LOCUS       NM_026678               1394 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus biliverdin reductase A (Blvra), mRNA.
ACCESSION   NM_026678
VERSION     NM_026678.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Chen,W., Tumanov,S., Fazakerley,D.J., Cantley,J., James,D.E.,
            Dunn,L.L., Shaik,T., Suarna,C. and Stocker,R.
  TITLE     Bilirubin deficiency renders mice susceptible to hepatic steatosis
            in the absence of insulin resistance
  JOURNAL   Redox Biol 47, 102152 (2021)
   PUBMED   34610553
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Kobachi,K., Kuno,S., Sato,S., Sumiyama,K., Matsuda,M. and Terai,K.
  TITLE     Biliverdin Reductase-A Deficiency Brighten and Sensitize
            Biliverdin-binding Chromoproteins
  JOURNAL   Cell Struct Funct 45 (2), 131-141 (2020)
   PUBMED   32581154
  REMARK    GeneRIF: Biliverdin Reductase-A Deficiency Brighten and Sensitize
            Biliverdin-binding Chromoproteins.
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Stec,D.E., Gordon,D.M., Nestor-Kalinoski,A.L., Donald,M.C.,
            Mitchell,Z.L., Creeden,J.F. and Hinds,T.D. Jr.
  TITLE     Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces
            Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice
  JOURNAL   Biomolecules 10 (3), 387 (2020)
   PUBMED   32131495
  REMARK    GeneRIF: Biliverdin Reductase A (BVRA) Knockout in Adipocytes
            Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese
            Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Bisht,K., Canesin,G., Cheytan,T., Li,M., Nemeth,Z., Csizmadia,E.,
            Woodruff,T.M., Stec,D.E., Bulmer,A.C., Otterbein,L.E. and Wegiel,B.
  TITLE     Deletion of Biliverdin Reductase A in Myeloid Cells Promotes
            Chemokine Expression and Chemotaxis in Part via a Complement
            C5a--C5aR1 Pathway
  JOURNAL   J Immunol 202 (10), 2982-2990 (2019)
   PUBMED   30952817
  REMARK    GeneRIF: macrophages lacking BVR-A are characterized by the
            expression of M1 polarization-associated chemokines, the levels of
            which depend in part on C5aR1 signaling.
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Meixiong,J., Vasavda,C., Green,D., Zheng,Q., Qi,L., Kwatra,S.G.,
            Hamilton,J.P., Snyder,S.H. and Dong,X.
  TITLE     Identification of a bilirubin receptor that may mediate a component
            of cholestatic itch
  JOURNAL   Elife 8, e44116 (2019)
   PUBMED   30657454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Whitby,F.G., Phillips,J.D., Hill,C.P., McCoubrey,W. and Maines,M.D.
  TITLE     Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor
            complex
  JOURNAL   J Mol Biol 319 (5), 1199-1210 (2002)
   PUBMED   12079357
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Thach,D.C., Kleeberger,S.R., Tucker,P.C. and Griffin,D.E.
  TITLE     Genetic control of neuroadapted sindbis virus replication in female
            mice maps to chromosome 2 and associates with paralysis and
            mortality
  JOURNAL   J Virol 75 (18), 8674-8680 (2001)
   PUBMED   11507212
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Suzuki,T. and Ikeda,H.
  TITLE     The mouse homolog of the bovine leukemia virus receptor is closely
            related to the delta subunit of adaptor-related protein complex
            AP-3, not associated with the cell surface
  JOURNAL   J Virol 72 (1), 593-599 (1998)
   PUBMED   9420263
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Peters,J., Ball,S.T. and von Deimling,A.
  TITLE     Localization of Blvr, biliverdin reductase, on mouse chromosome 2
  JOURNAL   Genomics 5 (2), 270-274 (1989)
   PUBMED   2793182
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   .
  TITLE     Abstracts of meeting presentations: Human gene mapping 7, Los
            Angeles Conference (1983), Seventh International Workshop on Human
            Gene Mapping
  JOURNAL   Cytogenet Cell Genet 37 (1-4), 399-616 (1984)
   PUBMED   6690234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY073963.1, BC052146.1 and CA983696.1.
            
            On Feb 6, 2007 this sequence version replaced NM_026678.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052146.1, AK172620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY073963.1         2-11
            11-270              BC052146.1         1-260
            271-857             CA983696.1         6-592
            858-1394            BC052146.1         848-1384
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..1394
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /note="biliverdin reductase A"
                     /db_xref="GeneID:109778"
                     /db_xref="MGI:MGI:88170"
     exon            1..74
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     exon            75..203
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1079
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /EC_number="1.3.1.24"
                     /note="BVR A; biliverdin-IX alpha-reductase"
                     /codon_start=1
                     /product="biliverdin reductase A"
                     /protein_id="NP_080954.4"
                     /db_xref="CCDS:CCDS16692.1"
                     /db_xref="GeneID:109778"
                     /db_xref="MGI:MGI:88170"
                     /translation="MSTEPKRKFGVVVVGVGRAGSVRIRDLKDPHSSAFLNLIGYVSR
                     RELGSLDNVRQISLEDALRSQEVDVAYICTESSSHEDYIRQFLQAGKHVLVEYPMALS
                     FAAAQELWELAAQKGRVLHEEHIELLMEEFEFLKREVAGKELLKGSLRFTASPLEEEK
                     FGFPAFSGISRLTWLVSLFGELSLISATMENRKEDQYMKMTVQLETQNKSPLSWIEEK
                     GPGLKRNRHISIHFKSGSLEEVPNVGVNKNIFLKDQDIFIQKLLGQVSAEDLAAEKKR
                     ILHCLELASDIQRLCHRKQ"
     exon            204..322
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     exon            323..442
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     exon            443..540
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     exon            541..648
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     exon            649..820
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1170
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1146..1151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="Blvra"
                     /gene_synonym="0610006A11Rik; 2500001N03Rik; Blvr"
                     /note="major polyA site"
ORIGIN      
        1 agcgctctgt ctgtagctgc tgggacgctg caatttgggc gcgctgaagc ggaagctcgt
       61 gagccgctgg taagctcccc cttacagtgt tgacatctaa agccagcgtg aaaactgtat
      121 ccatagagag ttcgcgcccc aagatcccga acctctctct ctcttcacgg acactgactg
      181 aagaggccaa gatgagtact gagccaaaga ggaaatttgg tgtggtagtg gttggtgttg
      241 gcagagctgg ctctgtgagg ataagggact tgaaggatcc acactcttca gcattcctaa
      301 acctgattgg atatgtgtcc agacgagaac ttgggagcct tgataatgta cggcagattt
      361 ctttggaaga tgctctccgc agccaagagg ttgatgtcgc ctatatttgc actgagagtt
      421 ccagccacga agactatata aggcagtttc ttcaggctgg caagcatgtc ctcgtggaat
      481 accccatggc attgtcattt gcggcagcgc aggagctgtg ggagctggct gcacagaaag
      541 ggagagtcct gcatgaggag cacatcgaac tcttgatgga agagttcgaa ttcctgaaaa
      601 gagaagtggc cgggaaggag ctgctaaaag gatctcttcg cttcacagcc agccccctgg
      661 aagaagagaa atttggcttc cctgcgttca gtggcatttc tcgcctgacc tggctggtct
      721 ccctctttgg ggagctttct cttatttctg ccaccatgga aaaccgaaaa gaagatcaat
      781 atatgaaaat gaccgtgcag ctcgagaccc agaacaaaag tccattatca tggattgaag
      841 agaaagggcc tggcttaaaa aggaacagac atataagcat ccacttcaaa tctgggtcct
      901 tggaggaagt gccaaatgta ggagtcaata agaacatttt cctgaaagat caggatatat
      961 ttatccagaa gctcttgggc caggtctctg cagaggacct ggctgctgag aagaagcgca
     1021 tcctgcattg cctggagctg gccagcgaca tccagaggct gtgccaccgg aagcagtgag
     1081 gaggaagctt cagatacctc tgaaacgggg ccagggtttg gtcttatcaa cactttagct
     1141 cttacaataa aatactctgg ataaacagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaa
//
