LOCUS       NM_009749                902 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus brain expressed X-linked 2 (Bex2), mRNA.
ACCESSION   NM_009749 XM_906271
VERSION     NM_009749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 902)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 902)
  AUTHORS   Jones,M.R., Lingampally,A., Ahmadvand,N., Chong,L., Wu,J.,
            Wilhem,J., Vazquez-Armendariz,A.I., Ansari,M., Herold,S.,
            Ornitz,D.M., Schiller,H.B., Chao,C.M., Zhang,J.S., Carraro,G. and
            Bellusci,S.
  TITLE     FGFR2b signalling restricts lineage-flexible alveolar progenitors
            during mouse lung development and converges in mature alveolar type
            2 cells
  JOURNAL   Cell Mol Life Sci 79 (12), 609 (2022)
   PUBMED   36445537
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 902)
  AUTHORS   Manford,A.G., Mena,E.L., Shih,K.Y., Gee,C.L., McMinimy,R.,
            Martinez-Gonzalez,B., Sherriff,R., Lew,B., Zoltek,M.,
            Rodriguez-Perez,F., Woldesenbet,M., Kuriyan,J. and Rape,M.
  TITLE     Structural basis and regulation of the reductive stress response
  JOURNAL   Cell 184 (21), 5375-5390 (2021)
   PUBMED   34562363
REFERENCE   4  (bases 1 to 902)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   5  (bases 1 to 902)
  AUTHORS   Navas-Perez,E., Vicente-Garcia,C., Mirra,S., Burguera,D.,
            Fernandez-Castillo,N., Ferran,J.L., Lopez-Mayorga,M.,
            Alaiz-Noya,M., Suarez-Pereira,I., Anton-Galindo,E., Ulloa,F.,
            Herrera-Ubeda,C., Cusco,P., Falcon-Moya,R., Rodriguez-Moreno,A.,
            D'Aniello,S., Cormand,B., Marfany,G., Soriano,E., Carrion,A.M.,
            Carvajal,J.J. and Garcia-Fernandez,J.
  TITLE     Characterization of an eutherian gene cluster generated after
            transposon domestication identifies Bex3 as relevant for advanced
            neurological functions
  JOURNAL   Genome Biol 21 (1), 267 (2020)
   PUBMED   33100228
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 902)
  AUTHORS   Baldisseri,D.M., Margolis,J.W., Weber,D.J., Koo,J.H. and
            Margolis,F.L.
  TITLE     Olfactory marker protein (OMP) exhibits a beta-clam fold in
            solution: implications for target peptide interaction and olfactory
            signal transduction
  JOURNAL   J Mol Biol 319 (3), 823-837 (2002)
   PUBMED   12054873
REFERENCE   7  (bases 1 to 902)
  AUTHORS   Williams,J.W., Hawes,S.M., Patel,B. and Latham,K.E.
  TITLE     Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in
            preimplantation stage mouse embryos
  JOURNAL   Mol Reprod Dev 61 (3), 281-287 (2002)
   PUBMED   11835573
  REMARK    Erratum:[Mol Reprod Dev. 2002 Sep;63(1):141.]
REFERENCE   8  (bases 1 to 902)
  AUTHORS   Yang,Q.S., Xia,F., Gu,S.H., Yuan,H.L., Chen,J.Z., Yang,Q.S.,
            Ying,K., Xie,Y. and Mao,Y.M.
  TITLE     Cloning and expression pattern of a spermatogenesis-related gene,
            BEX1, mapped to chromosome Xq22
  JOURNAL   Biochem Genet 40 (1-2), 1-12 (2002)
   PUBMED   11989783
REFERENCE   9  (bases 1 to 902)
  AUTHORS   Brown,A.L. and Kay,G.F.
  TITLE     Bex1, a gene with increased expression in parthenogenetic embryos,
            is a member of a novel gene family on the mouse X chromosome
  JOURNAL   Hum Mol Genet 8 (4), 611-619 (1999)
   PUBMED   10072429
  REMARK    Erratum:[Hum Mol Genet 1999 May;8(5):943]
REFERENCE   10 (bases 1 to 902)
  AUTHORS   Faria,T.N., LaRosa,G.J., Wilen,E., Liao,J. and Gudas,L.J.
  TITLE     Characterization of genes which exhibit reduced expression during
            the retinoic acid-induced differentiation of F9 teratocarcinoma
            cells: involvement of cyclin D3 in RA-mediated growth arrest
  JOURNAL   Mol Cell Endocrinol 143 (1-2), 155-166 (1998)
   PUBMED   9806360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY294227.1, AK132005.1 and AL671914.9.
            
            On Jun 17, 2010 this sequence version replaced NM_009749.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027529.1, CF551262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               BY294227.1         2-116
            116-901             AK132005.1         3-788
            902-902             AL671914.9         137814-137814       c
FEATURES             Location/Qualifiers
     source          1..902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.37 cM"
     gene            1..902
                     /gene="Bex2"
                     /gene_synonym="Bex1; REX-3"
                     /note="brain expressed X-linked 2"
                     /db_xref="GeneID:12069"
                     /db_xref="MGI:MGI:1338017"
     exon            1..186
                     /gene="Bex2"
                     /gene_synonym="Bex1; REX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            187..259
                     /gene="Bex2"
                     /gene_synonym="Bex1; REX-3"
                     /inference="alignment:Splign:2.1.0"
     exon            260..902
                     /gene="Bex2"
                     /gene_synonym="Bex1; REX-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..654
                     /gene="Bex2"
                     /gene_synonym="Bex1; REX-3"
                     /note="brain-expressed X-linked protein 2 homolog; reduced
                     expression protein 3; brain-expressed X-linked protein 1
                     homolog; protein BEX1"
                     /codon_start=1
                     /product="protein BEX2"
                     /protein_id="NP_033879.1"
                     /db_xref="CCDS:CCDS30413.1"
                     /db_xref="GeneID:12069"
                     /db_xref="MGI:MGI:1338017"
                     /translation="MESKVEQGVKNLNMENDHQEKEEKEEKPQDASKRDPIVALPFEA
                     GDYYVPRGGRRRFRVRQPIVHYRWDLMHRVGEPQGRMREENVQRFGDDVRQLMEKLRE
                     RQLSHSLRAVSTDPPHHDHHDEFCLMP"
ORIGIN      
        1 ggggcctcct gtcgcaccgg cctcccgaac agggggagcg ggcttggcag tgacgcaggg
       61 ccctcacgtg acccggggct gcagagcgac gcagccttgg gtgcagtcgt cacgagcgtc
      121 tggccagcag ctcggagctc ctctgcgcgc ggcgggctgg cagcgggccc gaggcgagcg
      181 ggacagattg actggaaacc gagagtccag gcggcagcgg gaattgacag gaggactacg
      241 ccgcaaggga taggcccagg agaaatggag tccaaagtgg aacaaggcgt gaaaaatctc
      301 aacatggaga atgaccatca ggaaaaggag gaaaaggaag aaaagccaca ggatgctagc
      361 aaaagggatc cgattgtggc cctgcctttc gaagctggag actactacgt gcctagagga
      421 ggtcgcaggc ggttccgggt tcggcagccc atcgtgcact acagatggga cctgatgcat
      481 agggttgggg agccccaggg aaggatgaga gaggagaacg tacagaggtt tggggatgat
      541 gtgagacagc tcatggagaa gctgagggaa aggcagctga gccacagcct gcgggcggtt
      601 agcactgacc cgcctcatca tgaccaccat gatgagtttt gccttatgcc ctgagtcctg
      661 agcttttctc tgaagatgac atggggaccc ctgctttcaa aacttacatg tttgtgatgt
      721 actgttgtaa tatttctggt gtcacttgtt tccccatggg gctccaactt ctgccagctt
      781 ctaattgaaa cttgtgtttt cgactcagtc ttacatttct ttttttgtta gcagaattta
      841 tctattgcat gggaagatgc tcagtatata ttgtgaacct aataaagcag atttaaaagg
      901 ct
//
