LOCUS       NM_007549               2475 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus B lymphoid kinase (Blk), mRNA.
ACCESSION   NM_007549
VERSION     NM_007549.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Li,W.W., Fan,X.X., Xu,Z.S., Zhu,Z.X., Zhu,Z.Y., Cao,X.J., Pei,D.S.,
            Wang,Y.Z., Zhang,J.Y., Wang,Y.Y. and Zheng,H.X.
  TITLE     BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP
            phosphorylation
  JOURNAL   J Cell Biol 223 (2) (2024)
   PUBMED   38078859
  REMARK    GeneRIF: BLK positively regulates TLR/IL-1R signaling by catalyzing
            TOLLIP phosphorylation.
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Li,W.W., Fan,X.X., Zhu,Z.X., Cao,X.J., Zhu,Z.Y., Pei,D.S.,
            Wang,Y.Z., Zhang,J.Y., Wang,Y.Y. and Zheng,H.X.
  TITLE     Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient
            activation and innate antiviral response
  JOURNAL   PLoS Pathog 19 (10), e1011742 (2023)
   PUBMED   37871014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Jiang,S.H., Athanasopoulos,V., Ellyard,J.I., Chuah,A., Cappello,J.,
            Cook,A., Prabhu,S.B., Cardenas,J., Gu,J., Stanley,M., Roco,J.A.,
            Papa,I., Yabas,M., Walters,G.D., Burgio,G., McKeon,K., Byers,J.M.,
            Burrin,C., Enders,A., Miosge,L.A., Canete,P.F., Jelusic,M.,
            Tasic,V., Lungu,A.C., Alexander,S.I., Kitching,A.R., Fulcher,D.A.,
            Shen,N., Arsov,T., Gatenby,P.A., Babon,J.J., Mallon,D.F., de Lucas
            Collantes,C., Stone,E.A., Wu,P., Field,M.A., Andrews,T.D., Cho,E.,
            Pascual,V., Cook,M.C. and Vinuesa,C.G.
  TITLE     Functional rare and low frequency variants in BLK and BANK1
            contribute to human lupus
  JOURNAL   Nat Commun 10 (1), 2201 (2019)
   PUBMED   31101814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Alexandropoulos,K., Cheng,G. and Baltimore,D.
  TITLE     Proline-rich sequences that bind to Src homology 3 domains with
            individual specificities
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3110-3114 (1995)
   PUBMED   7536925
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Islam,K.B., Rabbani,H., Larsson,C., Sanders,R. and Smith,C.I.
  TITLE     Molecular cloning, characterization, and chromosomal localization
            of a human lymphoid tyrosine kinase related to murine Blk
  JOURNAL   J Immunol 154 (3), 1265-1272 (1995)
   PUBMED   7822795
REFERENCE   8  (bases 1 to 2475)
  AUTHORS   Dymecki,S.M., Zwollo,P., Zeller,K., Kuhajda,F.P. and Desiderio,S.V.
  TITLE     Structure and developmental regulation of the B-lymphoid tyrosine
            kinase gene blk
  JOURNAL   J Biol Chem 267 (7), 4815-4823 (1992)
   PUBMED   1537861
REFERENCE   9  (bases 1 to 2475)
  AUTHORS   Kozak,C.A., Dymecki,S.M., Niederhuber,J.E. and Desiderio,S.V.
  TITLE     Genetic mapping of the gene for a novel tyrosine kinase, Blk, to
            mouse chromosome 14
  JOURNAL   Genomics 9 (4), 762-764 (1991)
   PUBMED   2037301
REFERENCE   10 (bases 1 to 2475)
  AUTHORS   Dymecki,S.M., Niederhuber,J.E. and Desiderio,S.V.
  TITLE     Specific expression of a tyrosine kinase gene, blk, in B lymphoid
            cells
  JOURNAL   Science 247 (4940), 332-336 (1990)
   PUBMED   2404338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK089888.1.
            
            On Jun 19, 2003 this sequence version replaced NM_007549.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089888.1, AK171640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.25 cM"
     gene            1..2475
                     /gene="Blk"
                     /note="B lymphoid kinase"
                     /db_xref="GeneID:12143"
                     /db_xref="MGI:MGI:88169"
     exon            1..419
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            420..525
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..1920
                     /gene="Blk"
                     /EC_number="2.7.10.2"
                     /note="p55-Blk; b lymphocyte kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Blk"
                     /protein_id="NP_031575.2"
                     /db_xref="CCDS:CCDS27200.1"
                     /db_xref="GeneID:12143"
                     /db_xref="MGI:MGI:88169"
                     /translation="MGLLSSKRQVSEKGKGWSPVKIRTQDKAPPPLPPLVVFNHLAPP
                     SPNQDPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLRSTGDWWLARSLVTGREGYV
                     PSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKD
                     ITTQGEVVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSKKGDGLCQKLTLPCVNLA
                     PKNLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFL
                     GEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDM
                     SAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFP
                     IKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPC
                     PETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP"
     exon            526..577
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            578..671
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            672..770
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            771..874
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1021
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1174
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1354
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1431
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1582
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1714
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2475
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Blk"
                     /note="putative"
     polyA_site      2475
                     /gene="Blk"
                     /note="putative"
ORIGIN      
        1 gggaaacacc agccgtgtgg tgaaccaaaa cccatgagaa aactttgggg tggcagaggg
       61 gcatcatgac cagcctggct gaaggtcagg tgcccatgaa acttcctcag aaacacctcc
      121 ggggctgagg agccagaagt ctccagaaga cttgactgga gggcagagct cccactgagc
      181 tgcttcttag ggctgttcat ggcggtctga tcacaacagg gggcacacac acctctgtgt
      241 gctgttggca ggaagccaca agccactgaa gctgactgag atgagaagaa tccatctggg
      301 gatgggattg gcttttctta actgggtcca gagcttctgg ttgccgctag aaagttcttc
      361 aaccacacag accctgggat ctgcacagct atgttgagaa gctactgaag ccctgcaagg
      421 atggggctgc tgagcagcaa gaggcaggtc agtgagaagg gcaagggctg gagccccgtg
      481 aagatccgca cccaggacaa ggctccccca cccctgccac ccctggttgt cttcaaccac
      541 cttgccccac catctcctaa ccaggaccca gatgaagagg agcgttttgt ggtggctctg
      601 tttgactatg ccgctgtgaa tgacagggac cttcaggtgc tgaagggtga gaagctccag
      661 gtcttgagga gcactggaga ctggtggttg gccaggtcac tcgtcacagg aagagaaggt
      721 tatgtgccca gcaactttgt ggccccagta gagactctgg aagtagaaaa atggttcttc
      781 aggaccatca gccggaagga tgctgagagg cagttgctgg ctccgatgaa caaggccggc
      841 tcctttctca tcagagagag tgagagcaat aaaggtgcct tttccctgtc cgtgaaagat
      901 atcaccaccc agggggaggt ggtcaagcac tataagatcc gatcactgga caatggaggc
      961 tattacatct ccccccggat cacctttccc accctccagg ccctggtgca gcactattca
     1021 aagaaagggg atggtttgtg tcagaagttg actctgccct gtgtgaacct ggccccgaag
     1081 aacctttggg cccaagatga atgggaaatc cccaggcagt ctctcaagtt ggtccggaaa
     1141 cttgggtctg ggcagtttgg cgaagtctgg atgggttatt acaaaaataa catgaaggtg
     1201 gccatcaaga ccctgaagga gggaaccatg tcaccggaag ctttcctggg cgaggccaac
     1261 gtgatgaaaa ccctgcagca tgagaggctg gttcgtctct acgctgtggt caccagagag
     1321 cccatttaca tcgtcactga atacatggcc agaggatgct tgctggattt tctgaagacc
     1381 gatgaaggta gcaggttgtc ccttccaagg ctgattgaca tgtcagccca ggttgcagag
     1441 gggatggctt acatagagcg catgaattcc atccaccgtg acctgcgggc agccaacatc
     1501 ctggtgtctg agacgttgtg ctgcaaaatc gctgacttcg gcttggccag gatcattgac
     1561 agtgaataca ctgcccaaga gggggccaag ttccccatca agtggaccgc cccggaggcc
     1621 atccacttcg gggtgtttac catcaaggct gatgtgtggt ccttcggagt cttgctgatg
     1681 gagattgtca cctatgggcg cgttccctac ccaggaatga gcaaccctga ggtcatccgt
     1741 agcctggagc acggctaccg aatgccatgc ccggagacat gtccaccgga gttgtacaat
     1801 gatatcatca ctgagtgctg gcggggccgg ccagaggagc ggcctacctt tgagttcctg
     1861 cagtcggtgt tggaggactt ctacacagcc acggagggcc aatatgagct gcagccctag
     1921 caaccaatgg tctcttcagg gctcccagcc tgagcctcct tctggactct gactttgggt
     1981 taatatgttc acacttagct cttcttccag gtaggttgca gaatcaggga agaatggtgt
     2041 gcctgcttct caagtgaggg agccaggaga caaagatggc ttcatggtga ggcatgagct
     2101 ctcaaggcac aacctcggtc cacctttcac tggctgtgtg cctttggcca agttactttg
     2161 ctgctctgtg tcgtctcttc cttgaatgta aaatgagcaa ggattgtgtt agaacttacc
     2221 tccagttgtg ttcagacccc gatagtcccg aaatcagtct gaccagttag cgatggacag
     2281 gatgtcaggc tgtcataacc cagagtgcaa tcagagctcc catttctctc accttttcag
     2341 tctcatcagc aagtgcctcc ctgtctgctg cttcagaact atgggtcaat cctccaggtc
     2401 ccctggctgt gtgcccccta cccatccctg catgcacact ttgggacttt tctataataa
     2461 agtcatgaga attgt
//
