LOCUS       NM_031397               5427 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BicC family RNA binding protein 1 (Bicc1), transcript
            variant 1, mRNA.
ACCESSION   NM_031397 XM_980548
VERSION     NM_031397.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5427)
  AUTHORS   Rothe,B., Ikawa,Y., Zhang,Z., Katoh,T.A., Kajikawa,E.,
            Minegishi,K., Xiaorei,S., Fortier,S., Dal Peraro,M., Hamada,H. and
            Constam,D.B.
  TITLE     Bicc1 ribonucleoprotein complexes specifying organ laterality are
            licensed by ANKS6-induced structural remodeling of associated ANKS3
  JOURNAL   PLoS Biol 21 (9), e3002302 (2023)
   PUBMED   37733651
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5427)
  AUTHORS   Liu,Z., Ou,C., Xiang,S., Xie,Q., Che,S., Zhang,D., Meng,L., Liu,Z.,
            Zhang,G., Wang,Y., Huang,Y., Zhang,W. and Deng,Y.
  TITLE     Expression and Regulatory Network Analysis of BICC1 for Aged
            Sca-1-Positive Bone Narrow Mesenchymal Stem Cells
  JOURNAL   Dis Markers 2022, 4759172 (2022)
   PUBMED   35756494
  REMARK    GeneRIF: Expression and Regulatory Network Analysis of BICC1 for
            Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5427)
  AUTHORS   Minegishi,K., Rothe,B., Komatsu,K.R., Ono,H., Ikawa,Y.,
            Nishimura,H., Katoh,T.A., Kajikawa,E., Sai,X., Miyashita,E.,
            Takaoka,K., Bando,K., Kiyonari,H., Yamamoto,T., Saito,H.,
            Constam,D.B. and Hamada,H.
  TITLE     Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the
            mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
  JOURNAL   Nat Commun 12 (1), 4071 (2021)
   PUBMED   34210974
  REMARK    GeneRIF: Fluid flow-induced left-right asymmetric decay of Dand5
            mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation
            complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5427)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   6  (bases 1 to 5427)
  AUTHORS   Aziz,N.
  TITLE     Animal models of polycystic kidney disease
  JOURNAL   Bioessays 17 (8), 703-712 (1995)
   PUBMED   7661851
  REMARK    Review article
REFERENCE   7  (bases 1 to 5427)
  AUTHORS   Flaherty,L., Bryda,E.C., Collins,D., Rudofsky,U. and
            Montogomery,J.C.
  TITLE     New mouse model for polycystic kidney disease with both recessive
            and dominant gene effects
  JOURNAL   Kidney Int 47 (2), 552-558 (1995)
   PUBMED   7723240
REFERENCE   8  (bases 1 to 5427)
  AUTHORS   Nauta,J., Ozawa,Y., Sweeney,W.E. Jr., Rutledge,J.C. and Avner,E.D.
  TITLE     Renal and biliary abnormalities in a new murine model of autosomal
            recessive polycystic kidney disease
  JOURNAL   Pediatr Nephrol 7 (2), 163-172 (1993)
   PUBMED   8476712
REFERENCE   9  (bases 1 to 5427)
  AUTHORS   Ozawa,Y., Nauta,J., Sweeney,W.E. and Avner,E.D.
  TITLE     A new murine model of autosomal recessive polycystic kidney disease
  JOURNAL   Nihon Jinzo Gakkai Shi 35 (4), 349-354 (1993)
   PUBMED   8341011
REFERENCE   10 (bases 1 to 5427)
  AUTHORS   Flaherty,L., Messer,A., Russell,L.B. and Rinchik,E.M.
  TITLE     Chlorambucil-induced mutations in mice recovered in homozygotes
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2859-2863 (1992)
   PUBMED   1557392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079680.34, AK076154.1, CX207788.1, BM936635.1, AC087891.12,
            CX237497.1 and BX637408.1.
            
            On Nov 18, 2016 this sequence version replaced NM_031397.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF319464.1, BC111523.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC079680.34        100224-100368       c
            146-2360            AK076154.1         143-2357
            2361-2361           CX207788.1         398-398
            2362-2576           AK076154.1         2359-2573
            2577-3171           BM936635.1         1-595
            3172-4470           AC087891.12        29305-30603
            4471-5001           CX237497.1         1-531
            5002-5427           BX637408.1         1-426               c
FEATURES             Location/Qualifiers
     source          1..5427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 36.75 cM"
     gene            1..5427
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /note="BicC family RNA binding protein 1"
                     /db_xref="GeneID:83675"
                     /db_xref="MGI:MGI:1933388"
     exon            1..270
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..3008
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein bicaudal C homolog 1; polycystic kidney mutation
                     of BALB/c origin; juvenile congenital polycystic kidney
                     disease"
                     /codon_start=1
                     /product="protein bicaudal C homolog 1 isoform 1"
                     /protein_id="NP_113574.1"
                     /db_xref="CCDS:CCDS23915.1"
                     /db_xref="GeneID:83675"
                     /db_xref="MGI:MGI:1933388"
                     /translation="MASQSEPGYLAAAQSDPGSNSERSTDSPVAGSEDDLVAAAPLLH
                     SPEWSEERFRVDRKKLEAMLQAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKS
                     KKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKV
                     MEDTGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARARIRELLPLVLMFELPIAGI
                     LQPVPDPNTPSIQHISQTYSVSVSFKQRSRMYGATVTVRGSQNNTNAVKEGTAMLLEH
                     LAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNVKHIMQRTGAQIHFPDPSNPQKKSTV
                     YLQGTIESVCLARQYLMGCLPLVLMFDMKEDIEVDPQVIAQLMEQLDVFISIKPKPKQ
                     PSKSVIVKSVERNALNMYEARKCLLGLESSGVSIATSLSPASCPAGLACPSLDILASA
                     GLGLTGLGLLGPTTLSLNTSATPNSLLNALNTSVSPLQSSSSGTPSPTLWAPPIANTA
                     SATGFSTIPHLMLPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGK
                     NISASINGHVQPANMKYGPLSTSSLGEKVLSSNHGDPSMQTAGPEQASPKSNSVEGCN
                     DAFVEVGMPRSPSHSGNAGDLKQMLGASKVSCAKRQTVELLQGTKNSHLHGTDRLLSD
                     PELSATESPLADKKAPGSERAAERAAAAQQKSERARLASQPTYVHMQAFDYEQKKLLA
                     TKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTAYEGSSL
                     SLSRSSSREHLASGSESDNWRDRNGIGPMGHSEFSAPIGSPKRKQNKSREHYLSSSNY
                     MDCISSLTGSNGCNLNSCFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDL
                     KELGITTFGARRKMLLAISELSKNRRKLFEPPNASCTSFLEGGASGRLPRQYHSDIAS
                     VSGRW"
     exon            271..317
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            318..387
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            388..467
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            468..626
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            627..680
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            681..875
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1127
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1259
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1446
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1608
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1805
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1938
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2095
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2261
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2301
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2456
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2613
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2774
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2874
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..5423
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5382..5387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /note="hexamer: AATAAA"
     polyA_site      5421
                     /gene="Bicc1"
                     /gene_synonym="Bic-C; bpk; jcpk"
                     /note="major polyA site"
ORIGIN      
        1 cgagctagcg ctgcggcgcg ccgagccaca tcggccgggg ccggggcggc ggcagcccga
       61 gcgccgctcg caccatggcc tcgcagagcg agccgggcta cctggcggcg gcgcagtcgg
      121 accccggctc caacagcgag cgcagcaccg actcgccggt ggccggctcc gaggacgatc
      181 tggtggccgc ggcgcccctc ttgcacagcc cggagtggag cgaggagcgc ttccgcgtgg
      241 acaggaagaa actcgaggcc atgctccaag ctgcagctga aggaaaaggc cgaagtgggg
      301 aagacttttt tcagaagatc atggaggaga caaacacgca gattgcatgg ccgtccaaac
      361 tgaagatcgg ggctaaatcc aagaaagatc cccacatcaa ggtttctggg aagaaagagg
      421 atgtgaagga agccaaagaa atgatcatgt ctgtcttaga cacaaaaagc aaccgcgtca
      481 cattgaagat ggatgtctcg cacacggagc actcccacgt catcggcaag ggtggtaaca
      541 acattaaaaa ggtcatggaa gacacgggct gccacatcca cttcccagac tccaacagga
      601 acaaccaggc agagaagagt aaccaggtgt ctatagcagg acagccagca ggagtagaat
      661 cggcccgagc aaggattcgg gagctgcttc ctttggtgct gatgtttgag ttaccgattg
      721 ccgggattct ccagccagtc cccgatccca acaccccgtc cattcagcac atctcacaaa
      781 cctacagcgt ttctgtgtcc tttaagcaga ggtctcgaat gtatggtgct acagtcacag
      841 tacgaggctc tcagaataac actaatgctg tgaaggaagg aacagccatg ctgttggaac
      901 accttgcggg aagcttggcc tccgccatcc ccgtgagcac acaactggac atagcagccc
      961 agcatcacct cttcatgatg ggccggaacg ggagcaacgt caaacacatc atgcagagga
     1021 caggggcgca gattcacttt cccgacccca gcaatccaca gaagaaatcc accgtctacc
     1081 tccagggcac cattgagtct gtctgcctag caaggcagta tctcatgggg tgtcttcctc
     1141 tggtgttgat gtttgatatg aaggaagaca ttgaagtgga cccacaggtc atcgcacagc
     1201 tgatggaaca gctggacgtc tttatcagta ttaaaccaaa gcccaaacag ccgagcaagt
     1261 ctgtgattgt gaaaagtgtt gagcgaaatg ccttaaatat gtatgaagca aggaagtgtc
     1321 tcctcggact tgaaagcagt ggggtttcca tagcaaccag tctatcccca gcatcgtgcc
     1381 ctgccggcct ggcctgtccc agcctggata tcttagcttc ggcaggcctc ggactcactg
     1441 gactaggttt attggggccc accacattgt cgctcaatac gtcagccacc ccaaactcac
     1501 tcctgaatgc tctcaacact tcggtcagtc ctttgcaaag ttcaagttct ggtactccca
     1561 gtcctacact gtgggcaccc ccaatcgcta acactgcaag cgccacaggt ttctctacga
     1621 taccacacct tatgcttccc tctactgccc aggccacatt aaccaatatt ttgctgtctg
     1681 gagtgcccac atacgggcac acggctccat ctcccccacc tggcttgact cctgttgatg
     1741 ttcacatcaa cagcatgcag acagaaggca aaaacatctc tgcgtctata aatggacatg
     1801 tgcagcctgc aaacatgaaa tacggtccgc tgtccacttc atcgcttggg gaaaaagtgc
     1861 tgagttcgaa tcatggtgac ccatccatgc agacagctgg gcccgaacag gcttctccta
     1921 aatcaaactc ggtggaaggc tgcaatgatg cctttgttga agtgggcatg cctcgaagtc
     1981 cctcccattc tggaaacgct ggcgacttga agcagatgct gggtgcctcc aaggtctcct
     2041 gtgccaagcg gcagacggtt gagctactgc agggcacgaa gaactcgcac ctccacggca
     2101 ctgacagact actctcagac cctgaactga gcgccacaga aagtccgctt gctgacaaga
     2161 aggccccggg gagcgaacgt gcagctgaga gggcagcagc tgcccagcag aaatcggaga
     2221 gggcccgcct ggcctcgcag ccaacatatg tccacatgca ggcatttgat tatgagcaga
     2281 agaaactatt agccaccaaa gcgatgttaa agaagccagt ggtgactgag gtcagaacac
     2341 ctacgaatac gtggagtggc ctgggattct caaagtccat gccggcagaa accattaagg
     2401 aactgaggag agccaaccac gtatcctata agcccacgat gaccaccgcc tatgagggct
     2461 cctcattgtc cctctcaagg tccagcagtc gtgagcacct ggcaagtgga agcgagtcag
     2521 acaactggag agaccggaat ggaataggcc ccatgggtca cagtgaattc tcagcaccaa
     2581 tcggcagccc caagcgcaag cagaacaaat caagagagca ctatctaagc agcagcaact
     2641 acatggactg catttcctcg ctgacgggaa gcaatggctg taacctgaac agctgcttca
     2701 aaggctccga cctccccgag cttttcagca agctgggcct aggcaaatac acggatgtct
     2761 tccagcagca agagatcgat cttcagacat tcctcaccct cacagatcag gatctgaagg
     2821 agctgggaat cacaaccttt ggtgcccgaa ggaaaatgct gctggcaatc tcagagctaa
     2881 gtaaaaaccg aagaaaactt tttgaaccac caaacgcatc atgcacctcc ttcctggaag
     2941 gcggagccag tgggaggctg cctcgccagt atcattcaga cattgcgagc gtcagtggcc
     3001 gctggtagcg gtaccttctg gacacgcacc tgctatcttg caaaggtgga cacgatccgt
     3061 ggacagtctt cactgcactc gcctgccctt ggcactcgga gtgtctggta tcaggaccaa
     3121 agtgttgatt tcgtacctgt acttcatggc caaaaaaaaa aaaaaaaaaa aaaagagaga
     3181 gagaaaagac aagagaagtg tctcatgttc tcatgttgcc ataaaagcac caaagggaga
     3241 aatgctttta taaactggca attggacaga atttgcaaaa tgagggtagg gctttgtttc
     3301 tttctattta cctatattac atatgcactg attttttttt tcatggtacc taaaatgaag
     3361 gagaattttg acatctggga tgccagaaaa cttagaagtt atttttgttg gcttgaactg
     3421 tcttggtgtt tggggatttg gaaaaaaaaa taatcaaggt ataattttct gctttaaaat
     3481 gatgagtgag gtcttccagc actttacacg gtctagttgc ccctcctgtg gaatctgtct
     3541 ctcatctctg tgtttctggt attggtacac tttttcctgg ctccatcaca tgtttatttg
     3601 aaatggtact ggaccttaat tagttcccat gcaggatttt ctgtactgtt gggaaatgtg
     3661 ggccacttgg ctctggacca aattcagttc atttatgtca acatcttagg aacccttggc
     3721 catgactgcc gtctactgac caggcacaaa agacaaacca aatggacttt gcaaaactaa
     3781 ctcttctcag ttggcatagt tagctgctgt ctgtattgct aaatttcaat ggctgtctga
     3841 aggccagggg gctggtcttt tagtatactg cgactaaagg acatttattt atatcaaact
     3901 tttattttta gatattataa gcatacagta gataactgat aagattgata ttttctagag
     3961 atttatggta gagattgagc tgcattcata actggagccc taggttgtca ctttatttaa
     4021 aaaaagacaa gcaaccattt gacgagacag cattgctgcc attatggaga gaagaggccc
     4081 tgcttcctta cccagtagct ccgccccctg tgggtcatga gactttcccc aaagtgcctt
     4141 tgtctgcctg gagtcaactt ggatccattg gaaacataga aagggtccag gggacagctt
     4201 atccaagagc taaattctga agggggagga aaaaaagaaa aagaaaaaaa aaaggctttc
     4261 taaatggcca gatttattgt taaaatctta tactgtgaaa gtccaagaga ttagcgaaca
     4321 ttatttcctg tctttgcaga ccatacaaag gttttcggtc caatgaaaaa aaccactcaa
     4381 gtgcctttct ctcttcagag ctatattctt accaaatgta cacaggtttt ttgggggggg
     4441 tgggagggaa cttttcccat agggcatgtt gtcagttacc tttagtgatg tgtttatgtt
     4501 aatatgttaa ggctttctgt gtgagataaa cccctccctc ctgttcttgg tagagaggag
     4561 ttggaggatc atgcacacag ctgggtgcct atgcaaattc gaggtacgaa atacttgcct
     4621 agcagtttct tcccgaggct aactctggtc actaaagaac tgaagggatt tttacacaga
     4681 gaaaaaaata aaaagttttt gctttgaaaa catcggctac ctggaagagt agacgatgac
     4741 cacgggcttg ccacagcggt aataatctac ttggcatcaa gctcagcctg accgcataag
     4801 gatacagaat tgaatcactt cctgtgcgag cattgtgtgc tcatgtgctc agatgaccgc
     4861 ccgaggctcg tcacatatcc ggttgaccac ctcagaggac tactcggtac tccactccac
     4921 tgagagctca gtgtggactc tgccatgcat ttatttgcta aagggaagag aggaaccaaa
     4981 tattcaatag tgagctggtg taggttatgt acacagtgct ttgatttcac gccaaaagga
     5041 aactgtccac tccaacttga ttaaataggg aggctaagga ataattaaaa acactggaag
     5101 gtttttctcc ctttctcttg atgtagcaaa gggaatatgg caccagggcc tgcagagttg
     5161 ttggtgttct ttgccatgca cggaatattt ggattgttcg aagtaatgtt aacttttagc
     5221 caacctggct gttctcctga ttggtcatct gtaaatatgg agcagacctg gattgtatgt
     5281 cttggggagt ccttgtcctt tttatcactt ttaaaaaacc cgtgagatgg gatcaatatt
     5341 gaaagtgggg attttttttc taaagtaatc tttacatgag aaataaattt atataatccc
     5401 tttgtatcgc tttctacatg ggaaaaa
//
