LOCUS       NM_009689                977 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus baculoviral IAP repeat-containing 5 (Birc5),
            transcript variant 1, mRNA.
ACCESSION   NM_009689
VERSION     NM_009689.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Canato,S., Sarate,R., Carvalho-Marques,S., Maia Soares,R., Song,Y.,
            Monteiro-Ferreira,S., Vieugue,P., Liagre,M., Grossi,G., Cardoso,E.,
            Dubois,C., Conway,E.M., Schenone,S., Sanchez-Danes,A. and
            Blanpain,C.
  TITLE     Survivin Promotes Stem Cell Competence for Skin Cancer Initiation
  JOURNAL   Cancer Discov 15 (2), 427-443 (2025)
   PUBMED   39526566
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Grego-Bessa,J., Gomez-Apinaniz,P., Prados,B., Gomez,M.J.,
            MacGrogan,D. and de la Pompa,J.L.
  TITLE     Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in
            Ventricular Development
  JOURNAL   Circ Res 133 (11), 927-943 (2023)
   PUBMED   37846569
REFERENCE   4  (bases 1 to 977)
  AUTHORS   Nagy,N., Kaber,G., Sunkari,V.G., Marshall,P.L., Hargil,A.,
            Kuipers,H.F., Ishak,H.D., Bogdani,M., Hull,R.L., Grandoch,M.,
            Fischer,J.W., McLaughlin,T.L., Wight,T.N. and Bollyky,P.L.
  TITLE     Inhibition of hyaluronan synthesis prevents beta-cell loss in
            obesity-associated type 2 diabetes
  JOURNAL   Matrix Biol 123, 34-47 (2023)
   PUBMED   37783236
REFERENCE   5  (bases 1 to 977)
  AUTHORS   Loredan,D.G., Devlin,J.C., Lacey,K.A., Howard,N., Chen,Z.,
            Zwack,E.E., Lin,J.D., Ruggles,K.V., Khanna,K.M., Torres,V.J. and
            Loke,P.
  TITLE     Single-Cell Analysis of CX3CR1+ Cells Reveals a Pathogenic Role for
            BIRC5+ Myeloid Proliferating Cells Driven by Staphylococcus aureus
            Leukotoxins
  JOURNAL   J Immunol 211 (5), 836-843 (2023)
   PUBMED   37466391
REFERENCE   6  (bases 1 to 977)
  AUTHORS   Kobayashi,K., Hatano,M., Otaki,M., Ogasawara,T. and Tokuhisa,T.
  TITLE     Expression of a murine homologue of the inhibitor of apoptosis
            protein is related to cell proliferation
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1457-1462 (1999)
   PUBMED   9990045
REFERENCE   7  (bases 1 to 977)
  AUTHORS   Lu,K.P. and Ramos,K.S.
  TITLE     Identification of genes differentially expressed in vascular smooth
            muscle cells following benzo[a]pyrene challenge: implications for
            chemical atherogenesis
  JOURNAL   Biochem Biophys Res Commun 253 (3), 828-833 (1998)
   PUBMED   9918813
REFERENCE   8  (bases 1 to 977)
  AUTHORS   LaCasse,E.C., Baird,S., Korneluk,R.G. and MacKenzie,A.E.
  TITLE     The inhibitors of apoptosis (IAPs) and their emerging role in
            cancer
  JOURNAL   Oncogene 17 (25), 3247-3259 (1998)
   PUBMED   9916987
  REMARK    Review article
REFERENCE   9  (bases 1 to 977)
  AUTHORS   Adida,C., Crotty,P.L., McGrath,J., Berrebi,D., Diebold,J. and
            Altieri,D.C.
  TITLE     Developmentally regulated expression of the novel cancer
            anti-apoptosis gene survivin in human and mouse differentiation
  JOURNAL   Am J Pathol 152 (1), 43-49 (1998)
   PUBMED   9422522
REFERENCE   10 (bases 1 to 977)
  AUTHORS   Tewari,M., Yu,M., Ross,B., Dean,C., Giordano,A. and Rubin,R.
  TITLE     AAC-11, a novel cDNA that inhibits apoptosis after growth factor
            withdrawal
  JOURNAL   Cancer Res 57 (18), 4063-4069 (1997)
   PUBMED   9307294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN724527.1, AB013819.1 and
            AI413910.1.
            
            On Feb 16, 2005 this sequence version replaced NM_009689.1.
            
            Summary: This gene is a member of the inhibitor of apoptosis (IAP)
            gene family, which encode negative regulatory proteins that prevent
            apoptotic cell death. IAP family members usually contain multiple
            baculovirus IAP repeat (BIR) domains, but this gene encodes
            proteins with only a single BIR domain. The encoded proteins also
            lack a C-terminus RING finger domain. In humans, gene expression is
            high during fetal development and in most tumors yet low in adult
            tissues. Antisense transcripts have been identified in human that
            regulate this gene's expression. At least three transcript variants
            encoding distinct isoforms have been found for this gene, although
            at least one of these transcript variants is a nonsense-mediated
            decay (NMD) candidate. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as survivin140,
            represents the most frequently occurring transcript and it encodes
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN724527.1, AB013819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CN724527.1         1-18
            19-961              AB013819.1         13-955
            962-977             AI413910.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     gene            1..977
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /note="baculoviral IAP repeat-containing 5"
                     /db_xref="GeneID:11799"
                     /db_xref="MGI:MGI:1203517"
     exon            1..225
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..537
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     survivin; baculoviral IAP repeat-containing protein 5;
                     apoptosis inhibitor survivin; apoptosis inhibitor 4"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 5
                     isoform 1"
                     /protein_id="NP_033819.1"
                     /db_xref="CCDS:CCDS25694.1"
                     /db_xref="GeneID:11799"
                     /db_xref="MGI:MGI:1203517"
                     /translation="MGAPALPQIWQLYLKNYRIATFKNWPFLEDCACTPERMAEAGFI
                     HCPTENEPDLAQCFFCFKELEGWEPDDNPIEEHRKHSPGCAFLTVKKQMEELTVSEFL
                     KLDRQRAKNKIAKETNNKQKEFEETAKTTRQSIEQLAA"
     exon            226..335
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            336..453
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /inference="alignment:Splign:2.1.0"
     exon            454..972
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      939..944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /note="hexamer: AATAAA"
     polyA_site      968
                     /gene="Birc5"
                     /gene_synonym="AAC-11; Api4; survivin40; TIAP"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgagg gcgtggggcc ggggctctcc cggcatgctc tgcggcgcgc ctccgcccgc
       61 gcgatttgaa tcctgcgttt gagtcgtctt ggcggaggtt gtggtgacgc catcatggga
      121 gctccggcgc tgccccagat ctggcagctg tacctcaaga actaccgcat cgccaccttc
      181 aagaactggc ccttcctgga ggactgcgcc tgcaccccag agcgaatggc ggaggctggc
      241 ttcatccact gccctaccga gaacgagcct gatttggccc agtgtttttt ctgctttaag
      301 gaattggaag gctgggaacc cgatgacaac ccgatagagg agcatagaaa gcactcccct
      361 ggctgcgcct tcctcactgt caagaagcag atggaagaac taaccgtcag tgaattcttg
      421 aaactggaca gacagagagc caagaacaaa attgcaaagg agaccaacaa caagcaaaaa
      481 gagtttgaag agactgcaaa gactacccgt cagtcaattg agcagctggc tgcctaatgc
      541 tgagcctttg ctgagataac ttggacctga gtgacatgcc acatctaagc cacgcatccc
      601 agcttttcca gccagggcct cctagcagga tcttagagaa ggagacagtg gtattttgaa
      661 actggatatc aaatattttt ggttttgctt taaagtggct acctctcttt ggttttgtgg
      721 ctttgctcta ttgtgacgtg gacttaagca ataaggaagt gatgaaggga cagtgttctc
      781 tgacaggacc tgtgggggtc ggggtgcctg tgcaaggtct tggttctgat tgtgatattt
      841 ccatacaggg ctgctaatgc agcccatggg taagtgtggt tatatgtgtt tgtgctgata
      901 attttgtcct gatgagtttt cctaccacgg ggtaacggaa taaaatcact tgaaaaagtg
      961 gactgtaagc tcaaaaa
//
