LOCUS       NM_001291061            2160 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus beaded filament structural protein 1, in lens-CP94
            (Bfsp1), transcript variant 1, mRNA.
ACCESSION   NM_001291061 XM_006498613
VERSION     NM_001291061.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Li,Y., Liu,X., Xia,C.H., FitzGerald,P.G., Li,R., Wang,J. and
            Gong,X.
  TITLE     CP49 and filensin intermediate filaments are essential for
            formation of cold cataract
  JOURNAL   Mol Vis 26, 603-612 (2020)
   PUBMED   32913386
  REMARK    GeneRIF: CP49 and filensin intermediate filaments are essential for
            formation of cold cataract.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2160)
  AUTHORS   Kumari,S., Gao,J., Mathias,R.T., Sun,X., Eswaramoorthy,A.,
            Browne,N., Zhang,N. and Varadaraj,K.
  TITLE     Aquaporin 0 Modulates Lens Gap Junctions in the Presence of
            Lens-Specific Beaded Filament Proteins
  JOURNAL   Invest Ophthalmol Vis Sci 58 (14), 6006-6019 (2017)
   PUBMED   29196765
  REMARK    GeneRIF: AQP0 modulates GJs in the presence of BF proteins to
            maintain lens transparency and homeostasis.
REFERENCE   4  (bases 1 to 2160)
  AUTHORS   FitzGerald,P., Sun,N., Shibata,B. and Hess,J.F.
  TITLE     Expression of the type VI intermediate filament proteins CP49 and
            filensin in the mouse lens epithelium
  JOURNAL   Mol Vis 22, 970-989 (2016)
   PUBMED   27559293
  REMARK    GeneRIF: CP49 and filensin have been considered robust markers for
            mouse lens fiber cell differentiation. The data reported here,
            however, document both proteins in the mouse lens epithelium, but
            only after 5 weeks of age, when lens epithelial growth and mitotic
            activity have slowed.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2160)
  AUTHORS   Basu,S., Rajakaruna,S., De Arcangelis,A., Zhang,L.,
            Georges-Labouesse,E. and Menko,A.S.
  TITLE     alpha6 integrin transactivates insulin-like growth factor
            receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial
            cell differentiation initiation
  JOURNAL   J Biol Chem 289 (7), 3842-3855 (2014)
   PUBMED   24381169
REFERENCE   6  (bases 1 to 2160)
  AUTHORS   Rendtorff,N.D., Hansen,C., Silahtaroglu,A., Henriksen,K.F. and
            Tommerup,N.
  TITLE     Isolation of the human beaded-filament structural protein 1 gene
            (BFSP1) and assignment to chromosome 20p11.23-p12.1
  JOURNAL   Genomics 53 (1), 114-116 (1998)
   PUBMED   9787085
REFERENCE   7  (bases 1 to 2160)
  AUTHORS   Masaki,S., Kamachi,Y., Quinlan,R.A., Yonezawa,S. and Kondoh,H.
  TITLE     Identification and functional analysis of the mouse lens filensin
            gene promoter
  JOURNAL   Gene 214 (1-2), 77-86 (1998)
   PUBMED   9651486
REFERENCE   8  (bases 1 to 2160)
  AUTHORS   Masaki,S. and Quinlan,R.A.
  TITLE     Gene structure and sequence comparisons of the eye lens specific
            protein, filensin, from rat and mouse: implications for protein
            classification and assembly
  JOURNAL   Gene 201 (1-2), 11-20 (1997)
   PUBMED   9409766
REFERENCE   9  (bases 1 to 2160)
  AUTHORS   Gounari,F., Karagianni,N., Mincheva,A., Lichter,P., Georgatos,S.D.
            and Schirrmacher,V.
  TITLE     The mouse filensin gene: structure and evolutionary relation to
            other intermediate filament genes
  JOURNAL   FEBS Lett 413 (2), 371-378 (1997)
   PUBMED   9280315
REFERENCE   10 (bases 1 to 2160)
  AUTHORS   Masaki,S. and Watanabe,T.
  TITLE     The gene Bfsp1 for the lens fiber cell beaded-filament structural
            protein CP94 maps to mouse chromosome 2
  JOURNAL   Genomics 22 (2), 449-450 (1994)
   PUBMED   7806233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807801.3.
            
            On Feb 22, 2023 this sequence version replaced NM_001291061.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB003147.1, SRR7345562.4764594.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               AL807801.3         79669-80036         c
            369-429             AL807801.3         75150-75210         c
            430-525             AL807801.3         66021-66116         c
            526-615             AL807801.3         62994-63083         c
            616-741             AL807801.3         58767-58892         c
            742-962             AL807801.3         48930-49150         c
            963-1048            AL807801.3         47177-47262         c
            1049-2160           AL807801.3         43621-44732         c
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 70.89 cM"
     gene            1..2160
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /note="beaded filament structural protein 1, in lens-CP94"
                     /db_xref="GeneID:12075"
                     /db_xref="MGI:MGI:101770"
     exon            1..368
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2022
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /note="isoform a is encoded by transcript variant 1;
                     filensin; lens fiber cell beaded-filament structural
                     protein CP 95; beaded filament structural protein in
                     lens-CP94"
                     /codon_start=1
                     /product="filensin isoform a"
                     /protein_id="NP_001277990.1"
                     /db_xref="CCDS:CCDS71154.1"
                     /db_xref="GeneID:12075"
                     /db_xref="MGI:MGI:101770"
                     /translation="MYRRSYVFQARQERYERAQPAGPAAQPGGTAPGLAALQALGERV
                     AVQVQRARALQQRHAGLRRQLDAFQRLGEQPGPEDALARHVEANLQRARDLTAEHARL
                     ERQEAEAQRALDEFRSKYENECECQLVLKEMLERLNKEADEALLRNLHLQLEAQFLQA
                     DISVAKDRYKKNLLEIQTYITVLQQIVQTAPQVSLVTGMRESGLLMQEKLFTEREVAA
                     LQNQLEEGREAVTHLQAQKAELQAQTTALEQAIKHAHECYDEELQLYNEQIENLRKEI
                     EEAERSLERSSYDCRQLAVAQQTLRNELDRYHRIIEIEGSRLSSVFIETPISLITPSH
                     GAPLSLGSSVKDLARAVQDITAAKPRQKALPKSLPKRKEIIAQDKVEETLEDAPLKPP
                     QEPKALQVERKAEGGSQPGAGGGHGVSPTQEGGPEDVPDGGQISKAFGKLCKVVKERV
                     SGHKEPEPEPPTDLFTKGRHVLVTGESSFVDPEFYSSSIPARGGVVISIEEDSMHHDG
                     HVEPSPGQPMPPVENGQGVPQGREGDHSNHQQGTDKNGLRAKEPKDLEEKDDDGKKEA
                     EGSRRPCPVIIPGPDEPSTSHSQTSGSNQGGPVGPASKSSSLLAKGPSKALSIKKVEV
                     VESIEKISTESIQTYEETSVIVETLIGKSKGNKKLGEKSLPDTRA"
     exon            369..429
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     exon            430..525
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     exon            526..615
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     exon            616..741
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     exon            742..962
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1048
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..2160
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2131..2136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /note="hexamer: ATTAAA"
     polyA_site      2157
                     /gene="Bfsp1"
                     /gene_synonym="CP95"
                     /note="major polyA site"
ORIGIN      
        1 cttccgggag ccatgtaccg ccgcagctac gtcttccagg cccgccagga gcgctacgag
       61 cgcgcccagc ccgcgggccc cgccgcccag cccgggggaa ccgcgcccgg cctggcagcg
      121 ctgcaggcgc tgggcgagcg cgtggcagtc caggtccagc gggcccgcgc gctccagcag
      181 cgccacgccg gcctgcggcg gcagctcgac gccttccagc gcctgggcga gcagcccggg
      241 cccgaggacg cgctcgcccg ccacgtcgag gccaatctgc agcgcgcccg ggacctgaca
      301 gccgagcacg cgcggctcga gaggcaggag gccgaggcgc agcgcgcgct cgacgagttc
      361 cgcagcaaat acgaaaatga gtgtgaatgt cagttggtgc taaaggaaat gctggaacgg
      421 cttaacaagg aagccgatga agccttattg cgtaacctgc accttcagtt ggaggcacag
      481 tttctgcagg cagatatcag tgtggccaag gacaggtaca agaagaatct tctggagatt
      541 cagacctaca tcaccgtcct gcagcagatc gtacagactg ctcctcaagt gtccctggtt
      601 actgggatga gggagtctgg cctcctcatg caggagaagc tgttcacaga acgggaagtg
      661 gctgccctgc agaaccagct ggaggagggc cgagaggcag tcacccacct gcaggcacag
      721 aaagctgagc tgcaggccca gaccacggcc ctggaacaag ctattaagca tgctcatgag
      781 tgttacgatg aggagctaca gctttacaac gagcagatcg aaaaccttcg gaaggagatc
      841 gaggaggcgg agcggtctct ggagaggtcg tcctatgact gcaggcagct agccgtggcc
      901 cagcagacgc tgaggaatga gctagaccgt tatcatcgga tcattgagat tgaaggcagc
      961 aggctgagct ctgttttcat tgagacgccc atctctctga tcaccccgag ccatggggcc
     1021 cctctcagcc ttggatccag tgtgaaagat cttgccaggg ccgtgcagga tattacagca
     1081 gctaaaccga gacagaaggc cctccccaag agccttccaa aaagaaagga gattatagct
     1141 caagataagg tggaggaaac tctggaagat gcaccattaa aacctccgca ggagccaaag
     1201 gcactgcagg tggaacggaa agcagaaggt ggctctcagc ccggagcagg gggaggacat
     1261 ggagtaagtc ccacacaaga agggggtcct gaggatgtgc cagacggggg ccagataagc
     1321 aaagcctttg ggaaactgtg caaagtagtg aaagagagag tgagcggcca caaagagccc
     1381 gagcctgagc cgcccacgga ccttttcacc aaaggacggc atgtactcgt cacaggggag
     1441 tctagttttg ttgaccccga gttctactcc tcctccatcc cagctagagg tggggtggtg
     1501 atttccattg aggaagactc tatgcatcat gacggccacg tagagccctc tcctggacag
     1561 cccatgccac ctgtggagaa tggacagggc gttccccagg gcagggaagg tgaccactca
     1621 aaccatcagc agggtacaga caagaatggg ttacgggcca aggaaccaaa agacctggag
     1681 gaaaaagatg atgatggcaa gaaggaagct gaggggagca ggagaccctg tcctgtgatc
     1741 atacctggtc ctgatgaacc atctacatcc cattcacaga cgtctgggtc caatcagggt
     1801 ggaccagtgg ggcctgcgag taagagcagt agcctgctgg caaagggccc ttcgaaggct
     1861 ctgtctatta agaaggtgga ggtggtggaa tccattgaga agatttcaac agagagtatt
     1921 cagacatatg aagagacttc cgtaattgtg gagactctga ttgggaagtc aaagggcaac
     1981 aagaaactgg gagagaagag cttgccagac acaagggctt gaaggaggaa agtgtccggg
     2041 cagtgtggga ggagggcttt gagatgggct cctgtttgga ttagatcata gtcaacctgt
     2101 ctgcattgca ggtgacctcc aatgaccttc attaaactgc tttctttttt gcttgcacca
//
