LOCUS       NM_001163175            2728 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus brain-enriched guanylate kinase-associated (Begain),
            transcript variant 5, mRNA.
ACCESSION   NM_001163175 XM_354696 XM_914385
VERSION     NM_001163175.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Katano,T., Konno,K., Takao,K., Abe,M., Yoshikawa,A., Miyakawa,T.,
            Sakimura,K., Watanabe,M., Ito,S. and Kobayashi,T.
  TITLE     Brain-enriched guanylate kinase-associated protein, a component of
            the post-synaptic density protein complexes, contributes to
            learning and memory
  JOURNAL   Sci Rep 13 (1), 22027 (2023)
   PUBMED   38086879
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2728)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
REFERENCE   4  (bases 1 to 2728)
  AUTHORS   Koppes,E., Shaffer,B., Sadovsky,E., Himes,K., Barak,Y., Sadovsky,Y.
            and Chaillet,J.R.
  TITLE     Klf14 is an imprinted transcription factor that regulates placental
            growth
  JOURNAL   Placenta 88, 61-67 (2019)
   PUBMED   31675530
REFERENCE   5  (bases 1 to 2728)
  AUTHORS   Katano,T., Fukuda,M., Furue,H., Yamazaki,M., Abe,M., Watanabe,M.,
            Nishida,K., Yao,I., Yamada,A., Hata,Y., Okumura,N., Nakazawa,T.,
            Yamamoto,T., Sakimura,K., Takao,T. and Ito,S.
  TITLE     Involvement of Brain-Enriched Guanylate Kinase-Associated Protein
            (BEGAIN) in Chronic Pain after Peripheral Nerve Injury
  JOURNAL   eNeuro 3 (5) (2016)
   PUBMED   27785460
  REMARK    GeneRIF: BEGAIN was highly localized at the synapse of inner lamina
            II in the spinal dorsal horn and that its expression was
            up-regulated after peripheral nerve injury in wild-type, but not in
            GluN2B Y1472F-KI, mice. Mechanical allodynia was significantly
            attenuated in BEGAIN-deficient mice, but no change was observed in
            terms of physiological threshold for mechanical stimuli.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2728)
  AUTHORS   Tierling,S., Gasparoni,G., Youngson,N. and Paulsen,M.
  TITLE     The Begain gene marks the centromeric boundary of the imprinted
            region on mouse chromosome 12
  JOURNAL   Mamm Genome 20 (9-10), 699-710 (2009)
   PUBMED   19641963
  REMARK    GeneRIF: A Begain transcript variant is preferentially expressed
            from the paternal allele.
REFERENCE   7  (bases 1 to 2728)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 2728)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158915.1 and BC080282.1.
            
            [WARNING] On Mar 1, 2025 this sequence was replaced by
            NM_001163175.2.
            
            On or before Jul 11, 2009 this sequence version replaced
            XM_914385.3, XM_354696.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158915.1, SRR7974084.27167.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               AK158915.1         2-731
            731-2707            AK158915.1         733-2709
            2708-2728           BC080282.1         2501-2521
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 59.98 cM"
     gene            1..2728
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /note="brain-enriched guanylate kinase-associated"
                     /db_xref="GeneID:380785"
                     /db_xref="MGI:MGI:3044626"
     exon            1..92
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1910
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /note="isoform 5 is encoded by transcript variant 5;
                     brain-enriched guanylate kinase-associated protein;
                     brain-enriched guanylate kinase-associated; brain-enriched
                     guanylate kinase-associated protein"
                     /codon_start=1
                     /product="brain-enriched guanylate kinase-associated
                     protein isoform 5"
                     /protein_id="NP_001156647.1"
                     /db_xref="CCDS:CCDS56862.1"
                     /db_xref="GeneID:380785"
                     /db_xref="MGI:MGI:3044626"
                     /translation="MWTGGRRPGRLRRAASAADMEKLSALQEQKGELRKRLSYTTHKL
                     EKLETEFDSTRHYLEIELRRAQEELDKVTEKLRRIQSNYMALQRINQELEDKLYRMGQ
                     HYEEEKRAMSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVH
                     KVSELPSDFQQRVSLHMEKHGCSLPSALCHPAYADSVPTCVIAKVLEKPDPGSLSSRM
                     SDASARDLGYRDGVEKSGPRPPYKGDIYCSDPALYCPDEREHARRPSVDTPVTDVGFL
                     RAQNSTDSAAEEEEEAEAAAFPEAYRREAYQGYAASLPTSSSYSSFSATSEEKEHAQA
                     GTLTASQQAIYLSSRDEFFNRKPSATYGSGPRFAKAASTLGSPLEAQVAPGFARTVSP
                     YPAEPYRYPASPGPQQALMPPNLWSLRAKPSGNRLAGEDIRGQWRPVSVEDVGAYSYQ
                     AGAAAGRAASPCNYSERYYGGGGGGGAAGGGSPGDKAEGRASPLYATYKADSFSEGDD
                     LSQGHLAEPCFLRAGGDLSLSPSRSADALAGYAASDGDGDRLRVQLCGAGSSPEPEHG
                     SRESLEPSSMEASPEMHPPTRLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN"
     exon            93..121
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /inference="alignment:Splign:2.1.0"
     exon            122..283
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /inference="alignment:Splign:2.1.0"
     exon            284..350
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /inference="alignment:Splign:2.1.0"
     exon            351..458
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /inference="alignment:Splign:2.1.0"
     exon            543..2712
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2690..2695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /note="hexamer: AATAAA"
     polyA_site      2712
                     /gene="Begain"
                     /gene_synonym="Gm897"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgctgg ggagccccgg ccgcgggctc gggcgcgcag agccggggcc atgtggacgg
       61 gtggccggcg gccgggccgg cttcgccggg cggcctctgc cgcagacatg gagaaactca
      121 gtgccctcca ggaacagaag ggcgagctgc gcaagcggct ctcctacacc acgcataagc
      181 tggagaagct ggagacggag tttgactcca cgcgccacta cctggagatt gagctgaggc
      241 gtgcccagga ggagctagac aaggtgacgg agaaactgcg caggattcag agcaactaca
      301 tggcgctgca gaggatcaac caagagctgg aggacaagct gtaccggatg ggccagcact
      361 atgaggaaga gaagcgtgcc atgagccatg agattgtcgc cctcaacagc cacctgctgg
      421 aggctaaggt gaccattgac aagctgtcgg aggacaacga gctctatagg aaggactgca
      481 atctagcggc ccagctgctg cagtgcagcc agacctacgg cagggtccat aaggtgtccg
      541 agctgccctc ggacttccaa cagcgcgtga gcctgcacat ggagaagcat ggctgcagcc
      601 tgccgtccgc actgtgccat ccggcctacg ccgacagcgt gcccacctgc gtcatcgcca
      661 aagtgctgga gaagccggac ccgggcagcc tgtcctcgcg catgtcggat gcctcggccc
      721 gcgacctggg ctaccgcgac ggagtggaga agtcgggccc gcggcccccg tacaagggag
      781 acatctactg cagcgaccca gctctctact gccccgacga gcgggagcac gcccggcgac
      841 ccagcgtgga cacgccggtg accgacgtgg gcttcctgcg ggcgcagaat tccaccgaca
      901 gcgcggcgga ggaggaggaa gaggccgagg cggcggcctt cccggaggcc taccgtcggg
      961 aggcctacca gggctacgcg gcctcgctgc ccacctccag ctcctactcc agcttcagcg
     1021 ccacgtccga ggagaaggag cacgcgcagg ccggcacgct gaccgcctcg cagcaggcca
     1081 tctacctgag cagccgcgac gagttcttca accgcaagcc ctccgccacc tacggcagcg
     1141 gccctcgctt cgccaaggcc gcgtccaccc tgggctcccc gctggaggcc caggtcgccc
     1201 caggctttgc tcggactgtg tctccgtacc cggccgagcc ctaccgctac ccggcctccc
     1261 ccggccccca gcaggctctc atgcctccaa acctgtggag cctgcgggcc aagccgagcg
     1321 ggaaccggct tgccggggag gacattcgag gccagtggcg gcccgtgagc gtggaggatg
     1381 tgggcgccta ctcctaccag gccggcgccg ctgccggccg cgctgcctcg ccctgcaact
     1441 actcggaacg ttactacggc ggcggcggcg gcgggggcgc cgctggcggc ggcagccccg
     1501 gcgacaaggc cgagggccgt gccagtcccc tctatgccac ctacaaggcc gatagtttct
     1561 cggagggcga tgacctgtct cagggtcatc tggccgagcc ctgcttcctc cgagcaggtg
     1621 gcgatctgag cctcagtccc agtcgttcgg ctgatgcgct cgctggctat gcagccagtg
     1681 atggggatgg agataggctc agggtgcagc tgtgtggggc tggcagtagc ccggagcccg
     1741 agcatggctc ccgcgagtcc ctggagccta gctccatgga ggcctctcct gaaatgcacc
     1801 ctcccactcg cctcagcccc cagcaggcct tcccaaggac tggaggctct gggctgagcc
     1861 gtaaggacag tctcactaaa gcccagctct acggtaccct gctcaactga ctgctatcag
     1921 cagactgcag tcaggcgctc cctaccaccc tgccccatat agggagtagc taaccccacc
     1981 ccctcgtccc aacccctgcc aaggaagtcc agttccagtt tcgcctgacc ctcctactac
     2041 caccccagta gaacctgaag agaccccctc tggcgcgtcg tcttgtccac cccagcctct
     2101 gctacagacc ccccagcctc tgctacaaac cccgaatatt tctgctctgc acccttccct
     2161 gaagtgagca tcccctgttt tgtaagtgaa gctatttttt tagggaaaga gagtgtttct
     2221 tcacgcactt gccgctagat tctgggtggc agccttggca aaccccacat gaaggtcctt
     2281 catttccagt gagggtgcat ggggcctgcc ccagggaagg ggaggctggg accctagagg
     2341 gaccagtctc cacaagaggg gagaagccag aaacaaggga acaagtggga agttctgtac
     2401 actgaggagg ggaaccaaag ccacttaggg cgcagaaaat gtcttctgct ctcgtctcac
     2461 agtgcagcca gcactccgcc ctgatccacc ctgagctttt ccatggcccg gcctgtgggc
     2521 ccaagagagg ccagggacac ccccagaaca gccggtgctc gttcctcccc ttcccctccc
     2581 gacaccacct gactctacct cagacatgag gctcctccct cctcccaccc ctgtgaacct
     2641 gtcttctgtg atgcatgcca gtctcttagt actgtatctc gaactcctta ataaaggaca
     2701 gcagtggaaa gaaaaaaaaa aaaaaaaa
//
