LOCUS       NM_009052                890 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus brain expressed X-linked 1 (Bex1), mRNA.
ACCESSION   NM_009052
VERSION     NM_009052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Wang,Q., Liang,N., Liu,C., Li,J., Bai,Y., Lei,S., Huang,Q., Sun,L.,
            Tang,L., Zeng,C., Tang,Y., He,X., Yang,T. and Wang,G.
  TITLE     BEX1 supports the stemness of hepatoblastoma by facilitating
            Warburg effect in a PPARgamma/PDK1 dependent manner
  JOURNAL   Br J Cancer 129 (9), 1477-1489 (2023)
   PUBMED   37715024
  REMARK    GeneRIF: BEX1 supports the stemness of hepatoblastoma by
            facilitating Warburg effect in a PPARgamma/PDK1 dependent manner.
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Martens,C.R., Dorn,L.E., Kenney,A.D., Bansal,S.S., Yount,J.S. and
            Accornero,F.
  TITLE     BEX1 is a critical determinant of viral myocarditis
  JOURNAL   PLoS Pathog 18 (2), e1010342 (2022)
   PUBMED   35192678
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 890)
  AUTHORS   Hibino,E., Ichiyama,Y., Tsukamura,A., Senju,Y., Morimune,T.,
            Ohji,M., Maruo,Y., Nishimura,M. and Mori,M.
  TITLE     Bex1 is essential for ciliogenesis and harbours biomolecular
            condensate-forming capacity
  JOURNAL   BMC Biol 20 (1), 42 (2022)
   PUBMED   35144600
  REMARK    GeneRIF: Bex1 is essential for ciliogenesis and harbours
            biomolecular condensate-forming capacity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Alexandre,Y.O., Schienstock,D., Lee,H.J., Gandolfo,L.C.,
            Williams,C.G., Devi,S., Pal,B., Groom,J.R., Cao,W., Christo,S.N.,
            Gordon,C.L., Starkey,G., D'Costa,R., Mackay,L.K., Haque,A.,
            Ludewig,B., Belz,G.T. and Mueller,S.N.
  TITLE     A diverse fibroblastic stromal cell landscape in the spleen directs
            tissue homeostasis and immunity
  JOURNAL   Sci Immunol 7 (67), eabj0641 (2022)
   PUBMED   34995096
REFERENCE   5  (bases 1 to 890)
  AUTHORS   Manford,A.G., Mena,E.L., Shih,K.Y., Gee,C.L., McMinimy,R.,
            Martinez-Gonzalez,B., Sherriff,R., Lew,B., Zoltek,M.,
            Rodriguez-Perez,F., Woldesenbet,M., Kuriyan,J. and Rape,M.
  TITLE     Structural basis and regulation of the reductive stress response
  JOURNAL   Cell 184 (21), 5375-5390 (2021)
   PUBMED   34562363
REFERENCE   6  (bases 1 to 890)
  AUTHORS   Williams,J.W., Hawes,S.M., Patel,B. and Latham,K.E.
  TITLE     Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in
            preimplantation stage mouse embryos
  JOURNAL   Mol Reprod Dev 61 (3), 281-287 (2002)
   PUBMED   11835573
  REMARK    GeneRIF: Trophectoderm-specific expression of the X-linked
            Bex1/Rex3 gene in preimplantation stage mouse embryos.
            Erratum:[Mol Reprod Dev. 2002 Sep;63(1):141.]
REFERENCE   7  (bases 1 to 890)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 890)
  AUTHORS   Vetter,D.E., Liberman,M.C., Mann,J., Barhanin,J., Boulter,J.,
            Brown,M.C., Saffiote-Kolman,J., Heinemann,S.F. and Elgoyhen,A.B.
  TITLE     Role of alpha9 nicotinic ACh receptor subunits in the development
            and function of cochlear efferent innervation
  JOURNAL   Neuron 23 (1), 93-103 (1999)
   PUBMED   10402196
REFERENCE   9  (bases 1 to 890)
  AUTHORS   Brown,A.L. and Kay,G.F.
  TITLE     Bex1, a gene with increased expression in parthenogenetic embryos,
            is a member of a novel gene family on the mouse X chromosome
  JOURNAL   Hum Mol Genet 8 (4), 611-619 (1999)
   PUBMED   10072429
  REMARK    Erratum:[Hum Mol Genet 1999 May;8(5):943]
REFERENCE   10 (bases 1 to 890)
  AUTHORS   Faria,T.N., LaRosa,G.J., Wilen,E., Liao,J. and Gudas,L.J.
  TITLE     Characterization of genes which exhibit reduced expression during
            the retinoic acid-induced differentiation of F9 teratocarcinoma
            cells: involvement of cyclin D3 in RA-mediated growth arrest
  JOURNAL   Mol Cell Endocrinol 143 (1-2), 155-166 (1998)
   PUBMED   9806360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY115963.1, CB194115.1 and AF097438.1.
            
            On May 6, 2004 this sequence version replaced NM_009052.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX767802.1, CB192839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BY115963.1         2-154
            154-858             CB194115.1         76-780
            859-890             AF097438.1         804-835
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.4 cM"
     gene            1..890
                     /gene="Bex1"
                     /gene_synonym="Bex2; Bex4; Rex3"
                     /note="brain expressed X-linked 1"
                     /db_xref="GeneID:19716"
                     /db_xref="MGI:MGI:1328321"
     exon            1..177
                     /gene="Bex1"
                     /gene_synonym="Bex2; Bex4; Rex3"
                     /inference="alignment:Splign:2.1.0"
     exon            178..254
                     /gene="Bex1"
                     /gene_synonym="Bex2; Bex4; Rex3"
                     /inference="alignment:Splign:2.1.0"
     exon            255..866
                     /gene="Bex1"
                     /gene_synonym="Bex2; Bex4; Rex3"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..646
                     /gene="Bex1"
                     /gene_synonym="Bex2; Bex4; Rex3"
                     /note="REX-3; reduced expression protein 3;
                     brain-expressed X-linked protein 1 homolog; reduced
                     expression 3; brain expressed gene 1; brain-expressed
                     X-linked protein 2 homolog; protein BEX2"
                     /codon_start=1
                     /product="protein BEX1"
                     /protein_id="NP_033078.2"
                     /db_xref="CCDS:CCDS30417.1"
                     /db_xref="GeneID:19716"
                     /db_xref="MGI:MGI:1328321"
                     /translation="MESKDQGVKNLNMENDHQKKEEKEEKPQDTIRREPAVALTSEAG
                     KNCAPRGGRRRFRVRQPIAHYRWDLMQRVGEPQGRMREENVQRFGGDVRQLMEKLRER
                     QLSHSLRAVSTDPPHHDHHDEFCLMP"
     regulatory      845..850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bex1"
                     /gene_synonym="Bex2; Bex4; Rex3"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="Bex1"
                     /gene_synonym="Bex2; Bex4; Rex3"
                     /note="major polyA site"
ORIGIN      
        1 gtgactagcc cacgcaggct cacacccctc gctgggtctc ggacctgccc tcgctcactc
       61 tctccagccc gccatcccta acggaggcac ctgttcctgg tggcgcagct cctggtggcg
      121 cagagcacgc gggcccgggc ggcgcggaaa gcagcaggag gaggaagagc ggagcaggtc
      181 tgagaagcag aagcttcgcg gcgcacctgg tggtgagcat ctctagaaag aggagaaggc
      241 aaggataggc ccaggagtaa tggagtccaa agatcaaggc gtgaaaaatc tcaacatgga
      301 gaatgaccat cagaaaaagg aggagaagga agaaaagcca caagatacca tcagaaggga
      361 gccagctgtg gccctgacct ccgaggctgg caaaaactgt gcacctagag gaggtcgcag
      421 gcggttccgg gttcggcagc ccatcgctca ctatagatgg gacctgatgc agagggttgg
      481 ggagccccag ggaaggatga gagaggagaa cgtacagagg tttgggggtg atgtgagaca
      541 gctcatggag aagctgaggg aaaggcagct gagccacagc ctgcgggcgg ttagcactga
      601 cccgcctcat catgaccacc atgatgagtt ttgcctcatg ccctgagtcc tgagcttttc
      661 tctgaagatg acatggggac ccctgccttg tgatgtacaa attttgaggt tactcctttt
      721 tatgtagatc tctccctgtt accagcttct aattgaaact tgtgtttttt actcggccta
      781 taattctttt gttagcagaa tttatcaatt gcatgggaag atccgtatta cctattgtga
      841 acctaataaa gcagatttaa aaggcaaaaa aaaaaaaaaa aaaaaaaaaa
//
