LOCUS       NM_008528               1783 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus B cell linker (Blnk), transcript variant 1, mRNA.
ACCESSION   NM_008528
VERSION     NM_008528.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Yang,Y.H., Xie,K.F., Yang,S., Wang,H., Ma,H.H., Zhou,M., Wang,Z.W.,
            Gu,Y. and Jia,X.M.
  TITLE     BLNK negatively regulates innate antifungal immunity through
            inhibiting c-Cbl-mediated macrophage migration
  JOURNAL   Proc Natl Acad Sci U S A 121 (43), e2400920121 (2024)
   PUBMED   39413134
  REMARK    GeneRIF: BLNK negatively regulates innate antifungal immunity
            through inhibiting c-Cbl-mediated macrophage migration.
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Kurata,M., Onishi,I., Takahara,T., Yamazaki,Y., Ishibashi,S.,
            Goitsuka,R., Kitamura,D., Takita,J., Hayashi,Y., Largaesapda,D.A.,
            Kitagawa,M. and Nakamura,T.
  TITLE     C/EBPbeta induces B-cell acute lymphoblastic leukemia and
            cooperates with BLNK mutations
  JOURNAL   Cancer Sci 112 (12), 4920-4930 (2021)
   PUBMED   34653294
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Zhang,P., Wang,Y., Qin,M., Li,D., Odhiambo,W.O., Yuan,M., Lv,Z.,
            Liu,C., Ma,Y., Dong,Y. and Ji,Y.
  TITLE     Involvement of Blnk and Foxo1 in tumor suppression in
            BCR-ABL1-transformed pro-B cells
  JOURNAL   Oncol Rep 45 (2), 693-705 (2021)
   PUBMED   33416167
  REMARK    GeneRIF: Involvement of Blnk and Foxo1 in tumor suppression in
            BCRABL1transformed proB cells.
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Dolezal,E., Infantino,S., Drepper,F., Borsig,T., Singh,A.,
            Wossning,T., Fiala,G.J., Minguet,S., Warscheid,B., Tarlinton,D.M.,
            Jumaa,H., Medgyesi,D. and Reth,M.
  TITLE     The BTG2-PRMT1 module limits pre-B cell expansion by regulating the
            CDK4-Cyclin-D3 complex
  JOURNAL   Nat Immunol 18 (8), 911-920 (2017)
   PUBMED   28628091
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Fu,C. and Chan,A.C.
  TITLE     Identification of two tyrosine phosphoproteins, pp70 and pp68,
            which interact with phospholipase Cgamma, Grb2, and Vav after B
            cell antigen receptor activation
  JOURNAL   J Biol Chem 272 (43), 27362-27368 (1997)
   PUBMED   9341187
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Wienands,J., Larbolette,O. and Reth,M.
  TITLE     Evidence for a preformed transducer complex organized by the B cell
            antigen receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 7865-7870 (1996)
   PUBMED   8755568
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Eicher,E.M., Shown,E.P., Bhat,D. and Seldin,M.F.
  TITLE     Corrected centromere orientation for mouse chromosome 19 MIT
            markers
  JOURNAL   Mamm Genome 4 (4), 223-225 (1993)
   PUBMED   8499657
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121873.3, AC126608.20 and AC117253.3.
            
            On Jul 24, 2018 this sequence version replaced NM_008528.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y17159.1, AF068182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC121873.3         23137-23346         c
            211-276             AC121873.3         1712-1777           c
            277-326             AC126608.20        59849-59898         c
            327-367             AC126608.20        55593-55633         c
            368-524             AC126608.20        53695-53851         c
            525-688             AC126608.20        51049-51212         c
            689-770             AC126608.20        43701-43782         c
            771-842             AC126608.20        42304-42375         c
            843-912             AC117253.3         1113-1182
            913-940             AC117253.3         2515-2542
            941-983             AC117253.3         3325-3367
            984-1068            AC117253.3         6413-6497
            1069-1100           AC117253.3         7271-7302
            1101-1177           AC117253.3         8942-9018
            1178-1261           AC117253.3         10313-10396
            1262-1417           AC117253.3         12087-12242
            1418-1783           AC117253.3         17377-17742
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.26 cM"
     gene            1..1783
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /note="B cell linker"
                     /db_xref="GeneID:17060"
                     /db_xref="MGI:MGI:96878"
     exon            1..210
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            211..276
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            277..326
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            327..367
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            368..524
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            525..688
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            689..770
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            771..842
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            843..912
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            913..940
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            941..983
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1068
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1100
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1177
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1261
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1417
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1783
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /note="hexamer: AATAAA"
     polyA_site      1783
                     /gene="Blnk"
                     /gene_synonym="BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65"
                     /note="major polyA site"
ORIGIN      
        1 acttcccctg tgcaggggtg tttgccagca gcctgtgggt tgctcgcaga agtcagttcc
       61 agtggcttga gttcttgagg ccagagcctt accatgctgc tccccaggaa gtccaggagc
      121 tgctgacacc cccctggaca gcgacacatc ctctctcaag aaaatggaca agctgaataa
      181 gataactgtc cctgccagcc agaagctgag acagcttcaa aagatggtcc atgatattaa
      241 gaacaatgaa ggtggaataa tggacaagat aaaaaagcta aaagtcaaag gccctccaag
      301 tgttcctcga agggactacg cattagacag ccctgcagat gaagaggagc agtggtcaga
      361 tgacttcgac agtgactatg aaaatccaga tgaacattcg gactccgaga tgtatgtgat
      421 gcctgccgag gagacgggcg acgattccta tgaaccgcct cccgctgagc agcagacacg
      481 ggtggtccat ccagccctgc ccttcacgag gggcgagtat gtagataatc gatccagcca
      541 gcggcactct ccgcccttca gcaagacact tcccagtaag cccagctggc cttcagcgaa
      601 agcgaggctg gcctccactc tgccagcccc caactctcta cagaagcctc aagtcccccc
      661 caagcccaaa gacctccttg aggatgaggc tgattatgtg gtccctgtgg aagataacga
      721 tgaaaactat atccatccca gagaaagcag cccgccgcct gctgagaagg ctcccatggt
      781 gaatagatca accaagccaa acagttcctc aaagcacatg tcgcctccag ggactgtcgc
      841 aggtcgaaac agtggggtct gggactccaa gtcatctttg cctgccgcac catccccact
      901 accacgggct gggaagaagc cagctacacc acttaagact actcccgttc ctcccctacc
      961 gaatgcatca aatgtttgtg aagaaaagcc tgttcctgct gagcgccacc gagggtctag
     1021 tcacagacaa gacactgtac agtcaccagt gtttcctccc acccagaaac ctgtccatca
     1081 aaagcctgta cccttgccaa ggttcccaga agcggggagc ccagctgcag atggaccgtt
     1141 ccacagcttc ccatttaatt cgacgtttgc agaccaggag gctgaactgc tcggtaagcc
     1201 ctggtatgct ggcgcctgtg accgcaagtc tgctgaagag gccttgcaca gatccaacaa
     1261 ggatggatcg tttcttattc ggaagagctc tggccatgat tccaagcagc cgtacaccct
     1321 agttgcgttc tttaacaagc gagtgtataa tattcctgta cggtttattg aagcaaccaa
     1381 acagtatgct ttgggaaaga agaaaaatgg tgaagagtac ttcggaagtg ttgtggaaat
     1441 cgtcaacagt caccagcaca accccctggt tcttattgac agtcagaata acacgaaaga
     1501 ttccacgaga ctgaaatatg ctgtgaaggt ttcataacga taccacggtt ccagacatgt
     1561 cctctgtttc ttcttttgag aaaacatcat attctggcta tgactcctca gcagtaagag
     1621 agaaaagatg aatgaagcca ctgaggcttc gtgaatgaat gaatctactc cttcctaggg
     1681 cgttcacacg agcttttcta tcacctgacc tgacgaagtc atagctgggg aggttcggtt
     1741 actatgatac taatattgtc caaataaatg tatttaaaag caa
//
