LOCUS       NM_177182               1225 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus basic helix-loop-helix family, member a9 (Bhlha9),
            mRNA.
ACCESSION   NM_177182
VERSION     NM_177182.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Bohic,M., Marics,I., Santos,C., Malapert,P., Ben-Arie,N., Salio,C.,
            Reynders,A., Le Feuvre,Y., Saurin,A.J. and Moqrich,A.
  TITLE     Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a
            Sexually Dimorphic Manner
  JOURNAL   Cell Rep 30 (3), 602-610 (2020)
   PUBMED   31968239
  REMARK    GeneRIF: Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked
            Pain in a Sexually Dimorphic Manner.
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Kataoka,K., Matsushima,T., Ito,Y., Sato,T., Yokoyama,S. and
            Asahara,H.
  TITLE     Bhlha9 regulates apical ectodermal ridge formation during limb
            development
  JOURNAL   J Bone Miner Metab 36 (1), 64-72 (2018)
   PUBMED   28324176
  REMARK    GeneRIF: that Bhlha9 regulates apical ectodermal ridge formation
            during limb/finger development.
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Schatz,O., Langer,E. and Ben-Arie,N.
  TITLE     Gene dosage of the transcription factor Fingerin (bHLHA9) affects
            digit development and links syndactyly to ectrodactyly
  JOURNAL   Hum Mol Genet 23 (20), 5394-5401 (2014)
   PUBMED   24852374
  REMARK    GeneRIF: Results show that Fingerin gene dosage links two different
            congenital limb malformations, syndactyly and ectrodactyly, which
            were previously postulated to share a common etiology.
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Klopocki,E., Lohan,S., Doelken,S.C., Stricker,S., Ockeloen,C.W.,
            Soares Thiele de Aguiar,R., Lezirovitz,K., Mingroni Netto,R.C.,
            Jamsheer,A., Shah,H., Kurth,I., Habenicht,R., Warman,M.,
            Devriendt,K., Kordass,U., Hempel,M., Rajab,A., Makitie,O.,
            Naveed,M., Radhakrishna,U., Antonarakis,S.E., Horn,D. and
            Mundlos,S.
  TITLE     Duplications of BHLHA9 are associated with ectrodactyly and tibia
            hemimelia inherited in non-Mendelian fashion
  JOURNAL   J Med Genet 49 (2), 119-125 (2012)
   PUBMED   22147889
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Kiso,M., Tanaka,S., Saba,R., Matsuda,S., Shimizu,A., Ohyama,M.,
            Okano,H.J., Shiroishi,T., Okano,H. and Saga,Y.
  TITLE     The disruption of Sox21-mediated hair shaft cuticle differentiation
            causes cyclic alopecia in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (23), 9292-9297 (2009)
   PUBMED   19470461
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048728.1.
            
            On Jun 3, 2009 this sequence version replaced NM_177182.3.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript and conservation data.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC048728.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1225              BC048728.1         1-1225
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.97 cM"
     gene            1..1225
                     /gene="Bhlha9"
                     /gene_synonym="A830053O21Rik; Fingerin"
                     /note="basic helix-loop-helix family, member a9"
                     /db_xref="GeneID:320522"
                     /db_xref="MGI:MGI:2444198"
     exon            1..1207
                     /gene="Bhlha9"
                     /gene_synonym="A830053O21Rik; Fingerin"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..775
                     /gene="Bhlha9"
                     /gene_synonym="A830053O21Rik; Fingerin"
                     /note="novel helix-loop-helix DNA-binding domain
                     containing protein; bHLHf42; class B basic
                     helix-loop-helix factor 42"
                     /codon_start=1
                     /product="class A basic helix-loop-helix protein 9"
                     /protein_id="NP_796156.3"
                     /db_xref="CCDS:CCDS25068.2"
                     /db_xref="GeneID:320522"
                     /db_xref="MGI:MGI:2444198"
                     /translation="MLRGTPGLGLGGLNRAEDFVEDLGRSCSEAGRNFGVLRRSSLDE
                     AEEAAGRKRERPTRSKARRMAANVRERKRILDYNEAFNALRRALQHDLGGKRLSKIAT
                     LRRAIHRITALSLVLRASPAPRWPCGHLECHGQAAQGSSTGNSSFSVPRSAPSPIAPS
                     LTRRDIASPLVPPTPRCASCSPHSHLGRPRVMAEVPNLAQTSGGNWRQCPGAPPVRPV
                     SWRWGSGLGYQHS"
     regulatory      1184..1189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlha9"
                     /gene_synonym="A830053O21Rik; Fingerin"
                     /note="hexamer: AATAAA"
     polyA_site      1207
                     /gene="Bhlha9"
                     /gene_synonym="A830053O21Rik; Fingerin"
                     /note="major polyA site"
ORIGIN      
        1 gccagcaaga gccatcagtc agtggaccag cagccttttg gacccaaata gctgaagctg
       61 tgagaccagg acataggcca tgctccgagg cacgccagga ctaggcctcg ggggcctgaa
      121 ccgggctgag gattttgtgg aggacttggg gcgctcctgc tcggaggctg gcaggaattt
      181 tggagtgctg aggaggagca gcttggacga ggcagaagag gcagctggca gaaagcgcga
      241 gcggcccaca cggtccaagg ctcggcgcat ggcggctaac gtgcgggagc gcaagcgcat
      301 cctggattac aacgaggcgt tcaacgcgct ccgccgggcg ctgcagcatg acctcggagg
      361 caagaggctc tccaagatcg ctacgctgcg cagggccatc caccgcatca ctgctctatc
      421 cttggtcctg cgtgccagtc cggcgccccg ctggccctgc ggacacctgg agtgtcacgg
      481 ccaggctgcc caaggctcga gcacggggaa ttccagcttc agtgttccgc ggtcagcgcc
      541 gtctcctata gcgcctagcc taacgcgcag ggacatcgcc agccccttag tgccgcctac
      601 accgcgctgc gcttcgtgtt ccccgcactc gcacttgggg cggcctaggg tgatggccga
      661 agtgcccaat ttggcccaaa cctccggggg aaactggcgt caatgtcctg gggctccccc
      721 tgttcgaccg gtttcgtggc ggtggggttc tgggctgggc taccagcact cttgatcgtg
      781 ccacccagag ggaagccggc ttggcccgag tgactgcaaa agagaagatg gcagaagtca
      841 tcctggacag agcaaaattg aatggggttg tgacttgcgt ggcaaaggag gatgtcttac
      901 catgggaagg aactaccggg ctcagggcag ccttcccaca tcccagcctg gggtggtgaa
      961 aaagaaggga gattttaggt ttggacttgg tcaacccctt gttcctggaa agtggccttt
     1021 gctttccttt gcttctgagc cctccttttc ccttgccgcc tttggaaagt gggacttgtg
     1081 ggactgtgtg ggtaggcagc tgctatgatc tgagggcata tgctgtggtc ctcttccccg
     1141 gtttgggctg ctgctgaact gagagaagcc cagaaaatga tcaaataaaa aggaaacatg
     1201 tcttctcaaa aaaaaaaaaa aaaaa
//
