LOCUS       NM_199028               6049 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus BEN domain containing 3 (Bend3), transcript variant 1,
            mRNA.
ACCESSION   NM_199028 XM_284862
VERSION     NM_199028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6049)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6049)
  AUTHORS   Yakhou,L., Azogui,A., Gupta,N., Richard Albert,J., Miura,F.,
            Ferry,L., Yamaguchi,K., Battault,S., Therizols,P., Bonhomme,F.,
            Bethuel,E., Sarkar,A., Greenberg,M.V.C., Arimondo,P.B.,
            Cristofari,G., Kirsh,O., Ito,T. and Defossez,P.A.
  TITLE     A genetic screen identifies BEND3 as a regulator of bivalent gene
            expression and global DNA methylation
  JOURNAL   Nucleic Acids Res 51 (19), 10292-10308 (2023)
   PUBMED   37650637
  REMARK    GeneRIF: A genetic screen identifies BEND3 as a regulator of
            bivalent gene expression and global DNA methylation.
REFERENCE   3  (bases 1 to 6049)
  AUTHORS   Pailles,M., Hirlemann,M., Brochard,V., Chebrout,M., Oudin,J.F.,
            Marks,H., Jouneau,A. and Bonnet-Garnier,A.
  TITLE     H3K27me3 at pericentromeric heterochromatin is a defining feature
            of the early mouse blastocyst
  JOURNAL   Sci Rep 12 (1), 13908 (2022)
   PUBMED   35974030
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6049)
  AUTHORS   Zhang,J., Zhang,Y., You,Q., Huang,C., Zhang,T., Wang,M., Zhang,T.,
            Yang,X., Xiong,J., Li,Y., Liu,C.P., Zhang,Z., Xu,R.M. and Zhu,B.
  TITLE     Highly enriched BEND3 prevents the premature activation of bivalent
            genes during differentiation
  JOURNAL   Science 375 (6584), 1053-1058 (2022)
   PUBMED   35143257
  REMARK    GeneRIF: Highly enriched BEND3 prevents the premature activation of
            bivalent genes during differentiation.
REFERENCE   5  (bases 1 to 6049)
  AUTHORS   Saksouk,N., Barth,T.K., Ziegler-Birling,C., Olova,N., Nowak,A.,
            Rey,E., Mateos-Langerak,J., Urbach,S., Reik,W.,
            Torres-Padilla,M.E., Imhof,A., Dejardin,J. and Simboeck,E.
  TITLE     Redundant mechanisms to form silent chromatin at pericentromeric
            regions rely on BEND3 and DNA methylation
  JOURNAL   Mol Cell 56 (4), 580-594 (2014)
   PUBMED   25457167
  REMARK    GeneRIF: BEND3 is a key factor in mediating a switch from
            constitutive to facultative heterochromatin.
            Erratum:[Mol Cell. 2015 Jan 8;57(1):202. Simboeck, Elisabeth
            [Added]]
REFERENCE   6  (bases 1 to 6049)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 6049)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060240.1 and AK122525.1.
            
            On Nov 1, 2007 this sequence version replaced NM_199028.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060240.1, CN537517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4448              BC060240.1         1-4448
            4449-4594           AK122525.1         4055-4200
            4595-6043           BC060240.1         4449-5897
            6044-6049           AK122525.1         5650-5655
FEATURES             Location/Qualifiers
     source          1..6049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.0 cM"
     gene            1..6049
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /note="BEN domain containing 3"
                     /db_xref="GeneID:331623"
                     /db_xref="MGI:MGI:2677212"
     exon            1..233
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /inference="alignment:Splign:2.1.0"
     exon            234..281
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2722
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /codon_start=1
                     /product="BEN domain-containing protein 3"
                     /protein_id="NP_950193.1"
                     /db_xref="CCDS:CCDS35892.1"
                     /db_xref="GeneID:331623"
                     /db_xref="MGI:MGI:2677212"
                     /translation="MNSTEISEDVEEVLKNNPVKAEGSDATLDCSRNSRASEKHLLES
                     VLTALHDSSKRKQLDSDGQPDSVPSVKRRRLIPEALLAGMRTRENSSPCQGNGEPASR
                     GRSGSCAWPAEEEPSTEATVPSYKKPLYGISHKIMEKKNPPSGDLLSPYELFEKANSS
                     SGPSPLRLLSESQKRECGVGVATDGDLNIYFLIQKMFYMLNGLTTNMSQLHSKMDLLS
                     LEVSRVKKQVSPSELVAKFQPPPEYQLTASELKQIAEQSLSCGDLACRLLLQLFPELF
                     SDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPNVKDTAVWQAECLPQLNDFFS
                     RFWAQREMEDSQPGGQVTNFFEADQVDAGHFLDNKDQEEALSLDRSSTIASDHVVDTQ
                     DLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRN
                     YTEIYFPDMQEEEAWLQQCAQRINDELEGLGLEGGSEGEAPRDDCYDSSSLPDDISVV
                     KVEDNFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEMPGSDCLLSKEQLRSIYESSLS
                     IGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPARIRLIRHYVQLLYPRAKN
                     DRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFE
                     GPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARL
                     LVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYEC
                     IPSIDERCRRPNRKKCDILKKAKKVEK"
     exon            282..478
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /inference="alignment:Splign:2.1.0"
     exon            479..6049
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6028..6033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /note="hexamer: TATAAA"
     polyA_site      6043
                     /gene="Bend3"
                     /gene_synonym="mKIAA1553"
                     /note="major polyA site"
ORIGIN      
        1 aaatgacaca cggagtcccg tcacgtcacg cgagagcgca gcgcacggac acacacaaag
       61 agaggggaaa atacacggcg cccgcccgcc cgccgccccc agccagtcgg cggggccgcc
      121 ccggccaggc cctgcgcgct cggcccccac tgcggcccgc gcgcccgccc cccgcacgtg
      181 gcgcccgaac tcggcgcggg tcccgctccg caaagtaaca actctcgtcc cagtggaata
      241 gaagatgaac tcaactgaaa tcagtgaaga tgtagaagaa gttctaaaaa ataaccccgt
      301 gaaggcagag ggcagcgacg ctaccttgga ctgctcccgg aactccaggg cctccgagaa
      361 gcaccttctg gagagcgtcc tcaccgccct ccacgattcc agcaagcgca agcagctgga
      421 cagcgacggc cagccagact ctgtccccag tgtgaagagg aggcggctga tacccgaggc
      481 gctcctggcc ggcatgcgca cccgtgagaa cagttcgccc tgccagggaa atggagagcc
      541 tgccagcagg ggcaggagtg gaagctgtgc atggcctgca gaagaggaac cttccactga
      601 ggccactgtc ccttcctaca agaagcccct gtatggcatc tcccacaaga tcatggagaa
      661 gaagaaccct ccctcgggag acctgctcag cccctatgag ctctttgaga aggcaaactc
      721 cagtagcggc ccttctcccc tgcgcctgct cagtgagtct cagaagcggg aatgtggtgt
      781 cggggttgcc accgatgggg acctcaacat ctacttcctg atccagaaga tgttctacat
      841 gctcaatgga ctcacgacta atatgtccca gcttcacagc aagatggacc tgctgtccct
      901 cgaggtgagc cgtgtcaaga agcaggtgag cccttccgag ctggtggcca agttccagcc
      961 cccgcccgag taccagctca ctgcttccga gctgaaacaa atcgccgagc agagcctgtc
     1021 ttgcggtgac ctagcctgtc gactcctttt gcagctcttc ccagagctct tcagcgacgt
     1081 ggacttctcc cgcggctgca gtgcctgtgg ctttgccgcc aagcggaagt tagagtcgct
     1141 gcacctgcag ctcatccgca actacgtaga ggtctactac cccaatgtga aggacacggc
     1201 tgtgtggcag gccgagtgct tgccgcagct caatgacttc ttcagccgct tctgggccca
     1261 gagagaaatg gaagacagcc agccaggcgg ccaggtcacc aacttcttcg aagcagacca
     1321 agtggatgcc ggccactttc tggacaacaa ggaccaagaa gaagctctgt ctctggaccg
     1381 cagcagcacc attgcctcag accacgtggt ggacactcag gacctcaccg agttcctaga
     1441 tgaagcctcc tctcccggtg agtttgctgt gttcctgcta caccggctct tcccggagct
     1501 gttcgaccac cggaagctgg gcgagcagta cagctgctat ggtgacgggg gcaagcagga
     1561 gctggacccc cagaggctgc agatcatccg caactacaca gagatctact tccctgacat
     1621 gcaggaggag gaggcttggc tgcagcagtg tgcccagcgc atcaatgacg agctggaggg
     1681 cctggggctg gagggaggca gcgagggtga ggcaccgcgg gacgactgct atgactcctc
     1741 tagcctgcca gacgacatct cggtggtcaa ggtagaggac aactttgaag gtgagcggcc
     1801 tggccggcgc tccaagaaga tctggctggt acccattgac tttgacaagt tggagatccc
     1861 gcagcccgac ttcgagatgc caggctcaga ctgccttctg agcaaggagc agctgcgcag
     1921 catctatgag agcagcctgt ccattggcaa cttcgcctcc cgcctgctcg tgcacctctt
     1981 cccggagctc ttcacccacg agaacctgcg caagcagtac aactgcagcg gctccctggg
     2041 caagaagcag ctggatccgg cccgcatcag gctgatccgc cactacgtgc agctcctcta
     2101 cccgagagcc aagaacgacc gcgtgtggac cctggagttc gtaggcaagc tggacgagcg
     2161 ctgtcggcgc agggacacgg agcagcgccg atcctaccag cagcaacgca aggtccatgt
     2221 gcctggcccc gagtgccggg acctagcaag ttacgcaatc aaccccgaga ggttccgtga
     2281 ggagtttgag gggccccctc tgcctcctga aaggagcagc aaagactttt gcaaaatacc
     2341 cttggacgag ctggtggtcc cctcacctga ctttccggtg ccttccccct acctgctgtc
     2401 agacaaggag gttcgtgaga tcgtgcagca gagcctgtcg gtgggcaact tcgcggcccg
     2461 gctcctggtc aggctcttcc cggaactctt cacgaccgag aacctccgac tgcagtacaa
     2521 ccactccggg gcttgtaaca agaagcagct ggaccccacg aggctgaggc tcatccgcca
     2581 ttacgtggaa gctgtctacc ccgtggagaa gatggaagag gtgtggcact atgaatgtat
     2641 acctagcatt gatgagcggt gtcgccgtcc caacaggaaa aagtgcgaca tcctcaagaa
     2701 agccaagaaa gtggagaagt gacagggttg gggctgccca gggacctggg tcaccgcagg
     2761 ctgagcagtg ggtgcccttg ggactgagca ttgctcagga gctcggatgg tacccacaga
     2821 ccggcacctt atgccagtgg ggagtggttt cctacatttg cacacgtaaa cacctaccca
     2881 gccacaagaa agaagccttg aatttggtct tttgtattta tgactttgtt ctgtgttccc
     2941 tggtggcaca gccggagttt tggggggggt ggggggtagc caagctgtga aatcagagaa
     3001 ttggtagggt agggtccctt cacagggcta gggtgccctc cctaaccctt acgattcaaa
     3061 attcaaattt agactagatg tggtagccca ccctctaggc agaggccact ggagtttgag
     3121 gccagtctag ttagtctgca gagtgaattc cagcccagtc agggctgaac aatgagaccc
     3181 tgtctgaaaa acaagaaaat gcaaacgtag caacttgttt ctctctcctc atgttttaca
     3241 tcttctattt ttatcttttt tttattatta aaatgaattt ttgaagaatc attaggctct
     3301 ttgggagcca ttttatttag aaaaaaatca taaaatattt gagatgagat gctgtaagat
     3361 tacttcagtt gctgggattt ttttaaagat gattttagat ttatgctttt ttcaaaaaag
     3421 aagaaatgcc atattcaggc attatgggta actgtggctt caggtggcat agtgactagt
     3481 tttactaatc ctgtgtctga tatctgattt tggaagagtc catagacccc cttagattca
     3541 gcagacggga tggattataa gtagtgtgta gcccctttct tattctatgt gagcttccgt
     3601 tctgcggtgg cccagcctgt ctgccgccgc cgtgtggtgc tcgctgtgta gatgagaaca
     3661 ctggaagatg atctgaatgt aggtagaacg gaggcgtggg tccttacagc cttcgtggga
     3721 gctgtgccct ccacacagat gttgctgtag agggacacat tgcaacacag tgtgtaggga
     3781 cagttttgtg tgatttacgg gtgagctttt gggttcaccg agaactgttt acttcccatg
     3841 tatttgtaca aagtccgtgt ccccagacct cagtgttagc tcctcccatg gtcttgaacc
     3901 tccaaagccc cagcctaggg ctcttttgca ggtgttggaa gaacccaaac catcttaaat
     3961 ggagtgccca caccccttcc cagtcccacc agaccttttc cctcaaacct tgcaggaagt
     4021 tctgccagcc taccctggcc cacccctagc atggaggtgc gtatctcttc cccttctgca
     4081 ctggggccag atgcctaaga aggaaaggag accgtgtttc ccaaactcag tgcatcgcat
     4141 ccccgaccta gaagactgag ttgcccgggg cagtcataaa acccttgtgg gacattacag
     4201 acgtgataac tttaatggct taatattttg ctacattaat atgcagaggt gatagaaata
     4261 atctatgaat tttctcataa agataagaac tttagttcta gtagaccaca tgatataatt
     4321 ttgcatgtac ccaatgggca ttcaattttc aatgctataa agcttctgtc ctctgtcatt
     4381 ctcagattat ttatgctata actgtaaacc taaattattg acattgagaa gtgcgcagag
     4441 actttgtggc acacacgaat ctccttataa gaagtgaggg gaggggcccc gcggagaaca
     4501 aggcaacctt cttgtgccca ggaagaaggt aatgggcagc cagaagagtc cccttccccc
     4561 ctcacttggc ctctctctaa tgccttagtt acacacacac acacacacac acacacacac
     4621 acacacgcta ccccaaagat ggctgtggca ctctctcact gcttccactg gttggagaga
     4681 attccatggg atttgttctg gtcttgagga tgtaaccgag aggattccaa gccatgtgaa
     4741 aattgtcctg ctttccagaa agtggagtgt ggccctgcaa catcagaagc acaatcggcc
     4801 attgagtttt tacaagtccc atctcgtcac atctgagaaa tggcgggctc taggaactga
     4861 gcgggacttt ttgtaaccca gagtgtgtta aattctggga acctgtattt tggtttcctt
     4921 aatactttaa ctatgtaggg cttctctcct cccaaccccc acctccaccc ccagtcccat
     4981 catcccttca gtgaaaaaga gctggtcact ctgggagctg tttcctgccc actggaccgt
     5041 atggtgtcct cactcaccca tccgtacagg gagttccagt gggcattttt ttttcatgaa
     5101 gcaatataaa tataaaatac ttattttttc agaatttaat ggttttcatg aaatctgttg
     5161 gcaactactt tccctgtcct catctaaatt ctttgtttgt gttttggatg atttttgcct
     5221 tgtatccaga ggactaaaga ttagccccga tattctgatg ttcactaaaa tagtatgtca
     5281 cagtaggtgg tagtggtctt ggttttctct gttagtaagc tgttaaagaa tgtctgaaga
     5341 tactcttgaa tgtacagtgt tcgaatcctg cttttattca tgtggccgtg tctgtctgat
     5401 ggcaaacgtt tgtcagggaa tcaatgtcta gtgtcgttag tgctcgctgc ccttcccctt
     5461 cagtgttgaa ccccaaacct tcctttcctt ttaagttagg aagtgagggg ttcatatcag
     5521 cagcaatcat caactgacca atgggatcta cttagtggcg actggatttg gcctgatcac
     5581 accacagtgt ggccatttgg gtccttgtag agattgtctc ggtttctact atccccccag
     5641 caactgcttc ctacctgatc cagagggacc tggagacccc tagttggagg tcactgggtc
     5701 attctgaagt ggggggtgag ggcccaaggg ctgtcactgc tgtgggcagt ctttgtctct
     5761 tgtagatcca gccttaatgt ctgacatccc aggaagcgca gaccctgcac aaagtggata
     5821 tcagagcgat actgtgagga gtaagtaagg agcataggtt taccaaagag aatgagctag
     5881 cacatcatgt ctgcctgtta cactgatctg agtgcaccct tagaaaactg aatgtaccac
     5941 agacccagga cagttttgga acttgtatgc tctctagcaa ctttgtgtga atttttatac
     6001 aagcactgtt ttattaatta tataaaatat aaaaatagaa aaactggtc
//
