LOCUS       NM_007546                943 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus BCL2-interacting killer (Bik), mRNA.
ACCESSION   NM_007546 XM_912791
VERSION     NM_007546.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 943)
  AUTHORS   Petrache,I. and Riches,D.W.
  TITLE     Reduced Bik expression drives low-grade airway inflammation and
            increased risk for COPD in females
  JOURNAL   J Clin Invest 134 (4), e177753 (2024)
   PUBMED   38357926
  REMARK    GeneRIF: Reduced Bik expression drives low-grade airway
            inflammation and increased risk for COPD in females.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 943)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 943)
  AUTHORS   Mebratu,Y.A., Jones,J.T., Liu,C., Negasi,Z.H., Rahman,M.,
            Rojas-Quintero,J., O'Connor,G.T., Gao,W., Dupuis,J., Cho,M.H.,
            Litonjua,A.A., Randell,S. and Tesfaigzi,Y.
  TITLE     Bik promotes proteasomal degradation to control low-grade
            inflammation
  JOURNAL   J Clin Invest 134 (4), e170594 (2023)
   PUBMED   38113109
  REMARK    GeneRIF: Bik promotes proteasomal degradation to control low-grade
            inflammation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 943)
  AUTHORS   Soni,S., Walton-Filipczak,S., Nho,R.S., Tesfaigzi,Y. and
            Mebratu,Y.A.
  TITLE     Independent role of caspases and Bik in augmenting influenza A
            virus replication in airway epithelial cells and mice
  JOURNAL   Virol J 20 (1), 78 (2023)
   PUBMED   37095508
  REMARK    GeneRIF: Independent role of caspases and Bik in augmenting
            influenza A virus replication in airway epithelial cells and mice.
            Erratum:[Virol J. 2023 May 15;20(1):95. doi:
            10.1186/s12985-023-02060-9.. PMID: 37189161]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 943)
  AUTHORS   Osterlund,E.J., Hirmiz,N., Nguyen,D., Pemberton,J.M., Fang,Q. and
            Andrews,D.W.
  TITLE     Endoplasmic reticulum protein BIK binds to and inhibits
            mitochondria-localized antiapoptotic proteins
  JOURNAL   J Biol Chem 299 (2), 102863 (2023)
   PUBMED   36603764
  REMARK    GeneRIF: Endoplasmic reticulum protein BIK binds to and inhibits
            mitochondria-localized antiapoptotic proteins.
REFERENCE   6  (bases 1 to 943)
  AUTHORS   Cory,S., Huang,D.C. and Adams,J.M.
  TITLE     The Bcl-2 family: roles in cell survival and oncogenesis
  JOURNAL   Oncogene 22 (53), 8590-8607 (2003)
   PUBMED   14634621
  REMARK    Review article
REFERENCE   7  (bases 1 to 943)
  AUTHORS   Amanna,I.J., Clise-Dwyer,K., Nashold,F.E., Hoag,K.A. and Hayes,C.E.
  TITLE     Cutting edge: A/WySnJ transitional B cells overexpress the
            chromosome 15 proapoptotic Blk gene and succumb to premature
            apoptosis
  JOURNAL   J Immunol 167 (11), 6069-6072 (2001)
   PUBMED   11714762
  REMARK    GeneRIF: Blk has been mapped to chromosome 15 and overexpressed in
            transitional B cells of A/WySnJ mice, which demonstrate a
            cell-autonomous defect leading to excessive apoptosis.
REFERENCE   8  (bases 1 to 943)
  AUTHORS   Reed,J.C.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   9  (bases 1 to 943)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
REFERENCE   10 (bases 1 to 943)
  AUTHORS   Hegde,R., Srinivasula,S.M., Ahmad,M., Fernandes-Alnemri,T. and
            Alnemri,E.S.
  TITLE     Blk, a BH3-containing mouse protein that interacts with Bcl-2 and
            Bcl-xL, is a potent death agonist
  JOURNAL   J Biol Chem 273 (14), 7783-7786 (1998)
   PUBMED   9525867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL583889.8.
            
            On Nov 17, 2006 this sequence version replaced NM_007546.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF048838.1, AK144937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AL583889.8         32702-32776         c
            76-223              AL583889.8         18196-18343         c
            224-322             AL583889.8         16475-16573         c
            323-440             AL583889.8         15941-16058         c
            441-943             AL583889.8         15003-15505         c
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.4 cM"
     gene            1..943
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /note="BCL2-interacting killer"
                     /db_xref="GeneID:12124"
                     /db_xref="MGI:MGI:1206591"
     exon            1..75
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /inference="alignment:Splign:2.1.0"
     exon            76..223
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..533
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /note="apoptosis inducer NBK; bik-like killer protein"
                     /codon_start=1
                     /product="bcl-2-interacting killer"
                     /protein_id="NP_031572.1"
                     /db_xref="CCDS:CCDS27703.1"
                     /db_xref="GeneID:12124"
                     /db_xref="MGI:MGI:1206591"
                     /translation="MSEARLMARDVIKTVPHDQVPQPPVASETPSMKEPVRDVDLMEC
                     VEGRNQVALRLACIGDEMDLCLRSPRLVQLPGIAIHRLAVTYSRTGVRGIFRSLIRSL
                     TNLRENIWSWRVLTPGAWVSPDQDPGQLFPMVLLVFLLLGGAWYLQLQ"
     exon            224..322
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /inference="alignment:Splign:2.1.0"
     exon            323..440
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /inference="alignment:Splign:2.1.0"
     exon            441..943
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      922..927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /note="hexamer: AATAAA"
     polyA_site      943
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk; Nbk"
                     /note="major polyA site"
ORIGIN      
        1 gactccgcca ccggcgtccc agccgagagg gtgttcgggc agttcgcccg ccgctacgcc
       61 agctcagctt ggcagaacac atgtcggagg cgagacttat ggccagagac gtcatcaaga
      121 ctgttccaca cgaccaggtc ccccaacctc cagtggcctc tgagactccc agcatgaagg
      181 agcctgtgag agacgtggac ctcatggagt gcgtggaagg cagaaaccag gtggccttga
      241 ggctggcctg catcggcgat gagatggacc tgtgtctgcg gagcccccgt ctggtccagc
      301 tgcctgggat tgctatacac agactcgctg tcacctacag ccggacaggt gtcagaggta
      361 ttttcaggag cttgattcga agcctcacca acctcaggga aaacatctgg tcctggagag
      421 tcttgactcc tggcgcctgg gtgtcacctg accaggaccc tgggcagctg tttccgatgg
      481 tgctgctggt cttcttgctg ctgggtgggg cctggtattt gcagcttcag tgaagtgcag
      541 ctggggcagg gctggtccct gccccccaac ccctagaggt gccggcaccc taactgaggt
      601 gttttctgac tgtccccccc cctttttata tatatattta actcaggata gtgctgagat
      661 ttcatacagg ttttctgggt ttttgtaagg caaatgaatt cactgtacct caggagcatt
      721 actggctaag tgcccctgag gcttggctgg cccttcttct cttgacccct gctcccttcc
      781 tctctgcagg ctggtcctgt ggccatcagt ggggggagtg ctggccacac ccctgtctgt
      841 gaagccttga ggcacaggat ctactggact agagtccttt ggggtggaga gttcaattaa
      901 gtggtgtttg caggcaagtt caataaaatg tttccagcca gtc
//
