LOCUS       NM_001110233             934 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus brain expressed X-linked 3 (Bex3), transcript variant
            2, mRNA.
ACCESSION   NM_001110233
VERSION     NM_001110233.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 934)
  AUTHORS   Manford,A.G., Mena,E.L., Shih,K.Y., Gee,C.L., McMinimy,R.,
            Martinez-Gonzalez,B., Sherriff,R., Lew,B., Zoltek,M.,
            Rodriguez-Perez,F., Woldesenbet,M., Kuriyan,J. and Rape,M.
  TITLE     Structural basis and regulation of the reductive stress response
  JOURNAL   Cell 184 (21), 5375-5390 (2021)
   PUBMED   34562363
REFERENCE   3  (bases 1 to 934)
  AUTHORS   Navas-Perez,E., Vicente-Garcia,C., Mirra,S., Burguera,D.,
            Fernandez-Castillo,N., Ferran,J.L., Lopez-Mayorga,M.,
            Alaiz-Noya,M., Suarez-Pereira,I., Anton-Galindo,E., Ulloa,F.,
            Herrera-Ubeda,C., Cusco,P., Falcon-Moya,R., Rodriguez-Moreno,A.,
            D'Aniello,S., Cormand,B., Marfany,G., Soriano,E., Carrion,A.M.,
            Carvajal,J.J. and Garcia-Fernandez,J.
  TITLE     Characterization of an eutherian gene cluster generated after
            transposon domestication identifies Bex3 as relevant for advanced
            neurological functions
  JOURNAL   Genome Biol 21 (1), 267 (2020)
   PUBMED   33100228
  REMARK    GeneRIF: Characterization of an eutherian gene cluster generated
            after transposon domestication identifies Bex3 as relevant for
            advanced neurological functions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 934)
  AUTHORS   Calvo,L., Anta,B., Lopez-Benito,S., Martin-Rodriguez,C., Lee,F.S.,
            Perez,P., Martin-Zanca,D. and Arevalo,J.C.
  TITLE     Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and
            Differentiation by Enhancing trkA Gene Transcription
  JOURNAL   J Neurosci 35 (18), 7190-7202 (2015)
   PUBMED   25948268
REFERENCE   5  (bases 1 to 934)
  AUTHORS   Ito,K., Yamazaki,S., Yamamoto,R., Tajima,Y., Yanagida,A.,
            Kobayashi,T., Kato-Itoh,M., Kakuta,S., Iwakura,Y., Nakauchi,H. and
            Kamiya,A.
  TITLE     Gene targeting study reveals unexpected expression of
            brain-expressed X-linked 2 in endocrine and tissue stem/progenitor
            cells in mice
  JOURNAL   J Biol Chem 289 (43), 29892-29911 (2014)
   PUBMED   25143383
REFERENCE   6  (bases 1 to 934)
  AUTHORS   Mukai,J., Hachiya,T., Shoji-Hoshino,S., Kimura,M.T., Nadano,D.,
            Suvanto,P., Hanaoka,T., Li,Y., Irie,S., Greene,L.A. and Sato,T.A.
  TITLE     NADE, a p75NTR-associated cell death executor, is involved in
            signal transduction mediated by the common neurotrophin receptor
            p75NTR
  JOURNAL   J Biol Chem 275 (23), 17566-17570 (2000)
   PUBMED   10764727
REFERENCE   7  (bases 1 to 934)
  AUTHORS   Brown,A.L. and Kay,G.F.
  TITLE     Bex1, a gene with increased expression in parthenogenetic embryos,
            is a member of a novel gene family on the mouse X chromosome
  JOURNAL   Hum Mol Genet 8 (4), 611-619 (1999)
   PUBMED   10072429
  REMARK    Erratum:[Hum Mol Genet 1999 May;8(5):943]
REFERENCE   8  (bases 1 to 934)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 934)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   10 (bases 1 to 934)
  AUTHORS   Kambouris,M., Triarhou,L.C., Dlouhy,S.R., Sangameswaran,L., Luo,F.,
            Ghetti,B. and Hodes,M.E.
  TITLE     Novel cDNA clones obtained by antibody screening of a mouse
            cerebellar cDNA expression library
  JOURNAL   Brain Res Mol Brain Res 25 (3-4), 183-191 (1994)
   PUBMED   7808216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV575702.1, AV574205.1, CF618290.1, CD774851.1 and AA681927.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU560602.1, AV574205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AV575702.1         2-223
            223-382             AV574205.1         135-294
            383-796             CF618290.1         332-745
            797-875             CD774851.1         18-96               c
            876-934             AA681927.1         1-59                c
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.64 cM"
     gene            1..934
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="brain expressed X-linked 3"
                     /db_xref="GeneID:12070"
                     /db_xref="MGI:MGI:1338016"
     exon            1..149
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /inference="alignment:Splign:2.1.0"
     exon            150..222
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..933
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..620
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="isoform a is encoded by transcript variant 2;
                     protein BEX3; brain-expressed X-linked protein 3 homolog;
                     nerve growth factor receptor-associated protein 1; granule
                     cell antiserum positive 27; p75NTR-associated Cell Death
                     Executor; nerve growth factor receptor (TNFRSF16)
                     associated protein 1"
                     /codon_start=1
                     /product="protein BEX3 isoform a"
                     /protein_id="NP_001103703.1"
                     /db_xref="CCDS:CCDS30419.1"
                     /db_xref="GeneID:12070"
                     /db_xref="MGI:MGI:1338016"
                     /translation="MANVHQENEEMEQPLQNGQEDRPVGGGEGHQPAANNNNNNHNHN
                     HNHHRRGQARRLAPNFRWAIPNRQMNDGLGGDGDDMEMFMEEMREIRRKLRELQLRNC
                     LRILMGELSNHHDHHDEFCLMP"
     regulatory      855..860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="hexamer: AATAAA"
     regulatory      868..873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="hexamer: AATAAT"
     polyA_site      875
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="major polyA site"
     polyA_site      906
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
     regulatory      911..916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
                     /note="hexamer: ATTAAA"
     polyA_site      933
                     /gene="Bex3"
                     /gene_synonym="DXWsu67e; Gcap27; Nade; Ngfrap1"
ORIGIN      
        1 gcgggcttgg cagtgacgca gggccctcac gtgacccggg gctgcagagc gacgcagcct
       61 tgggtgcagt cgtcacgagc gtctggccag cagctcggag ctcctctgcg cgcggcgggc
      121 tggcagcggg cccgaggcga gcgggacaga ttgactggaa gccgagagtc caggcggcag
      181 cgggaattga caggaggact acgccgcaag ggataggccc agcaaccagg aaacaaaatc
      241 tcatcatggc caatgtccac caggaaaacg aagagatgga gcagcccctg cagaatggac
      301 aggaagaccg ccctgtggga ggaggtgagg gccaccagcc tgctgcaaac aacaacaaca
      361 acaaccacaa ccataaccac aaccaccacc gaagaggcca ggctcgccga cttgccccta
      421 acttccgatg ggccattccc aacaggcaga tgaatgacgg gttgggtgga gatggagatg
      481 atatggaaat gttcatggag gagatgagag agatccggag aaagcttagg gagctacagc
      541 tgagaaattg tctacgcatc cttatggggg agctgtctaa ccaccacgat caccatgatg
      601 aattctgcct tatgccttga cttcggtcat tcccccctga gatccatact gtgactcccg
      661 ctgtagccct tttcctcgca ttttcctgac atgcctttaa tgacccgttt gtggtgagcc
      721 ttgtgttatt tccatgccat gtgccaggtg gggcttgtgt tgccagcttc taattggaga
      781 ttgccttccc actcagtgtg agtttctgtc aacagtgcag tgttgcccat tagcatggaa
      841 agcaatgtca agtcaataaa gcaactgaat aatcattatt gtgtccttaa agcataaata
      901 aacagttaag attaaaaaaa agagccacaa gaaa
//
