LOCUS       NM_007465               3333 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus baculoviral IAP repeat-containing 2 (Birc2),
            transcript variant 1, mRNA.
ACCESSION   NM_007465 XM_006509834
VERSION     NM_007465.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3333)
  AUTHORS   Schorn,F., Werthenbach,J.P., Hoffmann,M., Daoud,M.,
            Stachelscheid,J., Schiffmann,L.M., Hildebrandt,X., Lyu,S.I.,
            Peltzer,N., Quaas,A., Vucic,D., Silke,J., Pasparakis,M. and
            Kashkar,H.
  TITLE     cIAPs control RIPK1 kinase activity-dependent and -independent cell
            death and tissue inflammation
  JOURNAL   EMBO J 42 (22), e113614 (2023)
   PUBMED   37789765
REFERENCE   2  (bases 1 to 3333)
  AUTHORS   Sheldon,C., Farley,A., Ma,Q., Pu,W.T. and Lin,Z.
  TITLE     Depletion of VGLL4 Causes Perinatal Lethality without Affecting
            Myocardial Development
  JOURNAL   Cells 11 (18), 2832 (2022)
   PUBMED   36139407
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3333)
  AUTHORS   Gao,P., Ma,X., Yuan,M., Yi,Y., Liu,G., Wen,M., Jiang,W., Ji,R.,
            Zhu,L., Tang,Z., Yu,Q., Xu,J., Yang,R., Xia,S., Yang,M., Pan,J.,
            Yuan,H. and An,H.
  TITLE     E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing
            K29-linked cysteine ubiquitination of TRAF3
  JOURNAL   Nat Commun 12 (1), 1194 (2021)
   PUBMED   33608556
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3333)
  AUTHORS   Ebert,G., Lopaticki,S., O'Neill,M.T., Steel,R.W.J., Doerflinger,M.,
            Rajasekaran,P., Yang,A.S.P., Erickson,S., Ioannidis,L.,
            Arandjelovic,P., Mackiewicz,L., Allison,C., Silke,J., Pellegrini,M.
            and Boddey,J.A.
  TITLE     Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes
            Clearance of Plasmodium Liver Infection
  JOURNAL   Cell Rep 30 (13), 4343-4354 (2020)
   PUBMED   32234472
REFERENCE   5  (bases 1 to 3333)
  AUTHORS   Suhail,A., Rizvi,Z.A., Mujagond,P., Ali,S.A., Gaur,P., Singh,M.,
            Ahuja,V., Awasthi,A. and Srikanth,C.V.
  TITLE     DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal
            Inflammation via Expansion of Gamma-Delta T Cells
  JOURNAL   Cell Rep 29 (11), 3522-3538 (2019)
   PUBMED   31825833
REFERENCE   6  (bases 1 to 3333)
  AUTHORS   Warnakulasuriyarachchi,D., Ungureanu,N.H. and Holcik,M.
  TITLE     The translation of an antiapoptotic protein HIAP2 is regulated by
            an upstream open reading frame
  JOURNAL   Cell Death Differ 10 (8), 899-904 (2003)
   PUBMED   12867997
REFERENCE   7  (bases 1 to 3333)
  AUTHORS   Deveraux,Q.L. and Reed,J.C.
  TITLE     IAP family proteins--suppressors of apoptosis
  JOURNAL   Genes Dev 13 (3), 239-252 (1999)
   PUBMED   9990849
  REMARK    Review article
REFERENCE   8  (bases 1 to 3333)
  AUTHORS   LaCasse,E.C., Baird,S., Korneluk,R.G. and MacKenzie,A.E.
  TITLE     The inhibitors of apoptosis (IAPs) and their emerging role in
            cancer
  JOURNAL   Oncogene 17 (25), 3247-3259 (1998)
   PUBMED   9916987
  REMARK    Review article
REFERENCE   9  (bases 1 to 3333)
  AUTHORS   Liston,P., Lefebvre,C., Fong,W.G., Xuan,J.Y. and Korneluk,R.G.
  TITLE     Genomic characterization of the mouse inhibitor of apoptosis
            protein 1 and 2 genes
  JOURNAL   Genomics 46 (3), 495-503 (1997)
   PUBMED   9441758
REFERENCE   10 (bases 1 to 3333)
  AUTHORS   Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
  TITLE     The TNFR2-TRAF signaling complex contains two novel proteins
            related to baculoviral inhibitor of apoptosis proteins
  JOURNAL   Cell 83 (7), 1243-1252 (1995)
   PUBMED   8548810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030639.8, BC145985.1 and AA144490.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_007465.4.
            
            On or before Jul 3, 2015 this sequence version replaced
            XM_006509834.2, NM_007465.2.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.347442.1,
                                           SRR7974084.15498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                CT030639.8         116121-116188
            69-339              CT030639.8         117799-118069
            340-3289            BC145985.1         1-2950
            3290-3333           AA144490.1         347-390
FEATURES             Location/Qualifiers
     source          1..3333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..3333
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /note="baculoviral IAP repeat-containing 2"
                     /db_xref="GeneID:11797"
                     /db_xref="MGI:MGI:1197009"
     exon            1..68
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            69..1943
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     CDS             970..2808
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /EC_number="2.3.2.27"
                     /note="baculoviral IAP repeat-containing 3; IAP-2; mIAP-2;
                     inhibitor of apoptosis protein 2; apoptosis inhibitor 2;
                     cellular inhibitor of apoptosis 1; RING-type E3 ubiquitin
                     transferase BIRC2"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 2"
                     /protein_id="NP_031491.2"
                     /db_xref="CCDS:CCDS22811.1"
                     /db_xref="GeneID:11797"
                     /db_xref="MGI:MGI:1197009"
                     /translation="MDKTVSQRLGQGTLHQKLKRIMEKSTILSNWTKESEEKMKFDFS
                     CELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEK
                     HRQFYPSCSFVQTLLSASLQSPSKNMSPVKSRFAHSSPLERGGIHSNLCSSPLNSRAV
                     EDFSSRMDPCSYAMSTEEARFLTYSMWPLSFLSPAELARAGFYYIGPGDRVACFACGG
                     KLSNWEPKDDAMSEHRRHFPHCPFLENTSETQRFSISNLSMQTHSARLRTFLYWPPSV
                     PVQPEQLASAGFYYVDRNDDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKG
                     QEFVDEIQARYPHLLEQLLSTSDTPGEENADPTETVVHFGPGESSEDVVMMSTPVVKA
                     ALEMGFSRSLVRQTVQRQILATGENYRTVNDIVSVLLNAEDERREEEKERQTEEMASG
                     DLSLIRKNRMALFQQLTHVLPILDNLLEASVITKQEHDIIRQKTQIPLQARELIDTVL
                     VKGNAAANIFKNSLKEIDSTLYENLFVEKNMKYIPTEDVSGLSLEEQLRRLQEERTCK
                     VCMDREVSIVFIPCGHLVVCQECAPSLRKCPICRGTIKGTVRTFLS"
     exon            1944..2022
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2071
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2317
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2572
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2614
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..3332
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3310..3315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /note="hexamer: AATAAA"
     polyA_site      3330
                     /gene="Birc2"
                     /gene_synonym="Api1; Api2; Birc3; C-IAP1; C330006D17Rik;
                     cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1;
                     MIAP2; MIHB; MIHC; RNF48"
                     /note="major polyA site"
ORIGIN      
        1 ttttgggaag gctgcggatc aacaatcagg cgcctctgct tccagggcgc cgggggcctg
       61 actcggtgat tgatagtcct caagagtctt catgttctct tatgtttttc tagaaatcag
      121 cccactcatg gacatctgaa catttctata agacgctgcg gtttgctttg cagtgtgttc
      181 ttgtgtatga ttagttatat aaaatacgaa gttttcaaaa agaaggctag tgcaacagaa
      241 aagctttgct aaaacagatt cttagttatt tgaggtaaca aaagaaagcc atgtcttgaa
      301 ttgattcgtt cttaattata acagacttat agtggaaagg gccttaaaca caggcggact
      361 ttataaaatg cagtcttagg tttatgtgca aaatactgtc tgttgaccag atgtattcac
      421 atgatatata cagagtcaag gtggtgatat agaagattta acagtgaggg agttaacagt
      481 ctgtgcttta agcgcagttc ctttacagtg aatactgtag tcttaataga cctgagctga
      541 ctgctgcagt tgatgtaacc cactttagag aatactgtat gacatcttct ctaaggaaaa
      601 ccagctgcag acttcactca gttcctttca tttcatagga aaaggagtag ttcagatgtc
      661 atgtttaagt ccttataagg gaaaagagcc tgaatatatg ccctagtacc taggcttcat
      721 aactagtaat aagaagttag ttatgggtaa atagatctca ggttacccag aagagttcat
      781 gtgaccccca aagagtccta actagtgtct tggcaagtga gacagatttg tcctgtgagg
      841 gtgtcaattc accagtccaa gcagaagaca atgaatctat ccagtcaggt gtctgtggtg
      901 gagatctagt gtcaagtggt gagaaacttc atctggaagt ttaagcggtc agaaatacta
      961 ttactactca tggacaaaac tgtctcccag agactcggcc aaggtacctt acaccaaaaa
     1021 cttaaacgta taatggagaa gagcacaatc ttgtcaaatt ggacaaagga gagcgaagaa
     1081 aaaatgaagt ttgacttttc gtgtgaactc taccgaatgt ctacatattc agcttttccc
     1141 aggggagttc ctgtctcaga gaggagtctg gctcgtgctg gcttttatta tacaggtgtg
     1201 aatgacaaag tcaagtgctt ctgctgtggc ctgatgttgg ataactggaa acaaggggac
     1261 agtcctgttg aaaagcacag acagttctat cccagctgca gctttgtaca gactctgctt
     1321 tcagccagtc tgcagtctcc atctaagaat atgtctcctg tgaaaagtag atttgcacat
     1381 tcgtcacctc tggaacgagg tggcattcac tccaacctgt gctctagccc tcttaattct
     1441 agagcagtgg aagacttctc atcaaggatg gatccctgca gctatgccat gagtacagaa
     1501 gaggccagat ttcttactta cagtatgtgg cctttaagtt ttctgtcacc agcagagctg
     1561 gccagagctg gcttctatta catagggcct ggagacaggg tggcctgttt tgcctgtggt
     1621 gggaaactga gcaactggga accaaaggat gatgctatgt cagagcaccg cagacatttt
     1681 ccccactgtc catttctgga aaatacttca gaaacacaga ggtttagtat atcaaatcta
     1741 agtatgcaga cacactctgc tcgattgagg acatttctgt actggccacc tagtgttcct
     1801 gttcagcccg agcagcttgc aagtgctgga ttctattacg tggatcgcaa tgatgatgtc
     1861 aagtgctttt gttgtgatgg tggcttgaga tgttgggaac ctggagatga cccctggata
     1921 gaacacgcca aatggtttcc aaggtgtgag ttcttgatac ggatgaaggg tcaggagttt
     1981 gttgatgaga ttcaagctag atatcctcat cttcttgagc agctgttgtc cacttcagac
     2041 accccaggag aagaaaatgc tgaccctaca gagacagtgg tgcattttgg ccctggagaa
     2101 agttcggaag atgtcgtcat gatgagcacg cctgtggtta aagcagcctt ggaaatgggc
     2161 ttcagtagga gcctggtgag acagacggtt cagcggcaga tcctggccac tggtgagaac
     2221 tacaggaccg tcaatgatat tgtctcagta cttttgaatg ctgaagatga gagaagagaa
     2281 gaggagaagg aaagacagac tgaagagatg gcatcaggtg acttatcact gattcggaag
     2341 aatagaatgg ccctctttca acagttgaca catgtccttc ctatcctgga taatcttctt
     2401 gaggccagtg taattacaaa acaggaacat gatattatta gacagaaaac acagataccc
     2461 ttacaagcaa gagagcttat tgacaccgtt ttagtcaagg gaaatgctgc agccaacatc
     2521 ttcaaaaact ctctgaagga aattgactcc acgttatatg aaaacttatt tgtggaaaag
     2581 aatatgaagt atattccaac agaagacgtt tcaggcttgt cattggaaga gcagttgcgg
     2641 agattacaag aagaacgaac ttgcaaagtg tgtatggaca gagaggtttc tattgtgttc
     2701 attccgtgtg gtcatctagt agtctgccag gaatgtgccc cttctctaag gaagtgcccc
     2761 atctgcaggg ggacaatcaa ggggactgtg cgcacatttc tctcatgagt gaagaatggt
     2821 ctgaaagtat tgttggacat cagaagctgt cagaacaaag aatgaactac tgatttcagc
     2881 tcttcagcag gacattctac tctctttcaa gattagtaat cttgctttat gaagggtagc
     2941 attgtatatt taagcttagt ctgttgcaag ggaaggtcta tgctgttgag ctacaggact
     3001 gtgtctgttc cagagcagga gttgggatgc ttgctgtatg tccttcagga cttcttggat
     3061 ttggaatttg tgaaagcttt ggattcaggt gatgtggagc tcagaaatcc tgaaaccagt
     3121 ggctctggta ctcagtagtt agggtaccct gtgcttcttg gtgcttttcc tttctggaaa
     3181 ataaggattt ttctgctact ggtaaatatt ttctgtttgt gagaaatata ttaaagtgtt
     3241 tcttttaaag gcgtgcatca ttgtagtgtg tgcagggatg tatgcaggca aaacactgtg
     3301 tatataataa ataaatcttt ttaaaaagtg tta
//
