LOCUS       NM_001032298             473 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus bone gamma-carboxyglutamate protein 2 (Bglap2), mRNA.
ACCESSION   NM_001032298
VERSION     NM_001032298.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Yu,X.F., Teng,B., Li,J.F., Zhang,J.V., Su,Z. and Ren,P.G.
  TITLE     Novel Function of Osteocalcin in Chondrocyte Differentiation and
            Endochondral Ossification Revealed on a CRISPR/Cas9 bglap-bglap2
            Deficiency Mouse Model
  JOURNAL   Int J Mol Sci 25 (18), 9945 (2024)
   PUBMED   39337434
  REMARK    GeneRIF: Novel Function of Osteocalcin in Chondrocyte
            Differentiation and Endochondral Ossification Revealed on a
            CRISPR/Cas9 bglap-bglap2 Deficiency Mouse Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 473)
  AUTHORS   Paracha,N., Mastrokostas,P., Kello,E., Gedailovich,Y., Segall,D.,
            Rizzo,A., Mitelberg,L., Hassan,N. and Dowd,T.L.
  TITLE     Osteocalcin improves glucose tolerance, insulin sensitivity and
            secretion in older male mice
  JOURNAL   Bone 182, 117048 (2024)
   PUBMED   38378083
  REMARK    GeneRIF: Osteocalcin improves glucose tolerance, insulin
            sensitivity and secretion in older male mice.
REFERENCE   4  (bases 1 to 473)
  AUTHORS   Beamish,C.A., Lee,Y.K., Gaber,A.O., Chanana,P., Graviss,E.A.,
            Kloc,M., Gaber,M.W., Hsueh,W.A. and Sabek,O.M.
  TITLE     Osteocalcin protects islet identity in low-density lipoprotein
            receptor knockout mice on high-fat diet
  JOURNAL   J Endocrinol 261 (1), e230352 (2024)
   PUBMED   38305305
  REMARK    GeneRIF: Osteocalcin protects islet identity in low-density
            lipoprotein receptor knockout mice on high-fat diet.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 473)
  AUTHORS   Correa Pinto Junior,D., Canal Delgado,I., Yang,H., Clemenceau,A.,
            Corvelo,A., Narzisi,G., Musunuri,R., Meyer Berger,J.,
            Hendricks,L.E., Tokumura,K., Luo,N., Li,H., Oury,F., Ducy,P.,
            Yadav,V.K., Li,X. and Karsenty,G.
  TITLE     Osteocalcin of maternal and embryonic origins synergize to
            establish homeostasis in offspring
  JOURNAL   EMBO Rep 25 (2), 593-615 (2024)
   PUBMED   38228788
  REMARK    GeneRIF: Osteocalcin of maternal and embryonic origins synergize to
            establish homeostasis in offspring.
REFERENCE   6  (bases 1 to 473)
  AUTHORS   Sato,M. and Tada,N.
  TITLE     Preferential expression of osteocalcin-related protein mRNA in
            gonadal tissues of male mice
  JOURNAL   Biochem Biophys Res Commun 215 (1), 412-421 (1995)
   PUBMED   7575621
REFERENCE   7  (bases 1 to 473)
  AUTHORS   Amizuka,N., Warshawsky,H., Henderson,J.E., Goltzman,D. and
            Karaplis,A.C.
  TITLE     Parathyroid hormone-related peptide-depleted mice show abnormal
            epiphyseal cartilage development and altered endochondral bone
            formation
  JOURNAL   J Cell Biol 126 (6), 1611-1623 (1994)
   PUBMED   8089190
REFERENCE   8  (bases 1 to 473)
  AUTHORS   Hirota,S., Takaoka,K., Hashimoto,J., Nakase,T., Takemura,T.,
            Morii,E., Fukuyama,A., Morihana,K., Kitamura,Y. and Nomura,S.
  TITLE     Expression of mRNA of murine bone-related proteins in ectopic bone
            induced by murine bone morphogenetic protein-4
  JOURNAL   Cell Tissue Res 277 (1), 27-32 (1994)
   PUBMED   8055537
REFERENCE   9  (bases 1 to 473)
  AUTHORS   Johnson,T.L., Sakaguchi,A.Y., Lalley,P.A. and Leach,R.J.
  TITLE     Chromosomal assignment in mouse of matrix Gla protein and bone Gla
            protein genes
  JOURNAL   Genomics 11 (3), 770-772 (1991)
   PUBMED   1774075
REFERENCE   10 (bases 1 to 473)
  AUTHORS   Celeste,A.J., Rosen,V., Buecker,J.L., Kriz,R., Wang,E.A. and
            Wozney,J.M.
  TITLE     Isolation of the human gene for bone gla protein utilizing mouse
            and rat cDNA clones
  JOURNAL   EMBO J 5 (8), 1885-1890 (1986)
   PUBMED   3019668
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC102388.7, BY347938.1 and
            CJ326700.1.
            
            On Aug 6, 2015 this sequence version replaced NM_001032298.2.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            processed to generate a mature protein product. This protein
            product is a hormone that is secreted by osteoblasts and may
            function in bone remodeling and energy metabolism. Homozygous
            knockout mice for this gene exhibit a gradual increase in bone
            size, density and strength, as well as elevated adiposity and
            impaired glucose tolerance. This gene is present in a gene cluster
            with other related genes on chromosome 3. [provided by RefSeq, Aug
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ326623.1, CJ326788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC102388.7         112221-112222
            3-359               BY347938.1         1-357
            360-473             CJ326700.1         357-470
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.81 cM"
     gene            1..473
                     /gene="Bglap2"
                     /gene_synonym="Bglap1; Bgp; BGP2; mOC-B; Og2"
                     /note="bone gamma-carboxyglutamate protein 2"
                     /db_xref="GeneID:12097"
                     /db_xref="MGI:MGI:88157"
     exon            1..115
                     /gene="Bglap2"
                     /gene_synonym="Bglap1; Bgp; BGP2; mOC-B; Og2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..339
                     /gene="Bglap2"
                     /gene_synonym="Bglap1; Bgp; BGP2; mOC-B; Og2"
                     /note="osteocalcin-2; bone Gla protein 2;
                     gamma-carboxyglutamic acid-containing protein 2"
                     /codon_start=1
                     /product="osteocalcin-2 preproprotein"
                     /protein_id="NP_001027469.2"
                     /db_xref="CCDS:CCDS17473.1"
                     /db_xref="GeneID:12097"
                     /db_xref="MGI:MGI:88157"
                     /translation="MRTLSLLTLLALAALCLSDLTDAKPSGPESDKAFMSKQEGNKVV
                     NRLRRYLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYKRIYGITI"
     exon            116..148
                     /gene="Bglap2"
                     /gene_synonym="Bglap1; Bgp; BGP2; mOC-B; Og2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..206
                     /gene="Bglap2"
                     /gene_synonym="Bglap1; Bgp; BGP2; mOC-B; Og2"
                     /inference="alignment:Splign:2.1.0"
     exon            207..473
                     /gene="Bglap2"
                     /gene_synonym="Bglap1; Bgp; BGP2; mOC-B; Og2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaacaga caagtcccac acagcagctt ggtgcacacc tagcagacac catgaggacc
       61 ctctctctgc tcactctgct ggccctggct gcgctctgtc tctctgacct cacagatgcc
      121 aagcccagcg gccctgagtc tgacaaagcc ttcatgtcca agcaggaggg caataaggta
      181 gtgaacagac tccggcgcta ccttggagcc tcagtcccca gcccagatcc cctggagccc
      241 acccgggagc agtgtgagct taaccctgct tgtgacgagc tatcagacca gtatggcttg
      301 aagaccgcct acaaacgcat ctacggtatc actatttagg acctgtgctg ccctaaagcc
      361 aaactctggc agctcggctt tggctgctct ccgggacttg atcctccctg tcctctctct
      421 ctgccctgca agtatggatg tcacagcagc tccaaaataa agttcagatg agg
//
