LOCUS       NM_177235               2318 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BEN domain containing 6 (Bend6), transcript variant 1,
            mRNA.
ACCESSION   NM_177235
VERSION     NM_177235.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2318)
  AUTHORS   Yu,Y., Andreu-Agullo,C., Liu,B.F., Barboza,L., Toth,M. and Lai,E.C.
  TITLE     Regulation of embryonic and adult neurogenesis by Ars2
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31969356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2318)
  AUTHORS   Dai,Q., Ren,A., Westholm,J.O., Duan,H., Patel,D.J. and Lai,E.C.
  TITLE     Common and distinct DNA-binding and regulatory activities of the
            BEN-solo transcription factor family
  JOURNAL   Genes Dev 29 (1), 48-62 (2015)
   PUBMED   25561495
REFERENCE   4  (bases 1 to 2318)
  AUTHORS   Dai,Q., Andreu-Agullo,C., Insolera,R., Wong,L.C., Shi,S.H. and
            Lai,E.C.
  TITLE     BEND6 is a nuclear antagonist of Notch signaling during
            self-renewal of neural stem cells
  JOURNAL   Development 140 (9), 1892-1902 (2013)
   PUBMED   23571214
  REMARK    GeneRIF: BEND6 knock down increases neural stem cell self-renewal
            in neocortex.
REFERENCE   5  (bases 1 to 2318)
  AUTHORS   Ayoub,A.E., Oh,S., Xie,Y., Leng,J., Cotney,J., Dominguez,M.H.,
            Noonan,J.P. and Rakic,P.
  TITLE     Transcriptional programs in transient embryonic zones of the
            cerebral cortex defined by high-resolution mRNA sequencing
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14950-14955 (2011)
   PUBMED   21873192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057378.1.
            
            On Dec 20, 2003 this sequence version replaced NM_177235.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057378.1, AK134655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 12.85 cM"
     gene            1..2318
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /note="BEN domain containing 6"
                     /db_xref="GeneID:320705"
                     /db_xref="MGI:MGI:2444572"
     exon            1..56
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            57..264
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..990
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /note="isoform 1 is encoded by transcript variant 1; BEN
                     domain-containing protein 6"
                     /codon_start=1
                     /product="BEN domain-containing protein 6 isoform 1"
                     /protein_id="NP_796209.2"
                     /db_xref="CCDS:CCDS35533.1"
                     /db_xref="GeneID:320705"
                     /db_xref="MGI:MGI:2444572"
                     /translation="MQKILQTDDITDNQVLRKRKRKRTETANSENANSALEKAQRDPY
                     SGNAFLPGESSSDEETPLMELSKEELCNKIESLKEKLRSIRKENSRLRQSLVMLQVLP
                     QAVTQFEELVGMAETLLKSGGAVSTPASTLWRATNNSSPDSFASLCSNSNSTSSSPSS
                     VKAEEEQHPGEKQFTIERWQIARCNKSKPQKFINDLMQVLYTNEYMATHSLTGAKSST
                     SRDKVVKPAMNQNEVQEIIGVTKQVFPSADDVSIRRMIGQKLNNCTKKPNASKAPNSQ
                     DGILK"
     exon            265..442
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..663
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            664..856
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            857..976
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..2292
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2265..2270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2292
                     /gene="Bend6"
                     /gene_synonym="B230209C24Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgggctcccg cctccctgag cccgcccgga ggctggggct cggaggatgc agcaggaagc
       61 gagaaccgca tgcagaacag cggcacctac atgggcgttt ctgccatcgc cgttccggaa
      121 agcctgggct gactaattga gaaaatgcag aagatcttgc agacagatga catcaccgac
      181 aaccaagttc ttagaaaaag aaagaggaaa cggacagaga cagcaaactc agaaaatgcg
      241 aatagtgctc tggagaaagc acagagagac ccatattcag gaaatgcttt cctgcctggg
      301 gagagttcca gcgatgagga aactccctta atggaactgt ccaaggagga actttgtaac
      361 aaaatcgaaa gcctgaaaga aaaactaaga agcatccgga aggaaaacag ccggcttcga
      421 cagtctttgg tcatgctgca agtgttacct caggcagtca cacagtttga agaactggtt
      481 ggaatggcag agaccctcct taagagtgga ggagccgtgt ccacaccagc gtctactctc
      541 tggagagcaa caaacaactc ctccccagat tcgtttgcct ctctgtgcag taattccaac
      601 tctacttcca gctccccaag ttccgtgaag gctgaggaag agcagcatcc tggtgagaag
      661 cagttcacga ttgagagatg gcagattgcc cgttgtaata agagcaagcc tcagaaattt
      721 attaatgatt taatgcaagt actttacacg aatgagtaca tggccacaca cagtctgacg
      781 ggggcaaaat cctccacttc aagggacaag gttgtcaaac cagctatgaa tcagaatgaa
      841 gttcaagaaa tcataggagt aacgaagcag gtgtttccca gtgcggatga cgtctcaatc
      901 agacggatga taggacagaa gctgaacaac tgcacgaaga agccgaacgc gagcaaagct
      961 ccgaactctc aggatggtat cttaaaataa aacatgcttg gttttccgtc aaacattgga
     1021 atttgctgga gaacttgaga cacatcaagg actggctgta gtagccatgg ctttcctggt
     1081 ggagtaatgg actggctgaa gctgcatgca gagcccttac taattaacca gagaatgtct
     1141 gtcaaacaag catgcaatat ggtttctttg gaaatatgca tctttcacag ccccgaatac
     1201 ttccctgtaa actaacttaa gatgatatca gctcttgtca tagcaacaca aacatccacc
     1261 ctccagatca gtcgttgtct tcaacaaaca cttcaaatta ttactatcag tgactcctca
     1321 ttatggcttt tgtttggtgg ggaggggctt tagcaagctc ctgtttggta agaatacaat
     1381 tgaaataata cacgtctacc aataccatgg ctaaccaagt aatgatgact taacgttaaa
     1441 ccgtttgagt tattctgtga tccaaaaatg tgtgaaatag gattctagaa aaaaaccaaa
     1501 aacataaatg ccttttccgt attcagttat cccaacatgc ccctgaaagt ctaaaatccc
     1561 atctttgttt gttaattcca tgcgctgatt tttataatag tctcttagtc tatgaggaag
     1621 acacacccct cggtatccat tgtccagaac atactagatt cagatgtgta atagtagata
     1681 aatcacctaa agcgcacgta ggacatgata tcgtgcctgg tcagccatga tgctaaactg
     1741 cttaattttg acctgtttat ttccactgta gcagaaggaa aattaactgg aataaaaata
     1801 ccaatttaac tatggcatgg aaaatgccat tttgtaaatc aacaaaaaat aaaacattct
     1861 tcaaagactt ctcacttcat aaaaggtccc ctgactactt tgcaatgaga agctatgcct
     1921 ttctcttttt ctccccacgc cttcctttcc cctctgagac agggcttctc tgtgtaaccc
     1981 tggttatcct ggagctcact ctgtagacca ggcagggctc acactcagag atccacctgc
     2041 ctctgcctcc aaagttctgg gattaatggt gtgcatcacc atgcccagca aacctctgct
     2101 tcttgagtgt gtaacgtgac attgaagctt gggaaggagg attttaaagt gcagtgcagg
     2161 ggacccaggg actacactgt acaggctgct tggttaatag ttcagttgta caaaacaaat
     2221 actcacaatg aagtgaattg tgtgacattt gctactttta attaaataaa atttaactcc
     2281 attgaaaact aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
