LOCUS       NM_022884               2090 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus betaine-homocysteine methyltransferase 2 (Bhmt2),
            mRNA.
ACCESSION   NM_022884
VERSION     NM_022884.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Partearroyo,T., Murillo-Cuesta,S., Vallecillo,N.,
            Bermudez-Munoz,J.M., Rodriguez-de la Rosa,L., Mandruzzato,G.,
            Celaya,A.M., Zeisel,S.H., Pajares,M.A., Varela-Moreiras,G. and
            Varela-Nieto,I.
  TITLE     Betaine-homocysteine S-methyltransferase deficiency causes
            increased susceptibility to noise-induced hearing loss associated
            with plasma hyperhomocysteinemia
  JOURNAL   FASEB J 33 (5), 5942-5956 (2019)
   PUBMED   30753104
  REMARK    GeneRIF: BHMT plays a central role in the homeostasis of cochlear
            methionine metabolism and Bhmt2 up-regulation could carry out a
            compensatory role in cochlear protection against noise injury in
            the absence of BHMT
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Wymeersch,F.J., Skylaki,S., Huang,Y., Watson,J.A., Economou,C.,
            Marek-Johnston,C., Tomlinson,S.R. and Wilson,V.
  TITLE     Transcriptionally dynamic progenitor populations organised around a
            stable niche drive axial patterning
  JOURNAL   Development 146 (1) (2019)
   PUBMED   30559277
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Vinci,C.R. and Clarke,S.G.
  TITLE     Yeast, plants, worms, and flies use a methyltransferase to
            metabolize age-damaged (R,S)-AdoMet, but what do mammals do?
  JOURNAL   Rejuvenation Res 13 (2-3), 362-364 (2010)
   PUBMED   20370499
  REMARK    GeneRIF: the mouse liver extracts, containing the BHMT-2
            homocysteine methyltransferase candidate for a similar activity,
            recognizes (S,S)-AdoMet but not (R,S)-AdoMet.
REFERENCE   6  (bases 1 to 2090)
  AUTHORS   Liu,H.H., Lu,P., Guo,Y., Farrell,E., Zhang,X., Zheng,M., Bosano,B.,
            Zhang,Z., Allard,J., Liao,G., Fu,S., Chen,J., Dolim,K., Kuroda,A.,
            Usuka,J., Cheng,J., Tao,W., Welch,K., Liu,Y., Pease,J., de
            Keczer,S.A., Masjedizadeh,M., Hu,J.S., Weller,P., Garrow,T. and
            Peltz,G.
  TITLE     An integrative genomic analysis identifies Bhmt2 as a
            diet-dependent genetic factor protecting against
            acetaminophen-induced liver toxicity
  JOURNAL   Genome Res 20 (1), 28-35 (2010)
   PUBMED   19923254
  REMARK    GeneRIF: Betaine-homocysteine methyltransferase 2 (Bhmt2) was
            identified as a diet-dependent genetic factor that affected
            susceptibility to acetaminophen-induced liver toxicity in mice.
REFERENCE   7  (bases 1 to 2090)
  AUTHORS   Chadwick,L.H., McCandless,S.E., Silverman,G.L., Schwartz,S.,
            Westaway,D. and Nadeau,J.H.
  TITLE     Betaine-homocysteine methyltransferase-2: cDNA cloning, gene
            sequence, physical mapping, and expression of the human and mouse
            genes
  JOURNAL   Genomics 70 (1), 66-73 (2000)
   PUBMED   11087663
REFERENCE   8  (bases 1 to 2090)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 2090)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145901.1 and AA014354.1.
            
            On Apr 20, 2007 this sequence version replaced NM_022884.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013515.1, AK145901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1927              AK145901.1         2-1928
            1928-2090           AA014354.1         202-364
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.88 cM"
     gene            1..2090
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /note="betaine-homocysteine methyltransferase 2"
                     /db_xref="GeneID:64918"
                     /db_xref="MGI:MGI:1891379"
     exon            1..65
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1124
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /EC_number="2.1.1.10"
                     /note="betaine--homocysteine S-methyltransferase 2;
                     SMM-hcy methyltransferase"
                     /codon_start=1
                     /product="S-methylmethionine--homocysteine
                     S-methyltransferase BHMT2"
                     /protein_id="NP_075022.2"
                     /db_xref="CCDS:CCDS26689.1"
                     /db_xref="GeneID:64918"
                     /db_xref="MGI:MGI:1891379"
                     /translation="MAPAGSTRAKKGILERLDSGEVVVGDSGFLFTLEKRGFVKAGLW
                     TPEAVVEHPSAVRQLHTEFLRAGADVLQTFTFSATEDNMASKWEAVNAAACDLAQEVA
                     GGGGALVAGGICQTSLYKYHKDETRIKNIFRLQLEVFARKNVDFLIAEYFEHVEEAVW
                     AVEVLREVGAPVAVTMCIGPEGDMHDVTPGECAVKLARAGADIIGVNCRFGPWTSLQT
                     MKLMKEGLRDASLQAHLMVQCLGFHTPDCGKGGFVDLPEYPFGLEPRVATRWDIQKYA
                     REAYNLGIRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLNMHTKPWI
                     RARARREYWENLLPASGRPFCPSLSKPDA"
     exon            66..198
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..290
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..482
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..630
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..813
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1042
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..2090
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /note="hexamer: ATTAAA"
     polyA_site      1932
                     /gene="Bhmt2"
                     /gene_synonym="D13Ucla2"
                     /note="major polyA site"
ORIGIN      
        1 accgggaccc gcgcctgtac agcggcggcg acatggcacc agctggaagc actcgagcca
       61 agaagggcat cttggagcgt ctggacagcg gggaggtggt ggttggggac agcggctttc
      121 tcttcactct ggaaaagaga ggcttcgtga aggcggggct ttggactcca gaagcagtgg
      181 tagaacatcc aagtgcagtt cgtcaacttc acacagaatt cttgagagcg ggagctgatg
      241 tcttgcagac attcaccttt tctgctactg aagacaatat ggccagcaag tgggaagctg
      301 tgaatgcagc tgcctgtgac ctggcccagg aggtggctgg tggagggggt gctttggtgg
      361 cagggggcat ctgccagaca tcactctaca agtaccacaa ggatgaaact agaattaaaa
      421 acatttttcg actacagcta gaagtttttg ccaggaaaaa tgtggacttc ttgattgcag
      481 agtattttga gcatgtggaa gaagctgtat gggctgtcga agtcttgaga gaggtggggg
      541 cacctgtggc tgtgaccatg tgcatcggcc cagaggggga catgcacgac gtgacacctg
      601 gagagtgtgc ggtgaagctg gcgcgtgcag gggcggacat cattggggtc aactgccggt
      661 ttgggccctg gactagcttg cagaccatga agctcatgaa agagggcctc agagatgcca
      721 gcctgcaggc tcaccttatg gtccagtgct tgggcttcca cacaccggac tgtggcaagg
      781 gagggtttgt ggacctccca gagtatccct ttggcctgga gccaagagtt gccaccagat
      841 gggatattca aaaatacgcc agagaggcct acaacctggg gatcaggtac attggcggct
      901 gctgcggatt tgagccctac cacatcaggg cgattgcaga ggaactggcc ccagaaaggg
      961 gatttttgcc accggcttca gagaaacatg gcagctgggg aagtggtctg aacatgcaca
     1021 ccaaaccctg gatcagagca agggctagac gagaatactg ggagaatctg ctgccagcct
     1081 caggaagacc tttctgtcct tccctatcaa agccagatgc ataagaagca atgaaagaga
     1141 actctgaagt gacaagacag gaggaattag ccacaagccc cacctggaac ctttcttgct
     1201 gctgtcttca gcctaccctg ctcttctggc tgctgagcat ctatgagtgg tatcccttca
     1261 gttgtagtga catgtcactc ctgagcatgc tcatcagatg cagtggagat gcagaggcac
     1321 ctggacccca ccccacgccc cgctcactct ctgccgagta atgccacggg cctccatttg
     1381 aaggtcattg ggcatggcca gagttggctc tcagggtgga tttgacattc tcaaataatc
     1441 ccaagtcagc aagaagcaac cttggtgaat aattctggtg ttgaagctag gtcttgagct
     1501 acagtctcag gagaagagag gccaaagctg ttgtgagtga tggcaaggct attgaacagt
     1561 catgatgctt ggctttccag gatgacttct cgctttaaag tcctggaatt tgtaagtgca
     1621 tctttatagc catgcatggc tagattataa actactgatg gccaaggacc gtataatatg
     1681 cttcttacat tcctctctgc ttagctttat gccaaactta atcaccaatg ctcagggaaa
     1741 cacttgctga ttaaagcaaa acacatgaac cttgcaaggc cgttttagaa ctcagagagc
     1801 aagttcatct tgttctagca ctttctatgt tcatgtttgt tttgtacact gtgccccact
     1861 tttctgtttt tcacttcagt gtagcagtgt gtaacaatga gtaagattaa agataatttt
     1921 tcttttcaaa aatttgagta gcttgaatgg catcaatttc tttgggacaa tgatagcaaa
     1981 tgtgtgttgc ttgtcatgtt ttagctttta tgtttatcat gttgttgtat cagactactt
     2041 caaactcccc tctttaagta cttcctagaa tataaatgtg ggaagccgcc
//
