LOCUS       NM_024469               5995 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus basic helix-loop-helix family, member e41 (Bhlhe41),
            transcript variant 1, mRNA.
ACCESSION   NM_024469
VERSION     NM_024469.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5995)
  AUTHORS   Podlesny-Drabiniok,A., Novikova,G., Liu,Y., Dunst,J., Temizer,R.,
            Giannarelli,C., Marro,S., Kreslavsky,T., Marcora,E. and Goate,A.M.
  TITLE     BHLHE40/41 regulate microglia and peripheral macrophage responses
            associated with Alzheimer's disease and other disorders of
            lipid-rich tissues
  JOURNAL   Nat Commun 15 (1), 2058 (2024)
   PUBMED   38448474
  REMARK    GeneRIF: BHLHE40/41 regulate microglia and peripheral macrophage
            responses associated with Alzheimer's disease and other disorders
            of lipid-rich tissues.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5995)
  AUTHORS   Qi,H., Xu,L. and Liu,Q.
  TITLE     Knockdown of DEC2 expression inhibits the proliferation of
            mesangial cells through suppressed glycolysis and p38 MAPK/Erk
            pathway in lupus nephritis
  JOURNAL   Mol Med 29 (1), 99 (2023)
   PUBMED   37488524
  REMARK    Erratum:[Mol Med. 2023 Sep 14;29(1):124. doi:
            10.1186/s10020-023-00725-3.. PMID: 37710155]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5995)
  AUTHORS   Furukawa,T., Mimami,K., Nagata,T., Yamamoto,M., Sato,M. and
            Tanimoto,A.
  TITLE     Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer
            Development
  JOURNAL   Int J Mol Sci 24 (14), 11731 (2023)
   PUBMED   37511489
  REMARK    GeneRIF: Approach to Functions of BHLHE41/DEC2 in Non-Small Lung
            Cancer Development.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5995)
  AUTHORS   Jiang,X., Wang,Y., Xiao,Z., Yan,L., Guo,S., Wang,Y., Wu,H.,
            Zhao,X., Lu,X. and Wang,H.
  TITLE     A differentiation roadmap of murine placentation at single-cell
            resolution
  JOURNAL   Cell Discov 9 (1), 30 (2023)
   PUBMED   36928215
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5995)
  AUTHORS   Li,H., Tang,Y., Ren,J., Bai,R., Hu,L., Jia,W., Cao,Y., Hong,L.,
            Xu,M., Gao,S., Shi,Y., Pan,S., Wang,L., Zheng,K., Zhao,S. and
            Wang,H.
  TITLE     Identification of novel B-1 transitional progenitors by B-1
            lymphocyte fate-mapping transgenic mouse model Bhlhe41dTomato-Cre
  JOURNAL   Front Immunol 13, 946202 (2022)
   PUBMED   36189231
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5995)
  AUTHORS   Kawamoto,T., Noshiro,M., Sato,F., Maemura,K., Takeda,N., Nagai,R.,
            Iwata,T., Fujimoto,K., Furukawa,M., Miyazaki,K., Honma,S.,
            Honma,Ki. and Kato,Y.
  TITLE     A novel autofeedback loop of Dec1 transcription involved in
            circadian rhythm regulation
  JOURNAL   Biochem Biophys Res Commun 313 (1), 117-124 (2004)
   PUBMED   14672706
REFERENCE   7  (bases 1 to 5995)
  AUTHORS   Azmi,S., Sun,H., Ozog,A. and Taneja,R.
  TITLE     mSharp-1/DEC2, a basic helix-loop-helix protein functions as a
            transcriptional repressor of E box activity and Stra13 expression
  JOURNAL   J Biol Chem 278 (22), 20098-20109 (2003)
   PUBMED   12657651
  REMARK    GeneRIF: functions as a transcriptional repressor of E box activity
            and Stra13 expression
REFERENCE   8  (bases 1 to 5995)
  AUTHORS   Honma,S., Kawamoto,T., Takagi,Y., Fujimoto,K., Sato,F., Noshiro,M.,
            Kato,Y. and Honma,K.
  TITLE     Dec1 and Dec2 are regulators of the mammalian molecular clock
  JOURNAL   Nature 419 (6909), 841-844 (2002)
   PUBMED   12397359
  REMARK    GeneRIF: Dec1 and Dec2 are regulators of the mammalian molecular
            clock, and form a fifth clock-gene family.
REFERENCE   9  (bases 1 to 5995)
  AUTHORS   Azmi,S. and Taneja,R.
  TITLE     Embryonic expression of mSharp-1/mDEC2, which encodes a basic
            helix-loop-helix transcription factor
  JOURNAL   Mech Dev 114 (1-2), 181-185 (2002)
   PUBMED   12175508
  REMARK    GeneRIF: mSharp-1 may regulate the differentiation of several cell
            types during vertebrate development
REFERENCE   10 (bases 1 to 5995)
  AUTHORS   Fujimoto,K., Shen,M., Noshiro,M., Matsubara,K., Shingu,S.,
            Honda,K., Yoshida,E., Suardita,K., Matsuda,Y. and Kato,Y.
  TITLE     Molecular cloning and characterization of DEC2, a new member of
            basic helix-loop-helix proteins
  JOURNAL   Biochem Biophys Res Commun 280 (1), 164-171 (2001)
   PUBMED   11162494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA013582.1, BE985179.1,
            AB044090.1 and AC144936.4.
            
            On Nov 20, 2012 this sequence version replaced NM_024469.1.
            
            Summary: This gene encodes a basic helix-loop-helix protein
            expressed in various tissues. The encoded protein can interact with
            Arntl or compete for E-box binding sites in the promoter of Per1
            and repress Clock/Arntl's transactivation of Per1. This gene is
            believed to be involved in the control of circadian rhythm and cell
            differentiation. Defects in this gene are associated with the short
            sleep phenotype. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB044090.1, SRR7345562.2505016.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AA013582.1         1-44
            45-80               BE985179.1         659-694             c
            81-1501             AB044090.1         1-1421
            1502-5995           AC144936.4         133647-138140
FEATURES             Location/Qualifiers
     source          1..5995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..5995
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /note="basic helix-loop-helix family, member e41"
                     /db_xref="GeneID:79362"
                     /db_xref="MGI:MGI:1930704"
     exon            1..215
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1386
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /note="isoform 1 is encoded by transcript variant 1; basic
                     helix-loop-helix domain containing, class B3; class E
                     basic helix-loop-helix protein 41; bHLH transcriptional
                     factor Dec2; class B basic helix-loop-helix protein 3;
                     differentially expressed in chondrocytes protein 2"
                     /codon_start=1
                     /product="class E basic helix-loop-helix protein 41
                     isoform 1"
                     /protein_id="NP_077789.1"
                     /db_xref="CCDS:CCDS20697.1"
                     /db_xref="GeneID:79362"
                     /db_xref="MGI:MGI:1930704"
                     /translation="MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDT
                     YKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTAL
                     TEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCA
                     QLVSHLHAVATQLLTPQVPSGRGSGRAPCSAGAAAASGPERVARCVPVIQRTQPGTEP
                     EHDTDTDSGYGGEAEQGRAAVKQEPPGDSSPAPKRPKLEARGALLGPEPALLGSLVAL
                     GGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIP
                     AAAAAAAAAAFPCLSSVLSPPPEKAGATAGAPFLAHEVAPPGPLRPQHAHSRTHLPRA
                     VNPESSQEDATQPAKDAP"
     exon            216..279
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..387
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..499
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..5995
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2997..3002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /note="hexamer: AATAAA"
     polyA_site      3016
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /note="major polyA site"
     regulatory      3034..3039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /note="hexamer: ATTAAA"
     polyA_site      3056
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /note="major polyA site"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
                     /note="hexamer: AATAAA"
     polyA_site      4190
                     /gene="Bhlhe41"
                     /gene_synonym="6430520M22Rik; Bhlhb2l; Bhlhb3; DEC2;
                     Sharp1"
ORIGIN      
        1 ggggcggcca actgcttcac actttcaata ctgcactgaa gagggagagc gagacagcct
       61 ggagacgcac acatcccccc aaaatctctc caggcgaccg tcccacagat tacaggacag
      121 aaacctccaa atcgaaacgg acagccattg aacatggacg aaggaatccc tcatttgcaa
      181 gagagacagt tactggaaca tagggatttt ataggactgg actattcctc tttgtatatg
      241 tgtaaaccca aaaggagctt gaagcgagac gataccaagg atacctacaa gttaccgcac
      301 agattaatag aaaagaagag acgagaccga attaatgaat gcattgctca gctgaaagat
      361 ttactgcccg aacatctgaa attgacaaca ctggggcatt tggagaaagc agtagtcttg
      421 gaattaactt taaagcactt gaaagcgcta acagccttaa ctgagcagca gcatcagaag
      481 ataattgctt tacagaatgg ggagcgctct ctgaaatcgc cggtccaggc cgacttggat
      541 gcgttccact cggggtttca aacctgcgcc aaagaagtct tgcaatacct cgcgcgcttt
      601 gagagctgga cacccaggga gccgcgctgc gcacagctcg tcagccacct gcatgccgtg
      661 gccacccagc tcctgacgcc acaggtgccc tccggcaggg gctctgggcg cgcgccctgc
      721 agcgcggggg ctgcggccgc ctcgggtccc gagcgcgtcg cccgctgcgt gccggtcatc
      781 cagcggactc agcccggcac ggagccggaa cacgacacgg acaccgacag cggctacgga
      841 ggcgaggcgg agcagggccg cgcggccgtc aagcaggagc cacccgggga ctcgtcgcct
      901 gcgcccaaga ggccgaagct ggaggcgcgc ggcgcgctcc tgggcccgga gcccgcgctg
      961 ctcggctcgc tcgtggcgct tggcgggggc gcgcccttcg cgcagcccgc tgccgcgccc
     1021 ttctgcctgc ccttctatct gctgtcgccg tccgccgccg cctacgtaca gccctggcta
     1081 gacaagagcg gcctggacaa gtatctgtac cccgcggcgg ccgcgccctt cccgctgctg
     1141 tatcccggca tcccagcagc ggccgccgct gctgctgccg ccgctttccc ttgcttgtcg
     1201 tccgtgctgt cgccaccccc ggagaaggcc ggcgcgaccg ccggtgcccc gttcctggcg
     1261 cacgaggtgg cgcccccggg gccgctgcgc ccccagcacg cgcatagccg cacccacctg
     1321 ccgcgcgctg tgaacccgga gagctctcag gaagatgcca cgcagccggc caaggacgcc
     1381 ccctgaaccc agcattcctt ccagaacagg gcagggggct cccgaggagt cgccgggttt
     1441 ccaagttcaa acgtcctcta aagcgtgcca gggaggaaga gtaagcgatg ctcgacaggc
     1501 ttaggacaaa aacaggtgtt ttgtgtatgt ttggagttcc tgttttgtcc gtctcaccct
     1561 tttgccaccc cacccagtac cctttcacac cccctccccc gtccctgctg tcaaggagcc
     1621 tccctgataa atggttatct tctattactc tccttacctt tagttctcgt tcactctttc
     1681 caaatacaga ctctggttca ggagtctgtt gggtgggaga gccatgtgga atgacttaag
     1741 agtgcctggt accagggctc gacccaagcc tggaacagta gatgtgtctc ccaactgtcc
     1801 ccttaggagg tggtccatta cctgagagtc tctgagagtt acttttacat ggcagtattt
     1861 tgtattgttc atcttttttg gaaggtacct attttcaaag aagtgagaat gcttgttgcc
     1921 cggttatgag gtggctggag tgtgtctata ccttgcacct gttgggagaa attgagagtt
     1981 gggccatctt gaggcactgt ggtgggagct ggaagaggga ggttggagcc ttggcgcctt
     2041 tgctcgcact ttattgacaa attgacctca aaccctttgt ttcatgtctc agctcacaca
     2101 tatatgtcat aggttatata tttgtgtttc tgatccctca ttattttatc catcatggtc
     2161 ccaaattttt gtaacattac tttttttttt tttttttttt tttttttttt tttttttttg
     2221 gagaaggaca tggatgttaa agtgctctgg gctgggaaaa gaaaagtcca aacagattga
     2281 ttgttgaatt cttagatgac agaagtggag agaggggctt gcagtccctt gtgatgggaa
     2341 gtgctgtgaa catagagaag gccttgccag gcctctcaag gctgtatgta tttttcggga
     2401 gaccaaaacc agataccaga agaaagtttt tcaaaatcag gcataaacca agaccttgtc
     2461 tagatatttt tagtttgttg ccaaggtagc actgagaaat ctcacttgaa tgttacataa
     2521 ggggtgagac acaatagtga agaaagttac ctggggctgt gagtgttcgg gtcgtttgct
     2581 gctgctgttg ctactgtttg cctcaaacgc tgtgtttaaa caacgttaaa acttcttagc
     2641 ctaccaaggc ggctgtatgt acatagctgt tgatactccc aattaatgat gtctgacatg
     2701 ctatttttgt agggagaaga tacctgctaa tgatattttt agttaaaata tcttttgggg
     2761 cggacttggt gaaatgtttg cactttggtt acatgctttt actgcttggt gcaagcttac
     2821 gctgtcttaa attattaaac aaataaaaat attatctgca agaaaaacca gctggtttag
     2881 acaagtttag tatgtaaaga taagctagaa actatcttta tattctagta ttttcagcac
     2941 tccatattac ctaaatattg ccacactatt ttgtgattta aaagttctta ctaaggaata
     3001 aaatgtttat atatgatatg cgatggtcta ataattaaac gatactgggt acccaatgag
     3061 ttttcagaga ctgctgtgta caaggacctg agctcatctg cgtacttgga cgctttccgt
     3121 ttggttttgg ttttaatata tttaatcact ggtttctcca gggagactcc tggtttgggc
     3181 cttgggtccc cacttctccc agtctatctt aatgaaaacc acagaaggaa tagtctagca
     3241 ctcgctggaa ggtcgttcat tgtagaccca gtttgctaat gtttttttat gatttacctg
     3301 gtttgggtct gtgaccccag ataccctctc ttgtgtggtc tgctgtttct cttctgccca
     3361 ggtctgaaac acactagggg gagagatgtt tcattcatgc aaatattttg ccttcttaac
     3421 ttttacaaag tagccctggt attgggagtt tgccttggag ttcaggaaac aattttaggc
     3481 ttttctcaag cttaagatca tacctgtgct tggagacaaa gggctgtcca ctttctttgg
     3541 gtagtggtgt tgaacccctg acttaaggtg tatgagtgac agtttctaag aaactgtaag
     3601 ggaagcactc cctctgctga ctgtgacaag ctgactgtga caaggcatgg taaaccggaa
     3661 gccacagctc atacatctgc taggtcagtc ccctgaactc tgtaagggaa gaaagtcagg
     3721 caaggtcaca gaggcactgg ccagagcatg actaggccca gcatctccct ctacttgagg
     3781 acttcagctt tctgggccaa ggatgctggt tttgatgggc taaagctcct gaaactgaac
     3841 aaaccaacca cgggggcaaa ggaaacaaaa ttcagctaat gctgtcagct agaggctctg
     3901 tagagccttg ataatgtcag tcacgagaaa gatggcttgc cctaaattta aaattacata
     3961 aaaaaacagc attttaagta ttgtgagcta catcttgttg ccattattgt cacgactgaa
     4021 aagaagatgc aacagttgac atttgcatgg ttttgtaaca tgtaatagaa gctttctttt
     4081 ttactttggc caggtttata ggttgcttat tcagtctgaa gttataaata gtaacatgat
     4141 aaaattacga agttagggca gaaaataaaa atagtagttt ccgtattaca tctcatgtga
     4201 tctcgtgtgt ttctagggat ggtactcagg actttggaca atctgggcca gagtgctacc
     4261 actggcctgg gccctcagcc tctggaagct attatttgag tcagtggttg attttaatga
     4321 attaacagct gagtcagaac ccactaagga ggtagaagat ttgaaacatc agctgaactt
     4381 agtacatcat gtgatcttcc aacttaacaa ctacgaatct ttattcaata atgcagttag
     4441 tattcattaa ttttgcatcg atagacttag ggaactttgt gttgaattta taaatgttct
     4501 tactaaccag ctaaaattta cattttcaag gtgttggaaa ccacagctgt gaaactctac
     4561 ctggcattct agtcccatgg ttgtggaagt cctttgactt cacgctgtta ctggcttaag
     4621 agaccaagag atttgcgatt cctagcctgt ggtgagtgac cttagcctgg tgaccatagc
     4681 ctggtgacct tagcctggtc cttttctgtc actggtcagt caagtgtttg tcctctccat
     4741 aggaggtgac tgcttgagac cttgggaaga cagggctgga caagcagacc ttaaaggctt
     4801 tttatttcag gatgagcaga gtgatttaag actccttatg tgaagatata agcctcctca
     4861 tgtgaaagag gcattttttt tttgtctcag caagcacatc tcttactaaa aactcttttc
     4921 ttcatctgtt gaccctttat tccaatatat taagtccctc taccaactat tctcttgtta
     4981 atttaagcaa gttctaaata gatttataat atgctcactc ctacctcaag tgccagcttt
     5041 tcatgagtga atttggtgga gaattgagag aaaaatctca ttttctaggg acgggggatt
     5101 gcactgcaaa tgtgctagtc tcagagttcc gtgtctgcct taaaatcata tttctggtac
     5161 gattggaaca aactctaaac aaatacaaaa ctgtacttta aaaagagttg gtattttaaa
     5221 actctgagtc ttgagacact cccgtaaaca gcagacgctt ctaagttaat gtattatttt
     5281 tcttttcttt tctttggaaa aaaatagtgg aacgcacact aaagtttatt gtatctatcc
     5341 tgtgggatgt tctaggagct accctatgca tatgcaatgt ttctaacgat ctagggatgg
     5401 gagcatcaat gtaacacgat gtgtttttgt gtgtgcagtg tttgcacttg ggccggccca
     5461 tccggagcag ttgtgtcaga tgatttatac tgagtcggtt tcacaatgaa gcgctggctg
     5521 gcctggaact cctctatcga ccacatgcct ctctctctcc tgagtgttga gatgagaggc
     5581 gccaccacac ctggctacat ctgttttttc agggtttcag cctttcccta gccagtctgc
     5641 taactgtcac ttctcagtgg tcagagagag gcctccaaca catacctggt ttggtgcctg
     5701 tttactgtgg gcacggacag aaccacaccc attttcacac gtgtctaaaa tgggagaaaa
     5761 taggttcaga cagaggcccc aaaggccctg ctgtaagcaa atcatgtatg cttacattct
     5821 cagggatggt ttcttccaca agctatctct attttctaaa acttctagat tctcagcaga
     5881 gttccccatc agattatttg atatctacaa gtgctttcca ttattatgta aaaataaaag
     5941 ccgggtgcta atggtttcgg aggatagcag taagaataac attctcttga actaa
//
