LOCUS       NM_011913               2087 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus bestrophin 1 (Best1), mRNA.
ACCESSION   NM_011913 XM_129203
VERSION     NM_011913.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Chen,M., Kim,L., Lu,C.W., Zeng,H. and Vollrath,D.
  TITLE     An efficient inducible RPE-Selective cre transgenic mouse line
  JOURNAL   Exp Eye Res 202, 108370 (2021)
   PUBMED   33264655
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Kwak,H., Koh,W., Kim,S., Song,K., Shin,J.I., Lee,J.M., Lee,E.H.,
            Bae,J.Y., Ha,G.E., Oh,J.E., Park,Y.M., Kim,S., Feng,J., Lee,S.E.,
            Choi,J.W., Kim,K.H., Kim,Y.S., Woo,J., Lee,D., Son,T., Kwon,S.W.,
            Park,K.D., Yoon,B.E., Lee,J., Li,Y., Lee,H., Bae,Y.C., Lee,C.J. and
            Cheong,E.
  TITLE     Astrocytes Control Sensory Acuity via Tonic Inhibition in the
            Thalamus
  JOURNAL   Neuron 108 (4), 691-706 (2020)
   PUBMED   32905785
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Woo,J., Jang,M.W., Lee,J., Koh,W., Mikoshiba,K. and Lee,C.J.
  TITLE     The molecular mechanism of synaptic activity-induced astrocytic
            volume transient
  JOURNAL   J Physiol 598 (20), 4555-4572 (2020)
   PUBMED   32706443
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Pandit,S., Neupane,C., Woo,J., Sharma,R., Nam,M.H., Lee,G.S.,
            Yi,M.H., Shin,N., Kim,D.W., Cho,H., Jeon,B.H., Kim,H.W., Lee,C.J.
            and Park,J.B.
  TITLE     Bestrophin1-mediated tonic GABA release from reactive astrocytes
            prevents the development of seizure-prone network in
            kainate-injected hippocampi
  JOURNAL   Glia 68 (5), 1065-1080 (2020)
   PUBMED   31833596
  REMARK    GeneRIF: Bestrophin1-mediated tonic GABA release from reactive
            astrocytes prevents the development of seizure-prone network in
            kainate-injected hippocampi.
REFERENCE   5  (bases 1 to 2087)
  AUTHORS   Oh,S.J., Lee,J.M., Kim,H.B., Lee,J., Han,S., Bae,J.Y., Hong,G.S.,
            Koh,W., Kwon,J., Hwang,E.S., Woo,D.H., Youn,I., Cho,I.J., Bae,Y.C.,
            Lee,S., Shim,J.W., Park,J.H. and Lee,C.J.
  TITLE     Ultrasonic Neuromodulation via Astrocytic TRPA1
  JOURNAL   Curr Biol 29 (20), 3386-3401 (2019)
   PUBMED   31588000
  REMARK    Erratum:[Curr Biol. 2020 Mar 9;30(5):948. doi:
            10.1016/j.cub.2020.02.042.. PMID: 32155416]
REFERENCE   6  (bases 1 to 2087)
  AUTHORS   Kramer,F., Stohr,H. and Weber,B.H.
  TITLE     Cloning and characterization of the murine Vmd2 RFP-TM gene family
  JOURNAL   Cytogenet Genome Res 105 (1), 107-114 (2004)
   PUBMED   15218265
  REMARK    GeneRIF: cloning and characterization by combining biocomputational
            analyses and molecular genetic approaches
REFERENCE   7  (bases 1 to 2087)
  AUTHORS   Tsunenari,T., Sun,H., Williams,J., Cahill,H., Smallwood,P.,
            Yau,K.W. and Nathans,J.
  TITLE     Structure-function analysis of the bestrophin family of anion
            channels
  JOURNAL   J Biol Chem 278 (42), 41114-41125 (2003)
   PUBMED   12907679
REFERENCE   8  (bases 1 to 2087)
  AUTHORS   Marmorstein,L.Y., McLaughlin,P.J., Stanton,J.B., Yan,L., Crabb,J.W.
            and Marmorstein,A.D.
  TITLE     Bestrophin interacts physically and functionally with protein
            phosphatase 2A
  JOURNAL   J Biol Chem 277 (34), 30591-30597 (2002)
   PUBMED   12058047
REFERENCE   9  (bases 1 to 2087)
  AUTHORS   Stohr,H., Marquardt,A., Nanda,I., Schmid,M. and Weber,B.H.
  TITLE     Three novel human VMD2-like genes are members of the evolutionary
            highly conserved RFP-TM family
  JOURNAL   Eur J Hum Genet 10 (4), 281-284 (2002)
   PUBMED   12032738
REFERENCE   10 (bases 1 to 2087)
  AUTHORS   Petrukhin,K., Koisti,M.J., Bakall,B., Li,W., Xie,G., Marknell,T.,
            Sandgren,O., Forsman,K., Holmgren,G., Andreasson,S., Vujic,M.,
            Bergen,A.A., McGarty-Dugan,V., Figueroa,D., Austin,C.P.,
            Metzker,M.L., Caskey,C.T. and Wadelius,C.
  TITLE     Identification of the gene responsible for Best macular dystrophy
  JOURNAL   Nat Genet 19 (3), 241-247 (1998)
   PUBMED   9662395
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY105692.1, BY714344.1, AY450427.1, AK006549.1 and BX634624.1.
            
            On Nov 15, 2007 this sequence version replaced NM_011913.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY450427.1, BC139060.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BY105692.1         3-128
            127-663             BY714344.1         101-637
            664-975             AY450427.1         488-799
            976-1270            AK006549.1         595-889
            1271-2080           AY450427.1         1095-1904
            2081-2087           BX634624.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.24 cM"
     gene            1..2087
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /note="bestrophin 1"
                     /db_xref="GeneID:24115"
                     /db_xref="MGI:MGI:1346332"
     exon            1..176
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..364
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1868
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /note="vitelliform macular dystrophy protein 2 homolog;
                     best macular dystrophy; vitelliform macular dystrophy 2
                     homolog"
                     /codon_start=1
                     /product="bestrophin-1"
                     /protein_id="NP_036043.2"
                     /db_xref="CCDS:CCDS29568.1"
                     /db_xref="GeneID:24115"
                     /db_xref="MGI:MGI:1346332"
                     /translation="MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYY
                     SIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPW
                     PDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLA
                     GFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLR
                     TQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVF
                     TILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPPMER
                     DMYWNEAAPQPPYTAASARSRRHSFMGSTFNISLKKEDLELWSKEEADTDKKESGYSS
                     TIGCFLGLQPKNYHLPLKDLKTKLLCSKNPLLEGQCKDANQKNQKDVWKFKGLDFLKC
                     VPRFKRRGSHCGPQAPSSHPTEQSAPSSSDTGDGPSTDYQEICHMKKKTVEFNLNIPE
                     SPTEHLQQRRLDQMSTNIQALMKEHAESYPYRDEAGTKPVLYE"
     exon            365..459
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..693
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..848
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..926
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1079
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1160
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1312
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1656
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1831
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2082
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2057..2062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /note="hexamer: AATAAA"
     polyA_site      2078
                     /gene="Best1"
                     /gene_synonym="Bmd; mBest1; Vmd2"
                     /note="major polyA site"
ORIGIN      
        1 ggctgtaatg ttctgggtcc agaaccttca cccatcagcc ctatgtgctc tgcttgctcc
       61 ctgacatgac tctctaccag agggctagag agcatgggct ctgctaccat caaagtcttc
      121 tctgcacacc cttcattcct cagacctccc ttcaaaccct acagaaaccc taacaggacc
      181 caagcccacc tactgctgcc cagtgccaag ccatgactat cacctacaca aacaaagtag
      241 ccaatgcccg cctcggttcg ttctcgtccc tcctcctgtg ctggcgaggc agcatctaca
      301 agctgctgta tggagaattc cttgtcttca tattcctcta ctattccatc cgtggactct
      361 acagaatggt tctctcgagt gatcagcagc tgttgtttga gaagctggct ctgtactgcg
      421 acagctacat tcagctcatc cctatatcct tcgttctggg tttctatgtt acattggtgg
      481 tgagccgctg gtggagccag tacgagaact tgccgtggcc cgaccgcctc atgatccagg
      541 tgtctagctt cgtggagggc aaggatgagg aaggccgttt gctgcggcgc acgctcatcc
      601 gctacgccat cctgggccaa gtgctcatcc tgcgcagcat cagcacctcg gtctacaagc
      661 gctttcccac tcttcaccac ctggtgctag caggttttat gacccatggg gaacataagc
      721 agttgcagaa gttgggccta ccacacaaca cattctgggt gccctgggtg tggtttgcca
      781 acttgtcaat gaaggcctat cttggaggtc gaatccggga caccgtcctg ctccagagcc
      841 tgatgaatga ggtgtgtact ttgcgtactc agtgtggaca gctgtatgcc tacgactgga
      901 taagtatccc attggtgtac acacaggtgg tgacagtggc agtatacagc tttttccttg
      961 catgcttgat cgggaggcag tttctgaacc caaacaagga ctacccaggc catgagatgg
     1021 atctggttgt gcctgtcttc acaatcctgc aattcttatt ctacatgggc tggctgaagg
     1081 tggcagaaca gctcatcaac cccttcgggg aggacgatga tgattttgag actaactgga
     1141 tcattgacag aaacctgcag gtgtccctgt tgtccgtgga tgggatgcac cagaacttgc
     1201 ctcccatgga acgtgacatg tactggaacg aggcagcgcc tcagccgccc tacacagctg
     1261 cttctgccag gtctcgccgg cattccttca tgggctccac cttcaacatc agcctaaaga
     1321 aagaagactt agagctttgg tcaaaagagg aggctgacac ggataagaaa gagagtggct
     1381 atagcagcac cataggctgc ttcttaggac tgcaacccaa aaactaccat cttcccttga
     1441 aagacttaaa gaccaaacta ttgtgttcta agaaccccct cctcgaaggc cagtgtaagg
     1501 atgccaacca gaaaaaccag aaagatgtct ggaaatttaa gggtctggac ttcttgaaat
     1561 gtgttccaag gtttaagagg agaggctccc attgtggccc acaggcaccc agcagccacc
     1621 ctactgagca gtcagcaccc tccagttcag acacaggtga tgggccttcc acagattacc
     1681 aagaaatctg tcacatgaaa aagaaaactg tggagtttaa cttgaacatt ccagagagcc
     1741 ccacagaaca tcttcaacag cgccgtttgg accagatgtc aaccaatata caggctctaa
     1801 tgaaggagca tgcagagtcc tatccctaca gggatgaagc tggcaccaaa cctgttctct
     1861 atgagtgatg cctcacagcc tggccctgac ttgcaaggat gcccagcagg gcactgaccc
     1921 agtcaaaggc acacaagcag cgacacccag gagtgtgttc ccacgacagt ctagcatgta
     1981 actcagaacc aagagtactt aatagtcctg cctgaaaaca cctgtatttt acgatctttc
     2041 ccaaactaag gagtttaata aacgtgaata ttcttttagg tgaaaaa
//
