LOCUS       NM_001007583            2719 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus bestrophin 3 (Best3), mRNA.
ACCESSION   NM_001007583 XM_356501
VERSION     NM_001007583.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2719)
  AUTHORS   Zhang,T.T., Lei,Q.Q., He,J., Guan,X., Zhang,X., Huang,Y.,
            Zhou,Z.Y., Fan,R.X., Wang,T., Li,C.X., Shang,J.Y., Lin,Z.M.,
            Peng,W.L., Xia,L.K., He,Y.L., Hong,C.Y., Ou,J.S., Pang,R.P.,
            Fan,X.P., Huang,H. and Zhou,J.G.
  TITLE     Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates
            MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection
  JOURNAL   Circulation 148 (7), 589-606 (2023)
   PUBMED   37203562
  REMARK    GeneRIF: Bestrophin3 Deficiency in Vascular Smooth Muscle Cells
            Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic
            Dissection.
REFERENCE   2  (bases 1 to 2719)
  AUTHORS   Wu,L., Sun,Y., Ma,L., Zhu,J., Zhang,B., Pan,Q., Li,Y., Liu,H.,
            Diao,A. and Li,Y.
  TITLE     A C-terminally truncated mouse Best3 splice variant targets and
            alters the ion balance in lysosome-endosome hybrids and the
            endoplasmic reticulum
  JOURNAL   Sci Rep 6, 27332 (2016)
   PUBMED   27265833
  REMARK    GeneRIF: The authors propose that Best3V2 isoform in myoblasts may
            work as a tuner to control Ca(2+) release from intracellular Ca(2+)
            stores.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2719)
  AUTHORS   Golubinskaya,V., Elvin,J., Ebefors,K., Gustafsson,H., Mallard,C.,
            Nystrom,J. and Nilsson,H.
  TITLE     Bestrophin-3 is differently expressed in normal and injured mouse
            glomerular podocytes
  JOURNAL   Acta Physiol (Oxf) 214 (4), 481-496 (2015)
   PUBMED   25912364
  REMARK    GeneRIF: Our experiments present clear evidence of Best3 mRNA and
            protein expression in mouse kidney glomeruli
REFERENCE   4  (bases 1 to 2719)
  AUTHORS   Song,W., Yang,Z. and He,B.
  TITLE     Bestrophin 3 ameliorates TNFalpha-induced inflammation by
            inhibiting NF-kappaB activation in endothelial cells
  JOURNAL   PLoS One 9 (10), e111093 (2014)
   PUBMED   25329324
  REMARK    GeneRIF: results demonstrated that Best-3 is an endogenous
            inhibitor of NF-kappaB signaling pathway in endothelial cells,
            suggesting that forced Best-3 expression may be a novel approach
            for the treatment of vascular inflammatory diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2719)
  AUTHORS   O'Driscoll,K.E., Hatton,W.J., Burkin,H.R., Leblanc,N. and
            Britton,F.C.
  TITLE     Expression, localization, and functional properties of Bestrophin 3
            channel isolated from mouse heart
  JOURNAL   Am J Physiol Cell Physiol 295 (6), C1610-C1624 (2008)
   PUBMED   18945938
REFERENCE   6  (bases 1 to 2719)
  AUTHORS   Srivastava,A., Romanenko,V.G., Gonzalez-Begne,M., Catalan,M.A. and
            Melvin,J.E.
  TITLE     A variant of the Ca2+-activated Cl channel Best3 is expressed in
            mouse exocrine glands
  JOURNAL   J Membr Biol 222 (1), 43-54 (2008)
   PUBMED   18414923
REFERENCE   7  (bases 1 to 2719)
  AUTHORS   Qu,Z.Q., Yu,K., Cui,Y.Y., Ying,C. and Hartzell,C.
  TITLE     Activation of bestrophin Cl- channels is regulated by C-terminal
            domains
  JOURNAL   J Biol Chem 282 (24), 17460-17467 (2007)
   PUBMED   17442670
  REMARK    GeneRIF: These results suggest that an auto-inhibitory mechanism in
            C termini of bestrophin 3 may be universal among bestrophins
            investigated in the study.
REFERENCE   8  (bases 1 to 2719)
  AUTHORS   Qu,Z., Cui,Y. and Hartzell,C.
  TITLE     A short motif in the C-terminus of mouse bestrophin 3 [corrected]
            inhibits its activation as a Cl channel
  JOURNAL   FEBS Lett 580 (8), 2141-2146 (2006)
   PUBMED   16563389
  REMARK    GeneRIF: The channel activity of the mBest4 protein lacking the
            C-terminus (residues 353-669) was specifically inhibited by
            co-expression of C-terminal fragments of mBest4 having the
            inhibitory motif.
            Erratum:[FEBS Lett. 2007 Feb 6;581(3):580]
REFERENCE   9  (bases 1 to 2719)
  AUTHORS   Kramer,F., Stohr,H. and Weber,B.H.
  TITLE     Cloning and characterization of the murine Vmd2 RFP-TM gene family
  JOURNAL   Cytogenet Genome Res 105 (1), 107-114 (2004)
   PUBMED   15218265
REFERENCE   10 (bases 1 to 2719)
  AUTHORS   Stohr,H., Marquardt,A., Nanda,I., Schmid,M. and Weber,B.H.
  TITLE     Three novel human VMD2-like genes are members of the evolutionary
            highly conserved RFP-TM family
  JOURNAL   Eur J Hum Genet 10 (4), 281-284 (2002)
   PUBMED   12032738
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY450426.1.
            
            On Nov 29, 2004 this sequence version replaced XM_356501.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY450426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01766820
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 65.0 cM"
     gene            1..2719
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /note="bestrophin 3"
                     /db_xref="GeneID:382427"
                     /db_xref="MGI:MGI:3580298"
     exon            1..499
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..667
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..2525
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /note="vitelliform macular dystrophy 2-like 3; vitelliform
                     macular dystrophy 2-like protein 3"
                     /codon_start=1
                     /product="bestrophin-3"
                     /protein_id="NP_001007584.1"
                     /db_xref="CCDS:CCDS24188.1"
                     /db_xref="GeneID:382427"
                     /db_xref="MGI:MGI:3580298"
                     /translation="MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYT
                     AISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPW
                     PDRLMLLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEA
                     GFMTADERKLFDHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYR
                     SWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIF
                     TLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKK
                     DIYWDDSAARPPYTLAAADYCIPSFLGSTIQMGLSGSNFPAEDWLWNYEKHGNRHSVM
                     RRVKRFLSTHEHPGSPRRRRSFGRQASDSSMFLPPSPARDLLDVPSRNPHRGSPTRKQ
                     SRSQEGSPKLHSSMGELSTIRETSRTSTLQSLSPQSSVRSSPTKMPQVPEVLITAAEA
                     PAFSADSHQHDSTTSILSLEFTGVQPSGTEQQVEPSGTPPGDPNPQTTSASTERDLFK
                     FEEDLEDDRFPKRWSLPEFLESRHTSLGNLGPDPVSPRDALLLPDTETPSETNGIHPG
                     AGSALAPDILYLMESLDKETDILEFNNEHTGESPKGTPQRPRTWF"
     exon            668..762
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..996
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1151
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1229
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1382
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1463
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1615
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..2719
                     /gene="Best3"
                     /gene_synonym="mBest4; Vmd2l3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatggctcca taagaattta ttcttcattt catgcacaaa aagactgtcc taatcccctc
       61 tttggctact ggagtatgtt cagacctttt cagtagaaaa aggcttttct tccttgatcc
      121 caggccagag ttgaaatgaa tcttaactgg acttaaatgg cccagcatcc tcccgccacc
      181 gccgctgact tcttgttcaa aggggtactt tgggcggcag gtggagttat aattatagat
      241 tagaaaaaag caccatcagc agctgtcact tctgtttgtc cccagctata actgtcatca
      301 gtgggcaaac tggcacagac aggcctctgc aagtggaaaa acatttaacc ctggactcac
      361 tacacgctgg atcgccacag cagcaggaga actaggagga aacccagctg gtcaccagtg
      421 agggtggaag ccggcacctc ttcagggacg gcagatcgtt tgaagatttc tcttcccttg
      481 agagactcca aagaaataga acaaaaccac ccacgatgac tgtcacttac tccagtaaag
      541 tagcaaatgc aacatttttt ggatttcata ggttgcttct caagtggaga ggtagtatct
      601 acaagctgct gtacagggaa tttattgttt ttgctgttct ttacacagca atcagtctgg
      661 tgtacagatt gttacttaca ggagcccaaa aacgttactt tgaaaaatta tcaatttact
      721 gtgacagata tgctgaacaa attccagtaa cctttgtgct tgggttttac gtcactctgg
      781 tagtgaaccg atggtggaac cagtttgtga atctgccttg gccagacagg ctgatgctcc
      841 tcatttccag cagtgtccac gggagcgacc agcatgggcg cctgctcaga aggacgctga
      901 tgcgctacgt caacctgacg tccctgctca tcttccgctc ggtgagcacc gcggtgtaca
      961 agaggtttcc caccatggac cacgtggtcg aagcaggttt tatgacggca gatgagagga
     1021 aattattcga ccacctcaaa tcgcctcatc tgaagtactg ggttcccttc atttggtttg
     1081 gaaatcttgc aaccaaagcc cggaatgaag gcagaatcag agacagcgtt gatctacaat
     1141 cactgatgac tgaaatgaat cggtaccgct cttggtgcag cctcttattt ggttacgact
     1201 gggttggcat tccgctggtt tacacacagg tcgtcaccct cgccgtctac acgttcttct
     1261 ttgcgtgcct gatcggaagg cagttcctgg atcccaccaa aggctacgta ggacatgact
     1321 tggatctgta cgttcccatc ttcactctcc tccagttctt cttctacgca ggatggctca
     1381 aggttgcaga gcagctgatc aaccctttcg gggaagatga cgatgacttt gaaacaaact
     1441 ggtgcattga cagaaacctg caggtctctc tcttggctgt ggatgaaatg catatgagtt
     1501 tgcccaagat gaagaaggac atttactggg acgattctgc tgcccggcca ccgtacacac
     1561 tggcggctgc cgactactgc ataccgtcct ttctgggctc aacgatccaa atggggctgt
     1621 ccgggtccaa cttccccgca gaggactggc tgtggaacta cgagaaacac ggaaaccggc
     1681 actcagtgat gaggagggtc aagcgcttcc tgagtaccca cgagcatcct ggcagcccca
     1741 ggaggaggag gagcttcggc aggcaggcca gcgacagctc catgttctta cccccaagcc
     1801 cagctcggga tctgctggat gtgccgtcca ggaaccccca ccgaggctcg cccacacgga
     1861 agcaatcccg ctcccaagag ggcagcccca agctgcactc cagcatggga gaactgtcca
     1921 ccatcaggga gaccagccgt accagcacgc tgcagagcct gagcccgcag tccagcgtga
     1981 ggtcctcccc taccaaaatg ccccaggtcc ctgaggtcct aatcaccgcc gctgaagcac
     2041 cagcgttctc agcagacagc catcagcatg actccactac ctccatcttg agcctcgagt
     2101 tcaccggggt gcagccgagc gggactgagc agcaggtaga gccttcaggg accccacctg
     2161 gagaccccaa tccccagact acttcagcca gtactgaaag agacttgttc aagttcgagg
     2221 aagatctaga ggatgacaga tttcccaaaa ggtggagcct gccagagttt ctggagtcca
     2281 ggcacacctc gctgggaaac ttaggtccag atcctgtgag tccccgggat gctcttcttt
     2341 tacctgacac agaaacaccc tcagagacca acggaatcca tcctggggct ggctctgccc
     2401 tcgcccccga catcctgtac ttaatggaaa gtttggataa ggaaacagac atcttggagt
     2461 ttaacaacga gcacactgga gaatccccga agggaacacc acagcgcccc aggacctggt
     2521 tctaacccag ctccctactt tacataaagc tgtctgcacc agtcccggaa tcggccccca
     2581 ggaactggcc agcatttgga gaaatgatcc tactatacaa gctacttaga actctgaagg
     2641 gcgttatgat caaacacatc cacattgtct agcacacagg ggctttcatg gaagttttac
     2701 agcccaaatt gattaccgt
//
