LOCUS       NM_001359570             817 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus brain expressed X-linked 4 (Bex4), transcript variant
            3, mRNA.
ACCESSION   NM_001359570
VERSION     NM_001359570.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 817)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 817)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 817)
  AUTHORS   Manford,A.G., Mena,E.L., Shih,K.Y., Gee,C.L., McMinimy,R.,
            Martinez-Gonzalez,B., Sherriff,R., Lew,B., Zoltek,M.,
            Rodriguez-Perez,F., Woldesenbet,M., Kuriyan,J. and Rape,M.
  TITLE     Structural basis and regulation of the reductive stress response
  JOURNAL   Cell 184 (21), 5375-5390 (2021)
   PUBMED   34562363
REFERENCE   4  (bases 1 to 817)
  AUTHORS   Navas-Perez,E., Vicente-Garcia,C., Mirra,S., Burguera,D.,
            Fernandez-Castillo,N., Ferran,J.L., Lopez-Mayorga,M.,
            Alaiz-Noya,M., Suarez-Pereira,I., Anton-Galindo,E., Ulloa,F.,
            Herrera-Ubeda,C., Cusco,P., Falcon-Moya,R., Rodriguez-Moreno,A.,
            D'Aniello,S., Cormand,B., Marfany,G., Soriano,E., Carrion,A.M.,
            Carvajal,J.J. and Garcia-Fernandez,J.
  TITLE     Characterization of an eutherian gene cluster generated after
            transposon domestication identifies Bex3 as relevant for advanced
            neurological functions
  JOURNAL   Genome Biol 21 (1), 267 (2020)
   PUBMED   33100228
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 817)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 817)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 817)
  AUTHORS   Zhou,J., McCarrey,J.R. and Wang,P.J.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 817)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 817)
  AUTHORS   Alvarez,E., Zhou,W., Witta,S.E. and Freed,C.R.
  TITLE     Characterization of the Bex gene family in humans, mice, and rats
  JOURNAL   Gene 357 (1), 18-28 (2005)
   PUBMED   15958283
REFERENCE   10 (bases 1 to 817)
  AUTHORS   Koo,J.H., Saraswati,M. and Margolis,F.L.
  TITLE     Immunolocalization of Bex protein in the mouse brain and olfactory
            system
  JOURNAL   J Comp Neurol 487 (1), 1-14 (2005)
   PUBMED   15861462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671914.9, AL118340.1, AK010400.1 and BC090663.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1814547.1, AL118340.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL671914.9         210245-210317
            74-275              AL118340.1         8-209
            276-457             AL671914.9         211173-211354
            458-488             AL118340.1         392-422
            489-791             AK010400.1         485-787
            792-817             BC090663.1         762-787
FEATURES             Location/Qualifiers
     source          1..817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.4 cM"
     gene            1..817
                     /gene="Bex4"
                     /note="brain expressed X-linked 4"
                     /db_xref="GeneID:406217"
                     /db_xref="MGI:MGI:3606746"
     exon            1..171
                     /gene="Bex4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..206
                     /gene="Bex4"
                     /inference="alignment:Splign:2.1.0"
     exon            207..795
                     /gene="Bex4"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..568
                     /gene="Bex4"
                     /note="BEX1-like protein 1; brain-expressed X-linked
                     protein 4 homolog; brain expressed gene 4"
                     /codon_start=1
                     /product="protein BEX4"
                     /protein_id="NP_001346499.1"
                     /db_xref="CCDS:CCDS30414.1"
                     /db_xref="GeneID:406217"
                     /db_xref="MGI:MGI:3606746"
                     /translation="MASKFKQVILDLTVEKDKKDKKGGKASKQSEEEPHHLEEVENKK
                     PGGNVRRKVRRLVPNFLWAIPNRHVDRNEGGEDVGRFVVQGTEVKRKTTEQQVRPYRR
                     FRTPEPDNHYDFCLIP"
     regulatory      774..779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex4"
                     /note="hexamer: AATAAA"
     polyA_site      795
                     /gene="Bex4"
                     /note="major polyA site"
ORIGIN      
        1 agcccacgca ggctcacacc cctcgctggg tctcggacct gccctcgctc actctctcca
       61 gcccgccatc cctaacggag gcacctgttc ctggtggcgc agctcctggt ggcgcagagc
      121 acgcgggccc gggcggcgcg gaaagcagca ggaggaggaa gagcggagca ggtctgagaa
      181 gcagaagctt cgcggcgcac ctggtggagt gatggcatcc aaatttaaac aagtcatact
      241 ggatctcact gtggagaaag acaaaaaaga caaaaaaggt gggaaggcct ccaaacaaag
      301 tgaagaagaa ccccaccatc tggaagaggt tgaaaacaag aagcctgggg gaaatgtccg
      361 aaggaaagtc aggcgacttg tgcctaactt tctctgggcc ataccaaata ggcatgttga
      421 tcgcaatgaa gggggagagg atgttgggag atttgtagtg cagggaacag aagtcaagag
      481 aaagactacg gagcagcagg tgaggcctta caggcgtttc cgaaccccgg aacctgacaa
      541 tcattacgac ttttgcctca taccttgaaa tctaagattt tctctgagct cataaaatgg
      601 ctactgtttt acaagctctt atcaagtggg ggtatttttt ctgtaaactt ttggtgtttc
      661 cacttaacgg tttctatgta aaattgttta attgttgcat ttaattcaaa cattcctgtt
      721 agcatggcaa tttaacccat tttagaaaaa aatctttttc ataatttgaa attaataaag
      781 caattttaaa agcaaaaaaa aaaaaaaaaa aaaaaaa
//
