LOCUS       NM_015740                550 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus biogenesis of lysosomal organelles complex-1, subunit
            1 (Bloc1s1), mRNA.
ACCESSION   NM_015740
VERSION     NM_015740.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 550)
  AUTHORS   Zhang,J., Wang,S., Zhang,H., Yang,X., Ren,X., Wang,L., Yang,Y.,
            Yang,Y. and Wen,Y.
  TITLE     Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes
            cerebral ischemic injury via facilitating mitochondrial fission
  JOURNAL   Mol Med 30 (1), 173 (2024)
   PUBMED   39390372
  REMARK    GeneRIF: Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis
            promotes cerebral ischemic injury via facilitating mitochondrial
            fission.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 550)
  AUTHORS   Yang,C., Yang,Y., Hu,X., Tang,Q., Zhang,J., Zhang,P., Lu,X., Xu,J.,
            Li,S., Dong,Z., Zhu,L. and Wang,L.
  TITLE     Loss of GCN5L1 exacerbates damage in alcoholic liver disease
            through ferroptosis activation
  JOURNAL   Liver Int 44 (8), 1924-1936 (2024)
   PUBMED   38597373
  REMARK    GeneRIF: Loss of GCN5L1 exacerbates damage in alcoholic liver
            disease through ferroptosis activation.
REFERENCE   3  (bases 1 to 550)
  AUTHORS   Stewart,J.E., Crawford,J.M., Mullen,W.E., Jacques,A., Stoner,M.W.,
            Scott,I. and Thapa,D.
  TITLE     Cardiomyocyte-specific deletion of GCN5L1 reduces lysine
            acetylation and attenuates diastolic dysfunction in aged mice by
            improving cardiac fatty acid oxidation
  JOURNAL   Biochem J 481 (6), 423-436 (2024)
   PUBMED   38390938
  REMARK    GeneRIF: Cardiomyocyte-specific deletion of GCN5L1 reduces lysine
            acetylation and attenuates diastolic dysfunction in aged mice by
            improving cardiac fatty acid oxidation.
REFERENCE   4  (bases 1 to 550)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 550)
  AUTHORS   Xu,W., Ma,X., Wang,Q., Ye,J., Wang,N., Ye,Z. and Chen,T.
  TITLE     GCN5L1 regulates pulmonary surfactant production by modulating
            lamellar body biogenesis and trafficking in mouse alveolar
            epithelial cells
  JOURNAL   Cell Mol Biol Lett 28 (1), 90 (2023)
   PUBMED   37936104
  REMARK    GeneRIF: GCN5L1 regulates pulmonary surfactant production by
            modulating lamellar body biogenesis and trafficking in mouse
            alveolar epithelial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 550)
  AUTHORS   Salazar,G., Craige,B., Styers,M.L., Newell-Litwa,K.A.,
            Doucette,M.M., Wainer,B.H., Falcon-Perez,J.M., Dell'Angelica,E.C.,
            Peden,A.A., Werner,E. and Faundez,V.
  TITLE     BLOC-1 complex deficiency alters the targeting of adaptor protein
            complex-3 cargoes
  JOURNAL   Mol Biol Cell 17 (9), 4014-4026 (2006)
   PUBMED   16760431
  REMARK    GeneRIF: These results indicate that the BLOC-1 and AP-3 protein
            complexes affect the targeting of SNARE and non-SNARE AP-3 cargoes
            and suggest a function of the BLOC-1 complex in membrane protein
            sorting.
REFERENCE   7  (bases 1 to 550)
  AUTHORS   Gwynn,B., Martina,J.A., Bonifacino,J.S., Sviderskaya,E.V.,
            Lamoreux,M.L., Bennett,D.C., Moriyama,K., Huizing,M.,
            Helip-Wooley,A., Gahl,W.A., Webb,L.S., Lambert,A.J. and Peters,L.L.
  TITLE     Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak
            syndrome, encodes a novel component of the BLOC-1 complex
  JOURNAL   Blood 104 (10), 3181-3189 (2004)
   PUBMED   15265785
  REMARK    GeneRIF: Defects in all the 5 known components of BLOC-1, including
            RP, cause severe Hermansky Pudlak syndrome in mice, suggesting that
            the subunits are nonredundant and that BLOC-1 plays a key role in
            organelle biogenesis.
REFERENCE   8  (bases 1 to 550)
  AUTHORS   Starcevic,M. and Dell'Angelica,E.C.
  TITLE     Identification of snapin and three novel proteins (BLOS1, BLOS2,
            and BLOS3/reduced pigmentation) as subunits of biogenesis of
            lysosome-related organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 279 (27), 28393-28401 (2004)
   PUBMED   15102850
  REMARK    GeneRIF: Mutations in the human genes encoding Snapin and the BLOS
            proteins could underlie novel forms of Hermansky-Pudlak syndrome as
            seen in mouse models
REFERENCE   9  (bases 1 to 550)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 550)
  AUTHORS   Driessen,C.A., Winkens,H.J., Kuhlmann,L.D., Janssen,B.P., van
            Vugt,A.H., Deutman,A.F. and Janssen,J.J.
  TITLE     Cloning and structural analysis of the murine GCN5L1 gene
  JOURNAL   Gene 203 (1), 27-31 (1997)
   PUBMED   9426003
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003035.1.
            
            On Apr 6, 2007 this sequence version replaced NM_015740.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003035.1, CD769731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               AK003035.1         2-551
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.19 cM"
     gene            1..550
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /note="biogenesis of lysosomal organelles complex-1,
                     subunit 1"
                     /db_xref="GeneID:14533"
                     /db_xref="MGI:MGI:1195276"
     exon            1..150
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..467
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /note="BLOC-1 subunit 1; GCN5-like protein 1; general
                     control of amino acid synthesis, yeast homolog-like 1;
                     GCN5 general control of amino acid synthesis-like 1;
                     biogenesis of lysosome-related organelles complex-1,
                     subunit 1; protein acetyltransferase BLOC1S1"
                     /codon_start=1
                     /product="biogenesis of lysosome-related organelles
                     complex 1 subunit 1"
                     /protein_id="NP_056555.2"
                     /db_xref="CCDS:CCDS24299.1"
                     /db_xref="GeneID:14533"
                     /db_xref="MGI:MGI:1195276"
                     /translation="MLSRLLKEHQAKQNERKELQEKRRREAIAAATCLTEALVDHLNV
                     GVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIE
                     LDMRTIATALEYVYKGQLQSAPS"
     exon            151..223
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..356
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..550
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      527..532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /note="putative"
     polyA_site      550
                     /gene="Bloc1s1"
                     /gene_synonym="BLOS1; Gcn5l1"
                     /note="putative"
ORIGIN      
        1 gtgacgcctt ccgggtgagc caaggcatag tccagttcct gcagccttag ggaggggtcc
       61 gccgtgccca cacccagcca gactcgacca tgctgtcccg cctgctcaaa gaacaccaag
      121 ccaagcagaa cgaacgcaag gagctgcagg agaagaggag gagagaagct atcgctgcag
      181 cgacctgcct gaccgaagcg ttggtggatc acctcaacgt gggtgtggcc caggcctaca
      241 tgaaccagag aaagctggac catgaggtga agactctaca ggtccaggct gcccagtttg
      301 ccaagcagac aggccagtgg attggaatgg tggagaactt caaccaggca cttaaggaaa
      361 ttggggatgt ggagaactgg gctaggagca tcgagctgga catgcgcacc attgccactg
      421 cgctggaata cgtctacaaa gggcagctgc agtctgcacc atcctagact aaaacccacc
      481 cctcttactt caccctcctg gacaggaggg aaactggtga gccacgaata aaaacacaag
      541 cttccattct
//
