LOCUS       NM_021560               3207 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus basic helix-loop-helix family, member e22 (Bhlhe22),
            mRNA.
ACCESSION   NM_021560
VERSION     NM_021560.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Conrad,L.J., Grandi,F.C., Carlton,A.J., Jeng,J.Y., de Tomasi,L.,
            Zarecki,P., Marcotti,W., Johnson,S.L. and Mustapha,M.
  TITLE     The upregulation of K+ and HCN channels in developing spiral
            ganglion neurons is mediated by cochlear inner hair cells
  JOURNAL   J Physiol 602 (20), 5329-5351 (2024)
   PUBMED   39324853
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Alderman,P.J., Saxon,D., Torrijos-Saiz,L.I., Sharief,M., Page,C.E.,
            Baroudi,J.K., Biagiotti,S.W., Butyrkin,V.A., Melamed,A., Kuo,C.T.,
            Vicini,S., Garcia-Verdugo,J.M., Herranz-Perez,V., Corbin,J.G. and
            Sorrells,S.F.
  TITLE     Delayed maturation and migration of excitatory neurons in the
            juvenile mouse paralaminar amygdala
  JOURNAL   Neuron 112 (4), 574-592 (2024)
   PUBMED   38086370
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   4  (bases 1 to 3207)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3207)
  AUTHORS   Galazo,M.J., Sweetser,D.A. and Macklis,J.D.
  TITLE     Tle4 controls both developmental acquisition and early post-natal
            maturation of corticothalamic projection neuron identity
  JOURNAL   Cell Rep 42 (8), 112957 (2023)
   PUBMED   37561632
REFERENCE   6  (bases 1 to 3207)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   7  (bases 1 to 3207)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3207)
  AUTHORS   Brunelli,S., Innocenzi,A. and Cossu,G.
  TITLE     Bhlhb5 is expressed in the CNS and sensory organs during mouse
            embryonic development
  JOURNAL   Gene Expr Patterns 3 (6), 755-759 (2003)
   PUBMED   14643684
  REMARK    GeneRIF: Localization of Bhlhb5 mRNA expression in the central
            nervous system and sensory organs of the mouse embryo.
REFERENCE   9  (bases 1 to 3207)
  AUTHORS   Xu,Z.P., Dutra,A., Stellrecht,C.M., Wu,C., Piatigorsky,J. and
            Saunders,G.F.
  TITLE     Functional and structural characterization of the human gene
            BHLHB5, encoding a basic helix-loop-helix transcription factor
  JOURNAL   Genomics 80 (3), 311-318 (2002)
   PUBMED   12213201
  REMARK    GeneRIF: Mouse Bhlhb5 can strongly repress a human PAX6 promoter.
            A single exon encodes a 355-amino-acid bHLH protein.
REFERENCE   10 (bases 1 to 3207)
  AUTHORS   Kim,M.H., Gunnersen,J., Augustine,C. and Tan,S.S.
  TITLE     Region-specific expression of the helix-loop-helix gene BETA3 in
            developing and adult brains
  JOURNAL   Mech Dev 114 (1-2), 125-128 (2002)
   PUBMED   12175497
  REMARK    GeneRIF: BETA3 function is linked to the establishment rather than
            the initiation of neuronal fates
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC053007.1.
            
            On Mar 19, 2008 this sequence version replaced NM_021560.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC053007.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 4.98 cM"
     gene            1..3207
                     /gene="Bhlhe22"
                     /gene_synonym="Beta3; Beta3a; Bhlhb5"
                     /note="basic helix-loop-helix family, member e22"
                     /db_xref="GeneID:59058"
                     /db_xref="MGI:MGI:1930001"
     exon            1..3190
                     /gene="Bhlhe22"
                     /gene_synonym="Beta3; Beta3a; Bhlhb5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe22"
                     /gene_synonym="Beta3; Beta3a; Bhlhb5"
                     /note="hexamer: AATAAA"
     polyA_site      2558
                     /gene="Bhlhe22"
                     /gene_synonym="Beta3; Beta3a; Bhlhb5"
                     /note="major polyA site"
     regulatory      3169..3174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhe22"
                     /gene_synonym="Beta3; Beta3a; Bhlhb5"
                     /note="hexamer: ATTAAA"
     polyA_site      3188
                     /gene="Bhlhe22"
                     /gene_synonym="Beta3; Beta3a; Bhlhb5"
ORIGIN      
        1 gttaacctga ttgggtagaa agcgctgtcc caacaggcga gtcttcttca taataaccta
       61 ctcagagata atgatgtaaa agactccccc gtctgtggcg gcggctggtt gatgggtccg
      121 gaaatctctt gaaggtgaat ccaagcaaga taaacggtgc gtagagcagg cgcgggattg
      181 gactcagagg cggtagcggc ggcagccccg ctccctccga gaccagcctc ccaccatgag
      241 gggccgcggc ccatggtgag ccttagcagc cagcaccgtc ggctggagac gaagaagaag
      301 aagaagagga ggcggcgagc gcgggggaag gcgaaaaaga aaaagaaggg gacagggctg
      361 cgggcagcgt ggggaccgac gcacgcagca gctccggaac cccgccggcg cgcgtctgtg
      421 cggccgcctg actctccagc ccaggtggcg gctggcccgg acgatggaac gcgggttgca
      481 cctcggtgcg gcggccgcga gcgaagacga cctcttcctg cacaagagcc tgggcacctc
      541 cgccgccaag cgcctggagg cggcttttcg ctccacaccc ccgggcatgg acctgtccct
      601 ggcgcctcca actcgcgaac gcccggcgtc gtcctcgtcg cccctcggct gtttcgagcc
      661 cgctgatccc gaaggggctg ggctgctgct gcctccgccc ggaggaggcg gtggcgcgag
      721 cggcggcggc ggcggggtga gtgtcccggg gctgctcgtg ggctcagcgg gcgtgggggg
      781 cgagccgagc ctgagcagcc tgccggcggg ggctgccctg tgcctcaagt acggcgagag
      841 cgccggacgc ggctccgtgg ccgagagcag cgggggcgag cagagccccg acgacgacag
      901 cgacggccgc tgcgagctgg tgctgcgagc cgggggcccc gacccgcggg catcgccggg
      961 agcggggggc ggcagcgcca aggtggccga gggctgctcc aacgcccact tgcatggtgg
     1021 ctcgggcctc cccccggggg gccccacaag tggcggcgga agcggcggcg gtggcggcgg
     1081 cagcagcaag aaatccaaag agcagaaggc gttgcgcctc aacatcaacg ctcgcgagcg
     1141 ccggaggatg cacgacctga acgacgctct ggatgagctg cgcgcggtca ttccttacgc
     1201 gcacagccct tcagtgcgga agctctccaa aatcgccacg ctgctcctcg ccaagaacta
     1261 catcctcatg caggcacagg ccctggagga aatgcggcgc ttagtcgcct acctcaacca
     1321 aggccaggcc atctcggcag cctctcttcc cagctccgcg gccgcggctg cggcggccgc
     1381 tgccctgcac ccggcgctcg gcgcctacga gcaggcggcc ggctacccgt tcagtgcagg
     1441 gctgccgccc gctgcctcct gccccgagaa gtgtgcccta ttcaacagcg tctcgtccag
     1501 cctctgcaaa cagtgcacgg agaagcctta aacactccct tcttcgaaaa cctcgagacc
     1561 gaccccaaag ctagaggaaa gtgagaagct gctccccatt ccttttcctt tggtcctctc
     1621 ctaagttgtg aaacacttgc agggcaaaca aagcagaggc aggaacttag aagtatcaga
     1681 gacaaaccgg acattcagcc ttggcaagcc cggaatctcg gtctttgggg tggggaggga
     1741 ggggagaggg aggtttagtg cggatgaagt gtgcttcctt tttcccctca gaaaagtggc
     1801 aactttggtg gctccctaga tctcaaggaa gtacagtctt ctttggaggc gaaaataagt
     1861 tgaaaagtag tgcttgatta ttagacgaga aaagtactga gtggcaaaat actaatccta
     1921 ctaacacctg acaattggca agtgatgaaa gggagagggg ttcagagttg agaggctcgg
     1981 ggacagaata ttcattcaga caaatcagaa agggcactcg aaaatacatc ttgattctga
     2041 gccaggagaa aaacttgaaa tgcagacttt atttaagtgg aggggaaagc agagagacat
     2101 gttgctatga aagacttgta ttttttattg tctctgaact taaaattccg tgaaaatgct
     2161 caaagttttg gtgagagtga tattaaaaag caggctgtgg ctgaaagaat tgcatttaaa
     2221 atatttatgt gcaccttgtt gctttctact ctgcaatgat gtattaacaa tttatggtat
     2281 ttatttgtta ttcttcaatg atccacatca accgtattta ttatgtgtta aggtattggg
     2341 tcttaagtgt agattttttt aatgcttcta aaattctgtt ttatatatta acttacactg
     2401 tgtgcctagt gttcaaaggg tatatttgcc aacaaatatg aagagaaata ttgatgtatc
     2461 tgagctgctg aggtttttga aagggcattg gatattttca gttgcatcgt ccatgtattt
     2521 aaattgagct ttaataaatt gcttcagtcc aaaaattaca ggaaaggtgt attcttaatt
     2581 gatgaatgaa ttgatctctt ttccaaaagg ggacctattt gcattccaaa acagaaaaac
     2641 atcacagcaa tagattttac aagtaagaac atactaggca aatatatttt tcaggttgtg
     2701 ctgtgcattt taaaaggtct aatttaattg tttttaatat agatgtacat atataagtta
     2761 ttcctcctgt gatgacttat taagttaaaa gactggtttc atttgcttat ggtgtgaaat
     2821 cctttgttat ttttctaaga aaaataaaat ttaaaagaca tgaaatgaag ctacggaaga
     2881 ggaagaagct atttacccaa agcgagcttt cagttttagt ttgcatggcg atctgcctgc
     2941 ctttcctcct gtgaaaatcc agaacacccc cttttaaaat ggagtcttgc tattttccac
     3001 tccttacaga taatacaaat tcagtttgtc tggtgatttc agagctatga tggatctatc
     3061 agttggtttt ggatgtgtaa agaatgatat atatattaaa taggtcaatc agactatgac
     3121 agctatgtac gaccatttgt atgtgtatct atgtcagaaa gaatctttat taaaatattt
     3181 tgatcaaaca aaaaaaaaaa aaaaaaa
//
