LOCUS       NM_010800               3494 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus basic helix-loop-helix family, member a15 (Bhlha15),
            mRNA.
ACCESSION   NM_010800
VERSION     NM_010800.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3494)
  AUTHORS   Jeong,H., Lee,B., Cho,S.Y., Lee,Y., Kim,J., Hur,S., Cho,K.,
            Kim,K.H., Kim,S.H. and Nam,K.T.
  TITLE     Microbiota-derived short-chain fatty acids determine stem cell
            characteristics of gastric chief cells
  JOURNAL   Dev Cell 60 (4), 599-612 (2025)
   PUBMED   39642880
REFERENCE   2  (bases 1 to 3494)
  AUTHORS   Huang,K.T., Wagner,L.E., Takano,T., Lin,X.X., Bagavant,H.,
            Deshmukh,U. and Yule,D.I.
  TITLE     Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial
            function in a mouse model of early Sjogren's disease
  JOURNAL   Elife 13, 97069 (2024)
   PUBMED   39259200
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3494)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3494)
  AUTHORS   Mandlbauer,A., Sun,Q., Popitsch,N., Schwickert,T., Spanova,M.,
            Wang,J., Ameres,S.L., Busslinger,M. and Cochella,L.
  TITLE     Mime-seq 2.0: a method to sequence microRNAs from specific mouse
            cell types
  JOURNAL   EMBO J 43 (12), 2506-2525 (2024)
   PUBMED   38689024
REFERENCE   5  (bases 1 to 3494)
  AUTHORS   Wrynn,T., Min,S., Horeth,E., Osinski,J., Sinha,S. and Romano,R.A.
  TITLE     DeltaNp63 regulates Sfrp1 expression to direct salivary gland
            branching morphogenesis
  JOURNAL   PLoS One 19 (5), e0301082 (2024)
   PUBMED   38722977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3494)
  AUTHORS   Pin,C.L., Rukstalis,J.M., Johnson,C. and Konieczny,S.F.
  TITLE     The bHLH transcription factor Mist1 is required to maintain
            exocrine pancreas cell organization and acinar cell identity
  JOURNAL   J Cell Biol 155 (4), 519-530 (2001)
   PUBMED   11696558
REFERENCE   7  (bases 1 to 3494)
  AUTHORS   Lemercier,C., Brown,A., Mamani,M., Ripoche,J. and Reiffers,J.
  TITLE     The rat Mist1 gene: structure and promoter characterization
  JOURNAL   Gene 242 (1-2), 209-218 (2000)
   PUBMED   10721714
REFERENCE   8  (bases 1 to 3494)
  AUTHORS   Pin,C.L., Lemercier,C. and Konieczny,S.F.
  TITLE     Cloning of the murine Mist1 gene and assignment to mouse chromosome
            band 5G2-5G3
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 219-222 (1999)
   PUBMED   10575209
REFERENCE   9  (bases 1 to 3494)
  AUTHORS   Lemercier,C., To,R.Q., Carrasco,R.A. and Konieczny,S.F.
  TITLE     The basic helix-loop-helix transcription factor Mist1 functions as
            a transcriptional repressor of myoD
  JOURNAL   EMBO J 17 (5), 1412-1422 (1998)
   PUBMED   9482738
REFERENCE   10 (bases 1 to 3494)
  AUTHORS   Lemercier,C., To,R.Q., Swanson,B.J., Lyons,G.E. and Konieczny,S.F.
  TITLE     Mist1: a novel basic helix-loop-helix transcription factor exhibits
            a developmentally regulated expression pattern
  JOURNAL   Dev Biol 182 (1), 101-113 (1997)
   PUBMED   9073453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121845.3, AK020643.1 and AC139636.12.
            
            On Nov 10, 2012 this sequence version replaced NM_010800.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094061.1, AF049660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC121845.3         69712-69753         c
            43-1067             AK020643.1         2-1026
            1068-2761           AC121845.3         66331-68024         c
            2762-3494           AC139636.12        171365-172097       c
FEATURES             Location/Qualifiers
     source          1..3494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 83.05 cM"
     gene            1..3494
                     /gene="Bhlha15"
                     /gene_synonym="1810009C13Rik; Bhlhb8; MIST-1; Mist1"
                     /note="basic helix-loop-helix family, member a15"
                     /db_xref="GeneID:17341"
                     /db_xref="MGI:MGI:891976"
     exon            1..73
                     /gene="Bhlha15"
                     /gene_synonym="1810009C13Rik; Bhlhb8; MIST-1; Mist1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..3494
                     /gene="Bhlha15"
                     /gene_synonym="1810009C13Rik; Bhlhb8; MIST-1; Mist1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..718
                     /gene="Bhlha15"
                     /gene_synonym="1810009C13Rik; Bhlhb8; MIST-1; Mist1"
                     /note="basic helix-loop-helix domain containing, class B,
                     8; muscle, intestine and stomach expression 1"
                     /codon_start=1
                     /product="class A basic helix-loop-helix protein 15"
                     /protein_id="NP_034930.1"
                     /db_xref="CCDS:CCDS19847.1"
                     /db_xref="GeneID:17341"
                     /db_xref="MGI:MGI:891976"
                     /translation="MKTKNRPPRRRTPMQDTEATPGEQTPDRPQSGSGGSELTKGLRS
                     RTARASGGRGEVSRRRQGSGGRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHV
                     RADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQ
                     QQQQQQVAGAMLGVTEDQPQGHLQRYSTQIHSFREGS"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bhlha15"
                     /gene_synonym="1810009C13Rik; Bhlhb8; MIST-1; Mist1"
                     /note="hexamer: AATAAA"
     polyA_site      3494
                     /gene="Bhlha15"
                     /gene_synonym="1810009C13Rik; Bhlhb8; MIST-1; Mist1"
                     /note="major polyA site"
ORIGIN      
        1 gcccgtggtg gctaaagcta cgtgtccttg tcccccgtgg gcagcctctg cgcgtacggc
       61 ctcgaatccc cagttggaag ggcctcaccc agccaccacc tcctgggaaa accagcctgg
      121 agctatgaag accaaaaacc ggccccctcg gcgccgaaca cccatgcagg acacagaagc
      181 caccccagga gagcagacac ctgacagacc ccagtcaggc tcaggggggt cagagctgac
      241 aaagggtctc cggagcagga cagcgcgtgc aagcggaggt cggggagagg tcagccgccg
      301 gcgacagggg tctggtggcc gcagggagaa cagtgttcag aggcggctgg agagcaatga
      361 gcgagagagg cagcggatgc ataaactcaa caatgccttc caggcactgc gcgaggtcat
      421 cccgcacgtg cgggctgaca agaagctctc caagatcgag accctcacgc tggccaagaa
      481 ctatatcaag tcgctgaccg ccaccatact tactatgtcc agcagccgcc tcccggggct
      541 ggaggcacca ggtcctgcgc caggccctaa attataccag cactaccatc accagcagca
      601 gcaacagcag cagcagcagc aggtagctgg ggccatgctt ggtgtcactg aggaccagcc
      661 ccaaggccac ctgcaacgct actctacaca gatccacagc ttcagagagg ggagctagca
      721 cgcgcttcgg gctccggggc aggttggcag tgaggagcct gcctgctctt ctcagctgtt
      781 gtccctctgt gctgcaagct ccagactggt aatgacacta gtgaggtccc tgagggggtt
      841 ttgttgttga cataagccct ctcatggccc aagctggcct tgaactcctg atcctcctca
      901 cctccatctt ctctagggct gggattacag gcatacatca tgacatggtg ccacgctggg
      961 gactgagcta agggctgtgt gtgtgcgcac taagcaagct ctctagcaac cgagctgcat
     1021 ccccagccca aagttgactc gcagtaaatc cattttcctt gaaactcagc tcagacacca
     1081 gcatgtggca gtttttccta gccacccagg ggacaaggga gtgatctggg ccttcaactc
     1141 tccagggaaa gcctacctgt ccttgctgcc ctttgaccaa ggatgcacag gggtgggaca
     1201 gttcttgcct tccttaacaa ttgcatgtgt ggtggctaag ggacgactcc aggaaaaact
     1261 tgacttacaa atgtccctgc gactgctgag cctaaatatt gtggggctat gggaaactgg
     1321 acccaaagtg ccactcaatc cctcagggaa tatacagcaa agccaagatg gcgtcttgtt
     1381 tcctcatttt ataggattcc cctgggccca actcaacaac tggagttaaa aaggcctagc
     1441 caggcccaat ccataggact ttaaacgaga tctatctctc tctctctctc tctctctctc
     1501 tctctctctc tctctctctc tctctctctc tctctctcct ggaaaagctg cagtggccta
     1561 ggctgtggct gactactaca acctacccca aggatatgag gccctgtgta gagacaaggc
     1621 aggcctttat gtagaggacc cttgggcctc cgtacacgga gagacttgcc ctgggcctct
     1681 tatagacttc ccatggcgcc ccctctccat tacaggggta tacctcgtgc ttggtatctc
     1741 acagtgttct tggttggccc ctgggcttag ctcttggtac ctttggtgtt ttctctgagg
     1801 tggaagctgg agagaccggc atgtccctcc cccaacctgc tcattaataa ggagggtgag
     1861 tggttggcag ccaggcagcc tcaagcccag cttccgtcct ggggcgttcc tgccccactg
     1921 gctctgccgg gcttcacttc agactacttt gctgtcactt gtccttggcc tcttccttcc
     1981 tcccttgtct ctctgcccag aactgacctg gagttccttg aggcccatac accccacacc
     2041 cacctttaga atgacaggag tctctctcta tgtagctcag gctatcccta aactgatttt
     2101 tttgaacgtg tgcttggtcc atcctcctgc ctcagcccct ccctctgccc caagtgctct
     2161 gaacacagga tagggggaga accctggtac ccgaaagaac tagataatag atacactagg
     2221 cctgggggtg ttggtctcct tatcctggtg agacttgatt tgtatagctt tccagtcctg
     2281 gtctggtccc ttcctagatc gtccgtaggt caggtagaga ctggggggcc tgtgtgtctg
     2341 ttactgggga cggctactgg gaaaggtcag ggaatttgcc agtgtgagcg gaggccaggc
     2401 atgactccaa gctggaaaga caaagcccag atatctacct tgctatgggg gacttgccca
     2461 gtggaaagca aaggcctctg ccgacagaca gacctacaaa ccccatggct ggcttccgta
     2521 tgagccaagg ccagagcggg gctccttttg tccagccaaa cctctgccct aatgcccggc
     2581 tgccctaatg cccagggctg tccagggtct ctgtttggcg ggacctcagc ctcctggctc
     2641 tttgtccccc acaagctgcc ttttgtatac ccctgcttcc tagggggtga catgggccta
     2701 gctgtccagt tctttactgg tgacaggcag gacctacatg tcccttggcc acattacaaa
     2761 ggatctttag agactccggt cccgttagga gtctgggata gcaggaagcc ctattgctct
     2821 gtctccctgt cccaagccca gggtgctcct tcttttggaa ctggagcgta gggtgacctc
     2881 taacttactc cgtggggaag gatggtgaac ttccgcctcg atctcgtgtg ctgggactga
     2941 ggtatgtacc tccacaccca gtttagacag tgctgggaac tgaacccggg gcttagagca
     3001 tcttcagcaa gcctctaccg accaatctat gtccccagtg tgctctcttc tgtcctactg
     3061 ggtaatgggg ctgagtttat tcaagcccct gggcaagagg gctggagctg cccgggacac
     3121 ctaggctctg gtgtggggac caggcagagc ctttatgaag aggacccctg agcctctgta
     3181 catggagaga cttgccctgg gcctccagat ctcaccaacc tcacgtcagc acaagcagag
     3241 aaacctgaca tgtgacgcct caggaaaaag ccatgagaaa cagcagggcc tgcgccttgc
     3301 ctgtcacctc agtgacaatg tcccttaagt gacctggacc cgctattttt cccctagttc
     3361 cctgagtact agtaaaattg ccatctgtac ctgaaaatga agacttcaca gccattgtac
     3421 tctggtccta ggaatgggtg cccagagacc tgtgcctctg taacacaaat gtccaataaa
     3481 aatcttgtca gtca
//
