LOCUS       NM_007541                496 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus bone gamma carboxyglutamate protein (Bglap), mRNA.
ACCESSION   NM_007541
VERSION     NM_007541.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Yu,X.F., Teng,B., Li,J.F., Zhang,J.V., Su,Z. and Ren,P.G.
  TITLE     Novel Function of Osteocalcin in Chondrocyte Differentiation and
            Endochondral Ossification Revealed on a CRISPR/Cas9 bglap-bglap2
            Deficiency Mouse Model
  JOURNAL   Int J Mol Sci 25 (18), 9945 (2024)
   PUBMED   39337434
  REMARK    GeneRIF: Novel Function of Osteocalcin in Chondrocyte
            Differentiation and Endochondral Ossification Revealed on a
            CRISPR/Cas9 bglap-bglap2 Deficiency Mouse Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 496)
  AUTHORS   Vaghjiani,V.G., Cochrane,C.R., Jayasekara,W.S.N., Chong,W.C.,
            Szczepny,A., Kumar,B., Martelotto,L.G., McCaw,A., Carey,K.,
            Kansara,M., Thomas,D.M., Walkley,C., Mudge,S., Gough,D.J.,
            Downie,P.A., Peacock,C.D., Matsui,W., Watkins,D.N. and Cain,J.E.
  TITLE     Ligand-dependent hedgehog signaling maintains an undifferentiated,
            malignant osteosarcoma phenotype
  JOURNAL   Oncogene 42 (47), 3529-3541 (2023)
   PUBMED   37845394
REFERENCE   4  (bases 1 to 496)
  AUTHORS   Ruscitto,A., Chen,P., Tosa,I., Wang,Z., Zhou,G., Safina,I., Wei,R.,
            Morel,M.M., Koch,A., Forman,M., Reeve,G., Lecholop,M.K., Wilson,M.,
            Bonthius,D., Chen,M., Ono,M., Wang,T.C., Yao,H. and Embree,M.C.
  TITLE     Lgr5-expressing secretory cells form a Wnt inhibitory niche in
            cartilage critical for chondrocyte identity
  JOURNAL   Cell Stem Cell 30 (9), 1179-1198 (2023)
   PUBMED   37683603
REFERENCE   5  (bases 1 to 496)
  AUTHORS   Taieb,M., Ghannoum,D., Barre,L. and Ouzzine,M.
  TITLE     Xylosyltransferase I mediates the synthesis of proteoglycans with
            long glycosaminoglycan chains and controls chondrocyte hypertrophy
            and collagen fibers organization of in the growth plate
  JOURNAL   Cell Death Dis 14 (6), 355 (2023)
   PUBMED   37296099
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 496)
  AUTHORS   Sato,M. and Tada,N.
  TITLE     Preferential expression of osteocalcin-related protein mRNA in
            gonadal tissues of male mice
  JOURNAL   Biochem Biophys Res Commun 215 (1), 412-421 (1995)
   PUBMED   7575621
REFERENCE   7  (bases 1 to 496)
  AUTHORS   Goldberg,D., Gardiner,E., Morrison,N. and Eisman,J.
  TITLE     The osteocalcin and collagen type I (alpha 1) promoters share
            common basal regulatory units
  JOURNAL   DNA Cell Biol 14 (6), 519-528 (1995)
   PUBMED   7598807
REFERENCE   8  (bases 1 to 496)
  AUTHORS   Kingsmore,S.F., Spicer,A.P., Gendler,S.J. and Seldin,M.F.
  TITLE     Genetic mapping of the tumor-associated mucin 1 gene on mouse
            chromosome 3
  JOURNAL   Mamm Genome 6 (5), 378-379 (1995)
   PUBMED   7626896
REFERENCE   9  (bases 1 to 496)
  AUTHORS   Johnson,T.L., Sakaguchi,A.Y., Lalley,P.A. and Leach,R.J.
  TITLE     Chromosomal assignment in mouse of matrix Gla protein and bone Gla
            protein genes
  JOURNAL   Genomics 11 (3), 770-772 (1991)
   PUBMED   1774075
REFERENCE   10 (bases 1 to 496)
  AUTHORS   Celeste,A.J., Rosen,V., Buecker,J.L., Kriz,R., Wang,E.A. and
            Wozney,J.M.
  TITLE     Isolation of the human gene for bone gla protein utilizing mouse
            and rat cDNA clones
  JOURNAL   EMBO J 5 (8), 1885-1890 (1986)
   PUBMED   3019668
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ326308.1 and AA856059.1.
            
            On Nov 30, 2013 this sequence version replaced NM_007541.2.
            
            Summary: This gene encodes one of the most abundant non-collagenous
            proteins in bone tissue that is localized to the mineralized matrix
            of bone. The encoded preproprotein undergoes proteolytic processing
            and post-translational gamma carboxylation to generate a mature,
            calcium-binding protein. Mice lacking the encoded protein develop
            abnormalities of bone remodelling. This gene is located adjacent to
            two other osteocalcin-related genes on chromosome 3. [provided by
            RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX523252.1, CJ326308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               CJ326308.1         2-474
            474-496             AA856059.1         78-100
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.82 cM"
     gene            1..496
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
                     /note="bone gamma carboxyglutamate protein"
                     /db_xref="GeneID:12096"
                     /db_xref="MGI:MGI:88156"
     exon            1..115
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..339
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
                     /note="gamma-carboxyglutamic acid-containing protein; bone
                     gamma carboxyglutamate protein 1; osteocalcin; bone Gla
                     protein"
                     /codon_start=1
                     /product="osteocalcin preproprotein"
                     /protein_id="NP_031567.1"
                     /db_xref="CCDS:CCDS17474.1"
                     /db_xref="GeneID:12096"
                     /db_xref="MGI:MGI:88156"
                     /translation="MRTIFLLTLLTLAALCLSDLTDAKPSGPESDKAFMSKQEGNKVV
                     NRLRRYLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYKRIYGITI"
     exon            116..148
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..206
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..479
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      456..461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
     polyA_site      479
                     /gene="Bglap"
                     /gene_synonym="Bglap1; BGP; mOC-A; OC; OG1"
ORIGIN      
        1 gcagaacaga caagtcccac acagcagctt ggcccagacc tagcagacac catgaggacc
       61 atctttctgc tcactctgct gaccctggct gcgctctgtc tctctgacct cacagatgcc
      121 aagcccagcg gccctgagtc tgacaaagcc ttcatgtcca agcaggaggg caataaggta
      181 gtgaacagac tccggcgcta ccttggagcc tcagtcccca gcccagatcc cctggagccc
      241 acccgggagc agtgtgagct taaccctgct tgtgacgagc tatcagacca gtatggcttg
      301 aagaccgcct acaaacgcat ctatggtatc actatttagg acctgtgctg ccctaaagcc
      361 aaactctggc agctcggctt tggctgctct ccgggacttg atcctccctg tcctctctct
      421 ctgccctgca agtatggatg tcacagcagc tccaaaataa agttcagatg aggaagtgca
      481 aaaaaaaaaa aaaaaa
//
