LOCUS       NM_007550               4869 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus Bloom syndrome, RecQ like helicase (Blm), transcript
            variant 1, mRNA.
ACCESSION   NM_007550
VERSION     NM_007550.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4869)
  AUTHORS   Zhou Z, Yin H, Suye S, Ren Z, Yan L, Shi L and Fu C.
  TITLE     Fance deficiency inhibits primordial germ cell proliferation
            associated with transcription-replication conflicts accumulate and
            DNA repair defects
  JOURNAL   J Ovarian Res 16 (1), 160 (2023)
   PUBMED   37563658
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4869)
  AUTHORS   Huang T, Wu X, Wang S, Bao Z, Wan Y, Wang Z, Li M, Yu X, Lv Y, Liu
            Z, Chen X, Chan WY, Gao F, Lu G, Chen ZJ and Liu H.
  TITLE     SPIDR is required for homologous recombination during mammalian
            meiosis
  JOURNAL   Nucleic Acids Res 51 (8), 3855-3868 (2023)
   PUBMED   36938872
REFERENCE   3  (bases 1 to 4869)
  AUTHORS   Huang PH, Yang TY, Yeh CW, Huang SM, Chang HC, Hung YF, Chu WC, Cho
            KH, Lu TP, Kuo PH, Lee LJ, Kuo LW, Lien CC and Cheng HJ.
  TITLE     Involvement of a BH3-only apoptosis sensitizer gene Blm-s in
            hippocampus-mediated mood control
  JOURNAL   Transl Psychiatry 12 (1), 411 (2022)
   PUBMED   36163151
  REMARK    GeneRIF: Involvement of a BH3-only apoptosis sensitizer gene Blm-s
            in hippocampus-mediated mood control.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4869)
  AUTHORS   Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, Carparelli
            L, Ferro A, Nasu M, Kim JH, Suarez JS, Xu R, Tanji M, Takinishi Y,
            Minaai M, Novelli F, Pagano I, Gaudino G, Pass HI, Groden J,
            Grzymski JJ, Metintas M, Akarsu M, Morrow B, Hassan R, Yang H and
            Carbone M.
  TITLE     Heterozygous germline BLM mutations increase susceptibility to
            asbestos and mesothelioma
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33466-33473 (2020)
   PUBMED   33318203
  REMARK    GeneRIF: Heterozygous germline BLM mutations increase
            susceptibility to asbestos and mesothelioma.
REFERENCE   5  (bases 1 to 4869)
  AUTHORS   Mendez-Dorantes C, Tsai LJ, Jahanshir E, Lopezcolorado FW and Stark
            JM.
  TITLE     BLM has Contrary Effects on Repeat-Mediated Deletions, based on the
            Distance of DNA DSBs to a Repeat and Repeat Divergence
  JOURNAL   Cell Rep 30 (5), 1342-1357 (2020)
   PUBMED   32023454
  REMARK    GeneRIF: BLM has Contrary Effects on Repeat-Mediated Deletions,
            based on the Distance of DNA DSBs to a Repeat and Repeat
            Divergence.
REFERENCE   6  (bases 1 to 4869)
  AUTHORS   Seaman MS, Wang CR and Forman J.
  TITLE     MHC class Ib-restricted CTL provide protection against primary and
            secondary Listeria monocytogenes infection
  JOURNAL   J Immunol 165 (9), 5192-5201 (2000)
   PUBMED   11046052
REFERENCE   7  (bases 1 to 4869)
  AUTHORS   Walpita D, Plug AW, Neff NF, German J and Ashley T.
  TITLE     Bloom's syndrome protein, BLM, colocalizes with replication protein
            A in meiotic prophase nuclei of mammalian spermatocytes
  JOURNAL   Proc Natl Acad Sci U S A 96 (10), 5622-5627 (1999)
   PUBMED   10318934
REFERENCE   8  (bases 1 to 4869)
  AUTHORS   Bahr A, De Graeve F, Kedinger C and Chatton B.
  TITLE     Point mutations causing Bloom's syndrome abolish ATPase and DNA
            helicase activities of the BLM protein
  JOURNAL   Oncogene 17 (20), 2565-2571 (1998)
   PUBMED   9840919
REFERENCE   9  (bases 1 to 4869)
  AUTHORS   Chester N, Kuo F, Kozak C, O'Hara CD and Leder P.
  TITLE     Stage-specific apoptosis, developmental delay, and embryonic
            lethality in mice homozygous for a targeted disruption in the
            murine Bloom's syndrome gene
  JOURNAL   Genes Dev 12 (21), 3382-3393 (1998)
   PUBMED   9808625
REFERENCE   10 (bases 1 to 4869)
  AUTHORS   Seki T, Wang WS, Okumura N, Seki M, Katada T and Enomoto T.
  TITLE     cDNA cloning of mouse BLM gene, the homologue to human Bloom's
            syndrome gene, which is highly expressed in the testis at the mRNA
            level
  JOURNAL   Biochim Biophys Acta 1398 (3), 377-381 (1998)
   PUBMED   9655940
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB614580.1, Z98263.1 and AC110907.7.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by NM_007550.5.
            
            On Apr 14, 2009 this sequence version replaced NM_007550.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               BB614580.1         2-451
            451-4771            Z98263.1           158-4478
            4772-4869           AC110907.7         67178-67275         c
FEATURES             Location/Qualifiers
     source          1..4869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.65 cM"
     gene            1..4869
                     /gene="Blm"
                     /note="Bloom syndrome, RecQ like helicase"
                     /db_xref="GeneID:12144"
                     /db_xref="MGI:MGI:1328362"
     exon            1..348
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..4603
                     /gene="Blm"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1; bloom
                     syndrome protein homolog; mBLM; recQ helicase homolog;
                     Bloom syndrome homolog; Bloom syndrome, RecQ
                     helicase-like; recQ-like DNA helicase BLM"
                     /codon_start=1
                     /product="recQ-like DNA helicase BLM isoform 1"
                     /protein_id="NP_031576.4"
                     /db_xref="CCDS:CCDS52281.1"
                     /db_xref="GeneID:12144"
                     /db_xref="MGI:MGI:1328362"
                     /translation="MRIMAAVPLNNLQEQLQRHSARKLNNQPSLSKPKSLGFTFKKKT
                     SEGDVSVTSVSVVKTPALSDKDVNVSEAFSFTESPLHKPKQQAKIEGFFKHFPGRQQS
                     KGTCSEPSLPATVQTAQDTLCTTPKTPTAKKLPVAVFKKLEFSSSADSLSDWADMDDF
                     DMSASDAFASLAKNPATRVSTAQKMKKTKRNFFKPPPRKANAVKTDLTPPSPECLQVD
                     LTKESEEEEEEEEEAEGADCLSRDVICIDNDSASEELTEKDTQESQSLKAHLGAERGD
                     SEKKSHEDEAVFHSVQNTEYFEHNDNDYDIDFVPPSPEEIISTASSSLKCSSMLKDLD
                     DSDKEKGILSTSEELLSKPEEMTTHKSDAGTSKDCDAQQIRIQQQLIHVMEHICKLVD
                     TVPTDELEALNCGTELLQQRNIRRKLLAEAGFNGNDVRLLGSLWRHRPDSLDNTVQGD
                     SCPVGHPNKELNSPYLLSHSPSTEECLPTTTPGKTGFSATPKNLFERPLLNSHLQKSF
                     VSSNWAETPRMENRNESTDFPGSVLTSTTVKAQSKQAASGWNVERHGQASYDIDNFNI
                     DDFDDDDDDDDWENIMHNFPASKSSTATYPPIKEGGPVKSLSERISSAKAKFLPVVST
                     AQNTNLSESIQNCSDKLAQNLSSKNPKHEHFQSLNFPHTKEMMKIFHKKFGLHNFRTN
                     QLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTS
                     FDIPATYLTGDKTDSEAANIYLQLSKKDPIIKLLYVTPEKVCASNRLISTLENLYERK
                     LLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQL
                     KILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDT
                     MADTLQREGLAALAYHAGLSDSARDEVQHKWINQDNCQVICATIAFGMGIDKPDVRFV
                     IHASLPKSMEGYYQESGRAGRDGEISHCVLFYTYHDVTRLKRLIMMEKDGNYHTKETH
                     VNNLYSMVHYCENITECRRIQLLAYFGEKGFNPDFCKKYPDVSCDNCCKTKDYKTKDV
                     TDDVKNIIRFVQEHSSSPGTRNIGPAGRFTLNMLVDIFLGSKSAKVKSGIFGKGTTYS
                     RHNAERLFKKLILDKILDEDLYINANDQPIAYVMLGTKAHSVLSGHLKVDFMETENSS
                     SIKKQKALVAKVSQREEVVKKCLGELTEVCKLLGKVFGVHYFNIFNTATLKKLAESLS
                     SDPEVLLQIDGVTEDKLEKYGAEVIPVLQKYSEWTVPAEDGSPGARGAPEDTEEEEEE
                     APVSSHYFANQTRNERKRKKMSATHKPKRRRTSYGGFRAKGGSTTCRKTTSKSKFYGV
                     TGSRSASCASQATSSASRKLGIMAPPKPVNRTFLRPSYAFS"
     exon            349..450
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            451..1166
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1326
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1454
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1587
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..2258
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2450
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2569
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2683
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2782
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2931
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3038
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3199
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3395
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3586
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3725
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3925
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..4118
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4241
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            4242..4425
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
     exon            4426..4869
                     /gene="Blm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcccgag gccttggcca tttcaccagt catccgtccc aggttctccg agcctcgctt
       61 gtggcgagaa gcccagaccg gagtagagac ctggtgaccc agaaaaggcc atgtcaggcg
      121 gccgaggctc gagtctcact gtccacactt tccttaaggc cttgattgtc atacgcgaga
      181 aattagctca tctgcttccc gtagtttgtg tagtgctgca acgacccctc gtagcaatgc
      241 atgctttcga gacgccagaa gaggtggagg tgccctgttt ttaatcggag aagcaggagc
      301 tcagacctcg tttgccgaaa gggcgcgcgg gcttggatgc cagatgagga tcatggctgc
      361 tgttcctctg aacaatctac aagaacaact acagcgacac tcagccagaa aacttaataa
      421 tcaacccagc ctttcaaaac caaaatcttt aggttttact tttaaaaaga aaacatcaga
      481 gggtgatgtg tctgtcacta gtgtgtccgt agtaaaaaca cctgcgttaa gtgataaaga
      541 tgtgaacgtg tctgaggcct tttcattcac tgagtctcca ctccacaaac caaagcagca
      601 ggcaaagatt gaaggcttct ttaaacattt ccctggaagg cagcaaagca aggggacctg
      661 ctctgagccg tcactgccgg ccacggtaca gactgctcag gacactttgt gcactacccc
      721 caaaaccccc actgcgaaga aactgcccgt ggctgttttc aagaaattag aatttagttc
      781 ttctgcagac tccctcagtg actgggctga tatggatgac tttgatatgt cagcatcaga
      841 tgcgtttgct tcactggcta aaaatcctgc cacaagagta agcaccgctc agaaaatgaa
      901 aaagactaag agaaacttct ttaaaccacc acctcgtaaa gccaatgcag taaagactga
      961 cttgactcct ccctcccccg aatgcctgca agtggattta acgaaggaat cggaggagga
     1021 ggaggaggag gaggaggagg cggagggggc ggactgcctg agcagggatg tgatctgcat
     1081 tgacaatgat tctgcttctg aagagctcac ggagaaagac acgcaggaaa gccagtcttt
     1141 gaaagctcac ttgggagctg aaagaggtga cagtgaaaag aagagccatg aagacgaagc
     1201 tgtgttccat tcagttcaga acactgaata ctttgaacac aatgacaatg attatgatat
     1261 agattttgtt ccaccttctc cagaagaaat catctccact gcttcttcct cgttgaaatg
     1321 ttccagtatg ttaaaggatc ttgatgactc tgacaaagaa aagggcattc ttagcacctc
     1381 agaagagctt ctgtcaaaac cagaggaaat gaccacacac aagtctgatg caggaaccag
     1441 taaagactgt gatgcccagc agatacgcat acagcagcag cttattcatg tgatggagca
     1501 catctgtaag ttagttgata ctgttcctac tgatgaactg gaagctttga attgtgggac
     1561 cgaattgctt caacaacgaa acataaggag gaagctccta gctgaagcag gttttaatgg
     1621 aaatgacgtc agacttctgg gttctctgtg gaggcacagg cctgattcac ttgataacac
     1681 agtgcagggc gactcctgcc ctgtggggca tcctaataaa gagttaaatt ctccatacct
     1741 tctctcacat tccccttcca ctgaggaatg tttacccacc accactccag gaaagacagg
     1801 attctcagcc accccgaaga atctctttga aaggccgtta ttgaattccc atttacagaa
     1861 gtcctttgta agtagcaact gggctgaaac accaaggatg gaaaacagga acgaaagcac
     1921 tgacttccca gggagtgttc tcaccagcac cactgtgaaa gctcagagta aacaagctgc
     1981 ttcaggatgg aacgtagaga gacacggcca ggcttcctat gatatcgata actttaatat
     2041 tgatgacttt gatgatgatg atgatgatga tgactgggaa aacataatgc acaattttcc
     2101 agccagcaaa tcttccacag ccacctaccc acccatcaag gaaggtgggc cagttaaatc
     2161 tctctcagaa aggatttctt cagccaaggc aaagtttctt ccagtggtat caaccgctca
     2221 aaatacaaac ctctcagagt caattcagaa ttgctctgat aagctggccc aaaatttatc
     2281 atcaaaaaat ccaaaacatg aacattttca aagtcttaat tttcctcata caaaagaaat
     2341 gatgaagatt ttccataaga aatttggctt gcataatttt agaactaatc agctagaggc
     2401 gatcaatgct gcgctgcttg gtgaagactg ctttatccta atgcccactg gaggaggtaa
     2461 aagtttgtgc taccagctcc ctgcctgtgt ttctcctggg gtcacaattg tcatttctcc
     2521 cttgagatca ctaatagtag atcaagtcca aaagctgact tcctttgata ttccagctac
     2581 atatctgaca ggggataaga ctgactcaga agctgcaaat atttacctcc aattatccaa
     2641 aaaagaccca atcatcaagc ttttgtatgt tactccagag aaggtctgtg caagtaacag
     2701 gctgatttct actctggaga atctgtatga gcggaagctc ttggcacgtt ttgtcattga
     2761 tgaagcgcat tgtgtgagtc agtggggtca tgattttcgt caagattaca aaaggatgaa
     2821 tatgcttcgc cagaagtttc cttctgttcc agtgatggcc ctcacggcca cagcgaaccc
     2881 cagggtccag aaggacatcc tcactcagct gaagatcctc agacctcagg tgtttagcat
     2941 gagctttaac agacacaatc tgaagtacta tgtattaccc aagaagccca aaaaagtagc
     3001 atttgattgc ctagagtgga tcagaaagca tcacccttat gactcgggga taatttactg
     3061 cctctccagg agggaatgtg acacaatggc tgacacttta cagagagaag gcctggctgc
     3121 cctggcttac catgcgggcc tcagtgactc tgccagagat gaggtgcagc acaagtggat
     3181 caaccaggac aactgccagg ttatctgtgc gacaattgcg tttggaatgg gaattgacaa
     3241 acctgacgtg cgatttgtga ttcatgcatc tcttcctaaa tctatggagg gttattatca
     3301 agaatccggc cgagctggaa gagatgggga aatatctcac tgcgtgcttt tctatacata
     3361 tcatgatgtg accagactga agagacttat aatgatggaa aaagatggaa actatcatac
     3421 gaaggaaact cacgtcaata atctatatag catggtacat tactgtgaaa acataacgga
     3481 atgcagaaga atacagcttt tagcttactt tggtgaaaaa ggattcaacc ctgatttttg
     3541 taagaaatac ccagatgttt cttgtgacaa ttgctgtaaa acaaaggatt ataaaacaaa
     3601 agatgtgact gatgacgtga aaaatattat aagatttgtt caagaacaca gttcatcacc
     3661 aggaacaaga aatataggac ctgctggaag atttactctg aacatgctgg tcgacatttt
     3721 cttggggagc aagagtgcaa aagttaagtc tggaatattt ggaaagggga ctacatattc
     3781 acgacataat gccgaaagac tttttaaaaa gctgattcta gacaaaatcc tggatgaaga
     3841 cttatatatc aatgccaatg accaaccaat tgcctatgtg atgctaggaa caaaagccca
     3901 cagtgtgctg agtggccact tgaaggtgga cttcatggaa acggaaaatt ccagcagtat
     3961 taaaaaacaa aaagctttag tggccaaagt atcccagaga gaagaggtag ttaagaaatg
     4021 tcttggagaa cttacagagg tctgcaaatt gctggggaaa gtctttggtg tccattactt
     4081 caatattttt aatacagcca cactcaaaaa gcttgcagaa tctttatctt ctgatcctga
     4141 ggttttgctt cagattgatg gtgttaccga agacaagctg gaaaaatatg gtgcagaagt
     4201 gattccagta ttacagaagt actcagaatg gacagtgcca gctgaggatg gttccccagg
     4261 cgccagaggc gccccagagg acactgagga ggaggaggag gaagcgcctg tatcttctca
     4321 ctactttgca aatcaaacta gaaatgaaag aaagagaaag aaaatgtcag ccacccataa
     4381 gcccaagagg agaagaacta gttacggtgg cttcagagca aaggggggct ctactacatg
     4441 cagaaaaacg acttctaaaa gtaaattcta tggtgtaact ggatcccgct cggcctcatg
     4501 tgcttctcag gcaacatcat cagccagtag aaaactgggg attatggctc ctccaaagcc
     4561 tgtaaataga acgttcctca ggccttcata tgccttctcc taacagttct ctgcgcatag
     4621 atcttgtttg tcagcatctg accatctgtg aatagaaagc tgttagtctt gttacagcat
     4681 ttgaagtttt cacttctatc tattaatatt taaatgtatc tcatgtgata gttcttattt
     4741 ttaaataaac attttctttg gtgctactgc acatgtagtg gccattgttt ctcagagcat
     4801 ctgtaacaat tgtagcaatg gctgaatcat ccaccccagg aaatcccgag gggaacatga
     4861 ctgctgaag
//
