LOCUS       NM_021328               1559 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus bridging integrator 3 (Bin3), transcript variant 1,
            mRNA.
ACCESSION   NM_021328
VERSION     NM_021328.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Choquet,H., Melles,R.B., Anand,D., Yin,J., Cuellar-Partida,G.,
            Wang,W., Hoffmann,T.J., Nair,K.S., Hysi,P.G., Lachke,S.A. and
            Jorgenson,E.
  CONSRTM   23andMe Research Team
  TITLE     A large multiethnic GWAS meta-analysis of cataract identifies new
            risk loci and sex-specific effects
  JOURNAL   Nat Commun 12 (1), 3595 (2021)
   PUBMED   34127677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Simionescu-Bankston,A., Leoni,G., Wang,Y., Pham,P.P.,
            Ramalingam,A., DuHadaway,J.B., Faundez,V., Nusrat,A.,
            Prendergast,G.C. and Pavlath,G.K.
  TITLE     The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent
            processes in myogenesis
  JOURNAL   Dev Biol 382 (1), 160-171 (2013)
   PUBMED   23872330
  REMARK    GeneRIF: Bin3 forms a complex with Rac1 and Cdc42, Rho GTPases
            involved in actin polymerization, which are known to be essential
            for myotube formation.
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Xue,W., Kitzing,T., Roessler,S., Zuber,J., Krasnitz,A., Schultz,N.,
            Revill,K., Weissmueller,S., Rappaport,A.R., Simon,J., Zhang,J.,
            Luo,W., Hicks,J., Zender,L., Wang,X.W., Powers,S., Wigler,M. and
            Lowe,S.W.
  TITLE     A cluster of cooperating tumor-suppressor gene candidates in
            chromosomal deletions
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8212-8217 (2012)
   PUBMED   22566646
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Ramalingam,A., Duhadaway,J.B., Sutanto-Ward,E., Wang,Y.,
            Dinchuk,J., Huang,M., Donover,P.S., Boulden,J., McNally,L.M.,
            Soler,A.P., Muller,A.J., Duncan,M.K. and Prendergast,G.C.
  TITLE     Bin3 deletion causes cataracts and increased susceptibility to
            lymphoma during aging
  JOURNAL   Cancer Res 68 (6), 1683-1690 (2008)
   PUBMED   18339847
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   O'Shaughnessy,P.J., Abel,M., Charlton,H.M., Hu,B., Johnston,H. and
            Baker,P.J.
  TITLE     Altered expression of genes involved in regulation of vitamin A
            metabolism, solute transportation, and cytoskeletal function in the
            androgen-insensitive tfm mouse testis
  JOURNAL   Endocrinology 148 (6), 2914-2924 (2007)
   PUBMED   17332066
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Fowles,L.F., Bennetts,J.S., Berkman,J.L., Williams,E., Koopman,P.,
            Teasdale,R.D. and Wicking,C.
  TITLE     Genomic screen for genes involved in mammalian craniofacial
            development
  JOURNAL   Genesis 35 (2), 73-87 (2003)
   PUBMED   12533789
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Routhier,E.L., Burn,T.C., Abbaszade,I., Summers,M., Albright,C.F.
            and Prendergast,G.C.
  TITLE     Human BIN3 complements the F-actin localization defects caused by
            loss of Hob3p, the fission yeast homolog of Rvs161p
  JOURNAL   J Biol Chem 276 (24), 21670-21677 (2001)
   PUBMED   11274158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151836.3, CA562064.1, AK005992.1, BB682940.1 and AI464318.1.
            
            On Feb 3, 2018 this sequence version replaced NM_021328.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026543.1, AF244361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC151836.3         98060-98067
            9-44                CA562064.1         1-36
            45-1393             AK005992.1         2-1350
            1394-1530           BB682940.1         303-439
            1531-1559           AI464318.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.21 cM"
     gene            1..1559
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /note="bridging integrator 3"
                     /db_xref="GeneID:57784"
                     /db_xref="MGI:MGI:1929883"
     exon            1..104
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..858
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="bridging integrator 3 isoform 1"
                     /protein_id="NP_067303.1"
                     /db_xref="CCDS:CCDS27247.1"
                     /db_xref="GeneID:57784"
                     /db_xref="MGI:MGI:1929883"
                     /translation="MSWIPFKIGQPKKQIVSKTVERDFEREYGKLQQLEEQTKRLQKD
                     MKKSTDADLAMSKSAVKISQDLLSNPLCEQDQDFLHMVTALDTAMKRMDAFNQEKVNQ
                     IQKTVIEPLKKFSSIFPSLNMAVKRREQALQDYGRLQAKVEKYEEKEKTGPVLAKLHQ
                     AREELRPVREDFEAKNKQLLDEMPRFYGSRLDYFQPSFESLIRAQVIYYSEMHKIFGD
                     LTQQLDQPGHSDEQRERENETKLSELRALSIVADD"
     exon            105..153
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            154..194
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            195..256
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            257..393
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            394..434
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..576
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            577..711
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..1534
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1515..1520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1534
                     /gene="Bin3"
                     /gene_synonym="1700015F07Rik"
                     /note="major polyA site"
ORIGIN      
        1 cctcatcact tcctggagac tggccgaatc cggaagtgat cctcgagaac ctacttttct
       61 accgaggacc ccggcagtcg gcgtgggttt aggaccatga gctggattcc atttaagatc
      121 gggcagccca agaagcagat tgtttccaaa acagtggaga gagactttga aagggagtat
      181 ggaaaactgc agcagctgga agagcaaact aaacgcctgc agaaggacat gaagaaaagc
      241 accgatgccg acctggccat gtccaaatct gctgtgaaga tatcccagga cctactgtcc
      301 aacccactgt gtgagcagga ccaggacttt ctgcacatgg tgacagccct agacacagcc
      361 atgaaacgga tggatgcctt caaccaggag aaggtgaacc agatccaaaa gacagtgatt
      421 gaacctctga aaaagttcag cagcatattc ccaagcctca acatggcggt gaagcggcgg
      481 gagcaggcct tgcaggacta cgggaggctg caggccaagg tggagaagta cgaggaaaag
      541 gagaagactg gccccgtgct ggccaagctc caccaggccc gagaagagct acgtcctgtg
      601 cgggaagact ttgaggccaa gaataaacaa ctcctggatg agatgccgcg gttctatggc
      661 agccgacttg actatttcca acccagcttt gagtccctga tccgggcaca ggttatatac
      721 tactcagaaa tgcataagat ctttggagac ctgacccagc agcttgacca gccaggccac
      781 tcagatgagc agcgagagcg ggaaaatgag accaaactaa gtgaactccg agccctctcc
      841 atcgtggctg atgactgagc ccctgtccct caggagtcct tagactcttt gggacacagg
      901 tgacatctct ataggctttg ctcctagcgg gcatggattc atggacctcc caatggccag
      961 gcagttggag acaggtggcc actattgtac cttgccagtt ctctgactta aatgtctcca
     1021 tgtccttaag cctgatacta ggagcctcac aggctgctgc ttccctgtgt ccagtgctga
     1081 taagcaatgt agaaaaaccc tggggccttt ttacttccag aaccgtccag agtgtgctat
     1141 agtgtctggc caacaggagc ctttggaagg gcctgggctt cctgtggaac ttgaagcctt
     1201 agctgtctac ctccagagga cctactctag gaaagccacc atcctctcag gactctttag
     1261 actgctgggt gaggcacagt gccctggtct ctcagcctct ctgggccctt catgccaaca
     1321 caaccaaagc cagtccccta taggtccagc acagggacaa agcccaggag tttagctttc
     1381 ccttgaactg gggctttgtc tctagctgtc cactaggaaa tgttacatgt tgaactgctg
     1441 ccctcaaagc aaggctctgt ctcacctgta ttactggaat tttattttca cttgttattg
     1501 gaattttatt ttcaagtaaa gttttccagt aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
