LOCUS       NM_001270537            1981 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus bridging integrator 2 (Bin2), transcript variant 1,
            mRNA.
ACCESSION   NM_001270537
VERSION     NM_001270537.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1981)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1981)
  AUTHORS   Zhu,F.Y., Wang,L.L., Meng,T.G., Wang,R.L., Yang,Z.X., Cao,Y.,
            Zhu,G.Y., Jin,Z., Gao,L.L., Zeng,W.T., Wang,Z.B., Sun,Q.Y. and
            Zhang,D.
  TITLE     Inhibiting bridge integrator 2 phosphorylation leads to improved
            oocyte quality, ovarian health and fertility in aging and after
            chemotherapy in mice
  JOURNAL   Nat Aging 1 (11), 1010-1023 (2021)
   PUBMED   37118338
  REMARK    GeneRIF: Inhibiting bridge integrator 2 phosphorylation leads to
            improved oocyte quality, ovarian health and fertility in aging and
            after chemotherapy in mice.
REFERENCE   3  (bases 1 to 1981)
  AUTHORS   Volz,J., Kusch,C., Beck,S., Popp,M., Vogtle,T., Meub,M.,
            Scheller,I., Heil,H.S., Preu,J., Schuhmann,M.K., Hemmen,K.,
            Premsler,T., Sickmann,A., Heinze,K.G., Stegner,D., Stoll,G.,
            Braun,A., Sauer,M. and Nieswandt,B.
  TITLE     BIN2 orchestrates platelet calcium signaling in thrombosis and
            thrombo-inflammation
  JOURNAL   J Clin Invest 130 (11), 6064-6079 (2020)
   PUBMED   32750041
  REMARK    GeneRIF: BIN2 orchestrates platelet calcium signaling in thrombosis
            and thrombo-inflammation.
REFERENCE   4  (bases 1 to 1981)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   5  (bases 1 to 1981)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 1981)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123724.9.
            
            On Feb 15, 2019 this sequence version replaced NM_001270537.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.77358.1,
                                           SRR7345562.803900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC123724.9         128104-128194       c
            92-172              AC123724.9         121208-121288       c
            173-227             AC123724.9         115751-115805       c
            228-322             AC123724.9         115401-115495       c
            323-418             AC123724.9         114886-114981       c
            419-526             AC123724.9         111076-111183       c
            527-612             AC123724.9         110650-110735       c
            613-688             AC123724.9         108891-108966       c
            689-771             AC123724.9         107771-107853       c
            772-1498            AC123724.9         103504-104230       c
            1499-1981           AC123724.9         99773-100255        c
FEATURES             Location/Qualifiers
     source          1..1981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.37 cM"
     gene            1..1981
                     /gene="Bin2"
                     /note="bridging integrator 2"
                     /db_xref="GeneID:668218"
                     /db_xref="MGI:MGI:3611448"
     exon            1..91
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1528
                     /gene="Bin2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="bridging integrator 2 isoform 1"
                     /protein_id="NP_001257466.1"
                     /db_xref="CCDS:CCDS59622.1"
                     /db_xref="GeneID:668218"
                     /db_xref="MGI:MGI:3611448"
                     /translation="MAEGKAGGAAGLFAKQMQKKFSRAQEKVLQKLGKTVETKDERFE
                     QSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEVYSSDWDGHEDLKAI
                     VGNNDLLWEDYEEKLADQALRTMENYVSQFSEIKERIAKRGRKLVDYDSARHHLEAVQ
                     NAKKKDDAKMAKAEEDFSKAQIVFEDLNQELLEELPILYNSRIGCYVTVFQNISNLRD
                     VFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVQSCAASSPVS
                     PVSPVSPVTSPTSPSATSEPESVSATGEELTSEAGGEDSCESQESLKDEEADEAQSET
                     SSSEEEDEEDEEDEEDEEEPLPACNGPTPAPASPAAEVGSQEEALSSSAQSPGRGQTG
                     KDTPSPGDVVLRARASSEGAEQSKRAASIQRTSAPPSRPPPPRASGSGSCNAPGSPEG
                     SSQLCSPRASPDASSNPEPAETREKEGAGSSGPEEPRAVSTKSATQVFTSENTEL"
     exon            92..172
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..227
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..322
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..418
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..526
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..612
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..688
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..771
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1498
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1981
                     /gene="Bin2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bin2"
                     /note="hexamer: AATAAA"
     polyA_site      1980
                     /gene="Bin2"
                     /note="major polyA site"
ORIGIN      
        1 agccggcagg atggcagagg gcaaggcggg cggagcggct ggcctcttcg ccaagcagat
       61 gcagaagaag ttcagcaggg cccaggagaa ggttctgcag aaattgggga aaaccgtaga
      121 aaccaaagac gagcgatttg aacaaagtgc cagcaacttc taccaacagc aggcagaagg
      181 ccacaagctg tacaaggacc tgaagaactt ccttagtgca gtcaaagtga tgcatgaaag
      241 ctcaaagaga gtatcagaga ccctgcagga ggtctacagc agcgactggg atgggcatga
      301 ggacctgaag gccattgtgg ggaacaatga cctcctttgg gaagactatg aagagaaact
      361 ggctgaccag gccttgagga ccatggagaa ttatgtgtcg cagttcagcg agattaagga
      421 gaggattgcc aagcggggcc ggaaactggt agactacgat agtgcccgcc atcacctgga
      481 ggccgtgcag aatgctaaga agaaggatga cgccaagatg gctaaggcag aagaagactt
      541 cagcaaggcc cagattgtat ttgaagatct gaaccaggaa ctcctggagg agttgcctat
      601 tctttataac agtcgtattg gctgctatgt gactgtcttc caaaacattt ccaacctgag
      661 agacgtcttc tacagggaga tgagcaagtt gaaccacaat ctctacgaag tgatgagcaa
      721 actggagaaa caacattcca acaaagtctt tgtggtgaag ggcctgtcaa gcagcagccg
      781 gcgctcctta gtcatctctc ccccagtaca aagctgtgca gcctccagcc ctgtcagccc
      841 tgtcagccct gtcagccccg tgacctcacc cactagcccc tctgcgacca gtgagcctga
      901 gtctgtctca gccacgggag aggagctgac ctctgaggca gggggagagg acagctgtga
      961 gagtcaagag tccttaaagg atgaagaagc ggatgaagcc cagtcagaaa caagctcgtc
     1021 agaggaggag gacgaggagg acgaggagga tgaggaggat gaggaagagc ctctaccagc
     1081 ctgcaacggc cccaccccgg ccccagcctc tcctgcagct gaggtcggat cccaggagga
     1141 agctctgagc tcctcagctc agtctccggg cagaggtcag acagggaagg atactccttc
     1201 cccgggggat gtggtcctcc gtgcccgagc ctccagcgag ggagcagagc agagcaaaag
     1261 agcagcatcc atccagagga cgtcagctcc gcccagcagg cctccgccac ccagagcctc
     1321 aggcagcggg tcctgcaatg ccccaggctc tccagagggt tcttcacagc tgtgcagccc
     1381 cagggcctcc ccagacgcct cttctaatcc agaaccagca gaaaccagag aaaaggaagg
     1441 cgctggaagt tcaggcccag aagagccccg tgccgtctct accaagagcg ccacccaggt
     1501 atttaccagt gaaaacacgg agctctgaag agaaactgcc aaggacctaa gctcgcctgc
     1561 ccagagaagt ttctcaagca gagggccaag ggtacaagcc acatccaagc cacgtgctca
     1621 ggcagtgtga atacgtgccc tcggagaccc gcccgccatt gctggagtct gcaccagccg
     1681 gagggaggag ggcaccacac acacacacac acacacacac acacacacac acacacacat
     1741 acacacacac acacacggag cacacacaca cacacacaca cacacacaca cacacacaca
     1801 cggagcgttt tatcagaggc ttgagcagta ataatagaag cagggctgta ataatgccaa
     1861 agaaaagctt ccttaggcac gtccgcacgg tcagaggaca tgcatccagc cagccactca
     1921 cttggcaaag agttaaagct aaaacatttt cactactaaa taaagtatgg ttttgactaa
     1981 c
//
