LOCUS       NM_001290692            1789 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus beclin 2 (Becn2), mRNA.
ACCESSION   NM_001290692
VERSION     NM_001290692.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Zhang,B., He,Z., Guo,J., Li,F., Huang,Z., Zheng,W., Xing,W., Li,M.,
            Zhu,Y. and Yang,X.
  TITLE     Sesamin-mediated high expression of BECN2 ameliorates cartilage
            endplate degeneration by reducing autophagy and inflammation
  JOURNAL   Aging (Albany NY) 16 (2), 1145-1160 (2024)
   PUBMED   38284902
  REMARK    GeneRIF: Sesamin-mediated high expression of BECN2 ameliorates
            cartilage endplate degeneration by reducing autophagy and
            inflammation.
REFERENCE   2  (bases 1 to 1789)
  AUTHORS   Quiles,J.M., Najor,R.H., Gonzalez,E., Jeung,M., Liang,W.,
            Burbach,S.M., Zumaya,E.A., Diao,R.Y., Lampert,M.A. and
            Gustafsson,A.B.
  TITLE     Deciphering functional roles and interplay between Beclin1 and
            Beclin2 in autophagosome formation and mitophagy
  JOURNAL   Sci Signal 16 (770), eabo4457 (2023)
   PUBMED   36719945
  REMARK    GeneRIF: Deciphering functional roles and interplay between Beclin1
            and Beclin2 in autophagosome formation and mitophagy.
REFERENCE   3  (bases 1 to 1789)
  AUTHORS   Kim,Y.J., Kong,Q., Yamamoto,S., Kuramoto,K., Huang,M., Wang,N.,
            Hong,J.H., Xiao,T., Levine,B., Qiu,X., Zhao,Y., Miller,R.J.,
            Dong,H., Meltzer,H.Y., Xu,M. and He,C.
  TITLE     An autophagy-related protein Becn2 regulates cocaine reward
            behaviors in the dopaminergic system
  JOURNAL   Sci Adv 7 (8) (2021)
   PUBMED   33608268
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1789)
  AUTHORS   Zhu,M., Deng,G., Tan,P., Xing,C., Guan,C., Jiang,C., Zhang,Y.,
            Ning,B., Li,C., Yin,B., Chen,K., Zhao,Y., Wang,H.Y., Levine,B.,
            Nie,G. and Wang,R.F.
  TITLE     Beclin 2 negatively regulates innate immune signaling and tumor
            development
  JOURNAL   J Clin Invest 130 (10), 5349-5369 (2020)
   PUBMED   32865519
  REMARK    GeneRIF: Beclin 2 negatively regulates innate immune signaling and
            tumor development.
REFERENCE   5  (bases 1 to 1789)
  AUTHORS   Gui,X., Yang,H., Li,T., Tan,X., Shi,P., Li,M., Du,F. and Chen,Z.J.
  TITLE     Autophagy induction via STING trafficking is a primordial function
            of the cGAS pathway
  JOURNAL   Nature 567 (7747), 262-266 (2019)
   PUBMED   30842662
REFERENCE   6  (bases 1 to 1789)
  AUTHORS   Kuramoto,K., Wang,N., Fan,Y., Zhang,W., Schoenen,F.J.,
            Frankowski,K.J., Marugan,J., Zhou,Y., Huang,S. and He,C.
  TITLE     Autophagy activation by novel inducers prevents BECN2-mediated drug
            tolerance to cannabinoids
  JOURNAL   Autophagy 12 (9), 1460-1471 (2016)
   PUBMED   27305347
  REMARK    GeneRIF: a protein involved in macroautophagy/autophagy (a
            conserved lysosomal degradation pathway), BECN2 (beclin 2),
            mediates cannabinoid tolerance by preventing CNR1 recycling and
            resensitization after prolonged agonist exposure, and deletion of
            Becn2 rescues CNR1 activity in mouse brain and conveys resistance
            to analgesic tolerance to chronic cannabinoids
REFERENCE   7  (bases 1 to 1789)
  AUTHORS   Dong,X., Cheng,A., Zou,Z., Yang,Y.S., Sumpter,R.M. Jr., Huang,C.L.,
            Bhagat,G., Virgin,H.W., Lira,S.A. and Levine,B.
  TITLE     Endolysosomal trafficking of viral G protein-coupled receptor
            functions in innate immunity and control of viral oncogenesis
  JOURNAL   Proc Natl Acad Sci U S A 113 (11), 2994-2999 (2016)
   PUBMED   26929373
  REMARK    GeneRIF: Monoallelic loss of Becn2 accelerates progression of
            vGPCR-induced lesions resembling human Kaposi's sarcoma. Beclin 2
            is protects against the pathogenic effects of KSHV GPCR by
            facilitating its endolysosomal degradation.
REFERENCE   8  (bases 1 to 1789)
  AUTHORS   He,C., Wei,Y., Sun,K., Li,B., Dong,X., Zou,Z., Liu,Y., Kinch,L.N.,
            Khan,S., Sinha,S., Xavier,R.J., Grishin,N.V., Xiao,G.,
            Eskelinen,E.L., Scherer,P.E., Whistler,J.L. and Levine,B.
  TITLE     Beclin 2 functions in autophagy, degradation of G protein-coupled
            receptors, and metabolism
  JOURNAL   Cell 154 (5), 1085-1099 (2013)
   PUBMED   23954414
  REMARK    GeneRIF: Study identified a previously uncharacterized
            mammalian-specific protein, Beclin 2, which, like Beclin 1,
            functions in autophagy and interacts with class III PI3K complex
            components.[Beclin 2]
REFERENCE   9  (bases 1 to 1789)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB838749.1, KF511582.1 and CJ207428.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ207428.1, SRR1660817.298932.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BB838749.1         2-42
            42-1385             KF511582.1         1-1344
            1386-1789           CJ207428.1         126-529
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1789
                     /gene="Becn2"
                     /gene_synonym="Beclin-2; Gm104; Gm38100"
                     /note="beclin 2"
                     /db_xref="GeneID:226720"
                     /db_xref="MGI:MGI:2684950"
     exon            1..1360
                     /gene="Becn2"
                     /gene_synonym="Beclin-2; Gm104; Gm38100"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1385
                     /gene="Becn2"
                     /gene_synonym="Beclin-2; Gm104; Gm38100"
                     /codon_start=1
                     /product="beclin-2"
                     /protein_id="NP_001277621.1"
                     /db_xref="CCDS:CCDS78757.1"
                     /db_xref="GeneID:226720"
                     /db_xref="MGI:MGI:2684950"
                     /translation="MSPALFLCQRCKEPLKLLQQQGGPLEVQHHANTPTEIPVSAESQ
                     VRTSGRPHSDGGRVSQGSALCTFTLLTSGGPDSEGGTTSQGNACCTFTLLGESASMRT
                     MNTIQNTVLETFEILSDQKVVDHPLCVDCTDHLLMQLDDQLALLASDNQKYKSFQDRE
                     LLVSEEEREALHAELCAELSSLEQEEARLTQELEDLDGHHARVAAELRAAQAESKELY
                     KQHEQHRVEYSVFKMEQLELMDQLSSVENQLTYALSQQYRLRQTNIFNATFTISDEGP
                     LGVINNFRLGCLPGVRVGWTEISSAWGQTVLLLFSLSKIAGLQFQRYQLVPFGDHSYL
                     KSLTGDGVLPLFSDGSHSVFLNNKFDCGMKAFLDCLQQFVEEIERDERCPCLPYRIHV
                     KEGLMEDVWDSGECCSIRTHLNTEEEWSRALKFMLSDLKLILAWASLRFSRVQRP"
     exon            1361..1789
                     /gene="Becn2"
                     /gene_synonym="Beclin-2; Gm104; Gm38100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1764..1769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Becn2"
                     /gene_synonym="Beclin-2; Gm104; Gm38100"
                     /note="hexamer: AATAAA"
     polyA_site      1787
                     /gene="Becn2"
                     /gene_synonym="Beclin-2; Gm104; Gm38100"
                     /note="major polyA site"
ORIGIN      
        1 gcaaagaaaa ctagactctg gtgggagtgt ggaactctag aatgtctcct gccctcttcc
       61 tgtgccagcg ctgcaaagaa cccctgaaac tcttacagca gcaggggggg cccttggaag
      121 tccagcacca cgccaatacc cccacagaaa ttccagtttc tgcagagtcc caagtcagga
      181 cctccggcag accccactct gacggtggca gggtgtccca gggaagtgcc ctctgcactt
      241 ttactctgct tacctctggc ggaccggact ctgaaggtgg cacgacgtcc cagggaaatg
      301 cctgctgtac ctttactctg cttggtgaat ctgcctccat gagaactatg aacactatcc
      361 aaaatactgt cttagagacc ttcgaaatcc tctccgacca aaaggtggtg gaccacccgc
      421 tgtgtgtgga ctgtaccgac catcttctga tgcaactaga cgaccagctc gctctcctgg
      481 catctgacaa ccagaagtac aaaagtttcc aggacagaga gttgctggtg agtgaggaag
      541 agagggaggc gctacacgcg gagctttgtg ccgaactgtc cagtctggag caggaggaag
      601 caaggctgac ccaggagcta gaggatttag acggccatca tgcaagggta gccgctgaac
      661 tcagagcagc ccaggccgag agcaaggagc tgtataaaca gcatgagcag cacagggtcg
      721 agtactctgt tttcaagatg gaacagctgg agctgatgga ccagctgagc agtgtggaga
      781 accagctgac gtatgccctg agtcagcagt accgcttaag acagaccaat atcttcaacg
      841 ccacatttac catttcagat gagggtccct tgggcgttat caacaatttt aggctgggct
      901 gtctccccgg ggtccgggtg ggctggactg agatcagttc tgcctgggga cagacagtct
      961 tactgctctt cagcttgtcc aagatagctg gactgcaatt ccagagatat caactggttc
     1021 cctttgggga ccattcctat ctcaagtcct tgactggtga tggcgtgctg cccttattct
     1081 ctgatgggag ccacagcgtc ttcttgaata acaagtttga ctgtgggatg aaggccttcc
     1141 tggactgtct tcagcagttt gtggaggaga ttgagaggga tgagagatgc ccctgcctgc
     1201 cctacaggat ccatgtgaag gaagggctga tggaggatgt ctgggacagt ggggagtgct
     1261 gctccatcag gacccatctg aacacggagg aggagtggtc cagggctctg aaattcatgc
     1321 tttcggactt gaagttgatc cttgcttggg cttccttaag gttttccaga gtccagaggc
     1381 cttaagccct tccctggtgc caccactgcc ttagacccct gagtgctgac tgggcttgta
     1441 tgaaccaacc aagaatgagc aaaaattaca ttatttgctc agcatgaccc agatgtcact
     1501 gctgtggtcc ttagaccctc gtctctttcc cttgtagctg tttctcttgt tgttccccta
     1561 cacccaggca ttcaagatga agaggagaag gaattgccag gagaagtggg gctgagacct
     1621 gaacttcctg aagaattctg tggtgacttt actgtttaca gtggaccttt ggagggcagc
     1681 ggtcatgggg tgggaccttt cagggactgc gtttctgttg ttgtatagta taagcctttc
     1741 cttttcatct ctaagatgat tttaataaat gtcatgttct taaatgact
//
