LOCUS       NM_144923                865 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus biliverdin reductase B (Blvrb), transcript variant 1,
            mRNA.
ACCESSION   NM_144923
VERSION     NM_144923.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 865)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 865)
  AUTHORS   Zhou,H.L., Grimmett,Z.W., Venetos,N.M., Stomberski,C.T., Qian,Z.,
            McLaughlin,P.J., Bansal,P.K., Zhang,R., Reynolds,J.D., Premont,R.T.
            and Stamler,J.S.
  TITLE     An enzyme that selectively S-nitrosylates proteins to regulate
            insulin signaling
  JOURNAL   Cell 186 (26), 5812-5825 (2023)
   PUBMED   38056462
REFERENCE   3  (bases 1 to 865)
  AUTHORS   Chemaly,M., Marlevi,D., Iglesias,M.J., Lengquist,M., Kronqvist,M.,
            Bos,D., van Dam-Nolen,D.H.K., van der Kolk,A., Hendrikse,J.,
            Kassem,M., Matic,L., Odeberg,J., de Vries,M.R., Kooi,M.E. and
            Hedin,U.
  TITLE     Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque
            Hemorrhage and a Predictor of Ischemic Stroke in Patients with
            Symptomatic Carotid Atherosclerosis
  JOURNAL   Biomolecules 13 (6), 882 (2023)
   PUBMED   37371462
  REMARK    GeneRIF: Biliverdin Reductase B Is a Plasma Biomarker for
            Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in
            Patients with Symptomatic Carotid Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 865)
  AUTHORS   Nesbitt,N.M., Malone,L.E., Liu,Z., Jares,A., Gnatenko,D.V., Ma,Y.,
            Zhu,W. and Bahou,W.F.
  TITLE     Divergent erythroid megakaryocyte fates in Blvrb-deficient mice
            establish non-overlapping cytoprotective functions during stress
            hematopoiesis
  JOURNAL   Free Radic Biol Med 164, 164-174 (2021)
   PUBMED   33359909
  REMARK    GeneRIF: Divergent erythroid megakaryocyte fates in Blvrb-deficient
            mice establish non-overlapping cytoprotective functions during
            stress hematopoiesis.
REFERENCE   5  (bases 1 to 865)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 865)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158304.11.
            
            [WARNING] On Feb 4, 2025 this sequence was replaced by NM_144923.4.
            
            On Mar 21, 2007 this sequence version replaced NM_144923.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027279.1, BI147851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC158304.11        124262-124480       c
            220-384             AC158304.11        113038-113202       c
            385-474             AC158304.11        112806-112895       c
            475-603             AC158304.11        109763-109891       c
            604-865             AC158304.11        106477-106738       c
FEATURES             Location/Qualifiers
     source          1..865
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.9 cM"
     gene            1..865
                     /gene="Blvrb"
                     /note="biliverdin reductase B"
                     /db_xref="GeneID:233016"
                     /db_xref="MGI:MGI:2385271"
     exon            1..219
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..761
                     /gene="Blvrb"
                     /EC_number="1.5.1.30"
                     /note="isoform 1 is encoded by transcript variant 1; FR;
                     FLR; BVR-B; NADPH-flavin reductase; NADPH-dependent
                     diaphorase; biliverdin-IX beta-reductase; flavin reductase
                     (NADPH); SNO-CoA-assisted nitrosyltransferase;
                     S-nitroso-CoA-assisted nitrosyltransferase"
                     /codon_start=1
                     /product="flavin reductase (NADPH) isoform 1"
                     /protein_id="NP_659172.1"
                     /db_xref="CCDS:CCDS39848.1"
                     /db_xref="GeneID:233016"
                     /db_xref="MGI:MGI:2385271"
                     /translation="MTVKKIAIFGATGRTGLTTLAQAVQAGYEVTVLVRDSSRLPSEG
                     PQPAHVVVGDVRQAADVDKTVAGQEAVIVLLGTGNDLSPTTVMSEGTRNIVTAMKAHG
                     VDKVVACTSAFLLWDPTKVPPRLQDVTDDHIRMHKILQESGLKYVAVMPPHIGDQPLT
                     GAYTVTLDGRGPSRVISKHDLGHFMLRCLTTNEYDGHTTYPSHQYD"
     exon            220..384
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     exon            385..474
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     exon            475..603
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     exon            604..865
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgaggcgg aggctggaac cttgtctggt cccgccccct ccttctgggt cgaggaggac
       61 ccgcagcgcg cctcctcgca gccactgtgt tcccgcgcgt cctcggagtt ctcagctttt
      121 ccggccctgg accccgcagc atgactgtca agaagatcgc gatcttcggt gccaccggca
      181 ggaccgggct caccacactg gcgcaggcgg tgcaagcagg ttatgaggtg acggtgctgg
      241 ttcgagactc cagcaggctg ccgtcagaag gaccccagcc agcccatgtg gtggtgggag
      301 atgttcggca ggcggccgat gtggacaaga ctgtggctgg gcaggaagct gtcatcgtgc
      361 tactgggcac tggcaacgac ctcagtccca ctacagtaat gtccgagggc acccggaaca
      421 tcgtgacagc catgaaggca catggagtgg acaaggtcgt ggcctgcacc tcggccttcc
      481 tactatggga cccgaccaag gtgcccccac gcctgcagga cgtgaccgat gaccacatcc
      541 ggatgcataa gattctgcaa gagtcagggc tgaaatacgt ggcagtgatg cccccacaca
      601 taggagacca accactaact ggggcctaca cagtgaccct ggatggacga gggccctcga
      661 gggtcatatc caagcatgac ctgggccact tcatgctacg gtgcctcacc accaatgagt
      721 atgacggaca caccacctac ccctcccacc agtatgacta gcactctgac ctaggtgggg
      781 agggtcatgc atcctgagaa atgacacaaa tagaggggtc aataaatttt tagccaaaag
      841 cttcaaattc tttcaggaag cctaa
//
