LOCUS       NM_019584               2072 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus beclin 1, autophagy related (Becn1), transcript
            variant 1, mRNA.
ACCESSION   NM_019584 XM_905914
VERSION     NM_019584.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2072)
  AUTHORS   Wei,W., Gao,X., Qian,J., Li,L., Zhao,C., Xu,L., Zhu,Y., Liu,Z.,
            Liu,N., Wang,X., Jin,Z., Liu,B., Xu,L., Dong,J., Zhang,S., Wang,J.,
            Zhang,Y., Yu,Y., Yan,Z., Yang,Y., Lu,J., Fang,Y., Yuan,N. and
            Wang,J.
  TITLE     Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal
            hematopoiesis and survival
  JOURNAL   J Clin Invest 135 (3), e177375 (2025)
   PUBMED   39589832
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2072)
  AUTHORS   Garcia-Navarrete,C., Kretschmar,C., Toledo,J., Gutierrez,K.,
            Hernandez-Caceres,M.P., Budini,M., Parra,V., Burgos,P.V.,
            Lavandero,S., Morselli,E., Pena-Oyarzun,D. and Criollo,A.
  TITLE     PKD2 regulates autophagy and forms a protein complex with BECN1 at
            the primary cilium of hypothalamic neuronal cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167256 (2024)
   PUBMED   38782303
  REMARK    GeneRIF: PKD2 regulates autophagy and forms a protein complex with
            BECN1 at the primary cilium of hypothalamic neuronal cells.
REFERENCE   3  (bases 1 to 2072)
  AUTHORS   Dellorusso,P.V., Proven,M.A., Calero-Nieto,F.J., Wang,X.,
            Mitchell,C.A., Hartmann,F., Amouzgar,M., Favaro,P., DeVilbiss,A.,
            Swann,J.W., Ho,T.T., Zhao,Z., Bendall,S.C., Morrison,S.,
            Gottgens,B. and Passegue,E.
  TITLE     Autophagy counters inflammation-driven glycolytic impairment in
            aging hematopoietic stem cells
  JOURNAL   Cell Stem Cell 31 (7), 1020-1037 (2024)
   PUBMED   38754428
REFERENCE   4  (bases 1 to 2072)
  AUTHORS   Nakamura,Y., Sawai,T., Kakiuchi,K. and Arawaka,S.
  TITLE     Neuronal activity promotes secretory autophagy for the
            extracellular release of alpha-synuclein
  JOURNAL   J Biol Chem 300 (7), 107419 (2024)
   PUBMED   38815862
REFERENCE   5  (bases 1 to 2072)
  AUTHORS   Tam,T.H., Zhang,W., Tu,Y., Hicks,J.L., Farcas,S., Kim,D. and
            Salter,M.W.
  TITLE     Pain hypersensitivity is dependent on autophagy protein Beclin 1 in
            males but not females
  JOURNAL   Cell Rep 43 (6), 114293 (2024)
   PUBMED   38814784
  REMARK    GeneRIF: Pain hypersensitivity is dependent on autophagy protein
            Beclin 1 in males but not females.
REFERENCE   6  (bases 1 to 2072)
  AUTHORS   Yue,Z., Jin,S., Yang,C., Levine,A.J. and Heintz,N.
  TITLE     Beclin 1, an autophagy gene essential for early embryonic
            development, is a haploinsufficient tumor suppressor
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15077-15082 (2003)
   PUBMED   14657337
  REMARK    GeneRIF: beclin 1 is a critical component of mammalian autophagy,
            which has a role in tumor suppression
REFERENCE   7  (bases 1 to 2072)
  AUTHORS   Qu,X., Yu,J., Bhagat,G., Furuya,N., Hibshoosh,H., Troxel,A.,
            Rosen,J., Eskelinen,E.L., Mizushima,N., Ohsumi,Y., Cattoretti,G.
            and Levine,B.
  TITLE     Promotion of tumorigenesis by heterozygous disruption of the beclin
            1 autophagy gene
  JOURNAL   J Clin Invest 112 (12), 1809-1820 (2003)
   PUBMED   14638851
  REMARK    GeneRIF: beclin 1 is an autophagy gene that may contribute to the
            pathogenesis of cancers
REFERENCE   8  (bases 1 to 2072)
  AUTHORS   Yue,Z., Horton,A., Bravin,M., DeJager,P.L., Selimi,F. and Heintz,N.
  TITLE     A novel protein complex linking the delta 2 glutamate receptor and
            autophagy: implications for neurodegeneration in lurcher mice
  JOURNAL   Neuron 35 (5), 921-933 (2002)
   PUBMED   12372286
REFERENCE   9  (bases 1 to 2072)
  AUTHORS   Liang,X.H., Kleeman,L.K., Jiang,H.H., Gordon,G., Goldman,J.E.,
            Berry,G., Herman,B. and Levine,B.
  TITLE     Protection against fatal Sindbis virus encephalitis by beclin, a
            novel Bcl-2-interacting protein
  JOURNAL   J Virol 72 (11), 8586-8596 (1998)
   PUBMED   9765397
REFERENCE   10 (bases 1 to 2072)
  AUTHORS   Schito,M.L., Chobotar,B. and Barta,J.R.
  TITLE     Major histocompatibility complex class I- and II-deficient
            knock-out mice are resistant to primary but susceptible to
            secondary Eimeria papillata infections
  JOURNAL   Parasitol Res 84 (5), 394-398 (1998)
   PUBMED   9610637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077392.1, AK032176.1 and CB723507.1.
            
            On Jan 18, 2018 this sequence version replaced NM_019584.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK077392.1         2-20
            20-2057             AK032176.1         2-2039
            2058-2072           CB723507.1         670-684
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.58 cM"
     gene            1..2072
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /note="beclin 1, autophagy related"
                     /db_xref="GeneID:56208"
                     /db_xref="MGI:MGI:1891828"
     exon            1..155
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            156..284
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1504
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Bcl-2-interacting protein beclin; coiled-coil, myosin-like
                     BCL2-interacting protein; Beclin-1"
                     /codon_start=1
                     /product="beclin-1 isoform 1"
                     /protein_id="NP_062530.2"
                     /db_xref="CCDS:CCDS25462.1"
                     /db_xref="GeneID:56208"
                     /db_xref="MGI:MGI:1891828"
                     /translation="MEGSKASSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAP
                     LLTTAQAKPGETQEEEANSGEEPFIETRQDGVSRRFIPPARMMSTESANSFTLIGEAS
                     DGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNY
                     KRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAE
                     RLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNVFNATFHIWH
                     SGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNH
                     SYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPY
                     RMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK"
     exon            285..352
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            353..411
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            412..502
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            503..639
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            640..834
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            835..981
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1131
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1192
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1335
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..2059
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /note="hexamer: AATAAA"
     polyA_site      2055
                     /gene="Becn1"
                     /gene_synonym="Atg6"
                     /note="major polyA site"
ORIGIN      
        1 acttctggtc ctgggcggaa gtcttcagct agccgaccgg gaagtagctg aagaccgggc
       61 gatgggaact ctggaggtct cgctccgggg cggacccgag gccaccgtgc ccccgcggta
      121 gaacgagcct gggtggcggg ctccgggctc ctgaggcatg gaggggtcta aggcgtccag
      181 cagcaccatg caggtgagct tcgtgtgcca gcgctgtagc cagcctctga aactggacac
      241 gagcttcaag atcctggacc gggtcaccat ccaggaactc acagctccat tacttaccac
      301 agcccaggcg aaaccaggag agacccagga ggaagaggct aactcaggag aggagccatt
      361 tattgaaact cgccaggatg gtgtctctcg aagattcatc cccccagcca ggatgatgtc
      421 tacagaaagt gctaatagct tcactctgat cggggaggca tctgatggtg gcaccatgga
      481 gaacctcagc cggagactca aggtcactgg agacctgttt gacatcatgt cgggccagac
      541 cgatgtggat cacccgctgt gtgaggaatg cacagacact cttttagacc agctggacac
      601 tcagctcaat gtcactgaga atgaatgtca gaactacaaa cgctgtttgg agatcctaga
      661 gcagatgaat gaggatgaca gtgagcagct gcagagggag ctgaaggagc tggccttgga
      721 ggaggagagg ctgatccagg agctggaaga tgtggaaaag aaccgcaagg tggtggcaga
      781 gaacctggag aaggtccagg ctgaggcgga gagattggac caggaggaag ctcagtacca
      841 gcgggagtat agtgagttta aaaggcagca gctggagttg gatgacgaac tcaagagtgt
      901 ggagaaccag gtgcgctacg cccagatcca gctggacaag ctcaagaaaa ccaatgtctt
      961 caatgccacc ttccacatct ggcacagcgg acagtttggc acaatcaata atttcagact
     1021 gggtcgcttg cccagtgttc ctgtggagtg gaatgaaatc aatgctgcct ggggccagac
     1081 agtgctgctg ctccatgctt tggccaataa gatgggtctg aagtttcaga ggtaccgact
     1141 tgttccctat ggaaatcatt cctatctgga gtctctgaca gacaaatcta aggagttgcc
     1201 gttatactgt tctgggggtt tgcggttttt ctgggacaac aagtttgacc atgcaatggt
     1261 agcttttctg gactgtgtgc agcagttcaa agaagaggtg gaaaaaggag agactcgatt
     1321 ttgtcttccg tacaggatgg acgtggagaa aggcaagatt gaagacactg gaggcagtgg
     1381 cggctcctat tccatcaaaa cccagtttaa ctcggaggag cagtggacaa aagcgctcaa
     1441 gttcatgctg accaatctca agtggggtct tgcctgggtg tcctcacagt tctataacaa
     1501 gtgacttgct ccttagggga tgtttgcctt taaggtttta tactttgttt ggtttggaaa
     1561 gatgctttaa attaaatttg ggtaatatta aaccacatgt ttacaatacc aaaatccaca
     1621 aaagctactt tattttcaaa tatgacagat agtttccaga gtacgccatg tatagcaaag
     1681 aaccctgcca tagttttgac tcagccccat gcatcctttc cctctttcct gaaaacaact
     1741 aatttaaatt tgctttgttt tcttttttaa gttgaattga cgttaatgtg ttttcactgg
     1801 attttatctc tctcaacttc ctgcacttaa aatttgaaac agcaaaggtt tgagatgaga
     1861 tgcttgtggc acacagttgg gtgatgtggg gaaaggacac cgggtcagga gttgcaagtt
     1921 taactccgtc ctcacttgta gcattgaatg cctcctgtgc tgtctagtgg gactacagaa
     1981 tgctgtttga tactgtgtgc gacgtggaga gatttaatta tttgtaataa aggatttgct
     2041 atggtctatt aattaccaaa aaaaaaaaaa aa
//
