LOCUS       NM_009747               1680 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus bradykinin receptor, beta 2 (Bdkrb2), mRNA.
ACCESSION   NM_009747
VERSION     NM_009747.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1680)
  AUTHORS   Franco,T.M., Tavares,M.R., Novaes,L.S., Munhoz,C.D.,
            Peixoto-Santos,J.E., Araujo,R.C., Donato,J. Jr., Bader,M. and
            Wasinski,F.
  TITLE     Effects of Bradykinin B2 Receptor Ablation from Tyrosine
            Hydroxylase Cells on Behavioral and Motor Aspects in Male and
            Female Mice
  JOURNAL   Int J Mol Sci 25 (3), 1490 (2024)
   PUBMED   38338764
  REMARK    GeneRIF: Effects of Bradykinin B2 Receptor Ablation from Tyrosine
            Hydroxylase Cells on Behavioral and Motor Aspects in Male and
            Female Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1680)
  AUTHORS   Martins,L., Amorim,W.W., Gregnani,M.F., de Carvalho Araujo,R.,
            Qadri,F., Bader,M. and Pesquero,J.B.
  TITLE     Kinin receptors regulate skeletal muscle regeneration: differential
            effects for B1 and B2 receptors
  JOURNAL   Inflamm Res 72 (8), 1583-1601 (2023)
   PUBMED   37464053
  REMARK    GeneRIF: Kinin receptors regulate skeletal muscle regeneration:
            differential effects for B1 and B2 receptors.
REFERENCE   3  (bases 1 to 1680)
  AUTHORS   Qin,K., Xin,S., Li,G., Zhou,K., Pan,R., Chen,S., Tao,T., Li,C.,
            Tao,J., Han,R.P.S. and Tu,Y.
  TITLE     In vivo near-infrared fluorescence and SPECT-CT imaging of
            colorectal Cancer using the bradykinin B2R-specific ligand
            icatibant
  JOURNAL   J Photochem Photobiol B 239, 112648 (2023)
   PUBMED   36641883
  REMARK    GeneRIF: In vivo near-infrared fluorescence and SPECT-CT imaging of
            colorectal Cancer using the bradykinin B2R-specific ligand
            icatibant.
REFERENCE   4  (bases 1 to 1680)
  AUTHORS   Goncalves,E.C.D., Vieira,G., Goncalves,T.R., Simoes,R.R.,
            Brusco,I., Oliveira,S.M., Calixto,J.B., Cola,M., Santos,A.R.S. and
            Dutra,R.C.
  TITLE     Bradykinin Receptors Play a Critical Role in the Chronic
            Post-ischaemia Pain Model
  JOURNAL   Cell Mol Neurobiol 41 (1), 63-78 (2021)
   PUBMED   32222846
  REMARK    GeneRIF: Bradykinin Receptors Play a Critical Role in the Chronic
            Post-ischaemia Pain Model.
REFERENCE   5  (bases 1 to 1680)
  AUTHORS   Minville,V., Mouledous,L., Jaafar,A., Couture,R., Brouchet,A.,
            Frances,B., Tack,I. and Girolami,J.P.
  TITLE     Tibial post fracture pain is reduced in kinin receptors deficient
            mice and blunted by kinin receptor antagonists
  JOURNAL   J Transl Med 17 (1), 346 (2019)
   PUBMED   31640792
  REMARK    GeneRIF: Tibial post fracture pain is reduced in kinin receptors
            deficient mice and blunted by kinin receptor antagonists.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1680)
  AUTHORS   Borkowski,J.A., Ransom,R.W., Seabrook,G.R., Trumbauer,M., Chen,H.,
            Hill,R.G., Strader,C.D. and Hess,J.F.
  TITLE     Targeted disruption of a B2 bradykinin receptor gene in mice
            eliminates bradykinin action in smooth muscle and neurons
  JOURNAL   J Biol Chem 270 (23), 13706-13710 (1995)
   PUBMED   7775424
REFERENCE   7  (bases 1 to 1680)
  AUTHORS   Taketo,M., Yokoyama,S., Rochelle,J., Kimura,Y., Higashida,H.,
            Taketo,M. and Seldin,M.F.
  TITLE     Mouse B2 bradykinin receptor gene maps to distal chromosome 12
  JOURNAL   Genomics 27 (1), 222-223 (1995)
   PUBMED   7665180
REFERENCE   8  (bases 1 to 1680)
  AUTHORS   Kiehne,K. and Rozengurt,E.
  TITLE     Down-regulation of bradykinin receptors and bradykinin-induced Ca2+
            mobilization, tyrosine phosphorylation, and DNA synthesis by
            autocrine factors, tumor necrosis factor alpha, and interferon beta
            in Swiss 3T3 cells
  JOURNAL   J Cell Physiol 162 (3), 367-377 (1995)
   PUBMED   7532178
REFERENCE   9  (bases 1 to 1680)
  AUTHORS   Ma,J.X., Wang,D.Z., Chao,L. and Chao,J.
  TITLE     Cloning, sequence analysis and expression of the gene encoding the
            mouse bradykinin B2 receptor
  JOURNAL   Gene 149 (2), 283-288 (1994)
   PUBMED   7959003
REFERENCE   10 (bases 1 to 1680)
  AUTHORS   Hess,J.F., Borkowski,J.A., Stonesifer,G.Y., MacNeil,T.,
            Strader,C.D. and Ransom,R.W.
  TITLE     Cloning and pharmacological characterization of bradykinin
            receptors
  JOURNAL   Braz J Med Biol Res 27 (8), 1725-1731 (1994)
   PUBMED   7749364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068459.9.
            
            On Jun 10, 2003 this sequence version replaced NM_009747.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X78438.1, X69682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC068459.9         102883-102959
            78-181              AC068459.9         127908-128011
            182-1680            AC068459.9         131284-132782
FEATURES             Location/Qualifiers
     source          1..1680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.76 cM"
     gene            1..1680
                     /gene="Bdkrb2"
                     /gene_synonym="B(2); B2; B2R; BK-2; BK2; BK2R; BKR2; BRB2"
                     /note="bradykinin receptor, beta 2"
                     /db_xref="GeneID:12062"
                     /db_xref="MGI:MGI:102845"
     exon            1..77
                     /gene="Bdkrb2"
                     /gene_synonym="B(2); B2; B2R; BK-2; BK2; BK2R; BKR2; BRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            78..181
                     /gene="Bdkrb2"
                     /gene_synonym="B(2); B2; B2R; BK-2; BK2; BK2R; BKR2; BRB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1289
                     /gene="Bdkrb2"
                     /gene_synonym="B(2); B2; B2R; BK-2; BK2; BK2R; BKR2; BRB2"
                     /note="BK-2 receptor; kinin B2"
                     /codon_start=1
                     /product="B2 bradykinin receptor"
                     /protein_id="NP_033877.3"
                     /db_xref="CCDS:CCDS49160.1"
                     /db_xref="GeneID:12062"
                     /db_xref="MGI:MGI:102845"
                     /translation="MPCSWKLLGFLSVHEPMPTAASFGIEMFNVTTQVLGSALNGTLS
                     KDNCPDTEWWSWLNAIQAPFLWVLFLLAALENLFVLSVFFLHKNSCTVAEIYLGNLAA
                     ADLILACGLPFWAITIANNFDWVFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLAL
                     VKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMREYSEEGHNVTACVIVYPS
                     RSWEVFTNVLLNLVGFLLPLSVITFCTVRILQVLRNNEMKKFKEVQTERKATVLVLAV
                     LGLFVLCWVPFQISTFLDTLLRLGVLSGCWDEHAVDVITQISSYVAYSNSGLNPLVYV
                     IVGKRFRKKSREVYRVLCQKGGCMGEPVQMENSMGTLRTSISVERQIHKLQDWAGKKQ
                     "
     exon            182..1680
                     /gene="Bdkrb2"
                     /gene_synonym="B(2); B2; B2R; BK-2; BK2; BK2R; BKR2; BRB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaaggcgt gtcaggcagc cgctgaacct ggaccgaggg actccctaca acacagaacc
       61 ggctcgcttg agaaaaggag gatcctcact cctctttgtc cggcgtccaa atgccctgct
      121 cctggaagct actcgggttt ctgtcggtgc atgagcccat gcccaccgcg gcctcctttg
      181 gcatcgaaat gttcaacgtc accacacaag tcctcgggtc tgctcttaac gggacccttt
      241 cgaaggacaa ctgcccagac accgagtggt ggagttggct caatgccatc caggccccct
      301 tcctctgggt cctcttcctg ctggccgcac tggagaacct ctttgtcctc agcgtgttct
      361 tcctgcacaa aaacagctgc actgtggccg agatctacct gggcaacctg gcagcggcgg
      421 acctcatcct ggcctgcggg ttacctttct gggccatcac catcgccaat aactttgact
      481 gggtgtttgg agaggtgttg tgccgggtgg tgaacaccat gatctacatg aacctgtaca
      541 gcagcatctg cttcctgatg ctcgtgagta tcgaccgcta cctggcgctg gtgaagacca
      601 tgtccatggg ccggatgcgc ggggtgcgct gggccaaact ctacagcctg gtgatctggg
      661 gctgtacact gcttctgagt tcacccatgt tggtgttcag gaccatgagg gaatacagcg
      721 aagagggcca caatgtcacc gcctgcgtca tcgtctaccc gtcccgttcc tgggaggtgt
      781 tcaccaacgt gctgctgaac ctggtgggtt tcctcctgcc cctgagcgtc atcaccttct
      841 gcacggtgcg catcttgcag gtgctgagga acaacgagat gaagaagttc aaggaggtcc
      901 agacggagag gaaggccacc gtgctagtgc tggccgtcct ggggctcttt gtgctgtgtt
      961 gggtgccttt ccagatcagc accttcctgg acacgctgct gcgcctcggc gtgctgtccg
     1021 gatgctggga cgagcacgcc gtagacgtca tcacgcagat cagttcctac gtggcctaca
     1081 gcaacagcgg cctcaaccca ctggtgtacg tgatcgtggg caagcgcttc cggaagaagt
     1141 cccgagaggt gtaccgggtg ctgtgccaga aaggaggctg catgggagaa cccgtccaga
     1201 tggagaactc catggggact ttgagaacct cgatctccgt ggaacggcag atccacaagc
     1261 tgcaggactg ggcagggaag aaacagtgaa cagaagccac caggcaggac tactgccaag
     1321 tgtgtgagga ttggtgggac cggagctcct cagcctgggt tcaggaagga gcttgaagca
     1381 tcctaggcag ccccagggaa tcaggcaggt gactccagcc ctgtctcatg gcataagcat
     1441 gctgtgggga atgggtaccc tggggcacag cagggtcatt cttactgact gacgctctaa
     1501 ttctccatga gtggaggggt catgggtatg ggtgggagtg acagagcttc cttccctttt
     1561 ggggaaggac agatctcctg ccagctttgg ccctgtggct acatgcacag taggcatggc
     1621 cgcctcattt cccagtttca agggtataag atttattggt cttctgaagg ttaaattcta
//
