LOCUS       NM_001039179            6376 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus BICD cargo adaptor 2 (Bicd2), transcript variant 1,
            mRNA.
ACCESSION   NM_001039179
VERSION     NM_001039179.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6376)
  AUTHORS   Xiu,J., Li,J., Liu,Z., Wei,H., Zhu,C., Han,R., Liu,Z., Zhu,W.,
            Shen,Y. and Xu,Q.
  TITLE     Elevated BICD2 DNA methylation in blood of major depressive
            disorder patients and reduction of depressive-like behaviors in
            hippocampal Bicd2-knockdown mice
  JOURNAL   Proc Natl Acad Sci U S A 119 (30), e2201967119 (2022)
   PUBMED   35858435
  REMARK    GeneRIF: Elevated BICD2 DNA methylation in blood of major
            depressive disorder patients and reduction of depressive-like
            behaviors in hippocampal Bicd2-knockdown mice.
REFERENCE   2  (bases 1 to 6376)
  AUTHORS   Rossor,A.M., Sleigh,J.N., Groves,M., Muntoni,F., Reilly,M.M.,
            Hoogenraad,C.C. and Schiavo,G.
  TITLE     Loss of BICD2 in muscle drives motor neuron loss in a developmental
            form of spinal muscular atrophy
  JOURNAL   Acta Neuropathol Commun 8 (1), 34 (2020)
   PUBMED   32183910
  REMARK    GeneRIF: Loss of BICD2 in muscle drives motor neuron loss in a
            developmental form of spinal muscular atrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6376)
  AUTHORS   Will,L., Portegies,S., van Schelt,J., van Luyk,M., Jaarsma,D. and
            Hoogenraad,C.C.
  TITLE     Dynein activating adaptor BICD2 controls radial migration of
            upper-layer cortical neurons in vivo
  JOURNAL   Acta Neuropathol Commun 7 (1), 162 (2019)
   PUBMED   31655624
  REMARK    GeneRIF: Findings demonstrate a novel, cell-intrinsic role of BICD2
            in cortical neuron migration in vivo and provide new insights into
            BICD2-dependent dynein-mediated functions during cortical
            development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6376)
  AUTHORS   Gutierrez,P.A., Ackermann,B.E., Vershinin,M. and McKenney,R.J.
  TITLE     Differential effects of the dynein-regulatory factor
            Lissencephaly-1 on processive dynein-dynactin motility
  JOURNAL   J Biol Chem 292 (29), 12245-12255 (2017)
   PUBMED   28576829
  REMARK    GeneRIF: Data suggest that binding of Lis1 to DDB complex does not
            strongly disrupt processive motility along microtubules; motile DDB
            complex binds up to two Lis1 dimers; mutational analysis suggested
            that Lis1 binds directly to the dynein motor domains during DDB
            complex movement. (Lis1 = lissencephaly 1 protein; DDB complex =
            dynein-dynactin-BicD2 complex; BicD2 = bicaudal D homolog 2
            protein)
REFERENCE   5  (bases 1 to 6376)
  AUTHORS   Matsuto,M., Kano,F. and Murata,M.
  TITLE     Reconstitution of the targeting of Rab6A to the Golgi apparatus in
            semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on
            Golgi membranes and a concerted role of Rab6A/BICD2 interactions in
            Golgi-to-ER retrograde transport
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2592-2609 (2015)
   PUBMED   25962623
  REMARK    GeneRIF: several analyses of vesicular transport demonstrated that
            Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the
            endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells
REFERENCE   6  (bases 1 to 6376)
  AUTHORS   Teuling,E., van Dis,V., Wulf,P.S., Haasdijk,E.D., Akhmanova,A.,
            Hoogenraad,C.C. and Jaarsma,D.
  TITLE     A novel mouse model with impaired dynein/dynactin function develops
            amyotrophic lateral sclerosis (ALS)-like features in motor neurons
            and improves lifespan in SOD1-ALS mice
  JOURNAL   Hum Mol Genet 17 (18), 2849-2862 (2008)
   PUBMED   18579581
  REMARK    GeneRIF: BICD2-N transgene increased lifespan in 'low copy'
            SOD1-G93A ALS transgenic mice.
REFERENCE   7  (bases 1 to 6376)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 6376)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   9  (bases 1 to 6376)
  AUTHORS   Matanis,T., Akhmanova,A., Wulf,P., Del Nery,E., Weide,T.,
            Stepanova,T., Galjart,N., Grosveld,F., Goud,B., De Zeeuw,C.I.,
            Barnekow,A. and Hoogenraad,C.C.
  TITLE     Bicaudal-D regulates COPI-independent Golgi-ER transport by
            recruiting the dynein-dynactin motor complex
  JOURNAL   Nat Cell Biol 4 (12), 986-992 (2002)
   PUBMED   12447383
  REMARK    Erratum:[Nat Cell Biol. 2003 Jan;5(1):84.]
REFERENCE   10 (bases 1 to 6376)
  AUTHORS   Hoogenraad,C.C., Akhmanova,A., Howell,S.A., Dortland,B.R., De
            Zeeuw,C.I., Willemsen,R., Visser,P., Grosveld,F. and Galjart,N.
  TITLE     Mammalian Golgi-associated Bicaudal-D2 functions in the
            dynein-dynactin pathway by interacting with these complexes
  JOURNAL   EMBO J 20 (15), 4041-4054 (2001)
   PUBMED   11483508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF538535.1, AK122348.1 and BP775855.1.
            
            On Oct 22, 2013 this sequence version replaced NM_001039179.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122348.1, SRR1660813.226594.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CF538535.1         1-36
            37-6345             AK122348.1         10-6318
            6346-6376           BP775855.1         24-54               c
FEATURES             Location/Qualifiers
     source          1..6376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.22 cM"
     gene            1..6376
                     /gene="Bicd2"
                     /note="BICD cargo adaptor 2"
                     /db_xref="GeneID:76895"
                     /db_xref="MGI:MGI:1924145"
     exon            1..362
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..575
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..728
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..1190
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..2216
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2368
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..6352
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6323..6328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bicd2"
                     /note="hexamer: AATAAA"
     regulatory      6333..6338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bicd2"
                     /note="hexamer: AATAAA"
     polyA_site      6342
                     /gene="Bicd2"
                     /note="major polyA site"
     polyA_site      6352
                     /gene="Bicd2"
                     /note="major polyA site"
ORIGIN      
        1 cgcgtcaggg aggagcagtg cggcggcgcg ggcggccgtc ggggctgggc ggcggcagcg
       61 gcggctaaga gggcccggct tgtgggagcc aaggtgggag ccggcctcgg cgcgcggcca
      121 ccatgtccgc gccgtcggag gaggaggagt atgcgcgtct ggtgatggag gcgcagccgg
      181 agtggctgcg cgccgaggtg aagcggctgt cccacgagct ggccgagacc acgcgtgaga
      241 agatccaggc ggccgagtat ggactggcgg tgctggagga gaagcaccag ctcaagctgc
      301 agttcgagga gctcgaggtg gactatgagg ccatccgcag cgagatggag cagctcaaag
      361 aggcatttgg ccaggcacat acaaaccaca agaaggtggc tgctgatggt gagagccggg
      421 aggagagcct gatccaggag tcggcctcca aggagcagta ctacgtgcgg aaggtgctgg
      481 agctgcagac agagctgaaa cagctgcgca acgtcctcac caacacccag tctgagaatg
      541 agcgcctcac gtctgtggcc caggagctaa aagagatcaa ccagaatgtg gagatccagc
      601 gtggtcgcct gcgggatgac atcaaggagt acaagttccg ggaggcccgt ctacttcagg
      661 actactcaga gctggaggag gagaacatca gcctgcagaa acaagtgtct gtgctcaggc
      721 agaaccaggt ggagtttgag ggcctcaagc atgaaatcaa gcgcctggag gaggagacag
      781 agtacctcaa cagccagcta gaggatgcca tccggcttaa ggagatctct gaacggcagt
      841 tggaggaggc gctggagaca ctgaagacag agcgggagca gaagaacaac ctgcgcaagg
      901 agttgtcgca ctacatgagc atcaacgatt ccttctatac cagccacctg caggtctcct
      961 tagatggcct caagttcagt gatgatactg tcaccgcaga gcccaacaat gacgccgaag
     1021 ccctggtcaa tggctttgag cacagtggct tggtcaaatc atccttggac aacaagacat
     1081 ccacacccag gaaggatggc ctagctccac cctcccccag cctcgtctct gacctgctca
     1141 gtgagctcca catatctgag atccagaagc tgaaacagca gctggtgcag atggagcggg
     1201 agaaggtggg cctgctggca acactgcagg acacacagaa gcagctggag caggctcggg
     1261 gaaccctctc tgagcagcat gagaaggtga atcgtctcac agagaacctt agtgccctcc
     1321 ggcgcctgca ggctggcaag gagcgacaga cctcgttgga taatgagaag gaccgtgaca
     1381 gccacgaaga cggtgactac tatgaggtgg acatcaatgg gcctgagatc ctggcctgca
     1441 agtaccacgt ggctgtggct gaggctggcg agctccggga gcagctcaag gcgttgcgca
     1501 gcacacacga agctcgcgaa gcccagcacg cagaagaaaa gggccggtat gaggctgagg
     1561 gccaggcact cactgagaag atctctctgc tggagaaggc tagccaccag gaccgagagc
     1621 tgctggccca tctggaaaag gagctgaaga aggtgagcga tgtggctggt gagacccagg
     1681 gcagcctgaa tgtggctcag gatgagctgg tgaccttcag cgaggagctg gccaacctct
     1741 accaccatgt gtgcatgtgc aacaacgaga cgcccaaccg tgtcatgctc gactattatc
     1801 gtgagggcca gggcaaggct ggccgcacca gcccagaggg ccgcgggcgc cggtcacctg
     1861 tcctcttgcc caaggggctg ttggccacag aggtgggccg agcagatggt gggactgggg
     1921 acaacagtcc ttcacccagt tcttcactgc cgtcacctct gagtgacccc cgccgggaac
     1981 ctatgaacat ctacaacctg atcgccatca tccgagacca gatcaagcac ctgcaggcag
     2041 ccgtggaccg tacgaccgag ctgtcccggc agcggattgc ctcgcaggag ctgggccctg
     2101 ctgtggacaa ggacaaggaa gcactcatgg aggagatcct caagctgaag tccctgctga
     2161 gtaccaagcg ggagcagatc accacactgc gcaccgtgct caaggccaac aagcagacag
     2221 ctgaggtggc cctggccaac ctgaagagca agtatgagaa cgagaaggcc atggtgaccg
     2281 agaccatgat gaagctacgg aacgagctca aggccctcaa ggaagacgca gccaccttct
     2341 cctccctgcg tgccatgttt gccaccaggt gtgacgaata catcacacag ctggatgaga
     2401 tgcagcggca gctggcagct gccgaggacg agaagaagac ccttaactct ctgttgcgca
     2461 tggccatcca gcagaagctg gcgctcaccc agcggctgga gctgctggag ctggaccatg
     2521 aacagacccg caggggccgc agcaaggccg cctccaaggc caagccagcc tcaccgagcg
     2581 taagtcacac ctgcgcctgc gccagcgaga gggcggaggg cgccgggctg gccaaccagg
     2641 tgttctgcag cgagaagcac agcatttact gtgattaggg ctgtggggcg ccgcacacct
     2701 aacgtccgct tcacctcaac taacccagct gcagcagcgg gacagcagtg ctaggccgct
     2761 cctaacgtga ctaacgcaca gagggcggca ctctaggcaa gtggcagcgt tggggtacat
     2821 ctgtaaccag gacactttga gctttgtgct gcttttcatg ccacagcccc gcccccagga
     2881 tataccatgt cagttgctgt cctttgggat gctggtatca aaagtagggg tgaagctgca
     2941 cacctttgtg gaagacagcg gagtgaaagt tttccagggc ctccaggcac tgttagggaa
     3001 cccaagggtg agttcttccc tggacactca caggggcaga acctgagttg aaacttgcat
     3061 gttgctcgca tgtgtctaat atcagcactt gaaagcagtt ttgtgaggct ctagcctgca
     3121 tcataggact agcctaggtt agctcgctgt ggctggcata gtttcatgaa gagtttcctt
     3181 gtagtttgtg cagcatctca ctgctaacca catccaggat ggcagtccca gagggaatgg
     3241 accatctctg gttgcagcct gtgttctgca gtgagccccc acacctcaga cacgataacc
     3301 atagcccagg cagacagcgc agctgctcca tctcaaagat ccgcatgctg ctgtgtcctg
     3361 aaaggtgaca aattagcagg gcctgaggtc ctaggttttc tttcttgacg agagtgttcc
     3421 aagtgcctgg tcagaccttg gtccttggtt cagagcctat tatttggtcc tttgagatct
     3481 gcagcttgtg cttgggtctt ttcctagaag ttgtcagacc caaagaagca gtgttttgag
     3541 aactactagt gctctaccaa actgcacggc acagtagagc ccagctgtgt gctaggggac
     3601 tttttgtggg cccggagctg tgctcaaaac tggcaggtaa gagttgtgtg gttctcggtg
     3661 cagtttgtgg atactacaga aggaagaaag gcctccgagg gctctccttt tccagatgct
     3721 ctgtcagtgc ggagctgtgg catcagatca ggtgtgtgct ttagtgagtt gtaaaacagg
     3781 actctgctca gtatttctct ccctgtcccc atggggcatc tagtcttgag actccatctc
     3841 ccataatagc tgcttggctg tctctccctg tggaaaggca tctttcatga tgtggaacaa
     3901 ttactatcca atatggccct gtagtctctc aaacagcttt ctctttctct cccctggatc
     3961 ctggggtacc ccagtctgct cagattcttg gcagcacatg gtcgtacact gggggcagaa
     4021 caggccacac gtgtcccttg catgtccatc ctgggaatgg ctgcccgcat gcccacccaa
     4081 ccttctgcct ttctttctct ttgggccaga acgcagcttc tcttacactg tatggggctt
     4141 tgtggacact tggagcccca tcccctaaca cacatgcagg cctcctctgc caactaatgt
     4201 gctcgcgcac tcccagaaca agagctttag ctgtcagtga gcagggagtg gctctcgact
     4261 gatttctaat gctgtcttgt tttctcctgt tttcagctgt agagtagctg ctgggaggag
     4321 gcggccaccc ggccctgtca cacagcagcc cctccccctc ccctcctgtg gcccatgcag
     4381 aggaaggaag ggcagcctaa agtccactta gaaatgtttg gatatgccac tgtaattctt
     4441 ttcaaaatag cattccccaa gtttttaatg ggagaaaaaa aaaaaaaaag ctttactatt
     4501 gagaatgctg caatctgctg cttgggaagg tctctgtgtg gccgaagaac ctgcttccac
     4561 agccgccgcg ctgccaggct ctctaggggc ctgctggacg cctgccacag gctctcctta
     4621 ttacacatgc tcctttttta tccgatcaac ctgtgcactt ttgatatttt gatattatat
     4681 ttgcttcctt aattccttgc atagagacgg tctccagtgc cgtggtctgt gttcatggtc
     4741 ctgtagctgt ccgtcctggc tctgatgtgt tgacctgcgt caactcaagg tagagctgtg
     4801 ctccatggtg tgtagctaga cttcgggtga ggctccgacc cggcaaggag ctggccagtg
     4861 tatccacgct gtggttcagc agcctttaga ggacacggca ttgtggttca tgtttgaaat
     4921 tacagatttt aaatgccatg ttcattaaga aatccagggt attccaattc tggggttttt
     4981 catattgtat tattattatt attcttagga atagttcaat gtaacaagaa gaaaacttga
     5041 cctttgctct ggttaaaaca gtaataggca cttgaaagca taaattattg aatgagtagt
     5101 attacctaca aattccagag ttttctgggt tttaggacat tgtgaagcat gactgactaa
     5161 cagaatttta tacaactgca ccagtgaaat tccaaattgg aattgttttg ttattctggt
     5221 tgtcgtgcca aattgtggta cacttagaaa attctacagc cgtcgatttt caggtgttca
     5281 atttcaacac ctttttgtta gtaaccattg ccagtagtgc cttcatcagt tcagggaggt
     5341 gtcccagcca ggtcaggtct ccaggacggg cagcagtgga gagctagttg ggaatgctga
     5401 aggccattgt ggaccagcag gtacctgcct cactctgtac ttgggcatct tcattgaggg
     5461 agagagaaca gtgattgtgc aaaattctgt tagtcagtga ttcttcaatg caaattcagg
     5521 ggcttagaaa caagacagca cacaaacctg gactgtgctt tgggaaccaa atggacttca
     5581 tgggacaagc taagcaagct gtacagacat cacgtttgtg aagagctgag ggcgtcagga
     5641 gagccggcga agtcggcatg cgagtgggga agagggttag ccatagtatt ctttgcaaat
     5701 gtgaaagtca gacattatat cttctcttgc ttggtgtaac taatcactgt taatttcagg
     5761 aaacagaagt cagtaaaact ccttagtaaa ctccttgcta agtgaggttc agggtgtggt
     5821 caaattggta ctagtggagg gagggaaatt gtcctccagc ctaaaaaggg acaaattata
     5881 ataatataaa ttgttaagaa ttgaagaatt ctgtttcctg gaatgagcat ttcttattcc
     5941 tagttgttgg gactctttgc cttctgttac agtgttgatt catacaaaat attgttacat
     6001 ttaagataac atcatctgta tggggtattt atttgcaatg atgtctaagt actgtatttt
     6061 ttctgtgtgt taccttagtg tcagaatgtt ggtctttatt ttaaaagtca tatgcatgtt
     6121 ctcctgccaa ggcaccttac acagacccaa aacaaaacaa tgagcagatg ccttcagctt
     6181 ctgagaaaat gaggccaagt gaggagaagg cataggaagg tgagactagc tgagacttct
     6241 gtcatggctg atggcggacc gtctccacag ccagcacaca taggaaaact gggcctgggt
     6301 gaagagtcgc attggtagga ccaataaaga ataataaaac aattgaagca caaaaaaaaa
     6361 aaaaaaaaaa aaaaaa
//
