LOCUS       NM_009750                939 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus brain expressed X-linked 3 (Bex3), transcript variant
            1, mRNA.
ACCESSION   NM_009750 XM_975991
VERSION     NM_009750.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Manford,A.G., Mena,E.L., Shih,K.Y., Gee,C.L., McMinimy,R.,
            Martinez-Gonzalez,B., Sherriff,R., Lew,B., Zoltek,M.,
            Rodriguez-Perez,F., Woldesenbet,M., Kuriyan,J. and Rape,M.
  TITLE     Structural basis and regulation of the reductive stress response
  JOURNAL   Cell 184 (21), 5375-5390 (2021)
   PUBMED   34562363
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Navas-Perez,E., Vicente-Garcia,C., Mirra,S., Burguera,D.,
            Fernandez-Castillo,N., Ferran,J.L., Lopez-Mayorga,M.,
            Alaiz-Noya,M., Suarez-Pereira,I., Anton-Galindo,E., Ulloa,F.,
            Herrera-Ubeda,C., Cusco,P., Falcon-Moya,R., Rodriguez-Moreno,A.,
            D'Aniello,S., Cormand,B., Marfany,G., Soriano,E., Carrion,A.M.,
            Carvajal,J.J. and Garcia-Fernandez,J.
  TITLE     Characterization of an eutherian gene cluster generated after
            transposon domestication identifies Bex3 as relevant for advanced
            neurological functions
  JOURNAL   Genome Biol 21 (1), 267 (2020)
   PUBMED   33100228
  REMARK    GeneRIF: Characterization of an eutherian gene cluster generated
            after transposon domestication identifies Bex3 as relevant for
            advanced neurological functions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Calvo,L., Anta,B., Lopez-Benito,S., Martin-Rodriguez,C., Lee,F.S.,
            Perez,P., Martin-Zanca,D. and Arevalo,J.C.
  TITLE     Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and
            Differentiation by Enhancing trkA Gene Transcription
  JOURNAL   J Neurosci 35 (18), 7190-7202 (2015)
   PUBMED   25948268
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Ito,K., Yamazaki,S., Yamamoto,R., Tajima,Y., Yanagida,A.,
            Kobayashi,T., Kato-Itoh,M., Kakuta,S., Iwakura,Y., Nakauchi,H. and
            Kamiya,A.
  TITLE     Gene targeting study reveals unexpected expression of
            brain-expressed X-linked 2 in endocrine and tissue stem/progenitor
            cells in mice
  JOURNAL   J Biol Chem 289 (43), 29892-29911 (2014)
   PUBMED   25143383
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Mukai,J., Hachiya,T., Shoji-Hoshino,S., Kimura,M.T., Nadano,D.,
            Suvanto,P., Hanaoka,T., Li,Y., Irie,S., Greene,L.A. and Sato,T.A.
  TITLE     NADE, a p75NTR-associated cell death executor, is involved in
            signal transduction mediated by the common neurotrophin receptor
            p75NTR
  JOURNAL   J Biol Chem 275 (23), 17566-17570 (2000)
   PUBMED   10764727
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Brown,A.L. and Kay,G.F.
  TITLE     Bex1, a gene with increased expression in parthenogenetic embryos,
            is a member of a novel gene family on the mouse X chromosome
  JOURNAL   Hum Mol Genet 8 (4), 611-619 (1999)
   PUBMED   10072429
  REMARK    Erratum:[Hum Mol Genet 1999 May;8(5):943]
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Kambouris,M., Triarhou,L.C., Dlouhy,S.R., Sangameswaran,L., Luo,F.,
            Ghetti,B. and Hodes,M.E.
  TITLE     Novel cDNA clones obtained by antibody screening of a mouse
            cerebellar cDNA expression library
  JOURNAL   Brain Res Mol Brain Res 25 (3-4), 183-191 (1994)
   PUBMED   7808216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV575702.1, CF618290.1, CD774851.1 and AA681927.1.
            
            On Nov 2, 2007 this sequence version replaced NM_009750.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB209474.1, BI249717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               AV575702.1         2-376
            376-801             CF618290.1         320-745
            802-880             CD774851.1         18-96               c
            881-939             AA681927.1         1-59                c
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.64 cM"
     gene            1..939
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="brain expressed X-linked 3"
                     /db_xref="GeneID:12070"
                     /db_xref="MGI:MGI:1338016"
     exon            1..149
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /inference="alignment:Splign:2.1.0"
     exon            150..222
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..938
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..625
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="isoform a is encoded by transcript variant 1;
                     protein BEX3; brain-expressed X-linked protein 3 homolog;
                     nerve growth factor receptor-associated protein 1; granule
                     cell antiserum positive 27; p75NTR-associated Cell Death
                     Executor; nerve growth factor receptor (TNFRSF16)
                     associated protein 1"
                     /codon_start=1
                     /product="protein BEX3 isoform a"
                     /protein_id="NP_033880.1"
                     /db_xref="CCDS:CCDS30419.1"
                     /db_xref="GeneID:12070"
                     /db_xref="MGI:MGI:1338016"
                     /translation="MANVHQENEEMEQPLQNGQEDRPVGGGEGHQPAANNNNNNHNHN
                     HNHHRRGQARRLAPNFRWAIPNRQMNDGLGGDGDDMEMFMEEMREIRRKLRELQLRNC
                     LRILMGELSNHHDHHDEFCLMP"
     regulatory      860..865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="hexamer: AATAAA"
     regulatory      873..878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="hexamer: AATAAT"
     polyA_site      880
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="major polyA site"
     polyA_site      911
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="hexamer: ATTAAA"
     polyA_site      938
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
ORIGIN      
        1 gcgggcttgg cagtgacgca gggccctcac gtgacccggg gctgcagagc gacgcagcct
       61 tgggtgcagt cgtcacgagc gtctggccag cagctcggag ctcctctgcg cgcggcgggc
      121 tggcagcggg cccgaggcga gcgggacaga ttgactggaa gccgagagtc caggcggcag
      181 cgggaattga caggaggact acgccgcaag ggataggccc agaatagcaa ccaggaaaca
      241 aaatctcatc atggccaatg tccaccagga aaacgaagag atggagcagc ccctgcagaa
      301 tggacaggaa gaccgccctg tgggaggagg tgagggccac cagcctgctg caaacaacaa
      361 caacaacaac cacaaccata accacaacca ccaccgaaga ggccaggctc gccgacttgc
      421 ccctaacttc cgatgggcca ttcccaacag gcagatgaat gacgggttgg gtggagatgg
      481 agatgatatg gaaatgttca tggaggagat gagagagatc cggagaaagc ttagggagct
      541 acagctgaga aattgtctac gcatccttat gggggagctg tctaaccacc acgatcacca
      601 tgatgaattc tgccttatgc cttgacttcg gtcattcccc cctgagatcc atactgtgac
      661 tcccgctgta gcccttttcc tcgcattttc ctgacatgcc tttaatgacc cgtttgtggt
      721 gagccttgtg ttatttccat gccatgtgcc aggtggggct tgtgttgcca gcttctaatt
      781 ggagattgcc ttcccactca gtgtgagttt ctgtcaacag tgcagtgttg cccattagca
      841 tggaaagcaa tgtcaagtca ataaagcaac tgaataatca ttattgtgtc cttaaagcat
      901 aaataaacag ttaagattaa aaaaaagagc cacaagaaa
//
