LOCUS       NM_001163247            1178 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus baculoviral IAP repeat-containing 7 (Birc7), mRNA.
ACCESSION   NM_001163247 XM_283820 XM_914797
VERSION     NM_001163247.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Che,D., Li,Y., Hang,B., Li,K., Wang,K. and Wang,H.
  TITLE     Livin expression promotes keratinocyte release of inflammatory
            mediators in psoriasis
  JOURNAL   Skin Res Technol 30 (2), e13603 (2024)
   PUBMED   38332513
  REMARK    GeneRIF: Livin expression promotes keratinocyte release of
            inflammatory mediators in psoriasis.
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Wang,K., You,X., Qu,Z., Che,D. and Cao,X.
  TITLE     Livin is protective in UVB-induced skin photodamage by regulating
            keratinocyte activation and inflammatory responses
  JOURNAL   J Cell Mol Med 28 (4), e18124 (2024)
   PUBMED   38332512
  REMARK    GeneRIF: Livin is protective in UVB-induced skin photodamage by
            regulating keratinocyte activation and inflammatory responses.
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Che,D., Hang,B., Li,Y., Li,K., Wang,K. and Wang,H.
  TITLE     Livin upregulation in keratinocytes of psoriasis patients to
            promote adhesion molecule expression
  JOURNAL   Int J Dermatol 62 (7), 900-909 (2023)
   PUBMED   36916467
  REMARK    GeneRIF: Livin upregulation in keratinocytes of psoriasis patients
            to promote adhesion molecule expression.
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Godin,P., Tsoi,M., Paquet,M. and Boerboom,D.
  TITLE     YAP and TAZ are required for the postnatal development and the
            maintenance of the structural integrity of the oviduct
  JOURNAL   Reproduction 160 (2), 307-318 (2020)
   PUBMED   32520726
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Zhao,C.L., Han,S.N., Wang,Z.J., Wang,S.H., Zhao,G.Q., Zhang,X.F.
            and Wang,J.X.
  TITLE     Concomitant modulation of PTEN and Livin in gastric cancer
            treatment
  JOURNAL   Int J Mol Med 41 (5), 2901-2908 (2018)
   PUBMED   29436592
  REMARK    GeneRIF: The overexpression of PTEN concomitant with Livin gene
            silencing was confirmed as a feasible and effective in vitro and in
            vivo gene modulation method, which may represent a potential
            therapeutic strategy for the treatment of Gastric Cancer.
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Lin,X., Li,H.R., Lin,X.F., Yu,M.E., Tu,X.W., Hua,Z.D., Lin,M.,
            Xu,N.L., Han,L.L. and Chen,Y.S.
  TITLE     Silencing of Livin inhibits tumorigenesis and metastasis via VEGF
            and MMPs pathway in lung cancer
  JOURNAL   Int J Oncol 47 (2), 657-667 (2015)
   PUBMED   26094984
  REMARK    GeneRIF: Data showed that Livin knock-down suppressed cell
            proliferation and inhibited cell invasion, accompanied by
            downregulation of VEGF and MMP-2/-9. Its silencing resulted in the
            prevention of xenograft tumor formation.
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   De Maria,A. and Bassnett,S.
  TITLE     Birc7: A Late Fiber Gene of the Crystalline Lens
  JOURNAL   Invest Ophthalmol Vis Sci 56 (8), 4823-4834 (2015)
   PUBMED   26218911
  REMARK    GeneRIF: Birc7 is a late fiber gene of the mouse lens. Its
            expression in cells bordering the OFZ is consistent with a role in
            organelle degradation, a process in which the ubiquitin proteasome
            pathway has been implicated previously.
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Varfolomeev,E., Moradi,E., Dynek,J.N., Zha,J., Fedorova,A.V.,
            Deshayes,K., Fairbrother,W.J., Newton,K., Le Couter,J. and Vucic,D.
  TITLE     Characterization of ML-IAP protein stability and physiological role
            in vivo
  JOURNAL   Biochem J 447 (3), 427-436 (2012)
   PUBMED   22853455
  REMARK    GeneRIF: ML-IAP is dispensable for both normal mouse development
            and ocular homoeostasis.
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Liston,P., Fong,W.G. and Korneluk,R.G.
  TITLE     The inhibitors of apoptosis: there is more to life than Bcl2
  JOURNAL   Oncogene 22 (53), 8568-8580 (2003)
   PUBMED   14634619
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954707.18.
            
            On or before Jul 13, 2009 this sequence version replaced
            XM_914797.3, XM_283820.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.10571213.1,
                                           SRR7345562.2408063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               AL954707.18        188659-189149
            492-591             AL954707.18        190441-190540
            592-670             AL954707.18        190895-190973
            671-716             AL954707.18        191055-191100
            717-788             AL954707.18        192555-192626
            789-987             AL954707.18        192773-192971
            988-1178            AL954707.18        193456-193646
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.53 cM"
     gene            1..1178
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /note="baculoviral IAP repeat-containing 7"
                     /db_xref="GeneID:329581"
                     /db_xref="MGI:MGI:2676458"
     exon            1..491
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..982
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /EC_number="2.3.2.27"
                     /note="baculoviral IAP repeat-containing protein 7;
                     RING-type E3 ubiquitin transferase BIRC7"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 7
                     precursor"
                     /protein_id="NP_001156719.1"
                     /db_xref="CCDS:CCDS50840.1"
                     /db_xref="GeneID:329581"
                     /db_xref="MGI:MGI:2676458"
                     /translation="MFSPADLFRAAVFSMGPESRARDSVRGPELSHREDGSGRTQEQD
                     KPHCPCNHVLGQDCLDGQILGQLRPLSEEEESSGAAFLGEPAFPEMDSEDLRLASFYD
                     WPSTAGIQPEPLAAAGFFHTGQQDKVRCFFCYGGLQSWERGDDPWTEHARWFPRCQFL
                     LRSKGRDFVERIQTYTPLLGSWDQREEPEDAVSATPSAPAHGSPELLRSRRETQPEDV
                     SEPGAKDVQEQLRQLQEERRCKVCLDRAVSIVFVPCGHFVCTECAPNLQLCPICRVPI
                     CSCVRTFLS"
     exon            492..591
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..670
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            671..716
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            717..788
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            789..987
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1178
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1155..1160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /note="hexamer: AATAAA"
     polyA_site      1178
                     /gene="Birc7"
                     /gene_synonym="E130019N06; KIAP; Livin; ML-IAP"
                     /note="major polyA site"
ORIGIN      
        1 gacaccgcca ctgcctctga gcatctagca gcttgcagtt agaagcagga acaccacagc
       61 ctctgggaag gactagaggc aggagctgga acggtacaac accaggcaca ttcctgggct
      121 ggtgatgttc tcacctgcag acttattcag agctgctgtc ttttccatgg ggcctgagag
      181 tagggccagg gactcggtcc gtggcccaga actaagccac agggaagatg gcagtggccg
      241 cacacaggaa caggataaac cccactgtcc gtgtaaccat gtcctgggcc aggactgcct
      301 agatgggcag atcttaggcc agcttcggcc tctgtcagaa gaggaagaat cctctggggc
      361 tgccttcctt ggggagcctg ccttccctga gatggactca gaggatctcc ggctagcctc
      421 cttctacgac tggccatcta ctgcagggat tcagcctgag ccattggctg ctgctgggtt
      481 cttccacaca ggccagcagg acaaggtgag atgtttcttc tgctatgggg gtctacagag
      541 ctgggagcgt ggggatgacc cctggacaga gcatgcccga tggtttccca ggtgtcagtt
      601 cctgctacgg tcaaaaggaa gggactttgt ggaaagaatc cagacctaca cccctttgct
      661 gggatcctgg gatcagcgag aagaaccaga agatgcagtc tctgccactc cctcagctcc
      721 tgcccatgga agccctgagt tactcagatc cagaagagag acccagcctg aagatgtcag
      781 tgagccagga gccaaggatg ttcaggaaca gctgcgacag ctgcaggaag agaggagatg
      841 caaggtgtgc ctggaccgag ccgtctccat agtcttcgtg ccctgtggcc acttcgtctg
      901 caccgagtgt gctcccaacc tgcagctgtg ccctatctgc agggtgccta tctgtagctg
      961 tgtacgcaca ttcctgtcct aaaccaggaa ctacactgca gagtgggtac cctgcctgct
     1021 tcagcctgtc ccagatcata cagtgagtct gctggggaca tccagtgtcc cccacaaaca
     1081 gtacagcatg gaggaaaagt tcctggtttg tgtgaagagt gttctgctgt agcattttgg
     1141 atctacttga agataataaa gcagaagttc tcacccta
//
