LOCUS       NM_025976               3010 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus bifunctional apoptosis regulator (Bfar), transcript
            variant 1, mRNA.
ACCESSION   NM_025976
VERSION     NM_025976.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Das,A., Cheng,H., Wang,Y., Kinch,L.N., Liang,G., Hong,S.,
            Hobbs,H.H. and Cohen,J.C.
  TITLE     The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3
  JOURNAL   Proc Natl Acad Sci U S A 121 (6), e2312291121 (2024)
   PUBMED   38294943
  REMARK    GeneRIF: The ubiquitin E3 ligase BFAR promotes degradation of
            PNPLA3.
REFERENCE   2  (bases 1 to 3010)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 3010)
  AUTHORS   Mrowiec,K., Chadalski,M., Paszek,A., Vydra,N., Janus,P.,
            Pietrowska,M., Toma-Jonik,A., Gramatyka,M. and Widlak,W.
  TITLE     The periphilin 1-like BFAR isoform 3 is highly expressed in
            transcriptionally silent oocytes and involved in RNA metabolism
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (10), 119086 (2021)
   PUBMED   34175335
  REMARK    GeneRIF: The periphilin 1-like BFAR isoform 3 is highly expressed
            in transcriptionally silent oocytes and involved in RNA metabolism.
REFERENCE   4  (bases 1 to 3010)
  AUTHORS   Pei,S., Huang,M., Huang,J., Zhu,X., Wang,H., Romano,S., Deng,X.,
            Wang,Y., Luo,Y., Hao,S., Xu,J., Yu,T., Zhu,Q., Yuan,J., Shen,K.,
            Liu,Z., Hu,G., Peng,C., Luo,Q., Wen,Z., Dai,D. and Xiao,Y.
  TITLE     BFAR coordinates TGFbeta signaling to modulate Th9-mediated cancer
            immunotherapy
  JOURNAL   J Exp Med 218 (7) (2021)
   PUBMED   33914044
REFERENCE   5  (bases 1 to 3010)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3010)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154607.2, AK013874.1 and AI255749.1.
            
            On Apr 15, 2010 this sequence version replaced NM_025976.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027221.1, AK013874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC154607.2         65821-65972
            153-1809            AK013874.1         18-1674
            1810-2889           AC154607.2         96382-97461
            2890-3010           AI255749.1         1-121               c
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.45 cM"
     gene            1..3010
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /note="bifunctional apoptosis regulator"
                     /db_xref="GeneID:67118"
                     /db_xref="MGI:MGI:1914368"
     exon            1..221
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     exon            222..558
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1648
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="bifunctional apoptosis regulator isoform 1"
                     /protein_id="NP_080252.1"
                     /db_xref="CCDS:CCDS27966.1"
                     /db_xref="GeneID:67118"
                     /db_xref="MGI:MGI:1914368"
                     /translation="MEEPQKNDLSMREQEEEHPVRSSGPQISVSEFSCHCCYDTLVNP
                     TTLNCGHSFCRHCLALWWMSSKKTECPECREKWEGFPKVNILLRDAIEKLFPDAIRMR
                     VEDIQQNNDVVQSLAAFQKYGNDQNPLAPSTGRVNPQRGGGFFSGVLTALTGVAVILL
                     VYHWRSRESEHGLLVHKAVDKWTTEEVVLWLEQLGPWASLYRDRFLSERVNGRLLLTL
                     TEEEFSRAPYTIENSSHRRVILTELERVRALGVKPPQNLWEYKAVNPGRSLFLLYALK
                     SSPRLGLLYLYLFDYTDCFLPFIHTICPLQENSSGEDIFTKLLDLREPTWKQWREFLV
                     KYSFLPYQLIAEFAWDWLEVHYWTSRFLIVNAVLLSVLELFSFWRIWSRSELKTVPQR
                     MWSHFWKVSTQGLFMAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKEVRRLETQVL
                     "
     exon            559..763
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     exon            764..933
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1078
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1252
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1455
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..3003
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /note="hexamer: AATAAA"
     polyA_site      2998
                     /gene="Bfar"
                     /gene_synonym="3010001A07Rik; 3110001I22Rik; Bar; Rnf47"
                     /note="major polyA site"
ORIGIN      
        1 gttggtgcgc atgcgcccgc atgcccctag agcagccgct ctaggcagcc ggaggtcgca
       61 cggggttgag agcataaaga ggtctctcct ctatggttgc gggagctgat cgtagtcggc
      121 ccctaggccc aggttatttc cggaagcgaa gccttgtcct ctacttccgc ggggtcctgg
      181 caggtggcgg tgacagagtg ggtaccagga ctagtggcga gactttatga tgcattgcag
      241 cagtgtcctg agtctgaaag tgtctatgtg tatggatccc agaatttgct gagagatgga
      301 ggagcctcag aaaaatgacc tgagcatgag agagcaggag gaagagcatc ctgtcagaag
      361 cagcggccct cagatttctg tgagcgagtt ctcctgccac tgctgctacg acaccctggt
      421 taaccccacc accttgaact gtggccacag cttctgccgg cactgcctgg ctttatggtg
      481 gatgtcttca aagaagacag agtgtccaga atgcagagaa aaatgggaag gttttcctaa
      541 agtcaacatt ctcctcaggg atgccattga aaagttattt cctgatgcca ttagaatgcg
      601 agttgaagac attcagcaga ataatgatgt agtccaaagt cttgcagcct ttcagaaata
      661 tgggaatgat cagaatccct tagctcccag cacagggcga gtaaatcctc agagaggagg
      721 gggattcttc tccggtgttc tcacagcttt aactggtgtg gcagtcatcc tgcttgtgta
      781 tcattggcgc agcagagaat ctgaacatgg cctcctggtg cacaaggctg tagataagtg
      841 gacgacggaa gaagttgtcc tctggttaga acagctagga ccttgggcct ccctgtacag
      901 agacaggttc ttatctgaaa gagtaaatgg aaggttgctt ttaactttga cagaagaaga
      961 gttttccagg gcaccttata ccatagagaa cagtagccac agaagggtca tcctcacgga
     1021 gctggagcgt gtgagagccc tgggagtgaa gccaccgcag aatctctggg agtacaaggc
     1081 tgtcaacccg ggtagatccc tattcttgct ctacgctctc aagagctcac ccagacttgg
     1141 cttgctatac ctgtacctgt ttgactacac agactgcttc ctacccttca tccacaccat
     1201 ctgccctctg caggaaaaca gctctggcga ggacattttc accaagcttc tggacctgag
     1261 ggagcccacg tggaagcagt ggagagaatt cctcgtcaag tactcctttc ttccgtacca
     1321 gctgatcgcg gagtttgcct gggactggct ggaggtccac tactggacat ctcgcttcct
     1381 gatcgtcaat gccgtgctgc tctctgttct ggagttgttc tctttttgga ggatctggtc
     1441 gagaagtgag ctgaagacag tgccccagag gatgtggagc cacttctgga aagtatcgac
     1501 acaggggctt ttcatggcca tgttctggcc gcttattcct cagtttgtct gcaactgttt
     1561 attttactgg gctctgtact tcaacccaat tattaacatt gatctggtgg tcaaggaagt
     1621 ccgacggctg gaaacccaag tgttatgatg ggcagcaagg cccgagcgag cccgtgaatc
     1681 tacctgacaa ccaagctgtg acattcaaag agacaaggga ctcgtttcta cccctggtaa
     1741 tgcgaggtgc tgcttctgtg tgtcaaggct tcaaccaggt ccctcttcct ctgactctgg
     1801 caccatgcca gctgactgct acccaggtca gattggactc atggtcaata cccagccagt
     1861 cttcttacag ggacttgaga ggctcaggct actatgacca atagaagtga aagtcttggt
     1921 cataatttgg ggtgacatgc tgtcaaaagg ctaatataga ctgggtgtgg tagtgcacac
     1981 cttgaatctg agcactagga aaacaggcag gtggattttt gagttcaaga ccagagtggt
     2041 ctacagagtg agttctacaa cagccagggc tacatagagg aaccatgtct ctaaaaaaaa
     2101 aaaaaaagaa agaaagaaaa agaaaagaaa aaagaaagaa atcaaaacaa aacaaaaaga
     2161 agaaaagata aaaaggaagg ccattatggt cagtagccct aacctcacta actgacatac
     2221 tcccaaacca ggcttcttgg gccaggtctg tcccatgagt caaatttagg aaagcaagga
     2281 taggttttgt catagatatg gatagttgga catacaaaat aaagacctag aatccagtca
     2341 tagtttctca ctgaatagtt ggtaggtttc agaataaact cagagaaaac ttcaggctaa
     2401 gagacagtgc tgcgtagctg tgttgtttcc tgttatgagc attggaaatt gggttctcct
     2461 tctgtgagca tggagttgaa tggaatgccc accaggccga gtcttcttag atgactgagc
     2521 actgcttgat gttgtgtttt gaataattta atctgtacaa taaatacagt ataggctgat
     2581 caaggagcat tttgtaagct gccctcacac tatataatgg acaatcttta ttctgttctt
     2641 tagtataaca gcaagtataa ttatgccgag tcctgccatc ataagtatgg agtaagctaa
     2701 aggatgaccg ttatgcccgt gtagacatag tgtactcagc agatgtagaa tgtgagctca
     2761 tcagccttgg cctggctgaa acaggcttgc atccaacgtg agaccgacag acggacagac
     2821 ggacagacag aatgtatggg tgagagagag acagagacaa tgggagagag acagaaggag
     2881 agagtcagag agacttggta attcattaac tctttgtatc tcagagtgaa gatttgactt
     2941 aaactttgca ttgaaagttt ggaaaattac ttgaaataaa aaaagatttt tatacaaata
     3001 caaaaaaaaa
//
