LOCUS       NM_016668               2081 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus betaine-homocysteine methyltransferase (Bhmt), mRNA.
ACCESSION   NM_016668 XM_974155 XM_974190
VERSION     NM_016668.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Han,H.K., Mukherjee,S., Park,S.Y., Lee,J.H., Lee,E.H., Kim,S.,
            Lee,Y.H., Song,D.K., Lee,S., Bae,J.H. and Im,S.S.
  TITLE     Regulation of Betaine Homocysteine Methyltransferase by Liver
            Receptor Homolog-1 in the Methionine Cycle
  JOURNAL   Mol Cell Biol 44 (6), 245-258 (2024)
   PUBMED   38804232
  REMARK    GeneRIF: Regulation of Betaine Homocysteine Methyltransferase by
            Liver Receptor Homolog-1 in the Methionine Cycle.
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Liu,C., Zhang,Y., Wang,Y., Wang,N., Xu,J., Liang,X., Xiong,J.,
            Lu,S., Zhou,P., Liu,J. and Chen,S.
  TITLE     Betaine-homocysteine methyltransferase promotes adipocyte
            commitment and insulin resistance via p38 MAPK/Smad signaling
  JOURNAL   Obesity (Silver Spring) 31 (6), 1569-1583 (2023)
   PUBMED   37203331
  REMARK    GeneRIF: Betaine-homocysteine methyltransferase promotes adipocyte
            commitment and insulin resistance via p38 MAPK/Smad signaling.
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   Schwahn,B.C., Wendel,U., Lussier-Cacan,S., Mar,M.H., Zeisel,S.H.,
            Leclerc,D., Castro,C., Garrow,T.A. and Rozen,R.
  TITLE     Effects of betaine in a murine model of mild
            cystathionine-beta-synthase deficiency
  JOURNAL   Metabolism 53 (5), 594-599 (2004)
   PUBMED   15131763
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Swanson,D.A., Liu,M.L., Baker,P.J., Garrett,L., Stitzel,M., Wu,J.,
            Harris,M., Banerjee,R., Shane,B. and Brody,L.C.
  TITLE     Targeted disruption of the methionine synthase gene in mice
  JOURNAL   Mol Cell Biol 21 (4), 1058-1065 (2001)
   PUBMED   11158293
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Chadwick,L.H., McCandless,S.E., Silverman,G.L., Schwartz,S.,
            Westaway,D. and Nadeau,J.H.
  TITLE     Betaine-homocysteine methyltransferase-2: cDNA cloning, gene
            sequence, physical mapping, and expression of the human and mouse
            genes
  JOURNAL   Genomics 70 (1), 66-73 (2000)
   PUBMED   11087663
REFERENCE   10 (bases 1 to 2081)
  AUTHORS   Neece,D.J., Griffiths,M.A. and Garrow,T.A.
  TITLE     Isolation and characterization of a mouse betaine-homocysteine
            S-methyltransferase gene and pseudogene
  JOURNAL   Gene 250 (1-2), 31-40 (2000)
   PUBMED   10854776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY773713.1, AK077108.1, BG078929.2, CB948151.1 and AI114914.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_974190.1, XM_974155.1, NM_016668.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093510.1, BC110307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               BY773713.1         2-358
            358-689             AK077108.1         165-496
            690-887             BG078929.2         182-379
            888-1369            AK077108.1         696-1177
            1370-1501           CB948151.1         498-629
            1502-1581           AK077108.1         1310-1389
            1582-2081           AI114914.1         1-500               c
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.87 cM"
     gene            1..2081
                     /gene="Bhmt"
                     /note="betaine-homocysteine methyltransferase"
                     /db_xref="GeneID:12116"
                     /db_xref="MGI:MGI:1339972"
     exon            1..295
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1486
                     /gene="Bhmt"
                     /EC_number="2.1.1.5"
                     /codon_start=1
                     /product="betaine--homocysteine S-methyltransferase 1"
                     /protein_id="NP_057877.1"
                     /db_xref="CCDS:CCDS36748.1"
                     /db_xref="GeneID:12116"
                     /db_xref="MGI:MGI:1339972"
                     /translation="MAPVAGKKAKKGILERLNAGEVVIGDGGFVFALEKRGYVKAGPW
                     TPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEA
                     ACDIARQVADEGDALVAGGVSQTPSYLSCKSEVEVKKIFRQQLEVFMKKNVDFLIAEY
                     FEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIVGVNCH
                     FDPSVSLQTVKLMKEGLEAARLKAYLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVA
                     TRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSG
                     LDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSRPDAWGVTKGAAELMQQKEATTEQ
                     QLRELFEKQKFKSAQ"
     exon            296..428
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     exon            429..547
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     exon            548..739
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     exon            740..887
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1070
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1299
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2071
                     /gene="Bhmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhmt"
                     /note="hexamer: AATAAA"
     polyA_site      2071
                     /gene="Bhmt"
                     /note="major polyA site"
ORIGIN      
        1 atcttaactt cgcgtttcca cccatctagg agaccaatct cgacttctcc tcccacaggc
       61 agcttcccag ctagcccctg gcctaattca aaggctggtg ggcgtgttcc ctgcctgagg
      121 ccatgtgttg gacctggcca aggctaggga actctagctg ctgtataaag agaccagcag
      181 cggcccagca gcacagactt tgctgggaac agctaccctc caatccgcag ctgtgttcag
      241 cgccactcac tacaccggaa agatggcacc agttgctggc aagaaggcca agaaggggat
      301 cttagaacgc ttaaatgccg gagaagttgt gattggagat ggaggatttg tctttgcact
      361 ggaaaagagg ggctatgtaa aggctggacc ctggacccca gaagctgccg tggagcatcc
      421 tgaggcagtt cgtcagcttc atcgggagtt cctcagagct ggatcgaacg tcatgcagac
      481 cttcactttc tatgcaagtg aagacaagct ggaaaacaga ggaaactatg tggcagagaa
      541 gatttctggg cagaaagtca acgaagctgc ttgtgacatt gcacggcaag tggctgatga
      601 aggagacgct ttggttgcag gaggcgtgag ccagacgcct tcatacctta gctgcaagag
      661 tgaggtagaa gtgaaaaaga tatttcgcca acagctagag gtgttcatga agaagaacgt
      721 ggacttcctc attgcagagt attttgaaca tgttgaagaa gccgtgtggg cagtggaagc
      781 cttaaaagca tctggtaagc ccgtagcagc taccatgtgc attgggcccg agggagatct
      841 gcatggcgtg ccccctggag agtgtgccgt gcgtctggtg aaagcaggcg cctccattgt
      901 cggcgtgaac tgccacttcg accccagcgt cagcttacag actgtgaagc tcatgaagga
      961 gggtttggag gctgcgcggt tgaaagctta cctgatgagc cagcccctgg cctaccatac
     1021 ccctgactgt ggcaaacagg gatttattga tctcccagaa ttcccctttg gattggaacc
     1081 ccgagttgcc actagatggg atattcaaaa atatgccaga gaggcctaca acctgggggt
     1141 taggtacatt ggcggctgct gcggatttga gccctaccac atcagggcga ttgcagagga
     1201 gttggcccca gaaaggggat ttttgccacc ggcttcagaa aaacatggca gctggggaag
     1261 tggtttggac atgcacacca aaccctggat cagagcaagg gccagaaagg aatactggca
     1321 gaatctgcga atagcttccg gcaggccgta caacccttcc atgtcccggc cagatgcttg
     1381 gggcgtgact aagggagcag ccgagctgat gcagcagaag gaggccacta ctgagcagca
     1441 gctgagagag ctctttgaaa aacaaaaatt caagtctgca cagtagccac aggcaacagt
     1501 ttggggtaaa tccctccatg cctgggcctc aatgtgtgcc cggaaggaaa agatggctga
     1561 aagtcagtgt ttgtgttaat accagcctac acctatgatt ggtgctagtt agacaaaatg
     1621 gaatcacaaa taatagcatt ttacagttac aaaactatgt tttagaaatt tacttagaag
     1681 caaagaaagg aaaagtccac ggtaaatcct gaataaattt tctaagtacc tgccgtgtaa
     1741 caaacagtca tacagaagtc actgcggcaa agagaaagtc acctaggtgt gagtcccatt
     1801 tcaggcagga gtgtaggaca caaaccacca taaatgtcat agtaacttca gggaccatat
     1861 cataaaggac atagcaacca actttatcta aggtgctgct ggcagtggat cctaagatct
     1921 tttgagcatg acccttagag agaaacatcg aatgcaccag ccctgtaaaa cttaacatat
     1981 aaccacaaag aagaaacaat ggactgctat tctgtctgct tctattccat ttcattaata
     2041 aaaatgtgct ggttgaaaac cttcaagaca aaaaaaaaaa a
//
