LOCUS       NM_009668               2468 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus bridging integrator 1 (Bin1), transcript variant 1,
            mRNA.
ACCESSION   NM_009668
VERSION     NM_009668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2468)
  AUTHORS   Picas,L., Andre-Arpin,C., Comunale,F., Bousquet,H., Tsai,F.C.,
            Rico,F., Maiuri,P., Pernier,J., Bodin,S., Nicot,A.S., Laporte,J.,
            Bassereau,P., Goud,B., Gauthier-Rouviere,C. and Miserey,S.
  TITLE     BIN1 regulates actin-membrane interactions during IRSp53-dependent
            filopodia formation
  JOURNAL   Commun Biol 7 (1), 549 (2024)
   PUBMED   38724689
  REMARK    GeneRIF: BIN1 regulates actin-membrane interactions during
            IRSp53-dependent filopodia formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2468)
  AUTHORS   Westhoff,M., Del Villar,S.G., Voelker,T.L., Thai,P.N.,
            Spooner,H.C., Costa,A.D., Sirish,P., Chiamvimonvat,N., Dickson,E.J.
            and Dixon,R.E.
  TITLE     BIN1 knockdown rescues systolic dysfunction in aging male mouse
            hearts
  JOURNAL   Nat Commun 15 (1), 3528 (2024)
   PUBMED   38664444
  REMARK    GeneRIF: BIN1 knockdown rescues systolic dysfunction in aging male
            mouse hearts.
            Erratum:[Nat Commun. 2024 May 23;15(1):4397. doi:
            10.1038/s41467-024-48944-4.. PMID: 38782927]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2468)
  AUTHORS   Garcia-Agudo,L.F., Shi,Z., Smith,I.F., Kramar,E.A., Tran,K.,
            Kawauchi,S., Wang,S., Collins,S., Walker,A., Shi,K.X., Neumann,J.,
            Liang,H.Y., Da Cunha,C., Milinkeviciute,G., Morabito,S.,
            Miyoshi,E., Rezaie,N., Gomez-Arboledas,A., Arvilla,A.M.,
            Ghaemi,D.I., Tenner,A.J., LaFerla,F.M., Wood,M.A., Mortazavi,A.,
            Swarup,V., MacGregor,G.R. and Green,K.N.
  TITLE     BIN1K358R suppresses glial response to plaques in mouse model of
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 20 (4), 2922-2942 (2024)
   PUBMED   38460121
REFERENCE   4  (bases 1 to 2468)
  AUTHORS   Zhang,X., Zou,L., Tang,L., Xiong,M., Yan,X.X., Meng,L., Chen,G.,
            Xiong,J., Nie,S., Zhang,Z., Chen,Q. and Zhang,Z.
  TITLE     Bridging integrator 1 fragment accelerates tau aggregation and
            propagation by enhancing clathrin-mediated endocytosis in mice
  JOURNAL   PLoS Biol 22 (1), e3002470 (2024)
   PUBMED   38206965
  REMARK    GeneRIF: Bridging integrator 1 fragment accelerates tau aggregation
            and propagation by enhancing clathrin-mediated endocytosis in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2468)
  AUTHORS   Perdreau-Dahl,H., Lipsett,D.B., Frisk,M., Kermani,F., Carlson,C.R.,
            Brech,A., Shen,X., Bergan-Dahl,A., Hou,Y., Tuomainen,T., Tavi,P.,
            Jones,P.P., Lunde,M., Wasserstrom,J.A., Laporte,J., Ullrich,N.D.,
            Christensen,G., Morth,J.P. and Louch,W.E.
  TITLE     BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in
            Cardiomyocytes
  JOURNAL   Circ Res 132 (11), e188-e205 (2023)
   PUBMED   37139790
  REMARK    GeneRIF: BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule
            Growth in Cardiomyocytes.
REFERENCE   6  (bases 1 to 2468)
  AUTHORS   Mao,N.C., Steingrimsson,E., DuHadaway,J., Wasserman,W., Ruiz,J.C.,
            Copeland,N.G., Jenkins,N.A. and Prendergast,G.C.
  TITLE     The murine Bin1 gene functions early in myogenesis and defines a
            new region of synteny between mouse chromosome 18 and human
            chromosome 2
  JOURNAL   Genomics 56 (1), 51-58 (1999)
   PUBMED   10036185
  REMARK    GeneRIF: Bin1 is upregulated in somites during muscle development;
            Bin1 induction in differentiation is required for p21WAF1
            upregulation.
REFERENCE   7  (bases 1 to 2468)
  AUTHORS   Kadlec,L. and Pendergast,A.M.
  TITLE     The amphiphysin-like protein 1 (ALP1) interacts functionally with
            the cABL tyrosine kinase and may play a role in cytoskeletal
            regulation
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12390-12395 (1997)
   PUBMED   9356459
REFERENCE   8  (bases 1 to 2468)
  AUTHORS   Leprince,C., Romero,F., Cussac,D., Vayssiere,B., Berger,R.,
            Tavitian,A. and Camonis,J.H.
  TITLE     A new member of the amphiphysin family connecting endocytosis and
            signal transduction pathways
  JOURNAL   J Biol Chem 272 (24), 15101-15105 (1997)
   PUBMED   9182529
REFERENCE   9  (bases 1 to 2468)
  AUTHORS   Sakamuro,D., Elliott,K.J., Wechsler-Reya,R. and Prendergast,G.C.
  TITLE     BIN1 is a novel MYC-interacting protein with features of a tumour
            suppressor
  JOURNAL   Nat Genet 14 (1), 69-77 (1996)
   PUBMED   8782822
REFERENCE   10 (bases 1 to 2468)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ121020.1, BQ573238.1, BU707946.1, CF732768.1, CO426739.1,
            AW496330.1 and AI840452.1.
            
            On Mar 24, 2007 this sequence version replaced NM_009668.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                CJ121020.1         3-58
            57-671              BQ573238.1         28-642
            672-1018            BU707946.1         374-720
            1019-1599           CF732768.1         56-636
            1600-1936           CO426739.1         251-587
            1937-2443           AW496330.1         1-507               c
            2444-2468           AI840452.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.01 cM"
     gene            1..2468
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /note="bridging integrator 1"
                     /db_xref="GeneID:30948"
                     /db_xref="MGI:MGI:108092"
     exon            1..274
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1957
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /note="isoform 1 is encoded by transcript variant 1; myc
                     box-dependent-interacting protein 1; amphiphysin 2;
                     amphiphysin II; amphiphysin-like protein; SH3
                     domain-containing protein 9"
                     /codon_start=1
                     /product="myc box-dependent-interacting protein 1 isoform
                     1"
                     /protein_id="NP_033798.1"
                     /db_xref="CCDS:CCDS29119.1"
                     /db_xref="GeneID:30948"
                     /db_xref="MGI:MGI:108092"
                     /translation="MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQF
                     EQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANK
                     IAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESL
                     QTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEE
                     MNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVSLEKQHGS
                     NTFTVKAQPSDNAPEKGNKSPSPPPDGSPAATPEIRVNHEPEPASGASPGATIPKSPS
                     QLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTTPSQFEAPGPFSEQASLL
                     DLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGILPSGEPSSAEGSFAVAWPSQ
                     TAEPGPAQPAEASEVVGGAQEPGETAASEATSSSLPAVVVETFSATVNGAVEGSAGTG
                     RLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDW
                     NQHKELEKCRGVFPENFTERVQ"
     exon            275..355
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            356..410
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            411..505
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            506..601
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            602..709
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            710..802
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            803..888
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            889..964
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1047
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1195
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1324
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1432
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1456
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1564
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1636
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1747
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1849
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2455
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /note="hexamer: AAGAAA"
     polyA_site      2452
                     /gene="Bin1"
                     /gene_synonym="ALP-1; Amphl; BRAMP-2; SH3P9"
                     /note="major polyA site"
ORIGIN      
        1 gatccccgcg ttgctcactc gctctccccg cgcacgctcc gtctccgtca gtcccctgag
       61 ctgttctagt gcgcggcgtg gagccagggc tcaggctggt ggagcggccg gggctggagg
      121 ctgggagtgc ggcgcgcacg gcctccccgc gccattatcc gcgctcgctt cgggcgaggc
      181 cggcgccagg atggcagaga tggggagcaa gggggtgacg gcggggaaga tcgccagcaa
      241 cgtacagaag aagctgaccc gagcgcagga gaaggtcctg cagaaactgg ggaaggcgga
      301 cgagacgaag gacgagcagt ttgagcagtg tgtccagaac ttcaataagc agctgacaga
      361 gggtacccgg ctgcagaagg atcttcggac ctatctggct tctgttaaag cgatgcacga
      421 agcctccaag aagctgagtg agtgtcttca ggaggtgtat gagcccgagt ggcctggcag
      481 ggatgaagca aacaagattg cagagaacaa tgacctactc tggatggact accaccagaa
      541 gctggtggac caggctctgc tgaccatgga cacctaccta ggccagttcc ctgatatcaa
      601 gtcgcgcatt gccaagcggg ggcggaagct ggtggactat gacagtgccc ggcaccacta
      661 tgagtctctt caaaccgcca aaaagaagga tgaagccaaa attgccaagc ctgtctcgct
      721 gcttgagaaa gccgcccccc agtggtgcca aggcaaacta caggctcatc ttgtagctca
      781 aactaacctg ctccgaaatc aggcagaaga ggagctcatc aaagcccaga aggtgttcga
      841 ggagatgaac gtggatctgc aggaggagct gccatccctg tggaacagcc gtgtaggttt
      901 ctatgtcaac acgttccaga gcatcgcggg tctggaggaa aacttccata aagagatgag
      961 taagctcaat cagaacctca atgatgtcct ggtcagccta gagaagcagc acgggagcaa
     1021 caccttcaca gtcaaggccc aacccagtga caatgcccct gagaaaggga acaagagccc
     1081 gtcacctcct ccagatggct cccctgctgc tacccctgag atcagagtga accatgagcc
     1141 agagccggcc agtggggcct cacccggggc taccatcccc aagtccccat ctcagctccg
     1201 gaaaggccca cctgtccctc cgcctcccaa acacacccca tccaaggaga tgaagcagga
     1261 gcagattctc agcctttttg atgacgcatt tgtccctgag atcagcgtga ccaccccctc
     1321 ccagtttgag gcccctgggc ctttctcaga gcaggccagt ctactagacc tggacttcga
     1381 gccccttcca ccagtggcga gccccgtgaa ggcacccaca ccctctggtc agtcaatccc
     1441 atgggacctc tgggagccca cagagagtca agctggcatc ctgccttccg gggagcccag
     1501 ttctgctgag ggcagctttg ctgtggcctg gcccagccag acagccgagc cagggcccgc
     1561 ccaaccagca gaggcctccg aggtggtggg tggagcccag gagccagggg agacagcagc
     1621 cagtgaagca acctccagct ctcttccggc tgtggtggtg gagaccttct ccgcaactgt
     1681 gaatggggcg gtggagggca gcgctgggac tggacgcttg gacctgcccc cgggattcat
     1741 gttcaaggtt caagcccagc atgattacac ggccactgac actgatgagc tgcaactcaa
     1801 agctggcgat gtggtgttgg tgattccttt ccagaaccca gaggagcagg atgaaggctg
     1861 gctcatgggt gtgaaggaga gcgactggaa tcagcacaag gaactggaga aatgccgcgg
     1921 cgtcttcccg gagaatttta cagagcgggt gcagtgacgg aggagccttc ccgagtgtga
     1981 agaacctttc ccccaaagat gtgtgctttt cttttctttg tttttcttcc tctcttttct
     2041 gtttttgttt tgttttgaaa ttcttgaaaa gtgtcgggaa actggggggc ggaaacctaa
     2101 gccaagaggt atacccccaa agatgaggtg gttttccaaa gagccgtccg accccgttca
     2161 gtggacttct ccagtgttcc tgaagctgct gtgtcccccc ctagttgagt tcccgatgcc
     2221 cgcatgttca gggcgggccg ggggtgcaga gccaccgcca cacttgcctg acgcttggct
     2281 gcgccaccga gcagggcttg ggtcctcttc tggcagctgc cctgggcagg gcctgcacac
     2341 tggcccagcc tggttccgct ctgcagacca accgtgtgct gtttgaaaat aagccctagt
     2401 gttcaaaatg cagcgaaaca aacaaaaaag aaaaacctga caaaaccacc cagaaaaaaa
     2461 aaaaaaaa
//
