LOCUS       NM_011498               3113 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus basic helix-loop-helix family, member e40 (Bhlhe40),
            mRNA.
ACCESSION   NM_011498
VERSION     NM_011498.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3113)
  AUTHORS   Hendrix,S.V., Mreyoud,Y., McNehlan,M.E., Smirnov,A., Chavez,S.M.,
            Hie,B., Chamberland,M.M., Bradstreet,T.R., Webber,A.M.,
            Kreamalmeyer,D., Taneja,R., Bryson,B.D., Edelson,B.T. and
            Stallings,C.L.
  TITLE     BHLHE40 Regulates Myeloid Cell Polarization through IL-10-Dependent
            and -Independent Mechanisms
  JOURNAL   J Immunol 212 (11), 1766-1781 (2024)
   PUBMED   38683120
  REMARK    GeneRIF: BHLHE40 Regulates Myeloid Cell Polarization through
            IL-10-Dependent and -Independent Mechanisms.
REFERENCE   2  (bases 1 to 3113)
  AUTHORS   Nguyen,C., Kudek,M., Zander,R., Niu,H., Shen,J., Bauer,A.,
            Alson,D., Khatun,A., Chen,Y., Sun,J., Drobyski,W., Edelson,B.T. and
            Cui,W.
  TITLE     Bhlhe40 Promotes CD4+ T Helper 1 Cell and Suppresses T Follicular
            Helper Cell Differentiation during Viral Infection
  JOURNAL   J Immunol 212 (11), 1829-1842 (2024)
   PUBMED   38619295
  REMARK    GeneRIF: Bhlhe40 Promotes CD4+ T Helper 1 Cell and Suppresses T
            Follicular Helper Cell Differentiation during Viral Infection.
REFERENCE   3  (bases 1 to 3113)
  AUTHORS   Lin,L., Qiang,Z., Chen,K., Huo,Y., Liu,W. and Yang,J.
  TITLE     DEC1 deficiency protects against bone loss induced by ovariectomy
            through inhibiting inflammation
  JOURNAL   J Biomed Res 38 (6), 1-16 (2024)
   PUBMED   38807374
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 3113)
  AUTHORS   Podlesny-Drabiniok,A., Novikova,G., Liu,Y., Dunst,J., Temizer,R.,
            Giannarelli,C., Marro,S., Kreslavsky,T., Marcora,E. and Goate,A.M.
  TITLE     BHLHE40/41 regulate microglia and peripheral macrophage responses
            associated with Alzheimer's disease and other disorders of
            lipid-rich tissues
  JOURNAL   Nat Commun 15 (1), 2058 (2024)
   PUBMED   38448474
  REMARK    GeneRIF: BHLHE40/41 regulate microglia and peripheral macrophage
            responses associated with Alzheimer's disease and other disorders
            of lipid-rich tissues.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3113)
  AUTHORS   Hu,X., Zou,M., Zheng,W., Zhu,M., Hou,Q., Gao,H., Zhang,X., Liu,Y.
            and Cheng,Z.
  TITLE     Bhlhe40 deficiency attenuates LPS-induced acute lung injury through
            preventing macrophage pyroptosis
  JOURNAL   Respir Res 25 (1), 100 (2024)
   PUBMED   38402153
  REMARK    GeneRIF: Bhlhe40 deficiency attenuates LPS-induced acute lung
            injury through preventing macrophage pyroptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3113)
  AUTHORS   Beadling,C., Cereseto,A., Fan,W., Naramura,M. and Smith,K.A.
  TITLE     Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase
            transition and promotes cellular survival
  JOURNAL   Oncogene 20 (14), 1771-1783 (2001)
   PUBMED   11313924
REFERENCE   7  (bases 1 to 3113)
  AUTHORS   Sun,H., Mattei,M.G. and Taneja,R.
  TITLE     Assignment of stra13 to the sub-telomeric region of mouse
            chromosome 6 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 211-212 (1999)
   PUBMED   10702671
REFERENCE   8  (bases 1 to 3113)
  AUTHORS   Boudjelal,M., Taneja,R., Matsubara,S., Bouillet,P., Dolle,P. and
            Chambon,P.
  TITLE     Overexpression of Stra13, a novel retinoic acid-inducible gene of
            the basic helix-loop-helix family, inhibits mesodermal and promotes
            neuronal differentiation of P19 cells
  JOURNAL   Genes Dev 11 (16), 2052-2065 (1997)
   PUBMED   9284045
REFERENCE   9  (bases 1 to 3113)
  AUTHORS   Dear,T.N., Hainzl,T., Follo,M., Nehls,M., Wilmore,H., Matena,K. and
            Boehm,T.
  TITLE     Identification of interaction partners for the
            basic-helix-loop-helix protein E47
  JOURNAL   Oncogene 14 (8), 891-898 (1997)
   PUBMED   9050988
REFERENCE   10 (bases 1 to 3113)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153593.4.
            
            On Apr 28, 2007 this sequence version replaced NM_011498.3.
            
            Summary: This gene encodes a basic helix-loop-helix protein
            expressed in various tissues. The encoded protein can interact with
            Arntl or compete for E-box binding sites in the promoter of Per1
            and repress Clock/Arntl's transactivation of Per1. This gene is
            believed to be involved in the control of circadian rhythm and cell
            differentiation. [provided by RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048242.1, BC010720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC153593.4         104942-105305       c
            365-434             AC153593.4         104704-104773       c
            435-542             AC153593.4         104322-104429       c
            543-666             AC153593.4         103290-103413       c
            667-3113            AC153593.4         99009-101455        c
FEATURES             Location/Qualifiers
     source          1..3113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.85 cM"
     gene            1..3113
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /note="basic helix-loop-helix family, member e40"
                     /db_xref="GeneID:20893"
                     /db_xref="MGI:MGI:1097714"
     exon            1..364
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1520
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /note="basic helix-loop-helix domain containing, class B2;
                     E47 interaction protein 1; class B basic helix-loop-helix
                     protein 2; stimulated by retinoic acid gene 13 protein;
                     eip1 (E47 interaction protein 1); cytokine response gene
                     8; differentially expressed in chondrocytes protein 1"
                     /codon_start=1
                     /product="class E basic helix-loop-helix protein 40"
                     /protein_id="NP_035628.1"
                     /db_xref="CCDS:CCDS20400.1"
                     /db_xref="GeneID:20893"
                     /db_xref="MGI:MGI:1097714"
                     /translation="MERIPSAQPPPTCLPKAPGLEHGDLSGMDFAHMYQVYKSRRGIK
                     RSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLK
                     HVKALTNLIDQQQQKIIALQSGLQAGDLSGRNLEAGQEMFCSGFQTCAREVLQYLAKH
                     ENTRDLKSSQLVTHLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKN
                     CVPVIQRTFAPSGGEQSGSDTDTDSGYGGELEKGDLRSEQPYFKSDHGRRFAVGERVS
                     TIKQESEEPPTKKSRMQLSEEEGHFAGSDLMGSPFLGPHPHQPPFCLPFYLIPPSATA
                     YLPMLEKCWYPTSVPVLYPGLNTSAAALSSFMNPDKIPTPLLLPQRLPSPLAHSSLDS
                     SALLQALKQIPPLNLETKD"
     exon            365..434
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /inference="alignment:Splign:2.1.0"
     exon            435..542
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /inference="alignment:Splign:2.1.0"
     exon            543..666
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /inference="alignment:Splign:2.1.0"
     exon            667..3113
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2935..2940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /note="hexamer: AATAAA"
     regulatory      2940..2945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /note="hexamer: AATAAG"
     polyA_site      2958
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
     polyA_site      2967
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /note="major polyA site"
     regulatory      3084..3089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
                     /note="hexamer: ATTAAA"
     polyA_site      3110
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1;
                     Sharp2; Stra13; Stra14"
ORIGIN      
        1 attcacttgg ctcgcacggc gcagacagcg cagcgagcac acaccgccag tctgtgtgca
       61 gagcgggagc cagaagccgt ggggacaccc ggccatgcac gcccccaact gaagcgacac
      121 ctcaaagccg ctgctcctgg catcccagcg cattgcaagg aagctcaggc tagctcatag
      181 gaacatacct cttgagaccc tcggatcctc ccttccaggg cagccctttc tcagactcta
      241 ctaagtgcag acaggagcgc acagtggccc ctgctcgccg catcatggaa cggatcccca
      301 gcgcgcaacc acctcctacc tgcctgccca aagctccagg gctggagcac ggagacctgt
      361 cagggatgga ttttgcccac atgtaccaag tgtacaagtc caggcgggga ataaaacgga
      421 gcgaagacag caaggaaact tacaaactgc cgcaccggct gattgagaaa aagagacgtg
      481 accggattaa cgagtgcatt gcccagctga aggatctcct acccgaacat ctcaaactta
      541 ctactttggg tcacttggaa aaagcagtgg ttctggagct tacgttgaag cacgtgaaag
      601 cattgacaaa tctaattgat cagcagcagc agaaaatcat tgccctgcag agcggtttac
      661 aagctggtga tttgtcggga agaaatctcg aggcagggca agaaatgttc tgctcaggtt
      721 tccagacttg tgcccgtgag gtacttcagt acctggcgaa gcatgagaac actcgggacc
      781 tgaaatcttc ccagctcgtc actcatctcc atcgtgtggt ctcggagctg ctgcagggtg
      841 gtgcttccag gaaaccattg gactcggctc ccaaagccgt ggacttgaaa gagaagccca
      901 gcttcctagc caagggatca gaaggccctg ggaaaaactg tgtgccagtc atccagcgga
      961 cttttgctcc ctcgggtggg gagcagagcg gcagtgacac ggacacagac agtggctatg
     1021 gaggtgaatt ggagaagggg gacttgcgca gtgagcagcc gtacttcaaa agcgaccatg
     1081 gacgcaggtt cgccgtggga gaacgtgtca gcacaattaa gcaagaatcc gaagagcccc
     1141 ccaccaaaaa gagccgaatg cagctctcag aagaggaagg ccacttcgcg ggcagtgatc
     1201 tgatgggttc cccatttctt gggccacacc cacatcagcc tcctttttgc cttcccttct
     1261 atctcatccc accatcggcc actgcctacc tgcctatgct ggagaaatgc tggtacccca
     1321 cctctgtgcc agtgttatac ccaggcctca acacctcagc tgcagccctc tccagcttca
     1381 tgaacccaga caagataccg actcccttgc ttctgcccca gagactccct tctcctttgg
     1441 cacattcgtc cctcgactct tcggccttgc tccaggcttt gaagcagatc cctcctttaa
     1501 acttagaaac caaagactaa actctggagg gatctcctgc tgccttgctt tctttcctcc
     1561 ctaattccaa aaaccacaaa ggtttccctg agtgcagaga gatcagccca ccctgcagac
     1621 ccacagagaa gattcagagt gtgtgtgaga gtgagtgagt gtgcgtgcgt gcgtgcttgt
     1681 atgtatgttt gtatatgtag gacaataagt tccttctgac acaagggaga cacgagaagg
     1741 atagcctgac atcagatgac agactggagg actgtagcac atctctgggc gtttccctac
     1801 ccagagaaga gcccccccct ttgatacaaa tcggttggat tttcatatgc ttcaaaggct
     1861 tgatctgtga gtcactctcc agtttgggac atgggtctgt ctgtggcttt gagaaaaggt
     1921 actttcaaaa gagggctttc cagagcacag ctcacagcca gctgttagga ccccaccctt
     1981 ctccctttat tgtggaggtg actcacagca gactgacagt ggtcaggctg agctttctgc
     2041 taaggtggtg aggtcgccaa cactggcatg tctcggtagt ggtttgggca aatttctgca
     2101 ggtcccttcc ccccaacccc gtctctgatg aataaagacc atgagtggag ttccttaact
     2161 caggcttttg tgagtagttt actaaggaac tgaaaatggt cccctttgtc caagctgagc
     2221 tgctagggaa tcaaggtgaa ctagacccgt cctcaggcct ctggcacctg tttctagctc
     2281 tcacttctac ggcatgctgt ccaaggaacc aaaggaggct ctcggagatg cccccaaacg
     2341 tcccaaagta cacagagcta agtaatcaat tgctacactt attgcacagc tagacacgga
     2401 tttcaagtgt atcctaaagc tttgaaccaa gcttagcttc tcaaaggcct agcagagctt
     2461 tggcacccca agatcctttc tgtaggctat ttcctcttgc ccagcagtgg atggagcgtc
     2521 cttgctaaaa agggttccat ctcctttaag gacgttttat ttttgatcca gagtccttgt
     2581 ttccttgact tgctccacca gccctgcacc agctttccaa atgcactctg cttgtgttga
     2641 aattctccca tttttatttg ggcataaaag ttgttgcctt tatttgtaaa gctgttataa
     2701 atatatatta tataaatata tgacaaagga aaatgtttca gatgtctatt tgtataatta
     2761 cttgatctac acagtgagga aaaaaatgaa tgtatttctg tttttgaaga gaataatttt
     2821 tttctctagg gagaggcgag gttacagtgt ttatattttg gaaccttcct gaaggtgtga
     2881 aattgtaaat atttttatct aagtaaatgt taagcagttg ttttaaaaat acttaataaa
     2941 ataagctttt ttcctgtgga agagaaatgg tctccttggt tttaaaaata acttagtgtc
     3001 acggtacttt ctctgtcctc tcaactgagg acagtgacta gttaatcttg acataattgc
     3061 atttggcttg tcatgtgcct ggcattaaaa acaatattga gttcacataa tag
//
