LOCUS       NM_198161               2747 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus basic helix-loop-helix domain containing, class B9
            (Bhlhb9), transcript variant 1, mRNA.
ACCESSION   NM_198161
VERSION     NM_198161.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Zhou,J., McCarrey,J.R. and Wang,P.J.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Manavalan,A., Mishra,M., Sze,S.K. and Heese,K.
  TITLE     Brain-site-specific proteome changes induced by neuronal P60TRP
            expression
  JOURNAL   Neurosignals 21 (3-4), 129-149 (2013)
   PUBMED   23391701
  REMARK    GeneRIF: Our data suggests that in vivo overexpression of neuronal
            p60TRP significantly affects cognitive and neuroprotective
            capacities.
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Mishra,M., Manavalan,A., Sze,S.K. and Heese,K.
  TITLE     Neuronal p60TRP expression modulates cardiac capacity
  JOURNAL   J Proteomics 75 (5), 1600-1617 (2012)
   PUBMED   22172954
  REMARK    GeneRIF: in vivo neural over-expression of transgenic p60TRP with
            its neuroprotective therapeutic potential significantly affects
            cardiovascular capacities.
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Mishra,M. and Heese,K.
  TITLE     P60TRP interferes with the GPCR/secretase pathway to mediate
            neuronal survival and synaptogenesis
  JOURNAL   J Cell Mol Med 15 (11), 2462-2477 (2011)
   PUBMED   21199326
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683822.8.
            
            On Jul 18, 2022 this sequence version replaced NM_198161.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.350378.1,
                                           SRR13948564.3850362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AL683822.8         142068-142238
            172-253             AL683822.8         142986-143067
            254-310             AL683822.8         143402-143458
            311-418             AL683822.8         144513-144620
            419-2747            AL683822.8         144892-147220
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.31 cM"
     gene            1..2747
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /note="basic helix-loop-helix domain containing, class B9"
                     /db_xref="GeneID:70237"
                     /db_xref="MGI:MGI:1917487"
     exon            1..171
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /inference="alignment:Splign:2.1.0"
     exon            172..253
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /inference="alignment:Splign:2.1.0"
     exon            254..310
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..418
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..2747
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             709..2328
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /note="protein BHLHB9"
                     /codon_start=1
                     /product="G protein-coupled receptor associated sorting
                     protein 3"
                     /protein_id="NP_937804.1"
                     /db_xref="CCDS:CCDS30410.1"
                     /db_xref="GeneID:70237"
                     /db_xref="MGI:MGI:1917487"
                     /translation="MTGSKNKARAQAKLEKRASAQARAVAEREAANANRGAGKSRDKG
                     KGKAGSKSDAVAEVKAGSKGKVVAETKEGARPESKALVKGTSDFNHRTENKFARSTRK
                     DKPSSDNWFWAGEDSGINSWFWKGEELSNNSVAKCENKPSTSIQARAEEPAPRTSHKS
                     RSGAEEEEEENVIGNWFWEGDDTGFDTDPKPVFKIVKPQPVDEINEKDRPKDWSEVTI
                     WPKAPAVTPAVLGYRSQDSSEARSSSYIVLASNEEETSTACTKNTRSSLQSIPEYPFG
                     SDPCIQTLDEIRQQIKIREENGIKPFACPCKLECYLDSPEFEKLVNILKSTTDPLIHK
                     IAQIAMGIHKVHPFAQEFINEVGVVTLIESLLSFSSPEVSIKKAVITLNSSGDDRYNK
                     VEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVVSYFSELFHLLSQGNR
                     KTRNLVLKVFLNMSENPKAARDMINMKALAALKLIFNQKEAKANLVSAVAIFINIKEH
                     IRKGSIVVVDHLSYNTLTAIFREVKGIIERM"
     regulatory      2510..2515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /note="hexamer: AATAAA"
     polyA_site      2538
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /note="hexamer: AATAAA"
     polyA_site      2747
                     /gene="Bhlhb9"
                     /gene_synonym="2700087I09Rik; Gprasp3"
                     /note="major polyA site"
ORIGIN      
        1 ctgtttggtg cagagacgta ggggcgggac acgtctctgc cattccactc gcgcgcaaag
       61 cggtgggggt tctgtgagag gatccgccga ggacagagac cagccgggag caggaggggg
      121 acgcggggga gcccggacac ctgggccgtg cgcctggcca ggcaagtgga ggatccattt
      181 tctcaacatt tcaccttgaa catttgtttt aatgttcgaa tggacttaaa gtaaagaaga
      241 actttttgtg caggtcgact cttctccagc cagagggaag aatagcatct cccgagcatc
      301 ctgctttgtg ttctgctgcc tttgaagtca gttgggtggc ttttcatcag tggaagtgag
      361 gaaggaggaa ttcatcccat cacatcagca cactttagtg aagcctttct gaaaacctgt
      421 ctttctccac tggtagactt ggattgggag aagattgctt tcaacgggtc tgcctttgga
      481 aatcatcgtc ttctccctaa cctgagtgtg tctttaattt gtccctatcg ttgataagag
      541 actgtatgtc aaaaaagggg aatttcttaa cgactgaagt gacagttgtc ttggactctt
      601 tctgccaagt ttatctctga ctaagttaac aagtataaag tttccagccc ggaacaaaca
      661 gagaactaag gataagactc gacaggtgta tataactgtg cttcaaccat gactggttca
      721 aagaataagg ctagggcaca ggctaaacta gaaaaaaggg caagtgcaca agccagagct
      781 gtggcagaga gggaggctgc taatgccaac cgaggtgcag gcaaaagccg ggacaaaggg
      841 aaaggtaagg caggctctaa atcagatgca gtggcagagg tgaaggcagg gtctaaggga
      901 aaggtagttg ctgagacaaa agaaggagcg agaccagaat ctaaggctct agtaaaaggc
      961 acctcagatt tcaaccatag gactgagaac aagtttgcta gatccacacg taaagataag
     1021 cccagtagtg ataactggtt ctgggctgga gaagattctg gtattaattc ctggttctgg
     1081 aagggagaag agcttagtaa taattctgtt gctaagtgtg aaaataaacc tagtactagt
     1141 atccaggctc gtgctgagga gcccgcacct aggaccagcc acaagtctag gtcaggtgct
     1201 gaggaggagg aggaagagaa cgttattggg aactggtttt gggaaggcga tgacactggt
     1261 tttgatactg atcctaaacc tgtgttcaaa atagttaaac ctcagccagt ggatgaaatt
     1321 aatgaaaaag ataggccaaa ggactggtcc gaggtaacta tatggcccaa agctcctgct
     1381 gtaactccag cagtgttagg ttatagatcc caggattcat ctgaggcaag gtcctcttca
     1441 tacattgttc tggcctcaaa tgaagaggaa acttcaacag cctgtactaa gaatactcgt
     1501 tcaagcctac agtctatacc tgagtatcca tttggttctg atccttgcat ccagacctta
     1561 gatgaaatta gacagcaaat caagatcaga gaagagaatg gcatcaagcc cttcgcttgc
     1621 ccttgcaaac tggagtgcta tttggattct ccagaatttg aaaagcttgt taacatactt
     1681 aagtcaacta ctgatcctct tattcataaa atagcacaga ttgcaatggg tatacataag
     1741 gttcatccat ttgcccagga attcattaat gaagtgggcg tggtgacact tattgaaagc
     1801 ttgctcagtt tttcttcccc tgaggttagt attaaaaagg ctgtgattac tctgaactct
     1861 tccggggatg acagatacaa caaggtagag tttcatgtta agcatatgtg taaagaaact
     1921 gtgtccttcc ccttgaactc acctggccag caatctggat taaagataat agggcagctg
     1981 actaccgagt ctgtccatca ctacattgta gtcagctact tttcagagct tttccatttg
     2041 ctgtctcagg gaaatcgtaa gactaggaat cttgttttga aagtattttt gaatatgtct
     2101 gaaaatccca aggcagccag agatatgata aatatgaagg cgttagcagc attaaaactc
     2161 atctttaacc aaaaagaggc aaaagccaat cttgttagtg ctgtggccat ctttattaac
     2221 ataaaggagc atattagaaa gggttcaatt gtagtagtcg atcacttgag ttacaatact
     2281 cttacagcca tattccgtga agttaagggg attatcgaaa gaatgtaaag tgacccagaa
     2341 attaaagaga acactgaaca gtgtccaaaa tttgattggc tgtacatgcc caaagagttt
     2401 tgcataatat tttggtaatt actgctcaca catttttgtc ttaacatctt ttacatatta
     2461 ttacctgtgg caggttctag ctcaaagcta gaccattttt gatgtatcaa ataaatatta
     2521 acatcttgag ataaaaaagt ttattgattt ctatcttatc tagattagca aatttgtaac
     2581 attttactta aggaaactgt gatccaactc tcagaagtac tgtgtcttga gggttagtat
     2641 ctgcttagat ctgttggtgg ctccagagag caaaagagaa actactgctc ttgtaatcta
     2701 gttacagaaa taaggcatac gcaaataaag atatctgatg gtactta
//
