa gctgtttatt cttccttgta agaatccttt actataaata
     2581 tgggttaaag tataatgtat tagacagtta aatattttta ataaatgttt cccttgttct
     2641 ataa
//
