LOCUS       NM_031368                723 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus bone gamma-carboxyglutamate protein 3 (Bglap3),
            transcript variant 3, mRNA.
ACCESSION   NM_031368 NM_013480
VERSION     NM_031368.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 723)
  AUTHORS   Xu,Z., Yang,C., Wu,F., Tan,X., Guo,Y., Zhang,H., Wang,H., Sui,X.,
            Xu,Z., Zhao,M., Jiang,S., Dai,Z. and Li,Y.
  TITLE     Triple-gene deletion for osteocalcin significantly impairs the
            alignment of hydroxyapatite crystals and collagen in mice
  JOURNAL   Front Physiol 14, 1136561 (2023)
   PUBMED   37057181
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 723)
  AUTHORS   Yoshioka,H., Komura,S., Kuramitsu,N., Goto,A., Hasegawa,T.,
            Amizuka,N., Ishimoto,T., Ozasa,R., Nakano,T., Imai,Y. and
            Akiyama,H.
  TITLE     Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in
            spontaneous bone fractures
  JOURNAL   J Bone Miner Metab 40 (5), 839-852 (2022)
   PUBMED   35947192
REFERENCE   3  (bases 1 to 723)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   4  (bases 1 to 723)
  AUTHORS   Nie,X., Zheng,J., Ricupero,C.L., He,L., Jiao,K. and Mao,J.J.
  TITLE     mTOR acts as a pivotal signaling hub for neural crest cells during
            craniofacial development
  JOURNAL   PLoS Genet 14 (7), e1007491 (2018)
   PUBMED   29975682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 723)
  AUTHORS   Yang,T., Moore,M. and He,F.
  TITLE     Pten regulates neural crest proliferation and differentiation
            during mouse craniofacial development
  JOURNAL   Dev Dyn 247 (2), 304-314 (2018)
   PUBMED   29115005
REFERENCE   6  (bases 1 to 723)
  AUTHORS   Yang,Y., Topol,L., Lee,H. and Wu,J.
  TITLE     Wnt5a and Wnt5b exhibit distinct activities in coordinating
            chondrocyte proliferation and differentiation
  JOURNAL   Development 130 (5), 1003-1015 (2003)
   PUBMED   12538525
REFERENCE   7  (bases 1 to 723)
  AUTHORS   Tabernero,C., Zolotukhin,A.S., Bear,J., Schneider,R., Karsenty,G.
            and Felber,B.K.
  TITLE     Identification of an RNA sequence within an intracisternal-A
            particle element able to replace Rev-mediated posttranscriptional
            regulation of human immunodeficiency virus type 1
  JOURNAL   J Virol 71 (1), 95-101 (1997)
   PUBMED   8985327
REFERENCE   8  (bases 1 to 723)
  AUTHORS   Sato,M. and Tada,N.
  TITLE     Preferential expression of osteocalcin-related protein mRNA in
            gonadal tissues of male mice
  JOURNAL   Biochem Biophys Res Commun 215 (1), 412-421 (1995)
   PUBMED   7575621
REFERENCE   9  (bases 1 to 723)
  AUTHORS   Desbois,C., Hogue,D.A. and Karsenty,G.
  TITLE     The mouse osteocalcin gene cluster contains three genes with two
            separate spatial and temporal patterns of expression
  JOURNAL   J Biol Chem 269 (2), 1183-1190 (1994)
   PUBMED   8288580
REFERENCE   10 (bases 1 to 723)
  AUTHORS   Rahman,S., Oberdorf,A., Montecino,M., Tanhauser,S.M., Lian,J.B.,
            Stein,G.S., Laipis,P.J. and Stein,J.L.
  TITLE     Multiple copies of the bone-specific osteocalcin gene in mouse and
            rat
  JOURNAL   Endocrinology 133 (6), 3050-3053 (1993)
   PUBMED   8243336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102388.7, AA475384.1, AA016947.1, BY414395.1 and BY430398.1.
            
            On Mar 13, 2015 this sequence version replaced NM_031368.4.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI249950.1, BC055868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC102388.7         121091-121201
            112-119             AA475384.1         1-8
            120-325             AA016947.1         1-206
            326-564             BY414395.1         1-239
            565-717             BY430398.1         245-397
            718-723             AC102388.7         122301-122306
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.81 cM"
     gene            1..723
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /note="bone gamma-carboxyglutamate protein 3"
                     /db_xref="GeneID:12095"
                     /db_xref="MGI:MGI:88155"
     exon            1..359
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..583
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /note="osteocalcin-related protein; nephrocalcin; bone
                     gamma-carboxyglutamate protein, related sequence 1;
                     gamma-carboxyglutamic acid-containing protein 3"
                     /codon_start=1
                     /product="osteocalcin-related protein precursor"
                     /protein_id="NP_112736.3"
                     /db_xref="CCDS:CCDS17472.1"
                     /db_xref="GeneID:12095"
                     /db_xref="MGI:MGI:88155"
                     /translation="MRTLSLLTLLALAALCLSDLTDATPTGPESDKAFMSKQEGNKVV
                     NRLRRYLGASVPSPDPLEPTRELCELDPACDELSNQYGLKTAYRRIYGITI"
     exon            360..392
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /inference="alignment:Splign:2.1.0"
     exon            393..450
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /inference="alignment:Splign:2.1.0"
     exon            451..723
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      700..705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /note="hexamer: AATAAA"
     polyA_site      719
                     /gene="Bglap3"
                     /gene_synonym="Bglap-rs1; mOC-X; OC-X; ORG"
                     /note="major polyA site"
ORIGIN      
        1 caagtgatga ttctggccaa tggactgctg ttccgtggac agggcagatg gggcatggtt
       61 cagaggttat ataagggatt gcgattgggg gaggagatac agacagagag attcctgtgg
      121 agagacttat tcttggagag agactcctgc atgcatgttg aaaggttcct gaataaactg
      181 ctttgagaag aacatagtgt cgtcgtttct ttctgctggt cagaatcaga ggcaacagga
      241 gggtgcagaa cagacaagtc ccacacagca gcttggtgca cacctagcag acaccatgag
      301 gaccctctct ctgctcactc tgctggccct ggctgcgctc tgtctctctg acctcacaga
      361 tgccacgccc accggccctg agtctgacaa agccttcatg tccaagcagg agggcaataa
      421 ggtagtgaac agactccggc gctaccttgg agcttcagtc cccagcccag atcccctgga
      481 gcccacccgg gagctatgtg agcttgaccc tgcttgtgac gagctatcaa accagtatgg
      541 cttaaagacc gcctacagac gcatctacgg tatcactatt taggacctgt gctgccctaa
      601 agccaaactc tggcagctcg gctttggctg ctctccagaa cttgatcctc cctgtcctct
      661 ctctctgccc tgcaagtatg gatgtcacag cagctccaaa ataaagttca gatgaggaag
      721 tgc
//
