LOCUS       NM_080641               2520 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus basic helix-loop-helix family, member e23 (Bhlhe23),
            mRNA.
ACCESSION   NM_080641
VERSION     NM_080641.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Guo,Q. and Li,J.Y.H.
  TITLE     Defining developmental diversification of diencephalon neurons
            through single cell gene expression profiling
  JOURNAL   Development 146 (12) (2019)
   PUBMED   30872278
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Woods,S.M., Mountjoy,E., Muir,D., Ross,S.E. and Atan,D.
  TITLE     A comparative analysis of rod bipolar cell transcriptomes
            identifies novel genes implicated in night vision
  JOURNAL   Sci Rep 8 (1), 5506 (2018)
   PUBMED   29615777
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Liu,B., Zhou,K., Wu,X. and Zhao,C.
  TITLE     Foxg1 deletion impairs the development of the epithalamus
  JOURNAL   Mol Brain 11 (1), 5 (2018)
   PUBMED   29394901
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Iida,A., Iwagawa,T., Baba,Y., Satoh,S., Mochizuki,Y., Nakauchi,H.,
            Furukawa,T., Koseki,H., Murakami,A. and Watanabe,S.
  TITLE     Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation
            and differentiation
  JOURNAL   Dev Neurobiol 75 (9), 947-960 (2015)
   PUBMED   25556712
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 2520)
  AUTHORS   Pang,J.J., Abd-El-Barr,M.M., Gao,F., Bramblett,D.E., Paul,D.L. and
            Wu,S.M.
  TITLE     Relative contributions of rod and cone bipolar cell inputs to AII
            amacrine cell light responses in the mouse retina
  JOURNAL   J Physiol 580 (Pt. 2), 397-410 (2007)
   PUBMED   17255172
REFERENCE   7  (bases 1 to 2520)
  AUTHORS   Zhang,C.L., Zou,Y., Yu,R.T., Gage,F.H. and Evans,R.M.
  TITLE     Nuclear receptor TLX prevents retinal dystrophy and recruits the
            corepressor atrophin1
  JOURNAL   Genes Dev 20 (10), 1308-1320 (2006)
   PUBMED   16702404
REFERENCE   8  (bases 1 to 2520)
  AUTHORS   Bramblett,D.E., Pennesi,M.E., Wu,S.M. and Tsai,M.J.
  TITLE     The transcription factor Bhlhb4 is required for rod bipolar cell
            maturation
  JOURNAL   Neuron 43 (6), 779-793 (2004)
   PUBMED   15363390
REFERENCE   9  (bases 1 to 2520)
  AUTHORS   Zhou,C.J., Pinson,K.I. and Pleasure,S.J.
  TITLE     Severe defects in dorsal thalamic development in low-density
            lipoprotein receptor-related protein-6 mutants
  JOURNAL   J Neurosci 24 (35), 7632-7639 (2004)
   PUBMED   15342729
REFERENCE   10 (bases 1 to 2520)
  AUTHORS   Bramblett,D.E., Copeland,N.G., Jenkins,N.A. and Tsai,M.J.
  TITLE     BHLHB4 is a bHLH transcriptional regulator in pancreas and brain
            that marks the dimesencephalic boundary
  JOURNAL   Genomics 79 (3), 402-412 (2002)
   PUBMED   11863370
  REMARK    GeneRIF: BHLHB4 may modulate the expression of genes required for
            the differentiation and/or maintenance of pancreatic and neuronal
            cell types.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051155.1, AK044215.1 and BE986685.1.
            
            On Apr 26, 2009 this sequence version replaced NM_080641.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1626              AK051155.1         2-1627
            1627-2213           AK044215.1         1627-2213
            2214-2520           BE986685.1         64-370
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.34 cM"
     gene            1..2520
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
                     /note="basic helix-loop-helix family, member e23"
                     /db_xref="GeneID:140489"
                     /db_xref="MGI:MGI:2153710"
     exon            1..2520
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..829
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
                     /note="class B basic helix-loop-helix protein 4; basic
                     helix-loop-helix domain containing, class B4; beta-cell
                     E-box transactivating factor 4"
                     /codon_start=1
                     /product="class E basic helix-loop-helix protein 23"
                     /protein_id="NP_542372.2"
                     /db_xref="CCDS:CCDS17187.1"
                     /db_xref="GeneID:140489"
                     /db_xref="MGI:MGI:2153710"
                     /translation="MAELKSLSGDSYLALSHSYTATGHAYAAARGPETTRGFGASGPG
                     GDLPAAPASRVPAATVESSGEQSGDEDEAFERRRRRRGSGVAVDARRRPREQRSLRLS
                     INARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMR
                     RLVAYLNQGQGLAAPVAAAPLTPFGQAAIYPFSAGTALGPCPDKCATFSGSPSALCKH
                     CGEKP"
     regulatory      1954..1959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
                     /note="hexamer: CATAAA"
     polyA_site      1969
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
     polyA_site      1972
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
                     /note="major polyA site"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
                     /note="hexamer: ATTAAA"
     polyA_site      2251
                     /gene="Bhlhe23"
                     /gene_synonym="A930001L02Rik; Beta3b; BETA4; Bhlhb4"
ORIGIN      
        1 agagcggccc cggccggcca cgcgccttgg tgagaaggcg caggaagggt ggccggccgg
       61 agaggccacg cgcaggcccg gggactgaca gacagctgga caggtggacg cgcccgcagg
      121 gcaagaagcc atactgccgt agcgggctcc agaggtcatg gccgagctca agtcgctgtc
      181 gggggactcg tacctggcgc tgagccacag ctacacggcg accggccacg cctacgctgc
      241 agcgcgcgga ccggagacca cacgcggctt cggtgcatcg ggtccgggtg gcgacctccc
      301 ggcggctccc gcttctcgtg tccccgccgc gacggtggag agcagcggcg agcagagcgg
      361 cgacgaggac gaagccttcg agaggcggcg gcggcggcga gggtccgggg ttgcggttga
      421 cgcacggcgg cggccccggg agcagcgctc gctgaggctc agcatcaacg cgcgcgaacg
      481 gcgacgcatg catgacctga acgacgcgct ggacggactg cgcgcagtca tcccctacgc
      541 gcacagcccg tcggtgcgca agctctccaa gatagccaca cttctgctgg ccaaaaacta
      601 catcctcatg caggcgcagg ccctggagga gatgcggcgc ttggtagcat acctcaacca
      661 aggccagggc ctcgcggcgc cggtggccgc cgcgcctcta acgccctttg gccaggcagc
      721 gatttacccg ttctcggcgg gcaccgcgct cgggccctgc ccagacaagt gtgccacctt
      781 ctcaggatcg ccctcggcgc tttgcaaaca ctgcggcgag aagccctgag ggctccgatc
      841 ccctctgcag ccgcctttct atttagactg ttccctgtcc tcgctggcgg gactctatga
      901 gaaagcccag tactccgctt acagaactgt tgggtgcaga atgagaagtc cgtctgagaa
      961 agccagagag ttggcgctgg actctagacc ctgccgcatc cactgaacta tctcagctaa
     1021 aaggctacgg gagtgagcag ttagtgaatg gtcccacatc tgacaggtga ctgcccaagg
     1081 ctcaggagcg caggcacaga gcatcgcgct tgaccacatc ctagcgttgg atggggaacc
     1141 cagccccttc taagccaact tgcagggcct tgcttgcttc aactagacct gttcctcagg
     1201 acgggtgcgg cccctcacct cgggcctctg ttggctccaa gactccagac ccggcctaaa
     1261 agcaaaatta cgccgaggtc ctttggagag gtcgtggagg cagacgcagg aagatcccag
     1321 gaggtgagct ttacaacgtt ttccaagtct gagcttgttc tgttaacatt cttgcctgcc
     1381 cagaggctca ggaaattcaa gccagcctca aaagtctgtg gaaacatctc taaataagcc
     1441 tggagcgcca ccgccggcct cctgtgggct gagctgggtt tcacttcttt ctacttgtcc
     1501 caaggggact ggtggagccc tcacaacctg ctcagggcta cttgaccctg gagggtcagc
     1561 cgaagagtct agtctagctc caggaccaac caagtcccct ctgcgccagt tcgggaactt
     1621 ctggaggaag ccgggctacc ggtgagtacc cggtgaggtg ttggactgaa tgggaactgg
     1681 tcgctcccca aatcggacca cagcccagaa tcctgccact gtacctagtc tgagccttag
     1741 cccgcgcgtc tcagatgttg cctggttttc ctctgtggcc atcagcagct tccgcctcca
     1801 tttacccagt tttcttggct ttcattgatg caaagcaaat cgggagaggg ccactgctca
     1861 gcaaagcgcc tgtctatagc gcttaacttg aattaacgca ttggaaaagg cccttttgta
     1921 tttgcaaaat gacgtgtgtg attaagtctt attcataaag acgtatgctt aatactggtt
     1981 tctgctaatt tctatttttt atttcttaag tgtctttccc ctcccctaaa ataatctatt
     2041 ttgcacattt caaaacagac tgtttttcaa gttcgcttaa gatgaacagg gaaaactgga
     2101 aactcaagtg ttgttagctc tggggtcatt acccactatt atttttcaaa gtcttttatt
     2161 tatatttaga cgaggggtag tgtgcagaat aaagtactta aaacttattt ttttaaaaat
     2221 atgattaaaa tttaatatca aattaagtgt acatctatga tttgattcat aatttcaatt
     2281 gtcagacagt gatactggtt tggaatcctt ctacggcccc aagaaatgct gagattttac
     2341 aatggatcca tactccatta agagatgtgt gagttcatac gaaaaatgtg taggagtgtt
     2401 gggtggagac acaggggtga tcccaacctg caggaggcag agacaggggc atggggattc
     2461 tgagaccagc ctgagcaaca cagggaggct ctcttaggac aagaaaacaa ttaactttga
//
